Clinical trials: Neoplasm
Uterine Leiomyoma
Evaluation of Using Dienogest and N-Acetyl Cysteine on the Volume of Uterine Leiomyoma
This 2 arm randomized clinical trial will assess the impact of Dienogest and N-Acetyl Cysteine on volume reduction of uterine leiomyoma
- Trial name
- NCT06115408
- Testing
- Dienogest 2 MG, N-acetyl cysteine
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Breast Cancer
PROSPR/PCIPS Project 3: Communication of Personalized Breast Cancer Risk
In order to better communicate personal risk of breast cancer to women who have not yet initiated breast cancer screening (mammography), The Annenberg School of Communication at the University of Pennsylvania has created a…
- Trial name
- NCT01879189
- Testing
- Breast Cancer Screening Decision Aid
- Where
- 9 sites in United States
- Volunteers
- 1,302 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Detection Autoantibody of Myasthenia Gravis
The Specificity, Sensitivity and Clinical Correlation of CBA, RIPA and ELISA in Detecting AChR and MuSK IgG of Myasthenia Gravis
Myasthenia gravis (MG) is a neuromuscular junction (NMJ) disorder mediated by autoantibodies against AChR, MuSK or other autoantigens located at the post synaptic membrane of the neuromuscular junction.
- Trial name
- NCT05219097
- Testing
- CBA Assay
- Where
- 2 sites in China
- Volunteers
- 2,663 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University General Hospital
Melanoma (Skin Cancer), Artificial Intelligence (AI)
Artificial Intelligence Based Melanoma Early Diagnosis and Risk Prediction in Children, Adolescents and Young Adults
The goal of this study is to develop supportive diagnostic artificial intelligence algorithms to distinguish melanoma from nevi or other benign pigmented skin lesions, especially in younger patients (below the age of 30).
- Conditions
- Melanoma (Skin Cancer), Artificial Intelligence (AI), Pediatric Cancer
- Trial name
- AI-MEL (NCT06621810)
- Where
- 3 sites in Germany, Italy and 1 more
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- German Cancer Research Center
Pancreatic Cancer
Study of Combined RHUMAB VEGF and Capecitabine-based Chemoradiation for Patients With Locally Advanced Pancreatic Cancer
The goal of this clinical research study is to find the highest safe dose of the drug Bevacizumab that can be given in combination with chemoradiation for the treatment of pancreatic cancer.
- Trial name
- NCT00047710
- Testing
- Bevacizumab, Capecitabine, Radiotherapy
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Cancer
Bioavailability and Food Effect Study of Gelatin Formulation and Immediate Release Tablet Formulation of Afuresertib
This study is being conducted to measure the relative bioavailability of the original gelatin capsule formulation and a new formulation, immediate release (IR) tablet of Afuresertib (GSK2110183).
- Trial name
- NCT02040480
- Testing
- GSK2110183 Gelatin Capsule, GSK2110183 IR Tablet
- Where
- Australia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Tobacco Use Disorder, Lung Cancer
Assessing the Link Between Smoke Carcinogen Biomarkers and Lung Cancer Risk - 1
Lung cancer is the leading cause of cancer death in the United States. Currently it remains impossible to predict which smokers will get cancer. Each puff of a cigarette delivers a mixture of over 60 known carcinogens.
- Trial name
- NCT00218179
- Testing
- Non-intervention
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cancer, Metabolic Disease
An Observational Study On TheAccuracy Of Whole-Body Magnetic Resonance Imaging (Wb-Mri) ScreeningTo Predict Clinically Significant Diagnoses In General Population Subjects Interested In Proactive And Advanced General Preventive Healthcare.
This is a prospective, single-arm, observational study capturing data from whole-body magnetic resonance imagining (WB-MRI) from up to 100,000 male and female subjects 18 years of age or older recruited at multiple clinical sites…
- Conditions
- Cancer, Metabolic Disease, Aneurysm, Neurologic Disorder
- Trial name
- Hercules (NCT06212479)
- Testing
- MRI Scan
- Where
- United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Hercules
Polycystic Ovary Syndrome
Incretin Secretion in Women With Polycystic Ovary Syndrome (PCOS)
The incretin hormones are secreted from the gastrointestinal tract in response to nutrient ingestion, and are responsible for 70 % of insulin secretion in response to glucose.
- Trial name
- NCT00647023
- Testing
- metformin
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Benign Prostate Hypertrophy(BPH), Prostate Cancer (Diagnosis)
Application of Quantum Detection-Driven Artificial Intelligence Algorithms for Single-Molecule cfDNA Characterization in the Early Diagnosis of Prostate Cancer
This research project aims to develop a novel blood testing method integrating cutting-edge quantum sensing and artificial intelligence technologies to achieve precise, non-invasive early diagnosis of prostate cancer.
