Clinical trials: Neonatal
Premature Rupture of Membrane, Neonatal Infection
Correlation Between Premature Rupture of Membranes and Early-onset Neonatal Infections
This study hypothesizes that early-onset neonatal Infections are related to premature rupture of membrane (PROM) and that early intervention can improve the prognosis of newborns.
- Trial name
- NCT03251898
- Where
- 6 sites in China
- Volunteers
- 15,926 people, healthy volunteers welcome
- Sponsor
- Bayi Children's Hospital Affiliated to PLA Army General Hospital, China
Flat Feet, Flexible Flatfoot
Effect of Insole Added to Exercise in Patients With Bilateral Flexible Flatfoot
Pesplanus, commonly known as 'flatfoot,' is a common pathomechanical condition characterized by a lowered medial longitudinal arch (MLA) and exaggerated pronation.
- Conditions
- Flat Feet, Flexible Flatfoot, Balance; Distorted, Muscle Weakness
- Trial name
- NCT05056298
- Testing
- Custom made insole, Strengthening exercises of extrinsic foot muscles, Strengthening exercises of intrinsic foot muscles
- Where
- Egypt
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Horus University
Sickle Cell Disease, Sickle Cell Trait
Sickle Cell Hemoglobinopathies and Bone Health
This research study has two purposes. The first purpose is to determine whether having sickle cell trait (SCT) is a risk factor for the development of bone thinning at an earlier age than expected.
- Trial name
- NCT02306993
- Testing
- Healthy volunteers without SCT, Healthy volunteers with SCT, Volunteers with SCD
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- UConn Health
Retinopathy of Prematurity
Oral Propranolol Improve Retinopathy of Prematurity Outcomes in Very Preterm Infants
Retinopathy of prematurity (ROP) is a major cause of blindness and visual impairment in children in both developing and developed countries around the world.
- Trial name
- NCT02977000
- Testing
- Propranolol
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Huiqing Sun
Extremely Premature Newborn (Born Before 32 Weeks' Gestation)
Description of Changes in NIRS as a Function of Ductus Arteriosus Status in Very Premature Babies Born Before 32 WG at the DIJON University Hospital
Monitoring patent ductus arteriosus is currently performed using echocardiography, an operator-dependent examination which requires holding the child on their back and which is potentially time-consuming.
- Trial name
- CAPNIRS (NCT06153771)
- Testing
- Collection of brain and kidney NIRS measurements, echocardiography
- Where
- France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Apnea Prematurity
Nasogastric Versus Orogastric Route of Feeding in Preterm (<32 Weeks) Neonates
Enteral feeding tubes in newborns are used for feeding preterm and low birth weight babies in neonatal intensive care units as they often do not suck effectively owing to lack of coordination between sucking, swallowing and…
- Trial name
- NCT03073993
- Testing
- feeding tube insertion
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Max Super Speciality Hospital
Pain During Heal Lancing
Effects of Yakson Method and Swaddling on Pain and Physiological Parameters
Type of Study: The study was planned to be conducted in a randomized controlled experimental design. Place and Time of the Research: Institutional permission will be obtained from the Balcalı Training and Research Hospital in…
- Trial name
- NCT05518916
- Testing
- Nonfarmacology method
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Cavernous Malformation, Cerebral, Cavernous Angioma
Quantitative Susceptibility Biomarker and Brain Structural Property for Cerebral Cavernous Malformation Related Epilepsy
Cerebral cavernous malformation (CCM)-related epilepsy (CRE) impairs the quality of life in patients with CCM. Patients could not always achieve seizure freedom after surgical resection of the lesion, suggesting an inadequate…
- Conditions
- Cavernous Malformation, Cerebral, Cavernous Angioma, Cavernous Hemangioma, Cavernous Hemangioma of Brain
- Trial name
- CRESS (NCT04076449)
- Where
- 2 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- yuanli Zhao
Healthy
Fetal Aortic Pulsewave Velocity: A Novel Doppler Ultrasound Method of Measuring the Biophysical Properties of the Fetal Aorta
We are interested in determining if we can measure the blood flow in the descending aorta (large blood vessel in the abdomen) of healthy fetuses and fetuses with growth restriction. An increasing number of adult diseases (e.g.
- Trial name
- NCT00359034
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of British Columbia
Autosomal Aneuploidy
Feasibility Study of a New Screening Program for Major Aneuploidies (T21, T18, T13) in the Emilia-Romagna Region (SAPERER)
The study is promoted by the Emilia Romagna Region which identified in the Bologna AUSL the coordinating center (Unità Operativa Complessa Laboratorio Unico Metropolitano, LUM, Maggiore Hospital).
