Clinical trials: Neoplasm, Uterine
Neoplasm Cervix
Topical Curcumin for HPV Related Cervical Disease
The purpose of this study is to see if curcumin can suppress HPV infection in women with low-grade squamous intraepithelial lesions (LSIL) disease or treated high-grade squamous intraepithelial lesions (HSIL) disease.
- Trial name
- NCT04266275
- Testing
- Curcumin C3 Complex
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Lisa Flowers
Breast Cancer, Autoimmune Disease
Continuation of Follow-up of DES-Exposed Cohorts
Diethylstilbestrol (DES), a drug first synthesized in 1938, was administered to several million pregnant women in the U.S. and Europe for the prevention of spontaneous abortion and premature delivery.
- Conditions
- Breast Cancer, Autoimmune Disease, Prostate Cancer, Ovarian Cancer
- Trial name
- NCT00340600
- Where
- United States
- Volunteers
- 10,805 people
- Sponsor
- National Cancer Institute (NCI)
Uterine Cervical Neoplasms
Study of Zoledronic Acid Versus Observation on Bone Mineral Density and Incidence of Micrometastasis in Women Undergoing Pelvic Radiation for Cervical Cancer
The treatment of cervical cancer with chemotherapy and radiation will make women post menopausal (no estrogen from the ovaries), if a woman is not already in menopause. Estrogen plays a key role in maintaining bone health.
- Trial name
- NCT00966992
- Testing
- Zoledronic acid
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Washington University School of Medicine
Advanced Solid Tumors, MSI-H/dMMR Tumors
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099318 in Participants With Advanced Solid Tumors
The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics, and pharmacodynamics of INCB099318 in select solid tumors.
- Conditions
- Advanced Solid Tumors, MSI-H/dMMR Tumors, Cutaneous Squamous Cell Carcinoma, Urothelial Carcinoma, HCC
- Trial name
- NCT04272034
- Testing
- INCB099318
- Where
- 24 sites in United States, Belgium and 5 more
- Volunteers
- 105 people
- Sponsor
- Incyte Corporation
Non Small Cell Lung Cancer, Esophageal Cancer
Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors
The objective of this study is to evaluate the safety, tolerability, and efficacy of BL-B01D1 in patients with Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors.
- Conditions
- Non Small Cell Lung Cancer, Esophageal Cancer, Small Cell Lung Cancer, Nasopharyngeal Cancer
- Trial name
- NCT05983432
- Testing
- BL-B01D1
- Where
- 37 sites in United States, France and 3 more
- Volunteers
- 540 people
- Sponsor
- SystImmune Inc.
Endometrial Cancer
Calcium Channel Blocker Amlodipine for Endometrial Cancer Therapy
To explore the treatment efficacy of Progesterone Therapeutic Regimen Plus Amlodipine in patients with early endometrial carcinoma (EEC) for conservative treatment.
- Trial name
- NCT06942377
- Testing
- Amlodipine
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Peking University People's Hospital
HIV Infections, HPV-Related Cervical Carcinoma
Self-collected Vaginal and Urine Samples in HIV-positive Women
This study assesses topics as Human Immunodeficiency Virus (HIV), Human Papilloma Virus (HPV), and cancer screening methods. The focus will be on evaluating feasibility of implementing novel cancer screening modalities in a…
- Conditions
- HIV Infections, HPV-Related Cervical Carcinoma, Cervical Cancer, Coinfection, HIV
- Trial name
- NCT05783167
- Testing
- Self-sampling for HPV infection
- Where
- Guinea-Bissau
- Volunteers
- 502 people
- Sponsor
- University of Aarhus
Cervical Cancer, Precancerous Condition
Combined Digital Colposcopy Analysis to Improve Cervical Precancer and Cancer Detection
Precancerous lesions of the cervix occur frequently and are treatable. This justifies a population-based screening program. Following an abnormal Pap smear, patients are referred for a colposcopic exam to confirm the…
- Trial name
- MDC_Algo (NCT01094132)
- Testing
- Multispectral Digital Colposcope (MDC)
- Where
- 3 sites in United States, Canada
- Volunteers
- 551 people
- Sponsor
- British Columbia Cancer Agency
Carcinoma, Non-Small-Cell Lung, Colorectal Neoplasms
Study of LY3537982 in Cancer Patients With a Specific Genetic Mutation (KRAS G12C)
The purpose of this study is to find out whether the study drug, LY3537982, is safe and effective in cancer patients who have a specific genetic mutation (KRAS G12C).
- Conditions
- Carcinoma, Non-Small-Cell Lung, Colorectal Neoplasms, Endometrial Neoplasms, Ovarian Neoplasms
- Trial name
- NCT04956640
- Testing
- LY3537982, Pembrolizumab, Cetuximab
- Where
- 49 sites in United States, Australia and 4 more
- Volunteers
- 540 people
- Sponsor
- Eli Lilly and Company
Cervical Cancer, Adjuvant Chemotherapy
A Trial Comparing Adjuvant Chemotherapy With Observation After Concurrent Chemoradiotherapy of Cervical Cancer (With Pelvic or Para-aortic Node Involvement)
Cervical cancer with pelvic or para-aortic node involvement has a poor prognosis. Despite low-quality data, the routine practice to treat these patients is radiation with concurrent cisplatin.
- Conditions
- Cervical Cancer, Adjuvant Chemotherapy, Radiation, Lymph Node Metastases
- Trial name
- NCT03468010
- Testing
- chemoradiation, Paclitaxel, Cisplatin
- Where
- 8 sites in China
- Volunteers
- 432 people
- Sponsor
- Sun Yat-sen University
Endometrial Adenocarcinoma
PErsonalized TReatment for Endometrial Carcinoma
The goal of this clinical trial is to compare the efficacy of adjuvant therapies in women with stage I-II molecular integrated high-intermediate or high-risk endometrial carcinoma.
