Clinical trials: Neonatal Morbidity
Congenital Heart Defect
Cardiopediatric Home Monitoring Tool
We hypothesize that a home monitoring program combined with routine postoperative care significantly reduces morbidity and mortality after neonatal and pediatric cardiac surgery.
- Trial name
- OSCAR (NCT06741189)
- Testing
- Home monitoring, usual medical monitoring
- Where
- France
- Volunteers
- 186 people
- Sponsor
- Nantes University Hospital
Morbidity;Infant
Survival and nEonatal outComes of veRy Low Birth wEight Infants in Türkiye: Turkish Neonatal Society SECRETS-TR Study
The aim of this multi-center study was to evaluate the mortality rate and early neonatal outcomes of very low birth weight (VLBW) infants hospitalized in neonatal intensive care units (NICUs) in Türkiye.
- Trial name
- TNS-SECRETS (NCT06543524)
- Testing
- Care of premature infants
- Where
- Turkey (Türkiye)
- Volunteers
- 3,150 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Covid19, Breastfeeding, Exclusive
Exclusive Breastfeeding in Infants of Mothers Infected With Novel Coronavirus
COVID-19 pandemic emerges an issue for breastfeeding.Earlier in pandemic mothers who had COVID-19 were separated from their babies due to insufficient data but this approach was abandoned due to the lack of transmission via…
- Conditions
- Covid19, Breastfeeding, Exclusive, Newborn Morbidity
- Trial name
- NCT04925908
- Testing
- RT-PCR for SARS-Cov-2
- Where
- Turkey (Türkiye)
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Transient Tachypnea of the Newborn
Physiologically Based Cord Clamping To Improve Neonatal Outcomes After Elective Cesarean Delivery
Before birth, the baby's lungs are filled with fluid and babies do not use the lungs to breathe, as the oxygen comes from the placenta. As delivery approaches, the lungs begin to absorb the fluid.
- Trial name
- PhyCord1 (NCT06278415)
- Testing
- Physiological based cord clamping, Differed cord clamping
- Where
- 2 sites in Belgium
- Volunteers
- 50 people
- Sponsor
- Queen Fabiola Children's University Hospital
Vertical Human Immunodeficiency Virus Transmission, HIV Infection Pediatric
Increasing Neonatal HIV Test and Treat to Maximize the Long-Term Impact on Infant Health and Novel Infant Antiretroviral Treatment
This study aims to improve HIV healthcare services for mothers living with HIV and their newborns in Tanzania and Mozambique. The main questions it aims to answer are: 1) does enhancing screening with maternal HIV viral load…
- Conditions
- Vertical Human Immunodeficiency Virus Transmission, HIV Infection Pediatric, Infant Death, Infant Morbidity
- Trial name
- LIFE2Scale (NCT06267508)
- Testing
- Maternal HIV viral load testing at delivery for VHT risk assessment
- Where
- 2 sites in Mozambique, Tanzania
- Volunteers
- 6,000 people
- Sponsor
- Michael Hoelscher
covid19 Infection, Pregnancy Complications
Covid-19 in Pregnancy: a French Population-based Cohort of Women and Newborns
The purpose of this study is to characterize the incidence and clinical features of the maternal COVID 19 infection, as well as the associated morbidity of the mother and the child, in the French context
- Conditions
- covid19 Infection, Pregnancy Complications, Neonatal Complications
- Trial name
- Coropreg (NCT04463758)
- Testing
- An auto-questionnaire comprising three psychometric scales
- Where
- France
- Volunteers
- 6,015 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infants With Positive GBS Bacteremia
Clinical Outcome of Neonates With GBS Positive Culture-12 Year Retrospective Study
Streptococci group B (GBS) is a the major reason for morbidity and mortality in neonates. It can present as pneumonia ,meningitis or sepsis.The mortality today is 5-20% and even more in preterm babies.
- Trial name
- NCT00326313
- Volunteers
- 74 people
- Sponsor
- Sheba Medical Center
Newborn Morbidity, Pain
Epidemiology of Painful Procedures in Neonates
Sick or premature neonates are exposed to frequent painful and stressful procedures during their stay in neonatal intensive care units.
- Conditions
- Newborn Morbidity, Pain, Procedures, Intratracheal Intubation
- Trial name
- EPIPPAIN (NCT01346813)
- Where
- 21 sites in France
- Volunteers
- 1,000 people
- Sponsor
- Hôpital Armand Trousseau
Bronchopulmonary Dysplasia (BPD), Chronic Lung Disease of Newborn
Long-Term Burden of BPD and Health-Related Quality of Life (BronQ Family)
The objective of this study is to examine the long-term impact of having a child with Bronchopulmonary Dysplasia (BPD) on the parents and caregivers from the time of diagnosis through adulthood.
- Conditions
- Bronchopulmonary Dysplasia (BPD), Chronic Lung Disease of Newborn, HRQOL (Health Related Quality Of Life)
- Trial name
- BronQ Family (NCT07134387)
- Testing
- N/A, no intervention, participation in survey
- Where
- Germany
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Global Foundation for the Care of Newborn Infants
Pregnancy Complications, Pregnancy, High Risk
Active Pregnancy Against COVID-19
Historically and traditionally, the recommendations related to physical exercise during pregnancy have been based more on moral or cultural issues than on scientific evidence.
