Clinical trials: Neoplasm, Uterine
Cervical Intraepithelial Neoplasia
Phase 2 Clinical Trial to Evaluate the Safety and Efficacy of Plasmid DNA Therapeutic Vaccine(GX-188E)
The purpose of this study is to access the efficacy and safety of GX-188E according the protocol in patients with Cervical Intraepithelial Neoplasia 2, 2/3 or 3 (CIN3)
- Trial name
- NCT02596243
- Testing
- GX-188E
- Where
- 16 sites in Estonia, South Korea and 1 more
- Volunteers
- 134 people
- Sponsor
- Genexine, Inc.
Uterine Fibroid
Microwave Ablation for Uterine Fibroids
This study is aimed to evaluate the clinical safety and effectiveness of Microwave ablation (MWA) in treating patients with uterine fibroid.
- Trial name
- NCT04073485
- Testing
- Microwave ablation
- Where
- Hong Kong
- Volunteers
- 6 people
- Sponsor
- Chinese University of Hong Kong
Cervix Cancer
Study of Tumour Response to Tirapazamine During Treatment of Cervical Cancer
The purpose of this study is as follows: to determine whether tirapazamine damages cervical tumour DNA immediately after its administration to determine the blood flow and oxygen level of cervical tumour before and after…
- Trial name
- NCT00493376
- Testing
- Cervical tissue biopsy analysis: Comet assay, Biopsy: Measurement of histone gamma H2AX phosphorylation, Biopsy: Immunohistochemistry: Ca9, Glut1, HIF-1 alpha
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- British Columbia Cancer Agency
Cervical Cancer, Cervical Cancer Screening
My Self-Sampling for HPV Awareness, Results, and Empowerment
The overall objective of this study is to conduct formative research and pilot test the provider-level and patient-level components of the My Self-Sampling for HPV Awareness, Results, and Empowerment (MySHARE+) intervention.
- Conditions
- Cervical Cancer, Cervical Cancer Screening, HPV
- Trial name
- MySHARE+ (NCT07296159)
- Testing
- MySHARE+ mHealth Education Intervention, Healthcare Provider Prompt
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Daisy Le
Solid Tumor, Adult
FT538 in Combination With Monoclonal Antibodies in Advanced Solid Tumors
This is a Phase 1 dose-finding study of FT538 in combination with monoclonal antibodies.
- Trial name
- NCT05069935
- Testing
- FT538, Cyclophosphamide, Fludarabine
- Where
- 4 sites in United States
- Volunteers
- 16 people
- Sponsor
- Fate Therapeutics
Endometrial Cancer, Brachytherapy
A Novel Tapered Applicator for Vaginal Vault Brachytherapy
This study will assess the comfort and fit of a novel applicator for endometrial cancer patients who are candidates for vaginal brachytherapy. This study is only assessing the applicator fitting.
- Conditions
- Endometrial Cancer, Brachytherapy, Quality of Life
- Trial name
- NCT04318340
- Testing
- Tapered applicator, Standard applicator
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Yale University
HPV Infection, Nabothian Cyst
Nabothian Cyst Protects or Facilitates Against Cervical Cancer
Aim of the study to asses the realition between HPV infection, Nabothian Cyst and Cervical Intraepithelial lesions or Cervical Cancer
- Conditions
- HPV Infection, Nabothian Cyst, Cervical Cancer
- Trial name
- NCT04488991
- Testing
- Cervical Cancer Rate
- Where
- Turkey (Türkiye)
- Volunteers
- 1,005 people
- Sponsor
- Haseki Training and Research Hospital
Endometrial Cancer
Urinary miRNA in Endometrial Cancer Study
This study is a prospective feasibility study with the addition of a retrospective cohort study on the the expression of microRNA in urine in endometrial cancer patients.
- Trial name
- NCT03824613
- Testing
- Urinary miRNA
- Where
- United Kingdom
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Royal Cornwall Hospitals Trust
Symptomatic or Large Uterine Fibroids
Aromatase Inhibitors for Treatment of Uterine Leiomyomas
Fibroids are benign tumors that might results in bleeding. Surgery is their definitive treatment. Some medical therapies have been tried for women who wish to preserve their uterus.
- Trial name
- NCT00945360
- Testing
- Letrozole (aromatase inhibitor)
- Where
- Lebanon
- Sponsor
- American University of Beirut Medical Center
Breast Carcinoma, Cervical Carcinoma
Support Program for Adoption of Cancer Screening Interventions at a Rural Community-Based Organization
This pilot trial study uses a structural support program for adoption of cancer screening interventions at a rural community-based organization.
- Conditions
- Breast Carcinoma, Cervical Carcinoma, Colorectal Carcinoma, Malignant Solid Neoplasm
- Trial name
- NCT04208724
- Testing
- Training, Cancer Screening intervention, Survey Administration
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Uterine Myoma, Uterine Adenomyosis
Single Incision Laparoscopic Surgery (SILS) Versus Conventional Laparoscopic Hysterectomy
Multi-center prospective randomized trial of single port laparoscopic surgery (SILS) versus conventional 3-4 ports laparoscopic hysterectomy.