- Conditions
- Benign Prostate Hypertrophy(BPH), Prostate Cancer (Diagnosis), Prostate Neoplasm
- Trial name
- NCT07238959
- Testing
- Quantum Detection
- Where
- 7 sites in China
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
Cervical Cancer Prevention
Study on the Safety, Humoral Immune Response, and Memory B Cell Response Characteristics of Sequential 9-Valent HPV Vaccination
This is a single-center, prospective, open-label, partially randomized, matched-controlled trial designed as a cohort study. The study plans to enroll 360 healthy female participants aged 18 to 45 years, divided into three…
- Trial name
- NCT07530679
- Testing
- 9-valent HPV vaccination at months 0 and 6, 9-valent HPV vaccination at months 0 , 1 and 6
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Colonoscopy, Colorectal Cancer Screening
Triton 1.5 Robotic System for Diagnostic Colonoscopy in the Middle East
The purpose of this study is to gain early experience in the Triton 1.5 System in performing diagnostic, screening, surveillance, and basic therapeutic tasks (e.g., polypectomy for lesions ≤ 2 cm).
- Trial name
- CARE-UAE (NCT07835542)
- Testing
- Diagnostic Test: Diagnostic Colonoscopy
- Where
- United Arab Emirates
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Neptune Medical
Epilepsy, Functional Neurological Disorder
EXercise-induced PhysioLogical Adaptations In Neurological Disorders
The goal of this study is to investigate how a one-time exercise session influences different parameters of brain function in people with neurological diseases compared to healthy volunteers.
- Conditions
- Epilepsy, Functional Neurological Disorder, Mild Cognitive Impairment, Dementia
- Trial name
- EXPLAIN (NCT07883720)
- Testing
- Acute Exercise
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Pancreatic Cancer, Colon Cancer
Progressive Muscle Relaxation Exercises on Sleep, Fatigue and Pain in Pancreatic and Colon Cancer Patients
With regular practice, relaxation has been found to have many benefits such as reducing sensitivity to pain and fatigue, facilitating the transition to sleep, and improving quality of life.
- Trial name
- NCT06920082
- Testing
- Progressive muscle relaxation exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul Sabahattin Zaim University
Delirium
Early Diagnosis and Treatment Standardization of Delirium
1. Observe the characteristics of delirium patients, searching for early diagnostic methods or finding risk factors 2. Design a guideline for delirium, diagnosis or treatment
- Trial name
- NCT03199859
- Where
- South Korea
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Hereditary Cancer-Predisposing Syndrome
Inherited Risk Evaluation Tool (InheRET): Identifying Patients at Increased Risk for Hereditary Disease
This study will evaluate the impact InheRET™, an online family history gathering and risk assessment reporting tool, has on facilitating National Comprehensive Cancer Network(NCCN) guideline compliant referrals for cancer genetic…
- Trial name
- NCT04510896
- Testing
- InheRET, Patient Acceptance, Physician Acceptance Survey
- Where
- 4 sites in United States
- Volunteers
- 2,232 people, healthy volunteers welcome
- Sponsor
- InheRET, Inc
Medical Trainees in Oncology Programs
A Study to Implement and Evaluate REFLECT Communication Curriculum for Oncology Based Medical Graduate Students
The purpose of this study is to collect data from quarterly workshops (standardized patient simulations, reflective narratives, questionnaires, surveys, standardized patient and peer feedback, and participant critiques) of…
- Trial name
- NCT04557696
- Testing
- REFLECT Curriculum
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Cutaneous Squamous Cell Carcinoma of the Head and Neck, Healthy Subject
Magnetic Resonance (MR) Imaging & Blood Biomarkers for Head and Neck Cancer
The goal of this research study is to find out if using additional MRIs and biomarker testing can help researchers learn to predict how the tumor may change during radiation therapy.
- Conditions
- Cutaneous Squamous Cell Carcinoma of the Head and Neck, Healthy Subject, Head and Neck Cancer
- Trial name
- NCT03491176
- Testing
- Biospecimen Collection, Magnetic Resonance Imaging, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer
Peers Promoting Exercise Adoption and Maintenance Among Cancer Survivors
Exercise adoption enhances well-being and recovery from breast cancer. Researchers trained American Cancer Society volunteers to provide exercise counseling to breast cancer survivors and the survivors increased their exercise in…
- Trial name
- NCT02694640
- Testing
- Reach Plus, Reach Plus Phone, Reach Plus Message
- Where
- United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Healthy Participants
A Study to Investigate the Effect of Capivasertib on the Pharmacokinetics of Oral Rosuvastatin in Healthy Participants
The purpose of the study is to assess the effect of capivasertib on the pharmacokinetics (PK) of oral rosuvastatin in healthy participants.
- Trial name
- NCT07088913
- Testing
- Capivasertib, Rosuvastatin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
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