Clinical trials: Neoadjuvant Radiotherapy
Locally Advanced Rectal Cancer
Neoadjuvant Bevacizumab, Capecitabine and Radiation Therapy With or Without Oxaliplatin Locally Advanced Rectal Cancer
Phase II clinical trial, open-label, randomized, two arms, multicentre (possibly multinational). Academic, investigator initiated.
- Trial name
- AXEBEAM (NCT00828672)
- Testing
- Oxaliplatin, Bevacizumab, Capecitabine
- Where
- 9 sites in Belgium
- Volunteers
- 84 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pancreatic Cancer
A Pilot Study to Evaluate the Efficacy and Safety of Neoadjuvant Chemoradiotherapy With Capecitabine, . . .
In this study, a new chemotherapeutic agent, panitumumab, will be tested in combination with another chemotherapeutic drug, capecitabine, along with external radiotherapy, to find out whether this combination is effective and…
- Trial name
- PMABIIS (NCT01130701)
- Testing
- Neoadjuvant capecitabine, panitumumab and radiation
- Where
- United States
- Sponsor
- University of Massachusetts, Worcester
Resectable Stage IIA to IIIB Non-small Cell Lung Cancer
An Open Label, Randomized Study of Neoadjuvant Nivolumab and Chemotherapy, With or Without Sub-ablative Stereotactic Body Radiation Therapy, for Resectable Stage IIA to IIIB Non-small Cell Lung Cancer
An open label, randomized study of neoadjuvant nivolumab and chemotherapy, with or without sub-ablative stereotactic body radiation therapy, for resectable stage IIA to IIIB non-small cell lung cancer
- Trial name
- NCT05500092
- Testing
- Nivolumab, (8gy x 3), Platinum Doublet
- Where
- 4 sites in United States
- Volunteers
- 17 people
- Sponsor
- Montefiore Medical Center
Larynx Cancer, Hypopharyngeal Cancer
Neoadjuvant Chemoimmunotherapy Followed By Radiation Or Organ Preservation Surgery In Laryngeal/Hypopharyngeal Cancer
In the global landscape of cancer, head and neck malignancies are highly prevalent, with 878,000 new cases and 444,000 deaths recorded in 2020.
- Trial name
- NCT06039631
- Testing
- Surgery, Radiation, Toripalimab
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Fudan University
Locally Advanced Esophageal Squamous Cell Carcinoma
Exploring the Safety and Effectiveness of Toripalimab Combined With Neoadjuvant Radiotherapy and Chemotherapy in the Locally Advanced Esophageal Squamous Cell Carcinoma
The purpose of this study is to observe and evaluate the efficacy and safety of Toripalimab Combined With Neoadjuvant Radiotherapy and Chemotherapy in the Locally and Advanced Esophageal Squamous Cell Carcinoma
- Trial name
- NCT04888403
- Testing
- Toripalimab+Nedaplatin+Albumin Paclitaxel
- Where
- China
- Volunteers
- 45 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Breast Cancer
Neoadjuvant Chemotherapy Combined With Preoperative Radiotherapy for Locally Advanced Breast Cancer
Approximately 20% of breast cancer patients in our country are in the locally advanced stage. The relatively low overall survival rate, high recurrence rate and distant metastasis risk of these patients significantly affect the…
- Trial name
- NCT07164872
- Testing
- preoperative radiotherapy
- Volunteers
- 50 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Rectal Neoplasms
SCRT in TNT With or Without Chlorophyllin
The goal of this clinical trial is to see, if addition of chlorophyllin to neoadjuvant Chemo-radiotherapy can reduce the gastro-intestinal/genitourinary/hematological toxicity rates and improve the quality of life in patient's…
- Trial name
- SCOTCH (NCT05856305)
- Testing
- Chlorophyllin, Sodium Copper Complex
- Where
- 2 sites in India
- Volunteers
- 76 people
- Sponsor
- Tata Memorial Centre
Prostate Adenocarcinoma
Neoadjuvant Embolization and Cytoreduction in Prostate Cancer
The goal of this clinical trial is to find out whether prostate artery embolization (PAE) can help prevent or lessen urinary side effects caused by radiotherapy (RT) in people with prostate cancer, especially those who have…
- Trial name
- NCT07251829
- Testing
- Prostatic Artery Embolization
- Volunteers
- 35 people
- Sponsor
- Srinivas Raman
Prostate Cancer
Triptorelin, Flutamide, and External-Beam Radiation Therapy or External-Beam Radiation Therapy Alone in Treating Patients With Stage II or Stage III Prostate Cancer
RATIONALE: Androgens can cause the growth of prostate cancer cells. Drugs, such as triptorelin and flutamide, may stop the adrenal glands from making androgens. Radiation therapy uses high-energy x-rays to kill tumor cells.
