Clinical trials: Neoplasm, Uterine
Cervical Cancer
Definitive Hypofractionated Intensity-modulated Radiation Theraphy With Concurrent Chemotherapy in Cervical Cancer
This study aims to evaluate the efficacy and safety of hypofractionated intensity-modulated radiation therapy (IMRT) combined with concurrent chemotherapy in patients with cervical cancer.
- Trial name
- DEHIM_CCRT (NCT07439497)
- Testing
- Definitive hypofractionated intensity-modulated radiation theraphy, concurrent chemotherapy
- Where
- South Korea
- Volunteers
- 34 people
- Sponsor
- Samsung Medical Center
Cervical Cancer
Game Changers for Cervical Cancer Prevention
This randomized controlled trial will evaluate Game Changers for Cervical Cancer Prevention (GC-CCP) for increasing cervical cancer (CC) screening advocacy among intervention recipients (index participants) towards female social…
- Trial name
- GC-CCP (NCT06010160)
- Testing
- Game Changers for Cervical Cancer Prevention
- Where
- Uganda
- Volunteers
- 936 people, healthy volunteers welcome
- Sponsor
- RAND
Recurrent or Metastatic Cervical Cancer
Relacorilant and Nab-Paclitaxel in Recurrent or Metastatic Cervical Cancer
This phase II study will evaluate the efficacy and safety of relacorilant in combination with nab-paclitaxel in participants with recurrent or metastatic cervical cancer who have previously received platinum-based chemotherapy…
- Trial name
- STELLA (NCT07763496)
- Testing
- Relacorilant, Nab-paclitaxel
- Where
- 2 sites in France
- Volunteers
- 63 people
- Sponsor
- ARCAGY/ GINECO GROUP
Cancer
Laboratory Assay in Determining Cancer Resistance in Patients With Metastatic Cancer and in Healthy Participants
RATIONALE: Studying samples of blood and tissue in the laboratory from patients with cancer and from healthy participants may help doctors learn more about cancer.
- Trial name
- NCT00899496
- Testing
- immunological diagnostic method, physiologic testing
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Uterine Leiomyomas
Bleeding Control Methods in Open Myomectomy
Excessive intraoperative bleeding remains a major challenge during open myomectomy and may lead to postoperative anemia and increased morbidity.
- Trial name
- NCT07553091
- Testing
- Tourniquet application, Uterine artery bulldog clamp
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Yuzuncu Yil University
Cervical Dysplasia, Cervical High Grade Squamous Intraepithelial Lesion
REVEAL 1 (Evaluation of VGX-3100 and Electroporation for the Treatment of Cervical HSIL)
HPV-301 is a prospective, randomized, double-blind, placebo controlled Phase 3 study to determine the efficacy, safety, and tolerability of VGX-3100 administered by intramuscular (IM) injection followed by electroporation (EP)…
- Conditions
- Cervical Dysplasia, Cervical High Grade Squamous Intraepithelial Lesion, HSIL
- Trial name
- REVEAL 1 (NCT03185013)
- Testing
- VGX-3100, Electroporation (EP)
- Where
- 60 sites in United States, Argentina and 17 more
- Volunteers
- 201 people
- Sponsor
- Inovio Pharmaceuticals
Pregnancy Related, Pregnancy Complications
Relugolix Pregnancy Registry: An Observational Study of the Safety of Relugolix-Containing Therapy Exposure in Pregnant Women and Their Offspring
The Relugolix Pregnancy Registry is a prospective, observational cohort study designed to evaluate the association between relugolix-containing therapy exposure during pregnancy and subsequent maternal, fetal, and infant…
- Conditions
- Pregnancy Related, Pregnancy Complications, Pregnancy, High Risk
- Trial name
- NCT05739123
- Testing
- Relugolix-Containing Product
- Where
- United States
- Volunteers
- 728 people
- Sponsor
- Sumitomo Pharma Switzerland GmbH
Cervical Cancer
Image Based Brachytherapy in Locally Advanced Cervical Cancers - a Randomized Controlled Trial
Purpose of the study is to determine whether Image based brachytherapy is superior in terms of local control to Conventional radiograph based brachytherapy in locally advanced cervical cancers in a Phase III randomized setting.
- Trial name
- COMBAT-Cx (NCT03005743)
- Testing
- Magnetic Resonance Image based Brachytherapy, Conventional Radiograph based Brachytherapy
- Where
- India
- Volunteers
- 1,050 people
- Sponsor
- Tata Memorial Hospital
Ovarian Cancer, Uterine Cancer
Fosaprepitant Versus Aprepitant in the Prevention of Chemotherapy Induced Nausea and Vomiting
Nausea and vomiting are two of the more concerning adverse outcomes associated with chemotherapy in the treatment of gynecologic malignancies.
- Trial name
- NCT01432015
- Testing
- fosaprepitant, aprepitant
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Gynecologic Oncology Associates
Infections, Papillomavirus
Safety Study of GSK Biologicals' Human Papillomavirus Vaccine in 580299/008 Subjects From Canada or the US
This phase 3b study is designed to assess the safety of GlaxoSmithKline Biological's HPV vaccine GSK580299 in female subjects who took part in study 580299/008 and received the control vaccine (Hepatitis A vaccine).