- Conditions
- Pregnancy Complications, Pregnancy, High Risk, Pregnancy Induced Hypertension, Newborn Morbidity
- Trial name
- ACPREGCOV (NCT04563065)
- Testing
- Exercise program, Healthy lifestyle advise
- Where
- 2 sites in Spain
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Universidad Politecnica de Madrid
Impaired Glucose Tolerance, Fetal Macrosomia
Treatment of Impaired Glucose Tolerance in Pregnancy
The purpose of this study is to evaluate if treatment (insulin or diet) of pregnant women with impaired glucose tolerance (75-g OGTT with a fasting P-gluc <7.0 mmol/l and 2 h P-gluc >10.0 and <12.2 mmol/l) close to normoglycemia…
- Trial name
- TIP (NCT00625781)
- Testing
- Insulin aspart and Insulin human (isophane)
- Where
- Sweden
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Region Örebro County
Newborn Morbidity, Newborn Asphyxia
Cluster Randomized Controlled Trial Applying Helping Baby Breathe in Nepal
The cluster randomized controlled trial will be conducted in the selected health facilities/birthing centers of Sarlahi district in Nepal. Further from the selected health facilities.
- Conditions
- Newborn Morbidity, Newborn Asphyxia, Delivery Preterm
- Trial name
- SaLiN (NCT06213207)
- Testing
- Simulator based training to manage asphyxia and essential newborn care using neonatalie
- Where
- Nepal
- Volunteers
- 95 people
- Sponsor
- Integrated Development Foundation Nepal
Premature Birth, Respiratory Distress Syndrome in Premature Infant
Physiologically Based Cord Clamping To Improve Neonatal Outcomes In Moderate And Late Preterm Newborns
Before birth, the baby's lungs are filled with fluid and babies do not use the lungs to breathe, as the oxygen comes from the placenta. As delivery approaches, the lungs begin to absorb the fluid.
- Conditions
- Premature Birth, Respiratory Distress Syndrome in Premature Infant, Sepsis, Intraventricular Hemorrhage of Prematurity
- Trial name
- PhyCordPrem (NCT06280872)
- Testing
- Physiological Based Cord Clamping, Differed Cord Clamping
- Where
- 2 sites in Belgium
- Volunteers
- 180 people
- Sponsor
- Queen Fabiola Children's University Hospital
Hypothermia, Morbidity
Perinatal Hypothermia, Risk Factors and Long-Term Consequences in Guinea-Bissau, Westafrica
Low body temperature (hypothermia (HT)) at birth contributes to infant mortality in low-income countries. A study from Guinéa-Bissau indicates that HT results in an increased mortality rate, which persist at least two months…
- Conditions
- Hypothermia, Morbidity, Mortality
- Trial name
- NCT00429000
- Testing
- thermospot
- Where
- Guinea-Bissau
- Volunteers
- 788 people, healthy volunteers welcome
- Sponsor
- Bandim Health Project
Omphalitis, Infection
Impact of Umbilical Cord Cleansing With 4.0% Chlorhexidine on Neonatal Mortality
A community based trial that seeks to address the effect of umbilical cord cleansing using 4.0% chlorhexidine cleansing solution
- Trial name
- CHX (NCT00434408)
- Testing
- chx once, CHX x 7 days, dry cord care
- Where
- Bangladesh
- Volunteers
- 28,797 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Sickle Cell Disease, Pain Crisis Recurrent
Effectiveness of Laying-on-of-hands for Sickle Cell Disease
The objective of this study is to evaluate the effectiveness of 1-year administration of laying-on-of-hands on the morbidity and mortality of patients with sickle cell disease in Africa.
- Conditions
- Sickle Cell Disease, Pain Crisis Recurrent, Anemia, Infection
- Trial name
- NCT01518218
- Testing
- laying-on-of-hands
- Where
- Democratic Republic of the Congo
- Volunteers
- 40 people
- Sponsor
- MOA Health Science Foundation
Breastfeeding, Breastfeeding, Exclusive
Using the Electronic Health Record to Guide Management of Newborn Weight Loss
Weight loss is normal for healthy newborns in the first few days, especially for those exclusively breastfed, who may have low enteral intake for several days.
- Conditions
- Breastfeeding, Breastfeeding, Exclusive, Morbidity;Perinatal, Feeding, Bottle
- Trial name
- NCT03655314
- Testing
- NEWT, Usual care
- Where
- United States
- Volunteers
- 2,682 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Retinopathy of Prematurity, Neonatal Cholestasis
The Influence of Fish-oil Lipid Emulsions on Neonatal Morbidities
Docosahexaenoic acid (DHA) has been shown to be particularly important for fetal and neonatal development. Infants born prematurely are at special risk for DHA insufficiency.
- Trial name
- NCT01875510
- Testing
- Fish-oil emulsions, soybean-oil emulsion
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Dr. Sami Ulus Children's Hospital
Fetal Malnutrition
Assessment by the CANS Score Versus Anthropometry and Impact on Early Neonatal Morbidities
Assessment of malnutrition within 48 hours of birth through anthropometric indices as Weight, Length and Head circumference, Proportionality indices as MAC/HC ratio, Ponderal index and Body mass index, Clinical assessment of…
- Trial name
- NCT03466853
- Testing
- Clinical assessment of nutritional status (CANS) score, Anthropometric indices, Proportionality indices
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Cairo University
Thoracic Aorta Dilatation, Marfan Syndrome
Thoracic Aortic Dilatation Syndromes
Aortic dilatation syndromes are comprised by a group of different syndromes, of which Marfan syndrome is the best described. Many of the aorta dilatation associated syndromes are heritable connective tissue disorders but some…
- Trial name
- NCT02111668
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- University of Aarhus