Clinical trials: Neonatal Distress
Neonatal Respiratory Distress Related Conditions
Oscillatory Versus Non-oscillatory Nasal Continuous Airway Pressure Neonatal Respiratory Support
Controlled randomized trial looking at Standard nasal continuous airway pressure (CPAP) respiratory support versus High Frequency CPAP in neonates who require respiratory support or who are being extubated and require support…
- Trial name
- NCT03711565
- Testing
- Regular Nasal CPAP using a conventional ventilator, High Frequency Nasal CPAP
- Where
- United States
- Sponsor
- University of California, Davis
Premature Birth, Respiratory Distress Syndrome
Comparison of the Results of Transcutaneous Carbon Dioxide and Oxygen Pressure in Premature Neonates Who Underwent MIST Under HHHFNC or Nasal CPAP Methods
Intratracheal surfactant treatment is applied in Respiratory Distress Syndrome (RDS) Continious Positive Airway Pressure(CPAP) treatment.
- Conditions
- Premature Birth, Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal
- Trial name
- TCOPHC (NCT04505176)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Hacettepe University
Pulmonary Artery Doppler
Pulmonary Artery Doppler in Preeclamptic Mothers
Evaluation of Pulmonary artery Doppler parameters in fetuses of mothers with severe preeclampsia
- Trial name
- NCT06755073
- Testing
- Pulmonary artery Doppler ultrasound
- Where
- Egypt
- Volunteers
- 86 people
- Sponsor
- Assiut University
to Test the Hypothesis That NHFOV is More Effective Than nCPAP in the Treatment of Respiratory Distress Syndrome (RDS) in Verypreterm Neonates
NHFOV as Primary Support in Very Preterm Infants With RDS
This will be a prospective, multi-center, two-arms,parallel, randomized, controlled trial with a superiority design,conducted in China.
- Trial name
- NCT05141435
- Testing
- infants receive primary non-invasive respiratory support by mean of nCPAP, infants receive primary non-invasive respiratory support by mean of NHFOV
- Where
- 3 sites in China
- Volunteers
- 360 people
- Sponsor
- Jiulongpo No.1 People's Hospital
Respiratory Distress Syndrome
Trial to Assess the Safety and Tolerability of Lucinactant for Inhalation in Premature Neonates
The primary objective of this study is to evaluate the safety and tolerability of aerosolized surfactant, specifically lucinactant for inhalation, administered in escalating inhaled doses to preterm neonates 29 to 34 weeks…
- Trial name
- NCT02074059
- Testing
- Lucinactant for Inhalation, nCPAP alone
- Where
- 11 sites in United States
- Volunteers
- 80 people
- Sponsor
- Windtree Therapeutics
Neonatal Respiratory Distress Syndrome
Heated, Humidified High-flow Nasal (HHHFN) Cannula vs Nasal Continuous Positive Airway Pressure in Respiratory Distress in Premature Neonates
Newborn babies who have difficulty breathing may need breathing support to help them receive enough oxygen. Two commonly used methods are heated, humidified high-flow nasal cannula (HHFNC), which delivers warmed, moist air and…
- Trial name
- NCT07891494
- Testing
- Heated Humidified High-Flow Nasal Cannula therapy, nCPAP
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Pakistan Air Force (PAF) Hospital Islamabad
Respiratory Distress Syndrome, Preterm Pregnancy
Less Invasive Surfactant Administration in Late Preterm or Early Term Born Infants
The aim of this study is to see if giving less invasive surfactant administration (LISA) during high-flow nasal cannula (HFNC) oxygen treatment reduces the need for invasive ventilation in babies with breathing problems born 2-6…
- Conditions
- Respiratory Distress Syndrome, Preterm Pregnancy, Surfactant Deficiency Syndrome Neonatal
- Trial name
- NCT06421506
- Testing
- Less invasive surfactant administration during high flow nasal cannula treatment
- Where
- United Kingdom
- Volunteers
- 245 people
- Sponsor
- King's College Hospital NHS Trust
Transient Tachypnea Newborn, Cesarean Delivery Affecting Fetus
Misoprostol Before Elective Caesarean Section for Decreasing the Neonatal Respiratory Morbidity
Neonatal respiratory distress may occur in either term or preterm newborns with a higher relative risk in preterm, and whether born vaginally or through caesarean section, but in a higher percentage after elective caesarean…
- Trial name
- NCT03031353
- Testing
- Misoprostol
- Where
- Egypt
- Volunteers
- 170 people
- Sponsor
- Ain Shams University
Respiratory Distress Syndrome, Newborn
Efficacy Evaluation of Surfactant Administration Via Laryngeal Mask Airway
With the development of the Intubation Surfactant Extubation technic, in which surfactant is administered during a brief intubation followed by immediate extubation, surfactant therapy can be given during nasal continuous…
- Trial name
- NCT01173237
- Testing
- Use tracheal intubation for surfactant therapy, Use of Proseal laryngeal mask airway for surfactant therapy
- Where
- 2 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of Minas Gerais
Prematurity, Respiratory Distress Syndrome
Autologous Umbilical Cord Blood Transfusion for Preterm Neonates
This is a pilot study to test feasibility of collection, preparation and infusion of a baby's own (autologous) umbilical cord blood in the first 14 days after birth if the baby is born premature <35 weeks of gestation.