- Trial name
- NCT01483417
- Testing
- Single incision Laparoscopic hysterectomy, Conventional laparoscopic hysterectomy
- Where
- 8 sites in South Korea
- Volunteers
- 240 people
- Sponsor
- Samsung Medical Center
Cervical Cancer
Detection of Biomarkers in Abnormal Cervical Cells in Women With Abnormal Pap Test Results
RATIONALE: Examining biomarkers in abnormal cervical cells may improve the ability to detect these cells and plan effective treatment.
- Trial name
- NCT00004091
- Testing
- Papanicolaou test, cytology specimen collection procedure, fluorescent antibody technique
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Northwestern University
Uterine Cervical Neoplasms
Chemotherapy With Anlotinib in Advanced Cervical Cancer
STUDY HYPOTHESIS: The primary hypothesis is whether chemotherapy with Anlotinib improves overall survival in advanced cervical cancer. TRIAL DESIGN: The study is a prospective, single-arm, observational clinical study.
- Trial name
- NCT04695535
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Yang Shen
Cervical Cancer
Clinical Value of the Fertility-preserving Surgery in Cervical Cancer
Purpose: To evaluate the clinical value of preserving the ascending branch of the uterine artery in improving the uterine blood supply after radical trachelectomy (RT).
- Trial name
- NCT05806125
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Cervical Cancer Squamous Cell, Human Papilloma Virus Infection
Hybrid Capture Test on Mobile Unit Program to Improve Cervical Cancer Screening in Brazilian Rural and Remote Areas
This study evaluates the women cervical samples through molecular tests in order to: 1. Deploy the test careHPV (hybrid capture test) in mobile unities of the Barretos Cancer Hospital to evaluate their performance;
- Conditions
- Cervical Cancer Squamous Cell, Human Papilloma Virus Infection, Human Papilloma Virus-Related Carcinoma, Prevention
- Trial name
- careHPV (NCT01539668)
- Where
- 2 sites in Brazil
- Volunteers
- 5,079 people, healthy volunteers welcome
- Sponsor
- Barretos Cancer Hospital
Cancer of Cervix, Apoptosis
Prognostic Role of Inhibitor of Apoptosis Protein Overexpression on Recurrence Rate in Cervical Cancer
Overexpression of inhibitors of apoptosis proteins (IAPs) in patients treated for locally advanced cervical cancer with exclusive radio-chemotherapy may have a prognostic role on the local recurrence rate at 24 months.
- Trial name
- EPIcol (NCT06147960)
- Testing
- Immunohistochemistry
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Ovarian Cancer, Endometrial Cancer
Phase I BKM120/Abraxane in Solid Tumors, Expansion Phase Recurrent Endometrial or Ovarian Cancer
The purpose of the first part of this study or the dose escalation portion of the study is to determine what dose of BKM120 and Abraxane is safe to give when the two drugs are used at the same time in patients who are diagnosed…
- Conditions
- Ovarian Cancer, Endometrial Cancer, Recurrent Ovarian Cancer, Recurrent Endometrial Cancer
- Trial name
- NCT02117817
- Testing
- BKM120, Nabpaclitaxel
- Sponsor
- Rutgers, The State University of New Jersey
Uterine Cancer
A Retrospective Study on Multiple Classifier Endometrial Cancer
Endometrial cancer is not a single entity but rather a very heterogeneous group of diseases. Historically, endometrial cancer patients have been classified as endometrioid (type I) or non-endometrioid (type II) according to the…
- Trial name
- NCT05976113
- Testing
- Observation only
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Uterine Fibroids, Heavy Menstrual Bleeding
Efficacy and Safety of BG2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids.
The primary objective of this study is to demonstrate the superior efficacy versus placebo of BG2109 alone and in combination with add-back therapy for the reduction of heavy menstrual bleeding associated with uterine fibroids in…
- Trial name
- NCT05620355
- Testing
- BG2109, Add-back therapy
- Where
- 29 sites in China
- Volunteers
- 312 people
- Sponsor
- Bio Genuine (Shanghai) Biotech Co., Ltd.
Stage I Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8
Impact of Sentinel Lymph Node Mapping on Patient Reported Lower Extremity Limb Dysfunction in Stage I Endometrial Cancer
This phase III trial compares the effect of sentinel lymph node mapping to standard lymph node dissection in reducing the risk of swelling in the legs (lymphedema) in patients undergoing a hysterectomy for stage I endometrial…
- Trial name
- NCT05646316
- Testing
- Biospecimen Collection, Diagnostic Imaging Testing, Excisional Biopsy
- Where
- 60 sites in United States, South Korea
- Volunteers
- 428 people
- Sponsor
- NRG Oncology
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