- Trial name
- SAPERER (NCT04437992)
- Testing
- NIPT
- Where
- Italy
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Azienda Usl di Bologna
Hereditary Hemochromatosis
A Study to Evaluate BBI-001 in Healthy Volunteers and in Patients With Hereditary Hemochromatosis
This study will be conducted in two parts run in parallel. Part 1 of the study (Phase 1, randomized, double-blind, placebo-controlled, multiple ascending dose) will enroll healthy volunteers in 3 sequential dose escalating…
- Trial name
- NCT07371793
- Testing
- BBI-001
- Where
- Australia
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Bond Biosciences
Pregnancy, High Risk
Validation of a Non-invasive Hemoglobin Measurement Device in Pregnancy and Postpartum in Kenya, Pakistan, and Zambia
Accurate, precise, and comparable hemoglobin measurements is of great importance, both for clinical value in diagnosing anemia and ensuring pregnant women receive appropriate treatment.
- Trial name
- NCT05656352
- Testing
- Masimo Total Hemoglobin SpHb® Continuous Non-invasive Hemoglobin Monitoring Device, Complete Blood Count
- Where
- 4 sites in Kenya, Pakistan and 1 more
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- George Washington University
Down Syndrome
Effect of Sensory Integration on Gross and Balance on Children With Down Syndrome
To investigate the effect of sensory integration on gross motor function in children with Down syndrome. To investigate the effect of sensory integration on balance in children with Down syndrome.
- Trial name
- NCT07785011
- Testing
- BALANCE AND SENSORY INTEGRATION
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Raheel Sanad
Hemophilia
Predictors of Physical Activity in Adult Patients With Hemophilic Arthropathy
Introduction. The development of hemophilic arthropathy causes degenerative joint damage that leads to functional impairment, limiting physical activity and causing disability in patients with hemophilia. Objectives.
- Trial name
- NCT06960499
- Testing
- Surveys
- Where
- Spain
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Cystinosis
A Cohort of Patients With Cystinosis : Compliance to Cysteamine and Neurological Complications
Preventing late onset of Cystinosis such as neurological complications and improving compliance to cysteamine treatment remain major challenges in management of subjects with cystinosis.
- Trial name
- Crystobs (NCT02012114)
- Testing
- Cysteamine bitartrate
- Where
- France
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Muscular Dystrophies, Myopathies
Observational Study to Observe Variations of Gait Parameters in Patients With Neuromuscular Diseases
This study has the general objective of observing walking parameters during a clinical test to objectively estimate fatigue in patients with neuromuscular diseases.
- Conditions
- Muscular Dystrophies, Myopathies, Spinal Muscular Atrophy (SMA), Charcot Marie Tooth Disease
- Trial name
- NCT06666816
- Testing
- inapplicable
- Where
- 2 sites in Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Photoaging, Weight Loss
Evaluation of the Effects of a Biostimulator and Dermal Fillers for Cheek Augmentation and Contour Deficiencies
Adult subjects with a history of or currently taking glucagon-like peptide-1 (GLP-1) receptor agonist medication and moderate-to-severe cheek wrinkles and midface contour deficiencies will be treated with Sculptra correction of…
- Conditions
- Photoaging, Weight Loss, Skin Laxity, Photodamaged Skin
- Trial name
- NCT06351358
- Testing
- Sculptra treatment, Restylane Treatment
- Where
- 2 sites in United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Fetal Membranes, Premature Rupture, Premature Birth
The Use of Cranberries in Women With Preterm Premature Rupture of Membranes
Cranberries have been proved to reduce the rate of urinary tract infections in a population of women with recurrent urinary tract infections in previous studies.
- Trial name
- NCT00247104
- Testing
- Cranberries - Vaccinium macrocarpon
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Duchenne Muscular Dystrophy
DART Electrical Impedance Myography (EIM) Trial in Duchenne Muscular Dystrophy (DMD) and Healthy Controls
Physicians seek a method to assess neuromuscular disease that is both non-invasive and quantifiable. Many patients do not tolerate standard current day assessment tools (such as needle electromyogram), and Electrical Impedance…
- Trial name
- NCT01523964
- Testing
- Testing with EIM
- Where
- 6 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Dart Therapeutics. LLC
Hereditary Diseases
Multicenter Analysis of Genomic and Metabolic Data of Neonatal Genetic Diseases
object name: Multicenter analysis of genomic and metabolic data of neonatal genetic diseases. goal of study:(1) Gene sequencing data (138 genes related to 133 common genetic diseases) and tandem mass spectrometry metabolomics…
- Trial name
- MAOFGAMDNGD (NCT06183138)
- Testing
- Genomic sequencing
- Where
- China
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
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