Clinical trials: Neoplasm, Brain
Glioblastoma Multiforme, Anaplastic Astrocytoma
Pilot Study of Cabozantinib for Recurrent or Progressive Central Nervous System Tumors in Children
This pilot will study the feasibility and exploratory efficacy of using Cabozantinib for recurrent or refractory central nervous system tumors for which there are no curative options.
- Conditions
- Glioblastoma Multiforme, Anaplastic Astrocytoma, Malignant Brain Tumor, High Grade Glioma
- Trial name
- NCT02885324
- Testing
- Cabozantinib
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Indiana University
Brain Tumor
Cerebral Blood Circulation in Patients With Posterior Fossa Brain Tumor
The normal cerebral blood flow is guided by factors such as cerebral autoregulation (CA) and carbon dioxide reactivity (CO2R). Authors have demonstrated that CA and CO2R may be impaired in presence of intracranial tumors.Most…
- Trial name
- NCT01476670
- Testing
- Monitoring
- Where
- India
- Volunteers
- 20 people
- Sponsor
- All India Institute of Medical Sciences
Brain Tumors
Establishment of a Signature of Circulating microRNA as a Tool to Aid Diagnosis of Primary Brain Tumors in Adults
MIRNA is a prospective multi-center observational study designed to explore 762 plasma microRNAs in patients with malignant CNS tumours: 60 primary glioblastoma (GBM), 20 primary CNS lymphomas and 40 brain metastases in an…
- Trial name
- MIRNA (NCT03630861)
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pituitary Adenoma
Endocrine Outcome of Surgery for Pituitary Adenoma
Prospective and randomized compare between microsurgical and endoscopic transsphenoidal MRI assisted resection of pituitary adenomas.
- Trial name
- NCT03515603
- Testing
- Endoscopic resection, Microsurgical resection
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- University of Ulm
Newly Diagnosed or Recurrent Metastatic Melanoma Patients, Malignant Brain Tumors
PET Imaging of Patients With Melanoma and Malignant Brain Tumors Using an 124I-labeled cRGDY Silica Nanomolecular Particle Tracer: A Microdosing Study
Current tests to detect cancer, including CAT scans and MRI scans, are limited. PET scans use special dyes that are injected into a vein and can better localize possible cancer.
- Trial name
- NCT01266096
- Testing
- PET scan with 124I-cRGDY-PEG-dots
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Brain Malignancies, Pseudoprogression
Radiologic Pathologic Correlation of Imaging to Distinguish True Progression From Pseudoprogression in Brain Malignancies
To learn if advanced imaging methods can tell apart true progression (the disease has actually gotten worse) from pseudoprogression (the disease appears to have gotten worse, but it actually has not).
- Trial name
- NCT06199479
- Testing
- MRI Scan, CT Scan, Biopsy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer With Brain Metastasis
HER2-positive Breast Cancer With Brain Metastasis (GCC 1345)
Primary Objective: To determine if treatment with SRS followed by a HER-2 directed therapy regimen results in a 6-month distant brain relapse rate of less than 30%. Secondary Objectives: 1.
- Trial name
- NCT01924351
- Testing
- Stereotactic Radiosurgery plus HER-2 directed therapy in HER2-positive Breast Cancer with Brain Metastasis
- Where
- United States
- Sponsor
- University of Maryland, Baltimore
Pancreas Cancer, Lung Cancer
Stereotactic Magnetic Resonance Guided Radiation Therapy
This is a master prospective Phase I-II trial evaluating feasibility and efficacy of stereotactic magnetic resonance (MR) guided adaptive radiation therapy (SMART) in patients with cancer.
- Conditions
- Pancreas Cancer, Lung Cancer, Renal Cancer, Adrenal Metastases
- Trial name
- NCT04115254
- Testing
- MR-guided Linac
- Where
- 2 sites in United States
- Volunteers
- 397 people
- Sponsor
- Dana-Farber Cancer Institute
Intracranial Neoplasm
Application of New Technologies in the Resection of Intracranial Tumors
Main Outcome: To assess the effectiveness of new intraoperative technologies in the resection of intracranial tumors. Design: Prospective observational study.
- Trial name
- NCT03717766
- Testing
- intraoperative neuronavigation ultrasound, intraoperative tractography, intraoperative fluorescence, advanced neuronavigation and intraoperative neurophysiology
- Volunteers
- 100 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Brain and Central Nervous System Tumors
Surgery Plus Radiation Therapy With or Without Chemotherapy in Treating Children With Primitive Neuroectodermal Tumors of the CNS
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00003859
- Testing
- carboplatin, cyclophosphamide, etoposide
- Where
- United Kingdom
- Volunteers
- 230 people
- Sponsor
- Societe Internationale d'Oncologie Pediatrique
Refractory Cancer, CNS Tumors
A Study of Avutometinib for People With Solid Tumor Cancers
The purpose of this study is to find out whether avutometinib is a safe treatment for advanced or recurrent solid tumor cancers in children and young adults.
