Clinical trials: Neonatal Surgery
Acquired Adult Flatfoot Deformity, Flat Foot
Sinus Tarsi Implant as an Adjuvant Procedure to Medial Displacement Calcaneal Osteotomy in the Treatment of Mobile Adult Acquired Flatfoot Deformity
Background: Adult acquired flatfoot deformity (AAFD) is a deformity of the foot which leads to pain and an altered gait pattern. There are several different surgical interventions available for treatment of AAFD.
- Conditions
- Acquired Adult Flatfoot Deformity, Flat Foot, Flexible Flatfoot
- Trial name
- NCT06211504
- Testing
- ProStop, sinus tarsi implant (STI), Conventional surgery
- Where
- 10 sites in Sweden
- Volunteers
- 130 people
- Sponsor
- Region Skane
Skin Laxity, Skin Tightening
Effects of QUANTUM Probe for Skin Rejuvenation and Subdermal Retraction in Patients Undergoing High-Definition Liposculpture
This prospective study aims to evaluate the safety and effectiveness of Quantum, a fully internal bipolar radiofrequency probe, for the treatment of prominent skin laxity, providing patients with a more toned and youthful…
- Conditions
- Skin Laxity, Skin Tightening, Body Contouring Surgery, Skin Elasticity
- Trial name
- Quantum001 (NCT06958978)
- Testing
- Quantum RF
- Where
- Colombia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Total Definer Research Group
Pediatric Patients, Orthopedic Surgery
Nociception Level Index as a Verbal Tool of Pain in Children
60 children under 6 years old, scheduled for orthopedic surgery for limb fracture or neuromuscular and bone deformities will be randomized by closed envelope method into two groups (n=30) either receiving standard pain management…
- Conditions
- Pediatric Patients, Orthopedic Surgery, Extremity Fractures Lower, Extremity Fractures Upper
- Trial name
- NCT05716243
- Testing
- The nociception level index monitorization, The nociception level index measurement;postoperative
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Haseki Training and Research Hospital
Heart Defects, Congenital, Intensive Care Units, Pediatric
High-Flow Nasal Cannula vs. NIV After Extubation in Children Undergoing Heart Surgery
High-Flow Nasal Cannula vs. NIV After Extubation in Children Undergoing Heart Surgery
- Conditions
- Heart Defects, Congenital, Intensive Care Units, Pediatric, Respiration, Artificial, Extubation
- Trial name
- NCT07059689
- Testing
- High Flow Nasal Cannula (HFNC), Non-Invasive Ventilation (NIV)
- Where
- Indonesia
- Volunteers
- 114 people
- Sponsor
- Universitas Indonesia
Mandibular Prognathism, Orthognathic Surgery
Evaluating the Accuracy of Soft Tissue Prediction in Patients With Mandibular Prognathism After Orthognathic Surgery Using Handheld Scanner Versus Optical Scanner A Prospective Clinical Trial
Aim of study: To evaluate the accuracy of soft tissue prediction in orthognathic surgery using handheld scanners versus optical scanners.
- Trial name
- NCT06724497
- Testing
- face scanning pre and post orthognathic surgery
- Where
- Egypt
- Volunteers
- 11 people
- Sponsor
- Cairo University
Heart Defects, Congenital, Hyperglycemia
SPECS: Safe Pediatric Euglycemia in Cardiac Surgery
Critically ill children, including children undergoing heart surgery, commonly develop elevated blood glucose (also known as "blood sugar") levels during their illness, which can lead to poor health outcomes and an increased risk…
- Trial name
- SPECS (NCT00443599)
- Testing
- Insulin, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 989 people
- Sponsor
- Boston Children's Hospital
Sarcoma, Breast Cancer
Augmented Reality (AR): The Future of "Patient Information Leaflets
This project aims to assess a new type of Augmented Reality Patient Information leaflet, in order to demonstrate that it is a beneficial information resource to patients when facing the diagnosis of sarcoma, breast cancer or to…
- Conditions
- Sarcoma, Breast Cancer, Cleft Lip and Palate, Surgical Flap
- Trial name
- NCT04619030
- Testing
- Augmented Reality, Traditional leaflet
- Where
- 3 sites in United Kingdom
- Volunteers
- 20 people
- Sponsor
- NHS Greater Glasgow and Clyde
Minimally Invasive Pediatric Cardiac Surgery, Pediatric Cardiac Surgery
Precision TOF-Guided Sugammadex Versus Spontaneous Recovery for Early Extubation in Minimally Invasive Pediatric Cardiac Surgery
This prospective observational cohort study evaluates a precision neuromuscular management strategy in pediatric patients undergoing minimally invasive cardiac surgery (MICS).
- Conditions
- Minimally Invasive Pediatric Cardiac Surgery, Pediatric Cardiac Surgery, Early Extubation Pathway, TOF-Guided Sugammadex Administration
- Trial name
- TOF (NCT07798011)
- Testing
- Sugammadex
- Where
- Vietnam
- Volunteers
- 80 people
- Sponsor
- Dr. Nguyen Thi Thu Hang
Hypofibrinogenemia, Afibrinogenemia
Human Fibrinogen Concentrate in Pediatric Cardiac Surgery
The goal of the study is to determine whether the use of Human Fibrinogen Concentrate (RiaSTAP) will decrease blood loss and the need for component blood therapy in neonates and infants undergoing cardiopulmonary bypass.