- Conditions
- Prematurity, Respiratory Distress Syndrome, Anemia of Prematurity, Intraventricular Hemorrhage
- Trial name
- NCT01121328
- Testing
- Autologous cord blood transfusion for preterm neonates, Autologous cord blood transfusion
- Where
- Egypt
- Sponsor
- Sahar M.A. Hassanein, MD
Mild Respiratory Distress
Respiratory Transition Without Continuous Positive Airway Pressure
The primary aim of this research project is to determine if term neonates (37:0 to 41:6 weeks' gestational age) with mild respiratory distress can safely transition without continuous positive airway pressure (CPAP).
- Trial name
- NCT07390812
- Testing
- Transition without Continuous Positive Airway Pressure (CPAP), CPAP
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Hackensack Meridian Health
Respiratory Insufficiency of Prematurity
Nasal Intermittent Positive Pressure Ventilation in Premature Infants (NIPPV)
The machines and oxygen used to help very premature babies breathe can have side-effects, such as bronchopulmonary dysplasia (BPD).
- Trial name
- NIPPV (NCT00433212)
- Testing
- nCPAP, NIPPV
- Where
- 35 sites in United States, Austria and 8 more
- Volunteers
- 1,011 people
- Sponsor
- McMaster University
Respiratory Distress Syndrome, Newborn, Pulmonary Surfactants
Echography-guided Surfactant THERapy (ESTHER) For Preterm Infants With Respiratory Failure
Point-of-care ultrasound (POCUS) is the use of ultrasound by the bedside provider in real time to answer a specific question and guide medical management.
- Conditions
- Respiratory Distress Syndrome, Newborn, Pulmonary Surfactants, Intensive Care Units, Neonatal
- Trial name
- NCT06446453
- Testing
- Echography-guided Surfactant THERapy (ESTHER)
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Connecticut Children's Medical Center
Respiratory Distress Syndrome, Newborn
Comparison of CPAP Machines With Reusable vs Disposable Circuits
The study aims to assess the basic functionality of a newly designed CPAP machine with reusable circuits to existing machines with disposable circuits, for treatment of newborn infants diagnosed with respiratory distress…
- Trial name
- NCT03121612
- Testing
- CPAP
- Where
- India
- Volunteers
- 51 people
- Sponsor
- Medical Technology Transfer and Services Hong Kong Ltd
Pregnant Women Receive Celesten
Betamethasone and Severity of Hyaline Membrane Disease
Primary purpose: to study the relationship between betamethasone placental transfer and the occurrence and severity of the Hyaline Membrane Disease.
- Trial name
- b-Mhyalines (NCT01854840)
- Where
- France
- Volunteers
- 127 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Distress Syndrome
Sustained Lung Inflation in the Delivery Room in Preterm Infants at High Risk of Respiratory Distress Syndrome
BACKGROUND. Sustained lung inflation (SLI) associated to an adequate PEEP may help the efficacy of the respiratory effort in lung of preterm infants at risk for respiratory distress syndrome (RDS) and reduce need of mechanical…
- Trial name
- SLIS (NCT01440868)
- Testing
- Sustained lung inflation
- Where
- Italy
- Volunteers
- 276 people
- Sponsor
- University of Florence
Respiratory Distress Syndrome
Respiratory Distress and Elective Cesarean Section at Term
Cesarean section is a life-saving surgical operation for women and their newborns. In Egypt, caesarean sections are over-utilized. The rate increased from 27.6 % in 2008 to 51.8 % in 2014, reaching 72.2 % in 2021.
- Trial name
- NCT06874478
- Testing
- Ultrasound
- Where
- Egypt
- Volunteers
- 210 people
- Sponsor
- Assiut University
Mechanical Ventilation Complication, Respiratory Distress Syndrome in Premature Infant
Effect of Implementing Evidence Based Practices on Prevention of Associated Nasal Pressure Injuries Among Preterm Neonates With Non-Invasive Respiratory Support
This study aims to evaluate the effect of implementing evidence based practices on prevention of associated nasal pressure injuries among preterm neonates with non invasive respiratory support
- Trial name
- NCT06642285
- Testing
- Non Invasive Respiratory Support bundle
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Fetal Distress, Birth Asphyxia
Effect of Intrapartum Oxygen Administration on Fetal and Early Neonatal Outcomes
Introduction Birth asphyxia is one of leading causes of neonatal mortality in Uganda. It is associated with long term neuro-developmental complications among the babies that survive.
- Trial name
- Intra-O (NCT04043299)
- Testing
- 100% Oxygen, 21% oxygen
- Where
- Uganda
- Volunteers
- 1,108 people
- Sponsor
- Makerere University
Respiratory Distress Syndrome, Newborn, Endotracheal Intubation
An Educational Intervention to Improve the Success of Intubation in Newborns Using a Video Laryngoscope by Reducing the Time the Procedure Takes.
This research focuses on one of the most common problems in newborn medicine: breathing difficulties. Breathing problems are the most common reason for admission to our neonatal unit at the National Maternity Hospital.
- Conditions
- Respiratory Distress Syndrome, Newborn, Endotracheal Intubation, Neonatal Intubation Performance, Prematurity
- Trial name
- NINJA (NCT06898801)
- Testing
- Just-in-time video training
- Where
- Ireland
- Volunteers
- 140 people
- Sponsor
- University College Dublin