- Conditions
- Refractory Cancer, CNS Tumors, CNS Tumor, Adult, CNS Tumor, Childhood
- Trial name
- NCT06104488
- Testing
- Avutometinib
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Brain Neoplasms
The Effect of Vitamin D3 on Postoperative Pain in Patients Undergoing Craniotomy
Vitamin D is a hormone mainly synthesized in the skin in the presence of sunlight. Like other hormones, vitamin D plays a role in a wide range of processes in the body.
- Trial name
- NCT03614403
- Testing
- vitamin D
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Shahid Beheshti University
Amyotrophic Lateral Sclerosis (ALS), Myasthenia Gravis
Innovative Measures of Speech and Swallowing Dysfunction in Neurological Disorders
This study is evaluating the use of two painless, non-invasive technologies in the assessment of muscle health over time in both healthy volunteers and patients who have diseases that affect the nervous system.
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Myasthenia Gravis, Myopathies, Stroke
- Trial name
- QUESST (NCT02118805)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Astrocytoma, Glioma
Phase I Study of Orally Administered Aminolevulinic Acid for Resection of Malignant Astrocytomas
This research is being done to study the safety and utility of 5-aminolevulinic acid (5-ALA) (also known as Gliolan) for identifying brain tumor tissue during surgery.
- Trial name
- NCT01502605
- Testing
- 5-Aminolevulinic Acid
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Brain Metastases
Optimizing Neurocognition With Whole Brain Radiation Therapy (WBRT) Using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique
Study patients will receive Whole-brain radiation therapy (WBRT) - pulsed reduced dose rate (PRDR) within 14 days of registration. All patients will receive single daily fractions using 3D conformal radiotherapy.
- Trial name
- NCT05045950
- Testing
- Memantine -Twice Daily or Extended Release, WBRT utilizing the PRDR technique
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- Medical College of Wisconsin
Central Nervous System Neoplasms, Brain Tumor
B7-H3.CD28Z.CART in CNS Neoplasms
The purpose of this research study is to test the safety and effectiveness of a cell therapy at different doses for children and young adults with recurrent or progressive brain tumors.
- Conditions
- Central Nervous System Neoplasms, Brain Tumor, Brain Tumor, Recurrent, Brain Tumor, Pediatric
- Trial name
- NCT07390539
- Testing
- B7-H3.CD28Z.CART, Fludarabine, Cyclophosphamide
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Robbie Majzner
Hemianopsia, Virtual Reality
Effectiveness of a Visual Telerehabilitation Program on Visual Perception in Children, Adolescents and Young Adults With Hemianopsia Consecutive to a Brain Tumour
Evaluate the efficiency of audiovisual stimulation in virtual reality for improving the visual perception of children, adolescents, and young adults with hemianopia resulting from pediatric brain tumors.
- Conditions
- Hemianopsia, Virtual Reality, Visual Rehabilitation, Pediatric Brain Tumor
- Trial name
- REVIIH-BT (NCT07558395)
- Testing
- Visual Stimulation, standard of care
- Where
- 8 sites in Austria, Denmark and 5 more
- Volunteers
- 120 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Cancer
Patient and Provider Initiated Survivorship Care Planning
Objective: to describe and compare the implementation of two cancer survivorship care tools: (1) 'My Care Plan': a patient-initiated tool and (2) 'Survivorship Care Plan Builder': a provider-initiated tool.
- Trial name
- NCT02405819
- Testing
- 'My Care Plan', 'Survivorship Care Plan Builder'
- Where
- 2 sites in United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Brain Metastases
Improved Therapy Response Assessment in Metastatic Brain Tumors
TREATMENT is an observational study addressing the need for knowledge and adequate diagnostic biomarkers in the response assessment of patients with brain metastasis.
- Trial name
- TREATMENT (NCT03458455)
- Testing
- Magnetic Resonance Imaging, Stereotactic Radiosurgery, Ipilimumab, nivolumab or pembrolizumab
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital
Acute Ischemic Stroke, Active Cancer
Acute Ischemic Stroke in Patients With Active Cancer
The goal of this multicenter prospective observational study, conducted at 24 hospitals in Japan, is to learn about recurrent ischemic stroke in people with active cancer who develop acute ischemic stroke.
- Trial name
- CAT-AIS (NCT07819526)
- Where
- Japan
- Volunteers
- 500 people
- Sponsor
- Osaka University
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