Clinical trials: Neoadjuvant Chemotherapy
Assess the Variation of Apparent Diffusion Coefficient
Contribution of MRI in the Evaluation of Apparent Diffusion Coefficient and Prediction of Response to Neoadjuvant Chemotherapy in Breast Cancer
The main objective of the study is to assess the sensitivity and the specificity of the variation of apparent diffusion coefficient for prediction, after a course of neoadjuvant chemotherapy or after modification of the treatment…
- Trial name
- ADC (NCT01956513)
- Testing
- MRI (Magnetic resonance imaging)
- Sponsor
- Centre Jean Perrin
Locally Advanced Colon Cancer, pMMR
Chemotherapy Combined With or Without Short-Course Radiotherapy Versus Chemotherapy Alone as Neoadjuvant Therapy for High-Risk Locally Advanced Colon Cancer With pMMR/MSS
Locally advanced colon cancer, particularly T4 disease or colon cancer with bulky nodes, carries a poor prognosis and limited efficacy with neoadjuvant chemotherapy.
- Trial name
- TORCH-C2 (NCT07877597)
- Testing
- short-course radiotherapy, Serplulimab, CapOx(Capecitabine+ Oxaliplatin)
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Fudan University
Ovarian Cancer, Fallopian Tube Cancer
HIPEC After Initial CRS in Patients Who Have Received NACT
The majority of women diagnosed with ovarian, fallopian tube and primary peritoneal cancer present with advanced stage III and IV disease.
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Carcinoma
- Trial name
- NCT03540017
- Testing
- Cisplatin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Northwell Health
Stage IIA-IIIB NSCLC, Selective Mediastinal Lymph Node Sampling
Selective Mediastinal Lymph Node Sampling Versus Systematic medIastinal Lymph Node Dissection After Neoadjuvant Chemoimmunotherapy for Non-small Cell Lung Cancer (SCIENCE Study)
The SCIENCE trial is a multicenter, open-label, randomized, parallel, noninferiority investigator-initiated trial (IIT). This study aims to evaluate the prognostic differences between selective mediastinal lymph node sampling and…
- Conditions
- Stage IIA-IIIB NSCLC, Selective Mediastinal Lymph Node Sampling, Systematic medIastinal Lymph Node Dissection
- Trial name
- NCT07617389
- Testing
- selective mediastinal lymph node sampling, systematic mediastinal lymph node dissection
- Where
- China
- Volunteers
- 358 people
- Sponsor
- Wen-zhao ZHONG
Triple Negative Breast Cancer
A Study of Camrelizumab Plus Chemotherapy vs Placebo Plus Chemotherapy as Neoadjuvant Therapy in Participants With Triple Negative Breast Cancer (TNBC)
The purpose of this study is to evaluate the efficacy and safety of camrelizumab (an engineered anti-programmed death-ligand 1 [PD-1] antibody) plus chemotherapy vs placebo plus chemotherapy as neoadjuvant therapy in participants…
- Trial name
- NCT04613674
- Testing
- Camrelizumab Plus Chemotherapy
- Where
- China
- Volunteers
- 441 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Stage III Non-small-cell Lung Cancer
Study of Nivolumab for Non-Small Cell Lung Cancer (Stage III) Following Neoadjuvant Chemotherapy Plus Nivolumab and Definitive Concurrent Chemoradiation Therapy
The phase II, randomised Study is to explore the efficacy and safety of nivolumab as consolidation therapy in patients with locally advanced, unresectable non-small cell lung cancer (stage III) who have not progressed following…
- Trial name
- NCT04085250
- Testing
- Neoadjuvant therapy, Chemotherapy concurrent with radiotherapy, Radiotherapy
- Where
- 3 sites in China
- Volunteers
- 264 people
- Sponsor
- Sun Yat-sen University
Rectal Cancer Dukes B, Dukes C
Randomized Study on Neoadjuvant Radio-Chemotherapy in Rectal Carcinoma Dukes B and C
This clinical investigation examined the influence of preoperative radiotherapy in combination with postoperative 5-fluorouracil + leucovorin chemotherapy vs.