- Trial name
- NCT00799825
- Testing
- GSK Biological's HPV vaccine GSK580299 (Cervarix™)
- Where
- 48 sites in United States, Canada
- Volunteers
- 346 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Infections, Papillomavirus
Gynaecological Follow-up of a Subset of 580299/008 (NCT00122681) Study Subjects
This study is designed to provide up to four years of annual oncogenic HPV DNA testing and cervical cytology examination for NCT00122681 study subjects who displayed normal cervical cytology but tested positive for oncogenic HPV…
- Trial name
- NCT00937950
- Testing
- Gynaecological follow-up
- Where
- 83 sites in United States, Australia and 11 more
- Volunteers
- 2,022 people
- Sponsor
- GlaxoSmithKline
Cervical Cancer
Interest of PET Imagery With 18-FDG in the Extension Assessment of the Cervical Cancer
In cervical cancer prognosis factors are size of the tumour, pelvic and para-aortic lymph nodes involvement. The initial treatment taking is determined by lymph node evaluation.
- Trial name
- NCT00199680
- Testing
- PET
- Where
- 3 sites in France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Limoges
Genital Diseases, Female, Ovarian Diseases
Efficacy,Tolerability,Safety of Temsirolimus in Women With Platinum-refractory Ovarian Carcinoma or Advanced Endometrial Carcinoma
The purpose of this study is to determine the activity, tolerability and safety of Temsirolimus in women with ovarian cancer who progressed during the previous platinum chemotherapy alternatively within 6 months from completion…
- Conditions
- Genital Diseases, Female, Ovarian Diseases, Ovarian Neoplasms, Endometrial Neoplasms
- Trial name
- NCT01460979
- Testing
- Temsirolimus
- Where
- 18 sites in Germany
- Volunteers
- 47 people
- Sponsor
- AGO Study Group
Lynch Syndrome, Endometrial Neoplasms
Universal Screening for Lynch Syndrome in Women With Endometrial and Non-Serous Ovarian Cancer
This study will maximize identification of women with Lynch Syndrome using an enhanced screening strategy to identify those at risk.
- Conditions
- Lynch Syndrome, Endometrial Neoplasms, Ovarian Neoplasms, Colorectal Neoplasms
- Trial name
- LS2 (NCT02494791)
- Testing
- Questionnaire, Educational Material
- Where
- Canada
- Volunteers
- 886 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Cervical Cancer
Nimotuzumab Plus Tislelizumab for Recurrent and Metastatic Cervical Cancer
Patients with recurrent or metastatic cervical cancer have very poor prognosis. For eligible patients, radiotherapy remains the choice, which has the most effective impact on the survival periods.
- Trial name
- NCT06039891
- Testing
- Nimotuzumab、Tislelizumab
- Volunteers
- 55 people
- Sponsor
- Peking Union Medical College Hospital
Endometrial Cancer, Cervical Stromal Invasion
Radiomics Based Multimodal Transvaginal Ultrasound Imaging in Endometrial Cancer
Retrospectively collect preoperative transvaginal B-mode ultrasound (BMUS), color Doppler flow imaging (CDFI) and three-dimensional ultrasound (3D-US) images and clinical data in patients with non-endometrial cancer diseases and…
- Conditions
- Endometrial Cancer, Cervical Stromal Invasion, Transvaginal Ultrasound
- Trial name
- NCT05387460
- Testing
- radiomics
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Tongji Hospital
Cervical Cancer
A Study of RC48-ADC Combination With Zimberelimab Injection Therapies at Least First-line Platinum-containing Standard Therapy Failed With Recurrent or Metastatic Cervical Cancer
This study will evaluate the efficacy,safety of RC48-ADC in Combination with Zimberelimab Injection for the Treatment ,at least first-line platinum-containing standard therapy failed in HER2-expressing subject with Recurrent or…
- Trial name
- NCT06155396
- Testing
- Disitamab Vedotin, Zimberelimab
- Where
- 12 sites in China
- Volunteers
- 116 people
- Sponsor
- RemeGen Co., Ltd.
HIV (Human Immunodeficiency Virus), HPV
Feasibility Study Comparing One vs Two Probes for Thermal Ablation Among Cervical Cancer Screen Positive WLWH in C1001P-CS9 South Africa
Cervical cancer disproportionately affects women in low- and middle-income countries (LMICs), particularly women living with HIV (WLWH) who have a 6-fold increased risk of cervical cancer compared to women in the general…
- Conditions
- HIV (Human Immunodeficiency Virus), HPV, Cervical Precancer, Cervical Neoplasia
- Trial name
- NCT07645378
- Testing
- Thermal ablation (TA) with 1 probe, Thermal ablation (TA) with 2 probes
- Where
- South Africa
- Volunteers
- 200 people
- Sponsor
- Fred Hutchinson Cancer Center
Cervical Dysplasia
A Phase II Single-arm Intervention Trial of Nelfinavir in Patients With Grade 2/3 or 3 Cervical Intraepithelial Neoplasia
Preliminary data showed that Nelfinavir has selective apoptotic effects on HPV+ cervical tumor cell lines. Furthermore, in a Phase I clinical trial, the combination of NFV and chemoradiotherapy showed acceptable toxicity and…
- Trial name
- NCT01925378
- Testing
- Nelfinavir
- Where
- United States
- Sponsor
- The University of Texas Health Science Center, Houston
Cervix Cancer, Cervical Cancer
Study of Pembrolizumab and Lenvatinib in Metastatic and Recurrent Cervix Cancer (LenPem Cervix)
The main purpose of this study is to gather information about an investigational drug combination, Lenvatinib in combination with pembrolizumab, that may help to treat cervical cancers.
- Trial name
- NCT06266338
- Testing
- Pembrolizumab, Lenvatinib
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Texas Southwestern Medical Center
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