Clinical trials: Neonatal
Pseudohypoparathyroidism Type 1A, Albright Hereditary Osteodystrophy
Energy Expenditure and Body Composition in Pseudohypoparathyroidism 1a
The investigators would like to learn more about the metabolic consequences of pseudohypoparathyroidism type 1a in children, adolescents and adults with this condition.
- Trial name
- NCT01398774
- Where
- United States
- Volunteers
- 519 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Neonatal Resuscitation
Outcomes of Neonatal Resuscitation
The primary objective of this study is to describe mortality of newborns who received basic, advanced or no neonatal resuscitation immediately after birth at Shoklo Malaria Research Unit.
- Trial name
- NCT02840682
- Where
- Thailand
- Volunteers
- 15,073 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Hypoxic-Ischemic Encephalopathy, Pain
The Effect of Maternal Scent and Knitted Octopus Application on Pain in Infants Diagnosed With Neonatal Asphyxia and Receiving Therapeutic Hypothermia Treatment
This study was designed to determine the effects of maternal scent and knitted octopus application on pain in infants born with asphyxia beyond 36 weeks' gestation and receiving Therapeutic Hypothermia (TH) treatment in the…
- Trial name
- Pain in HIE (NCT07526233)
- Testing
- scent
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Alev Sivasli
Down Syndrome, SARS-CoV-2 Vaccination
Prospective Monitoring of Antibody Response Following COVID-19 Vaccination in Patients With Down Syndrome.
The risk of severe course of SARS-CoV-2 infection in people with Down Syndrome is substantially increased. The risk of death is 3-10 fold higher than in healthy people.
- Trial name
- PRIDE (NCT05145348)
- Testing
- Immune response to Sars-CoV-2 vaccinations; including COVID-19 vaccin Moderna, Comirnaty (Pfizer) and Vaxzevria (AstraZeneca)
- Where
- Netherlands
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Prader Willi Syndrome, Hyperphagia
Functional Connectome in Prader-Willi Syndrome: Neuroimaging and AI to Assess Therapeutic Impact
The goal of this observational study is to explore brain network changes and identify patterns related to hyperphagia, hormonal treatment effects, and cognitive deficits in adults with Prader-Willi Syndrome (PWS).
- Conditions
- Prader Willi Syndrome, Hyperphagia, Behavior Disorders
- Trial name
- NCT06900335
- Testing
- GH treatment (Somatropin), Eating
- Where
- Spain
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Corporacion Parc Tauli
Hypospadias and Epispadias
Comparison of Pudendal Nerve Block and Caudal Block for Hypospadias in Young Children
The purpose of this randomized blinded prospective study is to compare the analgesic efficacy and duration of a Pudendal Nerve Block (PNB) to a Caudal Block (CB) for pediatric patients, ages 6 months to 2 years, undergoing…
- Trial name
- NCT03145415
- Testing
- Caudal block, Bilateral Pudendal block
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Hemophilia A, Hemophilia B
Gaining Insight Into the Complexity of Pain in Patients With Haemophilia
Joint pain has been reported as a major problem in people with haemophilia (PwH). Therefore, haemophilia in adults seems clinically more related to a musculoskeletal disorder than a bleeding disorder, with many patients reporting…
- Trial name
- NCT05606640
- Testing
- Biopsychological pain assessment
- Where
- 2 sites in Belgium
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Adrenal Hyperplasia, Congenital
Role of the Protein Osteoprotegerin in the Bone Health of Women With Congenital Adrenal Hyperplasia
21-hydroxylase deficiency (21-OHD) is an inherited disorder that results from a mutation on the CYP21A2 gene. It affects the adrenal glands and is the most common cause of congenital adrenal hyperplasia (CAH).
- Trial name
- NCT00694525
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Office of Rare Diseases (ORD)
Sickle Cell Disease
Utilizing A Single Session Problem-Solving Intervention With Caregivers of Pediatric Patients Receiving Chronic Transfusion to Treat Sickle Cell Disease
This study seeks to utilize an innovative approach of a single session problem-solving intervention to address psychosocial factors affecting patient outcomes within the pediatric sickle cell population.