- Trial name
- NCT00309517
- Testing
- Fluourouracil, Leucovorin, MAb 17-1A
- Where
- 8 sites in Austria
- Volunteers
- 700 people
- Sponsor
- Austrian Breast & Colorectal Cancer Study Group
Cervical Cancer Stage IVA, Cervical Cancer Metastatic
a Single Arm, Phase II Multicenter Clinical Trial to Evaluate the Efficacy and Safety of the Combination Therapy of Iparomlimab and Tuvonralima b and Chemotherapy ± Bevacizumab Induction Therapy Followed by Concurrent Chemoradiotherapy in Patients With Advanced Cervical Cancer .
This study is a single arm, phase II multicenter clinical trial to evaluate the efficacy and safety of the combination therapy of Iparomlimab and Tuvonralimab(QL1706) and chemotherapy ± bevacizumab induction therapy followed by…
- Trial name
- NCT07035808
- Testing
- 2 cycles of combined drug induction therapy: every 3 weeks for 2 cycles; After ,synchronous radiotherapy and chemotherapy combined immunotherapy
- Volunteers
- 46 people
- Sponsor
- Zhejiang Cancer Hospital
Non-small Cell Lung Cancer
Neoadjuvant Immunotherapy With Chemotherapy for Stage I-IIIB Non-Small Cell Lung Cancer Patients
A phase II, single-arm, open-label study that assesses feasibility, safety and efficacy of combined neoadjuvant chemotherapy and immunotherapy with PD-(L)1 inhibitor in stage I-IIIB NSCLC adult patients followed by adjuvant…
- Trial name
- NCT04941417
- Testing
- PD-1 inhibitor
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College
Breast Cancer
Magnetic Resonance Imaging in Women Receiving Chemotherapy for Stage III Breast Cancer
RATIONALE: Diagnostic procedures such as magnetic resonance imaging (MRI) may help determine the effectiveness of chemotherapy in killing breast cancer and allow doctors to plan more effective treatment.
- Trial name
- ACRIN 6657 (NCT00043017)
- Testing
- MRI/MRS, gadopentetate dimeglumine
- Where
- 11 sites in United States
- Volunteers
- 356 people
- Sponsor
- American College of Radiology Imaging Network
Primary Breast Cancer
mULM to Support Breast Cancer Diagnosis and Therapy
The goal of this project is to adapt the super-resolution ultrasound imaging technology motion-model Ultrasound Localization Microscopy (mULM) to clinical application.
- Trial name
- NCT05445050
- Testing
- Application and measurement of tumor vascularization using diagnostic contrast enhanced ultrasound (CEUS)
- Where
- Germany
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Rectal Cancer
Consolidation Chemotherapy for Locally Advanced Mid or Low Rectal Cancer After Neoadjuvant Concurrent Chemoradiotherapy
This trial is to assess the efficacy and feasibility of consolidation chemotherapy after neoadjuvant chemoradiotherapy for locally advanced mid or low rectal cancer.
- Trial name
- NCT02843191
- Testing
- Chemotherapy
- Where
- 14 sites in South Korea
- Volunteers
- 358 people
- Sponsor
- Kyung Hee University Hospital at Gangdong
Breast Cancer, Invasive Breast Cancer
A Study of an Alternative Treatment Approach (Preoperative Radiotherapy, Then Mastectomy, Then Immediate Reconstruction Surgery) in People With T4 Breast Cancer
The purpose of this study to test an alternative treatment approach that involves giving participants radiotherapy before their mastectomy (preoperative radiotherapy) and performing immediate reconstruction surgery at the time of…
- Trial name
- NCT05412225
- Testing
- Pre-neoadjuvant radiotherapy (NART) biopsy, Neoadjuvant radiotherapy, Unilateral total mastectomy with axillary lymph node dissection
- Where
- 7 sites in United States
- Volunteers
- 60 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer, Aging
The Impact of a Physical Activity Program on Biomarkers of Aging During Chemotherapy for Breast Cancer
This study will look at whether or not participating in a physical activity intervention during chemotherapy for breast cancer can prevent a marker of aging called p16 from having a large increase after chemotherapy.