- Trial name
- PETREC (NCT05655260)
- Testing
- Comparison of chemotherapy vs. chemoradiotherapy, Comparison of VBT vs. WPRT
- Where
- Finland
- Volunteers
- 300 people
- Sponsor
- University of Helsinki
Uterine Leiomyomas
Therapeutic MRI Guided High Intensity Focused Ultrasound Ablation of Uterine Fibroids
This study is to collect supplementary safety and technical effectiveness data of Philips MRI guided High Intensity Focused Ultrasound (HIFU) in ablating uterine tissue associated with symptomatic fibroids in a 3T MRI scanner.
- Trial name
- HIFU (NCT01141062)
- Testing
- Philips MR-guided HIFU
- Where
- 2 sites in Canada
- Volunteers
- 15 people
- Sponsor
- Philips Healthcare
Cervical Cancer
International Validation Study of Sentinel Node Biopsy in Early Cervical Cancer
SENTICOL III is large prospective multicenter international randomized study designed to validate the Sentinel Lymph Node (SLN) mapping technique in early cervical cancer.
- Trial name
- SENTICOLIII (NCT03386734)
- Testing
- SLN biopsy only, SLN biopsy + PLN dissection
- Where
- 106 sites in Belgium, Brazil and 12 more
- Volunteers
- 989 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Uterine Fibroids (UF)
A Study to Evaluate Changes in Hair in Adult Participants Taking Oral Oriahnn Capsules With Heavy Menstrual Bleeding (HMB) Associated With Uterine Fibroids (UF)
Uterine Fibroids (UF) are benign smooth muscle neoplasms of the uterus that affect women of reproductive age. UFs are one of the leading causes of hospitalizations for gynecological disorders and often lead to hysterectomy.
- Trial name
- Pink Orchid (NCT06058728)
- Where
- United States
- Sponsor
- AbbVie
Cervical Cancer, Cervical Intraepithelial Neoplasias
Diagnostic Imaging Aid for Management of Cervical Lesions
A handheld digital colposcope which utilizes flurorescent light is being tested for the rapid detection and management of cervical lesions.
- Conditions
- Cervical Cancer, Cervical Intraepithelial Neoplasias, Digital Colposcopy, Precancerous Cervical Lesions
- Trial name
- FFC (NCT02406365)
- Testing
- Diagnostic imaging aid for one-visit management of cervical lesions
- Where
- United States
- Volunteers
- 618 people
- Sponsor
- Brookdale University Hospital Medical Center
Advanced Solid Tumors, MSI-H or dMMR Advanced Solid Tumors
EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors
The goal of this clinical trial is to determine the most effective dose of EIK1005 that a person can take safely. Additionally, this study will test how well EIK1005 is tolerated alone and in combination with pembrolizumab in…
- Conditions
- Advanced Solid Tumors, MSI-H or dMMR Advanced Solid Tumors, MSI-H/dMMR Gastric Cancer, MSI-H/dMMR Colorectal Cancer
- Trial name
- NCT07262619
- Testing
- EIK1005, pembrolizumab (KEYTRUDA® )
- Where
- 45 sites in United States, Australia and 13 more
- Volunteers
- 160 people
- Sponsor
- Eikon Therapeutics
Endometrial Cancer
A Phase 2 Study of Mirvetuximab Soravtansine (IMGN853) and Pembrolizumab in Endometrial Cancer (EC)
This research study is studying a drug combination as a possible treatment for endometrial cancer. The drugs involved in this study are: mirvetuximab soravtansine (IMGN853) pembrolizumab
- Trial name
- NCT03835819
- Testing
- Pembrolizumab, IMGN853
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- Dana-Farber Cancer Institute
Advanced Solid Tumor, Recurrent Endometrial Cancer
Study of ART0380 in Patients With Biologically Selected Solid Tumors
This interventional study will evaluate the efficacy and safety of ART0380 as monotherapy in patients whose tumors have a biology to predict for sensitivity to inhibition of Ataxia-Telangiectasia Mutated and Rad3-related protein…
- Conditions
- Advanced Solid Tumor, Recurrent Endometrial Cancer, Metastatic Cancer
- Trial name
- ARTIST (NCT05798611)
- Testing
- ART0380
- Where
- 15 sites in United States, France and 1 more
- Volunteers
- 36 people
- Sponsor
- Artios Pharma Ltd
BRCA Hereditary Ovarian Carcinoma, Fallopian Tube High Grade Serous Adenocarcinoma
Uterine Lavage to Detect Ovarian Cancer Risk
This clinical trial develops a non-surgical approach using uterine lavage samples to screen for progression to ovarian cancer in high-risk patients carrying BRCA mutations.
- Conditions
- BRCA Hereditary Ovarian Carcinoma, Fallopian Tube High Grade Serous Adenocarcinoma, Ovarian High Grade Serous Adenocarcinoma, Primary Peritoneal High Grade Serous Adenocarcinoma
- Trial name
- NCT07772869
- Testing
- Uterine Lavage, Archive Sample, Survey Administration
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Washington
Endometrial Cancer
The Clinical Utility of DNA Methylation Testing in Patient-collected Urine and Vaginal Samples to Detect Endometrial Cancer: a Case-control Study
The goal of this observational case-control study is to investigate the use of DNA-methylation testing in patient-collected urine and vaginal samples to detect endometrial cancer.
- Trial name
- NCT06846775
- Testing
- DNA-methylation testing in patient-collected urine and vaginal samples
- Where
- 3 sites in Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
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