- Conditions
- Hypofibrinogenemia, Afibrinogenemia, Bleeding Disorders
- Trial name
- RiaSTAP (NCT02822599)
- Testing
- RiaStAP, Saline
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Nicklaus Children's Hospital f/k/a Miami Children's Hospital
Arteriovenous Fistula, Arteriovenous Graft
A Randomised Trial Comparing Supraclavicular Block vs Supraclavicular and Pecs II Block in Arteriovenous Grafting
This study evaluates the addition of Pecs II block to ultrasound-guided supraclavicular brachial plexus block in patients undergoing arteriovenous graft creation surgery.
- Conditions
- Arteriovenous Fistula, Arteriovenous Graft, Kidney Failure, Chronic, Renal Failure, End-stage
- Trial name
- NCT02331030
- Testing
- Supraclavicular, Pecs II block, Ropivacaine 0.5% 20ml
- Where
- Singapore
- Volunteers
- 36 people
- Sponsor
- Changi General Hospital
Neonates, Infants Aged 0 Days to 12 Months Scheduled for Elective Surgery
Upper Airway Ultrasound to Predict Difficult Laryngoscopy in Neonates and Infants
Upper airway ultrasound (UA-US) has been utilized in adults to predict difficult laryngoscopy (Cormick-Lehane view 3 or 4) and difficult tracheal intubation (DTI) (≥3 intubation attempts) and with moderate-to-high sensitivity and…
- Trial name
- NCT07444528
- Testing
- Upper airway ultrasound
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Single-ventricle, Heart Diseases
Colchicine in Postoperative Fontan Patients
The investigators found that there is inflammation in the chest drainage in patients after the Fontan operation. The investigators want to test the theory that Colchicine, an anti- inflammatory medication, can decrease the…
- Trial name
- CPFP (NCT03575572)
- Testing
- Colchicine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Michigan
Polydactyly Toe, Thumb Hypoplasia
Clonidine for Tourniquet-related Pain in Children
This study is designed as a randomized, placebo-controlled, double-blinded, clinical trial with two parallel groups. This study investigates the association between a single dose of the drug, Clonidine, and the total amount of…
- Conditions
- Polydactyly Toe, Thumb Hypoplasia, Trigger Finger, Polydactyly; Fingers
- Trial name
- CLOTCH (NCT04564430)
- Testing
- Catapresan, Saline
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Right Ventricle, Pulmonary Valve Stenosis
Follow Up on Freestyle Valves in Children
The purpose of this study is to determine if the Medtronic Freestyle porcine valve is effective over a long period of time when it is used to replace the valve that normally allows blood to flow from the right lower pumping…
- Conditions
- Right Ventricle, Pulmonary Valve Stenosis, Pulmonary Valve Atresia
- Trial name
- NCT00385112
- Testing
- Echocardiogram
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Emory University
Basal Cell Nevus Syndrome
Extension Study of Patidegib Topical Gel, 2% in Subjects With Gorlin Syndrome (Basal Cell Nevus Syndrome)
This is a multicenter, open label extension study evaluating the safety of Patidegib Topical Gel, 2%, applied topically twice daily to the face of adult subjects with Gorlin syndrome.
- Trial name
- NCT04308395
- Testing
- Patidegib Topical Gel, 2%
- Where
- 37 sites in United States, Belgium and 7 more
- Volunteers
- 108 people
- Sponsor
- Sol-Gel Technologies, Ltd.
Infant, Newborn
Risk Related Assistance During Stabilization In Newborns At Birth
Approximately 10% of term infants and up to 50% of preterm infants less than 32 weeks require stabilization and / or ventilatory support at the time of transition at birth.
- Trial name
- NCT05023694
- Testing
- Video recordings, Video recordings after corrective measures in adverse events
- Where
- Spain
- Volunteers
- 128 people
- Sponsor
- Manuel Sanchez Luna
Impaired Oxygen Delivery, Congenital Heart Disease
Restrictive Versus Liberal Transfusion Protocol in Infants Undergoing Cardiac Surgery
In neonates and infants </= 10 kg following cardiac surgery for congenital heart disease a more restrictive red blood cell (RBC) transfusion strategy will be as effective as, and possibly superior to, a liberal RBC strategy.
- Trial name
- NCT01484886
- Testing
- Red blood cell transfusion
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- University of Rochester
Fuchs' Endothelial Dystrophy, Pseudophakic Bullous Keratopathy
The Effect Of Preoperative Parameters On Success After DMEK Surgery
The aim of this study is to evaluate the effect of preoperative parameters on surgical results in Descemet Membrane Endothelial Keratoplasty (DMEK) surgery.
- Conditions
- Fuchs' Endothelial Dystrophy, Pseudophakic Bullous Keratopathy, Descemet's Membrane; Defect, Herpetic Keratitis
- Trial name
- NCT04420429
- Testing
- Descemet membrane endothelial keratoplasty (DMEK)
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Beyoglu Eye Research and Education Hospital
Low Cardiac Output Syndrome
Two Inodilators Postsurgery in Neonates
Congenital heart defects are the most prevalent group of congenital malformations in newborns. Surgery-related low cardiac output syndrome (LCOS) could be one of the reason for the unfavourable outcome of this population.
- Trial name
- NCT01576094
- Testing
- Milrinone, Levosimendan
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario la Paz
Congenital Heart Disease, Periventricular Leucomalacia
Randomized Trial of Maternal Progesterone Therapy
Neurodevelopmental disability is now recognized as the most common long-term complication after cardiac surgery in neonates. Research studies have shown that progesterone is critical to the development of the brain and in a…
- Conditions
- Congenital Heart Disease, Periventricular Leucomalacia, Brain Development, Cardiac Surgery
- Trial name
- NCT02133573
- Testing
- Progesterone, Vaginal lubricant
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Children's Hospital of Philadelphia
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