Clinical trials: Neoplasm
Colorectal Cancer
The Clinical Application of 68Ga Labeled ssDNA Aptamer Sgc8 in Healthy Volunteers and Colorectal Patients
The protein tyrosine kinase-7 (PTK7) is overexpressed in various types of human cancers. As a specific imaging agent of PTK7, 68Ga-Sgc8 was investigated in this study to assess its safety, biodistribution and dosimetric…
- Trial name
- NCT03385148
- Testing
- 68Ga-Sgc8
- Where
- 2 sites in China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Bone Tumor
Comparing of the Pharmacokinetic, Pharmacodynamic, Safety and Immunogenicity of MW032 and Xgeva® in Healthy Adults
A randomized, double-blind and parallel group study to compare the pharmacokinetic, safety and pharmacodynamic of MW032 and Xgeva® in healthy adults.
- Trial name
- MW032 (NCT04798326)
- Testing
- MW032, Xgeva®
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mabwell (Shanghai) Bioscience Co., Ltd.
Metrorrhagia, Menorrhagia
Surgical Success After Laparoscopic vs Abdominal Hysterectomy
The purpose of the proposed pilot study is to investigate the effectiveness, cost, safety, and long-term impact on quality of life of laparoscopic hysterectomy (LH) in relation to abdominal hysterectomy (AH) for the treatment of…
- Conditions
- Metrorrhagia, Menorrhagia, Leiomyoma, Adenomyosis
- Trial name
- NCT01793584
- Testing
- Laparoscopic hysterectomy, Abdominal hysterectomy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Early Diagnosis, Cancer
Role of Genomic Imprinting in Cancer Diagnosis
The current research focus for cancer diagonosis is classical genetics, named "driving genes". However, not all cancer patients have typical genetic alterations, especially at early stage.
- Conditions
- Early Diagnosis, Cancer, Biomarker, Genomic Imprinting
- Trial name
- NCT03882684
- Testing
- In-situ imprinting detection
- Where
- China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Chinese Alliance Against Lung Cancer
Breast Cancer
The Radiation Metabolic Signature of Patient Undergoing Radiotherapy. A Pilot Study
Rationale: Local radiotherapy applied in the treatment of tumors changes the metabolic profile in the exposed area and/or systemically and specific radiation biomarkers can be identified in the respective matrices.
- Trial name
- NCT01975558
- Testing
- Sampling at baseline, one week after baseline, two weeks after baseline, Sampling at baseline, during radiotherapy and after
- Where
- Switzerland
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Actinic Keratosis
Efficacy of Iontophoresis-assisted AFL-PDT in Actinic Keratosis
Iontophoresis is a transdermal drug-delivery technique that enhances the transport of ionic species across membranes and may have significant benefit for the treatment of actinic keratosis (AK) by ablative fractional laser-primed…
- Trial name
- NCT02670655
- Testing
- lidocaine/prilocaine (5%) application, 2940-nm Er:YAG AFL pretreatment, MAL application
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Dong-A University
Infratentorial Neoplasms
Effects of the Prone and the Sitting Positions on the Brain Oxygenation in Posterior Fossa Surgery
The sitting or prone positions are used for posterior fossa surgery. Although the sitting position may cause hemodynamic instability, venous air embolism, it also provides optimum access to midline lesions, decreases intracranial…
- Trial name
- NCT02933749
- Testing
- SctO2, BIS
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Adenomyosis, Leiomyoma
New Inflammation Markers for Distinguishing Uterine Adenomyosis and Leiomyoma
Both pelvic masses and preoperative diagnosis of them have still continued as an important investigation subject. It is important to discriminate the diagnoses of leiomyoma and adenomyosis before operation especially among…
- Conditions
- Adenomyosis, Leiomyoma, Inflammation
- Trial name
- NCT02997787
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kayseri Education and Research Hospital
Non-small Cell Lung Cancer Stage II, Bevacizumab
Study to Evaluate the Safety and Efficacy of Serplulimab Plus Bevacizumab and Chemotherapy in NSCLC Patients With Brain Metastases
A multicenter, single-arm, open study to evaluate the safety and efficacy of Serplulimab in combination with bevacizumab and first-line chemotherapy in driver negative non-squamous NSCLC patients with brain metastases
- Conditions
- Non-small Cell Lung Cancer Stage II, Bevacizumab, Immunotherapy, Brain Metastases
- Trial name
- SUPER BRAIN (NCT05807893)
- Testing
- Serplulimab combined with bevacizumab and first-line chemotherapy
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Bladder Cancer
Evaluation of the PhageTech Virus BioResistor
To evaluate the effectiveness of the PhageTech Virus BioResistor to detect bladder cancer biomarkers.