- Trial name
- NCT04606160
- Testing
- Single Session Problem-Solving Intervention
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Premature Birth
The Impact of NICU Music Therapy for Preterm Infants and Caregivers
This study aims to provide initial evidence for the use of music therapy in the NICU in a UK context. In other countries, such as the US and the Netherlands, music therapy is routinely provided in the NICU and research has…
- Trial name
- NCT06844396
- Testing
- Music Therapy
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Anglia Ruskin University
Pancreatic Cancer
Analyzing Childhood Recall Antigens in Patients With Pancreatic Cancer
The investigator is developing an immune therapy against pancreatic cancer. Immune cells, known as "T cells with tumor killing capacity", are involved in this immune therapy.
- Trial name
- NCT03848182
- Testing
- Gemcitabine, TT vaccine booster
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Low-Birth-Weight
Formative Research to Develop an Intervention Package to Promote Practice of Kangaroo Mother Care for Low Birth Weight and Preterm Infants in a Community (CKMC)
The study is being conducted to develop an intervention to assess the feasibility of implementing Kangaroo Mother Care (KMC) for low birth weight (LBW) and preterm babies in a community setting.
- Trial name
- CKMC (NCT02613624)
- Where
- India
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Society for Applied Studies
Choroideremia
The Short-term Effects of Simvastatin on the Vision of Males Affected by Choroideremia
Primary objective: To examine the short-term effects of of simvastatin on the vision on males with choroideremia, evaluated by full-field scotopic threshold testing.
- Trial name
- NCT01654562
- Testing
- Simvastatin
- Where
- Canada
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Feeding; Difficult, Newborn
Effect of SINC Feeding Protocol on Weight Gain, Transition to Oral Feeding and the Length of Hospitalization
Feeding is one of the most common problems encountered by preterm infants. Besides, effective and safe feeding is one of the important discharge criteria.
- Trial name
- NCT03371927
- Testing
- SINC Feeding Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Newborn Morbidity
Impact of Explanation Given to Parents on Rate of Post-partum Influenza Vaccination
The aim of this study is to determine whether an explanation to parents for the need for post-partum influenza vaccination will influence their compliance.
- Trial name
- NCT03053674
- Testing
- Oral and written explanation, Follow-up questionnaire
- Where
- Israel
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Cleft Lip and Palate
Effectiveness of Nasal-alar Elevator Combined With Taping Vs. Taping Alone on Improving the Nose Esthetics and Maxillary Arch Dimensions in Infants With Unilateral Complete Cleft Lip and Palate
This randomized trial is designed to assess the effectiveness of nasal elevator as a presurgical infant orthopedics on improvement of nose esthetics vs taping alone.
- Trial name
- NCT04331379
- Testing
- Nasal Elevator, Taping Alone
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cairo University
Neonatal Disease, Necrotizing Enterocolitis
A Genome-Wide Association Study for Neonatal Diseases
This is an observational study to identify genetic risks for neonatal diseases, necrotizing enterocolitis (NEC) using genome-wide association study (GWAS) and enterotype investigation.
- Trial name
- NCT04074824
- Where
- Hong Kong
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Patent Ductus Arteriosus
Treating the Resistant Patent Ductus Arteriosus (PDA)
Persistent postnatal ductal patency may have significant adverse hemodynamic effects, frequently necessitating therapeutic intervention in order to facilitate ductal closure.
- Trial name
- NCT00616382
- Testing
- Indomethacin, Pentoxifylline
- Where
- Israel
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Healthy
Study of PF 04965842 Effect on MATE1/2K Activity in Healthy Participants
This is a Phase 1, randomized, 2 way crossover, open label study of the effect of PF-04965842 on metformin (a probe for MATE1/2K activity) PK in healthy adult participants.
- Trial name
- NCT03796182
- Testing
- Metformin, PF-04965842
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Jaundice, Neonatal, Neonatal Diseases and Abnormalities
Evaluation of Bili-ruler, a Low-cost, Plastic Icterometer for Community-based Screening of Jaundice in Newborns
Newborn jaundice, or accumulation of bilirubin molecules in blood, affects 60-80% of newborns and, in severe cases, places newborns at risk of brain damage and death.
- Conditions
- Jaundice, Neonatal, Neonatal Diseases and Abnormalities, Neonatal Hyperbilirubinemia, Screening Tool
- Trial name
- NCT06687746
- Testing
- Bili-ruler
- Where
- 5 sites in India, Kenya and 2 more
- Volunteers
- 4,060 people, healthy volunteers welcome
- Sponsor
- George Washington University
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