Clinical trials: Negative Symptoms With Primary Psychotic Disorder
Negative Symptoms With Primary Psychotic Disorder, Schizophrenia
rTMS Add on Value for Amelioration of Negative Symptoms of Schizophrenia
Treatment of depression with repetitive transcranial magnetic stimulation (rTMS) has shown high evidence using high-frequency left dorsolateral prefrontal cortex (DLPFC) stimulation.
- Trial name
- RADOVAN (NCT04318977)
- Testing
- high-frequency rTMS, TBS
- Where
- 4 sites in Czechia, Germany
- Volunteers
- 62 people
- Sponsor
- University of Regensburg
Psychosis, Negative Symptoms With Primary Psychotic Disorder
Add-on MEmaNtine to Dopamine Modulation to Improve Negative Symptoms at First Psychosis
Antipsychotics affects the brain's dopamine system, and the drugs reduce delusions, hallucinations, and disorganized thinking, which are cardinal symptoms of psychotic disorders. However, negative symptoms e.g.
- Trial name
- AMEND (NCT04789915)
- Testing
- Memantine
- Where
- Denmark
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Bjorn H. Ebdrup
Cognitive Impairment With Primary Psychotic Disorder, Negative Symptoms With Primary Psychotic Disorder
Cognitive Effects of Adjuvant Vortioxetine in Early Schizophrenia
Clinical trial to assess the efficacy of Vortioxetine compared with treatment as usual in early schizophrenia.
- Trial name
- CAVES (NCT04895488)
- Testing
- Vortioxetine, Usual Antipsychotic Treatment
- Where
- Spain
- Volunteers
- 37 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Psychosis, Schizophrenia
Goals in Focus: CBT for Motivational Negative Symptoms of Psychosis
This pilot feasibility trial aims to evaluate the "Goals in Focus" intervention for motivational negative symptoms in people with psychosis.
- Conditions
- Psychosis, Schizophrenia, Negative Symptoms With Primary Psychotic Disorder
- Trial name
- GIF (NCT05252039)
- Testing
- Goals in Focus
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University of Hamburg-Eppendorf
Schizophrenia
Modafinil Augmentation Therapy for Excessive Daytime Sleepiness and Negative Symptoms in Patients With Schizophrenia
The purpose of this study is to test the effect of modafinil on the negative symptoms, such as blunted affect and social withdrawal, of schizophrenic patients and to determine modafinil's effect on excessive daytime sleepiness.
- Trial name
- NCT00546403
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Veterans Medical Research Foundation
Schizophrenia, Depression
Validating Reward-related Biomarkers (RTOC)
Deficits or abnormalities in reward processing are present in a number of psychiatric disorders. The overarching objective of the study is to conduct initial validation work towards optimising three experimental tasks - which…
- Conditions
- Schizophrenia, Depression, Motivation, Anhedonia, Physical
- Trial name
- RTOC (NCT04024371)
- Testing
- Self-rating Questionnaires, Measures of Reward processing/reinforcement learning, Additional Schizophrenia-specific Questionnaires and Interviews
- Where
- 4 sites in Germany, Greece and 2 more
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Maastricht University