Clinical trials: Neonatal Morbidity
Respiratory Distress Syndrome, Newborn, Transient Tachypnea of the Newborn
Efficacy of Antenatal Steroids in Reducing Respiratory Morbidities in Late Preterm Infants
The hypothesis of the study is that administration of antenatal steroid to women at high risk of preterm birth after 34 weeks of gestation would reduce the risk of respiratory complications, specifically Respiratory Distress…
- Trial name
- NCT01206946
- Testing
- Betamethasone, Normal Saline
- Where
- 5 sites in Lebanon
- Volunteers
- 700 people
- Sponsor
- American University of Beirut Medical Center
Previable Labour With Intact Membranes
A Combination of Antibiotics to Decrease Neonatal Morbidity and Mortality for Previable Threatened Labor
The purpose of this study is to determine whether a combination of antibiotics (cephalosporin 3rd generation, clarithromycin, metronidazole) are effective to prolong pregnancies complicated with previable threatened labour with…
- Trial name
- ECHEC-MAT (NCT06572761)
- Testing
- Combination of antibiotics, Emergency cerclage, Vaginal progesterone
- Where
- France
- Volunteers
- 350 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Premature Birth
Assessment of the Impact of the Return Home of Premature Newborns Less Than 2 Kilos Morbidity/Mortality
The aim of this study is to evaluate the impact of discharge from hospital with a weight of less than 2 kilos. To do this, the investigator will look at the short-term and long-term outcome of newborns weighing less than 2 kilos…
- Trial name
- Petit-Poids (NCT06224764)
- Testing
- Mother and Father questionnaires
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hôpital NOVO
Respiratory Morbidities
Respiratory Morbidities and Outcome in Late Preterm in Neonatal ICU
Aim of the work: To assess the respiratory morbidities \& outcomes in late preterm infants in the neonatal ICU of Assiut university children's Hospital.
- Trial name
- NCT05823064
- Volunteers
- 20 people
- Sponsor
- Assiut University
Patent Ductus Arteriosus, Circulation
Liver Regional Oxygen Saturation in Preterm Patent Ductus Arteriosus
This study evaluates the usefulness of liver perfusion and oxygenation status using regional oxygen saturation (RSO2) values obtained via near-infrared spectroscopy in assessing the hemodynamical significance of patent ductus…
- Conditions
- Patent Ductus Arteriosus, Circulation, Newborn Morbidity, Premature Birth
- Trial name
- NCT05639309
- Testing
- near-infrared spectroscopy based cerebral/somatic oximeter system (INVOS™ system manufactured by Medtronics)
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul St. Mary's Hospital
Neonatal Respiratory Distress Related Conditions, Meconium
Amnioinfusion's Protective Effects on Respiratory and Longitudinal Pediatric Outcomes After Intrapartum Meconium Exposure
Meconium in the amniotic fluid occurs in about one out of seven pregnancies and increases the chance that a newborn may have breathing problems after birth.
- Conditions
- Neonatal Respiratory Distress Related Conditions, Meconium, Perinatal Morbidity, Neonatal Acidosis
- Trial name
- PEARL (NCT07274527)
- Testing
- Intrauterine pressure catheter, Standard obstetric care at discretion of delivery provider
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- Medical College of Wisconsin
Neonatal Respiratory Distress Syndrome
Effect of Antenatal Corticosteroids on Neonatal Morbidity.
It will be a randomized controlled trial. There will be two study groups. Study group 1 will be given dexamethasone while study group 2 will be given betamethasone. The control group will be given placebo.
- Trial name
- NCT03446937
- Testing
- Dexamethasone Sodium Phosphate Injection, Betamethasone Sodium Phosphate Injection (Medication), Water for injection
- Where
- Nigeria
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ahmadu Bello University Teaching Hospital
Morbidity;Newborn
Antenatal Steroids Effect on Mortality and Respiratory Outcomes in Preterm Infants
The aim is to evaluate the impact of a complete course of antenatal steroids treatment on mortality and main morbidities in a current population of preterm infants.
- Trial name
- NCT04214795
- Testing
- Observational study. Postnatal variables are recorded
- Where
- Spain
- Volunteers
- 710 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Neonatal Hypocalcemia, Neonatal Sepsis
Effects of Cord Blood 25-hydroxy-vitamin D Level on Early Neonatal Morbidities
Cholecalciferol (vitamin D3) is a prohormone and its active form is 1,25 dihydroxycholecalciferol. This hormone has effect on both calcium, phosphorus and bone metabolism and also bone morrow, muscle, heart and immune system.
- Trial name
- NCT02147327
- Volunteers
- 120 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Morbidity;Newborn, Morality
Improving Outcome of Very Preterm Infants Using Collaborative Quality Improvement
A multicenter interventional study using evidence-based collaborative quality improvement to reduce mortality and major morbidities of very preterm infants in six neonatal centers in Shanghai
- Trial name
- NCT04531839
- Testing
- Evidence-based collaborative quality improvement
- Where
- 6 sites in China
- Sponsor
- Children's Hospital of Fudan University
Infant, Newborn, Diseases, Airway Morbidity
Integrated Prediction of Extubation Outcome by the Spontaneous Breathing Trial in Newborn Infants
Prolonged mechanical ventilation (MV) is associated with significant adverse effects in newborn infants and clinicians aim at its minimum possible duration.