- Trial name
- NCT02167932
- Testing
- Walk With Ease
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Rectal Cancer
Short-course Radiation (SCRT) Followed by 6 Cycles of Cadonilimab Plus MFOLFOX6 As Neoadjuvant Therapy for Patients with Locally Advanced Rectal Cancer (LARC): a Multicenter, Two-arm Parallel, Open-label, Randomised Phase III Trial (NeoCaCRT-III)
The goal of this clinical trial is to learn if neoadjuvant short-course radiation (SCRT) followed by 6 cycles of cadonilimab plus mFOLFOX6 works to treat patients with locally advanced rectal cancer (LARC).
- Trial name
- NeoCaCRT-III (NCT06832917)
- Testing
- AK104 plus, Chemo only
- Volunteers
- 238 people
- Sponsor
- Wan He
Breast Cancer
Study to Assess Effectiveness of Giving Combination of Standard Chemotherapy Drugs Versus Combination of Standard Chemotherapy and New Drug Ixabepilone When Given Before Surgical Removal of Early Stage Breast Cancer
The study will evaluate the effectiveness of ixabepilone when given after doxorubicin plus cyclophosphamide (AC) compared to standard treatment of paclitaxel given after doxorubicin plus cyclophosphamide in patients with early…
- Trial name
- NCT00455533
- Testing
- Ixabepilone, Paclitaxel, Cyclophosphamide
- Where
- 49 sites in United States, Argentina and 13 more
- Volunteers
- 384 people
- Sponsor
- Bristol-Myers Squibb
NSCLC, Neoadjuvant Therapy
A Phase II Randomized Trial of Neoadjuvant Ivonescimab or Penpulimab Plus Chemotherapy in Resectable NSCLC
This is a randomized, open-label, multicenter phase II study. The trial plans to enroll 164 subjects with resectable stage IIA-IIIB (N2) NSCLC.
- Conditions
- NSCLC, Neoadjuvant Therapy, Immunotherapy, AK112
- Trial name
- NEOINSPIRE (NCT07086326)
- Testing
- Ivonescimab+Chemo, Penpulimab+Chemo
- Where
- 5 sites in China
- Volunteers
- 164 people
- Sponsor
- Yang Fan, MD
Advanced Gastric Carcinoma
Study on Neoadjuvant Chemotherapy for Advanced Gastric Cancer
Gastric cancer is the second cause of cancer related death and China has the most gastric cancer patients in the world. Although systemic strategies, including adjuvant chemotherapy, postoperative chemoradiotherapy, perioperative…
- Trial name
- NCT02163291
- Testing
- paclitaxel liposome
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University
Breast Neoplasms
Tailoring NEOadjuvant Therapy in Hormone Receptor Positive, HER2 Negative, Luminal Breast Cancer.
The aim of this prospective, randomized, multicenter, open-label, phase II study is to test if chemotherapy can be replaced by the combination of ribociclib plus letrozole as a neo-adjuvant therapy for patients with…
- Trial name
- NEOLBC (NCT03283384)
- Testing
- Letrozole, Chemotherapy, Ribociclib plus letrozole
- Where
- 29 sites in Netherlands
- Volunteers
- 100 people
- Sponsor
- Borstkanker Onderzoek Groep
Stage III Sinonasal Squamous Cell Carcinoma AJCC v6 and v7, Stage IVA Sinonasal Squamous Cell Carcinoma AJCC v7
Chemotherapy Before Surgery and Radiation Therapy or Surgery and Radiation Therapy Alone in Treating Patients With Nasal and Paranasal Sinus Cancer That Can Be Removed by Surgery
This phase II trial studies how well chemotherapy before surgery and radiation therapy works compared to surgery and radiation therapy alone in treating patients with nasal and paranasal sinus cancer that can be removed by…
- Trial name
- NCT03493425
- Testing
- Carboplatin, Cisplatin, Docetaxel
- Where
- 154 sites in United States
- Volunteers
- 82 people
- Sponsor
- ECOG-ACRIN Cancer Research Group