- Trial name
- NCT00104741
- Testing
- flutamide, triptorelin, radiation therapy
- Where
- 31 sites in France
- Volunteers
- 378 people
- Sponsor
- UNICANCER
Breast Neoplasms, Radiotherapy; Complications
Efficacy of Preoperative Radiotherapy for Non-responder Patients After Neoadjuvant Chemotherapy
Neoadjuvant chemotherapy (NACT) is widely used for locally advanced breast cancer cases. As the key factor is to achieve pathologic complete response (pCR), several physicians tried administering radiotherapy before surgery to…
- Conditions
- Breast Neoplasms, Radiotherapy; Complications, Survivorship, Breast Cancer
- Trial name
- NCT05274594
- Testing
- Radiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people
- Sponsor
- Istanbul Breast Society
Breast Cancer
A Randomized Controlled Study on the Efficacy and Safety of Neoadjuvant Radiotherapy Combined with Systemic Therapy for Early-stage Breast Cancer
A total of 340 early-stage breast cancer patients with axillary lymph node biopsy-confirmed positivity were enrolled and divided into two groups.
- Trial name
- NCT06769919
- Testing
- Neoadjuvant radiotherapy
- Where
- China
- Volunteers
- 340 people
- Sponsor
- Xijing Hospital
Cancer of the Cervix
Cetuximab, Cisplatin, and Radiotherapy in Women With Locally Advanced Cervical Carcinoma
The anti-tumor activity of cetuximab prior to chemoradiotherapy and the safety and tolerability of cetuximab with concurrent chemoradiation will be determined in women with locally advanced or metastatic cervical carcinoma.
- Trial name
- NCT00292955
- Testing
- Cetuximab
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Virginia
Locally Advanced Rectal Cancer
SMART TNT for the Conservative Management of Locally Advanced Rectal Cancer
The purpose of this research study is to find out how safe and effective is treating patients with locally advanced rectal cancer (LARC) with chemotherapy first and then follow with radiation therapy to a higher dose than what is…
- Trial name
- SMART TNT (NCT05412082)
- Testing
- Intensity-modulated radiation therapy, 5-fluorouracil, Leucovorin
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Miami
Early Stage Non-small Cell Lung Cancer
Predicting Cell Death by Radiation Therapy in Early Stage Non-small Cell Lung Cancer: a Prospective Translational Trial
Surgical resection with mediastinal lymph node sampling is currently the therapy of choice for early stage (I-II) non-small cell lung cancer (NSCLC).
- Trial name
- PEARL-1 (NCT01138722)
- Testing
- hypofractionated radiation therapy followed by surgery
- Where
- 2 sites in Belgium
- Volunteers
- 1 people
- Sponsor
- University Hospital, Ghent
Rectal Cancer
Total Neoadjuvant Therapy With mFOLFOX and Short-course Radiation in Resectable Rectal Cancer
This is phase 2 trial of neoadjuvant therapy and short-course radiotherapy in resectable rectal cancer.
- Trial name
- NCT04643366
- Testing
- Chemotherapy, Radiation Therapy
- Where
- 4 sites in United States
- Volunteers
- 64 people
- Sponsor
- Virginia Commonwealth University
Prostate Cancer
Goserelin, Flutamine, and Radiation Therapy in Treating Patients With Locally Advanced Prostate Cancer
RATIONALE: Patient abstract not available PURPOSE: Patient abstract not available
- Trial name
- NCT00767286
- Testing
- flutamide, goserelin acetate, low-LET cobalt-60 gamma ray therapy
- Sponsor
- Radiation Therapy Oncology Group
Bladder Cancer
Neoadjuvant Chemo (Gemcitabine and Cisplatin) With Radical Cystectomy or Radiotherapy in Patients With Bladder Cancer
The purpose of this study is to evaluate efficacy of gemcitabine and cisplatin combined with either radical cystectomy or radiotherapy in the treatment of bladder cancer.
- Trial name
- NCT00490880
- Testing
- gemcitabine, cisplatin, radical cystectomy
- Where
- Poland
- Volunteers
- 2 people
- Sponsor
- Eli Lilly and Company
Breast Cancer, Sentinel Lymph Node
Axillary Management in Breast Cancer Patients With Needle Biopsy Proven Nodal Metastases After Neoadjuvant Chemotherapy
The aim of this study is to assess whether, omitting further axillary treatment (ALND and ART) for patients with early stage breast cancer and axillary nodal metastases on needle biopsy, who after NACT have no residual cancer in…
- Conditions
- Breast Cancer, Sentinel Lymph Node, Neoplasm, Breast
- Trial name
- ATNEC (NCT04109079)
- Testing
- Axillary lymph node dissection, Axillary radiotherapy, Breast or chest wall radiotherapy
- Where
- 98 sites in Ireland, United Kingdom
- Volunteers
- 1,900 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Sarcoma
Combination Chemotherapy, Surgery, and Radiation Therapy in Treating Children With Advanced Soft Tissue Sarcoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00002804
- Testing
- filgrastim, doxorubicin hydrochloride, ifosfamide
- Where
- 9 sites in United States, Puerto Rico and 1 more
- Volunteers
- 43 people
- Sponsor
- Children's Oncology Group
Nasopharyngeal Carcinoma, Malnutrition
Effect of Chemoradiotherapy on Nutritional Status in Advanced NPC Patients
This is an prospective，open-label, none-interventional, observational， multicenter phase II clinical trial. The purpose of this study is to observe the effect of neoadjuvant chemotherapy followed by concurrent chemoradiation…
- Trial name
- NCT02575547
- Testing
- cisplatin and docetaxel
- Where
- China
- Volunteers
- 186 people
- Sponsor
- Zhao Chong