- Trial name
- NCT03956511
- Testing
- Spontaneous Breathing Trial
- Where
- United Kingdom
- Volunteers
- 46 people
- Sponsor
- Ourania Kaltsogianni
Fetal Growth Restriction
Prostaglandins Versus Trans-cervical Balloon for Induction of Labor in Fetal Growth Restriction (PROBIN)
The goal of this randomized trial is to compare two methods of induction in a fetal growth restriction population. The main question it aims to answer is: Is trans-cervical balloon superior to prostaglandins in reducing the…
- Trial name
- PROBIN (NCT05674487)
- Testing
- Trans-cervical balloon, Misoprostol
- Where
- France
- Volunteers
- 774 people
- Sponsor
- University Hospital, Bordeaux
Maternal Death, Maternal Morbidity
BetterBirth: A Trial of the WHO Safe Childbirth Checklist Program
The purpose of this study is to measure the impact of a checklist-based childbirth safety program (the WHO Safe Childbirth Checklist Program) on reduction of severe maternal, fetal, and newborn harm in institutional deliveries in…
- Conditions
- Maternal Death, Maternal Morbidity, Stillbirth, Neonatal Death
- Trial name
- BetterBirth (NCT02148952)
- Testing
- WHO Safe Childbirth Checklist Program
- Where
- India
- Volunteers
- 157,689 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
PreTerm Neonate, Extubation Readiness
Prospective Multicentre Mixed Methods Study to Explore Extubation Practices and Respiratory Outcomes in Extremely Preterm Neonates.
The purpose of this observational study is to learn about neonatologists' perceptions of extubation readiness and extubation and reintubation practices in extremely preterm infants in the first 2 weeks of life using prospective…
- Conditions
- PreTerm Neonate, Extubation Readiness, Extubation Failure, Respiratory Morbidity
- Trial name
- CERAINE (NCT06808997)
- Where
- 31 sites in France
- Volunteers
- 166 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Asphyxia Neonatorum, Morbidity;Newborn
Effects of Probiotic Mixture Supplementation and Evaluation of Intestinal Mucosal Tolerance and Gut Microbiome in Newborns With Perinatal Asphyxia Receiving Hypothermic Treatment
The VISNAT trial is a PILOT STUDY due to absence of previous evidences in literature on using probiotic in newborns with perinatal asphyxia.
- Trial name
- VISNAT (NCT04145713)
- Testing
- Probiotic mixture
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Policlinico Hospital
Infant, Premature, Diseases, Airway Morbidity
Optimising Ventilation in Preterms With Closed-loop Oxygen Control
Many premature infants require respiratory support in the newborn period. Mechanical ventilation although life-saving is linked to complications for the lungs and other organs and its duration should be kept to a minimum.
- Conditions
- Infant, Premature, Diseases, Airway Morbidity, Mechanical Ventilation Complication
- Trial name
- NCT05030337
- Testing
- Closed-loop automated oxygen control (Oxygenie, SLE 6000)
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- King's College Hospital NHS Trust
Heart Defects, Congenital
Lactate Levels During Cardiopulmonary Bypass in Pediatric Patients
Many variables measured in critically ill patients have been used to estimate severity of disease, prognosticate morbidity and mortality, evaluate costs of treatment, and finally indicate specific treatment and monitor the…
- Trial name
- NCT02618707
- Testing
- Lactate
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Respiratory Disorders, Intensive Care, Neonatal
Timing of Planned Caesarean Section and Morbidity of the Newborn
The caesarean section rate is rising globally. About 10% of the newborns are submitted to a neonatal department after planned caesarean section, primarily with respiratory disorders.
- Trial name
- NCT00835003
- Testing
- Elective caesarean section
- Where
- 7 sites in Denmark
- Volunteers
- 1,273 people
- Sponsor
- Aarhus University Hospital
Extreme Prematurity, Intraventricular Hemorrhage
Single-dose Prophylactic INdomethacin in Extremely Preterm Infants
In Canada, about 900 babies each year are born very early (<26 weeks of gestation) and have a high chance of dying or having a serious bleed in the brain.
- Conditions
- Extreme Prematurity, Intraventricular Hemorrhage, Morbidity;Newborn
- Trial name
- SPIN (NCT06572917)
- Testing
- Indomethacin
- Where
- 15 sites in United States, Australia and 1 more
- Volunteers
- 500 people
- Sponsor
- University of British Columbia
Sudden Unexplained Infant Death, Apnea of Newborn
Advanced Wireless Sensors for Neonatal Care in the Delivery Room
The goals of this observational study is to assess whether a new advanced wireless skin sensor vital sign monitoring system can effectively monitor the vital signs of healthy newborn infants (≥ 35 weeks gestational age).
- Conditions
- Sudden Unexplained Infant Death, Apnea of Newborn, Newborn Morbidity, Newborn Asphyxia
- Trial name
- AWARD (NCT06693817)
- Testing
- Wireless skin sensors vital sign monitoring system, Wired vital sign monitoring system
- Where
- 5 sites in Brazil, Canada and 2 more
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Guilherme Sant'Anna, MD