- Trial name
- NCT04756284
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- PhageTech, Inc.
Lymphedema, Breast Neoplasm
Presentation of First Time Attenders at Lymphedema Clinics
The first aim of this research project is to identify what factors motivate patients to seek assessment for early lymphedema and further, to gain insight into the signs and symptoms of developing lymphedema and the concurrent…
- Trial name
- NCT03687749
- Where
- 2 sites in Australia, Belgium
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Breast Cancer
Pilot Study: Combined Molecular Breast Imaging/Ultrasound System for Diagnostic Evaluation of MBI-detected Lesions
A combined molecular breast imaging / ultrasound system will enable coregistration of a functional abnormality seen on Molecular Breast Imaging (MBI) with the corresponding anatomical abnormality seen on ultrasound.
- Trial name
- MBI/US (NCT01806558)
- Testing
- Molecular Breast Imaging
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Colon Cancer, Breast Cancer
A Digimed Oncology PharmacoTherapy Registry
DigiMeds™ are medications with FDA-approved ingestible sensors (IS), a wearable sensor patch (patch), and a mobile app, which records time-stamped medication type and dose alongside biometric activity.
- Conditions
- Colon Cancer, Breast Cancer, Rectal Cancer
- Trial name
- ADOPTR (NCT04088955)
- Testing
- DigiMeds
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Proteus Digital Health, Inc.
High Risk Population of Gastric Cancer
Application of OE in Diagnosis of EGC
The main purpose of this study is to evaluate application value of OE mode 2 in the diagnosis of early gastric cancer The Secondary purpose is to evaluate application value of OE mode 1 in differentiating the diagnosis of…
- Trial name
- NCT04720521
- Testing
- OE+white light
- Where
- China
- Volunteers
- 2,454 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Lung Cancer
Project Lung Cancer Screening in Southern Denmark
One thousand randomly selected voluntary citizens aged 60-74 years old, who are heavy current or former smokers with an increased risk of developing lung cancer may be included in the project.
- Trial name
- PLUS (NCT06537804)
- Testing
- Screening by low-dose CT scan
- Where
- 2 sites in Denmark
- Volunteers
- 1,332 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Colorectal Cancer
A Model for the Early Diagnosis of Colorectal Cancer by the Detection of 5-hydroxymethylcytosine (5-hmC) in Plasma Cell-free DNA
In this study, the investigators establish a model for the early diagnosis of colorectal cancer based on detection of 5-hydroxymethylcytosine (5-hmC) in training group and validate the effectiveness of the model using a…
- Trial name
- NCT03599947
- Where
- China
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Fudan University
Oral Cancer, Oral Leukoplakia
Oral Cancer Screening and Education in Hong Kong
This study will be conducted to obtain data on oral cancer risk factors to generate machine learning models with good predictive accuracy for stratifying individuals with high-oral cancer risk and delineating high-risk and…
- Conditions
- Oral Cancer, Oral Leukoplakia, Oral Submucous Fibrosis, Proliferative Verrucous Leukoplakia
- Trial name
- NCT04487938
- Testing
- No intervention utilised
- Volunteers
- 3,190 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Anxiety, Evidence-based Practice
The Effect of Music on Anxiety and Caregiver Burden in Family Caregivers of Patients With Lung Cancer
This randomized controlled trial evaluated the effects of a 7-day self-selected music intervention on caregiver burden and anxiety among first-degree family caregivers of patients with lung cancer.
- Conditions
- Anxiety, Evidence-based Practice, Caregiver Burden, Nursing
- Trial name
- NCT07847138
- Testing
- Music intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Izmir Bakircay University
Breast Carcinoma
What Women Want: Real Time Results During Screening Mammography in the Era of Patient-Experience Driven Care
This study explores why patients may want to receive real-time imaging results during a screening mammogram appointment at an MD Anderson breast imaging center.
- Trial name
- NCT04794816
- Testing
- Questionnaire Administration
- Volunteers
- healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Prostate Cancer Stage, PSMA
99mTc-QULIC-5-P1 SPECT Imaging in Patients With Prostate Cancer
99mTc-QULIC-5-P1 is a new radiotracer targeting PSMA, which is promising as an excellent imaging agent applicable to PSMA positive prostate cancer.
- Conditions
- Prostate Cancer Stage, PSMA, SPECT
- Trial name
- NCT06419348
- Testing
- 99mTc-QULIC-5-P1
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
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