Clinical trials: Neglected Diseases
Trypanosomiasis, African, Sleeping Sickness
Fexinidazole in Human African Trypanosomiasis Due to T. b. Rhodesiense
The ultimate goal of this study is to show that fexinidazole offers an alternative over the existing treatments of Human African trypanosomiasis due to Trypanosoma brucei rhodesiense (r-HAT): melarsoprol in patients with stage 2…
- Conditions
- Trypanosomiasis, African, Sleeping Sickness, Trypanosoma Brucei Rhodesiense; Infection
- Trial name
- NCT03974178
- Testing
- Fexinidazole
- Where
- 2 sites in Malawi, Uganda
- Volunteers
- 45 people
- Sponsor
- Drugs for Neglected Diseases
Stroke, Neurologic Disorder
Evaluation of Bioness Integrated Therapy System (BITS) Touch Screen Technology to Improve Field Awareness
The Bioness Integrated Therapy System (BITS) (Bioness Inc. Valencia, CA) Touch Screen is an FDA approved device comprised of an interactive touchscreen and diverse program options to challenge patients through the use of visual…
- Conditions
- Stroke, Neurologic Disorder, Traumatic Brain Injury, Acquired Brain Injury
- Trial name
- NCT04930822
- Testing
- Table Top Visual Intervention, Bioness Integrated Therapy System Visual Intervention
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Gaylord Hospital, Inc
Substance Use
Brief Intervention in At-Risk First-time Mothers
Preliminary controlled trial of a brief intervention designed to reduce child maltreatment risk among low-income pregnant mothers.
- Trial name
- NCT00230009
- Testing
- Brief motivational intervention
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Stroke, Hemispatial Neglect
Guanfacine for the Treatment of Spatial Neglect and Impaired Vigilance
To find out if spatial neglect following stroke and brain injury can be reduced using guanfacine, a drug that was shown to improve neglect in two stroke patients in a previous pilot study (Malhotra et al, 2006).
- Trial name
- GASNIV (NCT00955253)
- Testing
- Guanfacine
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- Imperial College London
Aphasia, Spatial Neglect
Prism Adaptation in Left Brain Stroke
Of the 15,000 Veterans who are hospitalized for stroke each year more than half experience spatial and motor impairments and pain.
- Conditions
- Aphasia, Spatial Neglect, Stroke
- Trial name
- NCT04387162
- Testing
- Prism Adaptation Treatment
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- VA Office of Research and Development
Hemispatial Neglect
Effectiveness of Mirror Therapy in Stroke Patients With Unilateral Neglect - A Randomized Controlled Trial
Hemi spatial neglect, or the tendency to ignore stimuli originating in a portion of the environment contra lateral to a cerebral lesion, can be a major source of functional handicap after stroke.
- Trial name
- MUST (NCT01735877)
- Testing
- Mirror therapy, Control group
- Where
- India
- Volunteers
- 48 people
- Sponsor
- Christian Medical College and Hospital, Ludhiana, India
Spatial Neglect, Dysphagia
Identifying and Treating Arousal Related Deficits in Neglect and Dysphagia
The purpose of this study is to examine how stroke can alter arousal, alertness, neglect and dysphagia, and whether a medication, modafinil, can improve arousal.
- Trial name
- NCT01085903
- Testing
- Modafinil, Baseline, CPS
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- University of Arkansas
Hookworm Infection, Hookworm Disease
Safety and Immunogenicity Study of Na-GST-1 With or Without CpG
Na-GST-1 is a protein expressed during the adult stage of the hookworm life cycle that is thought to play a role in the parasite's degradation of host hemoglobin for use as an energy source.
- Trial name
- NCT02143518
- Testing
- Na-GST-1/Alhydrogel®, CpG 10104
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Stroke
Feasibility of Measuring Vertical Perception in Acute Stroke
The goal of this observational study is to establish if it is feasible to identify vertical perception deficits in people with acute stroke.
- Trial name
- NCT06301815
- Testing
- Scale for Contraversive Pushing, Catherine Bergego Scale, Bucket Test
- Where
- United Kingdom
- Volunteers
- 53 people
- Sponsor
- University of Winchester
Healthy Volunteers
First in Man Clinical Trial of Emodepside (BAY 44-4400)
This study will investigate the safety, tolerability, and pharmacokinetics of single ascending doses of emodepside (BAY 44-4400) in healthy male volunteers.
- Trial name
- NCT02661178
- Testing
- emodepside (BAY 44-4400)
- Where
- United Kingdom
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Drugs for Neglected Diseases