Clinical trials: Neoplasm
Breast Cancer
Reconstructions With Back Donor Site Flaps and Validation of Quality of Life Scales
The latissimus dorsi flap is the oldest and most used technique for breast reconstruction. Nonetheless, there are few studies evaluation the long-term effect of harvesting one of the muscles of the back.
- Trial name
- NCT04526561
- Testing
- Latissimus dorsi flap, Thoracodorsal artery perforator flap to breast, Deep inferior epigastric perforator flap
- Where
- Sweden
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Skin Cancer
TLR4 Polymorphisms and Risk of Skin Cancer
Toll-like receptors (TLRs) play a key role in the innate immune system. Toll-like receptor-4 (TLR4) in particular, appears to play a role in susceptibility to cancer.
- Trial name
- NCT03122366
- Testing
- Detection of single nucleotide polymorphisms (SNP)
- Where
- United States
- Volunteers
- 392 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Refractory Solid Tumors, Lymphomas
A Double-Blind Study in Healthy Volunteers to Assess the Effect of E7080 on the QTc Interval
This is a double-blind (vis-a-vis lenvatinib), randomized, placebo-controlled, three-treatment, three-way crossover study in healthy subjects. There are two phases in this study: Pre-Randomization and Randomization.
- Trial name
- NCT01525394
- Testing
- Lenvatinib, Moxifloxacin 400 mg
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
IORT-Intra-Operative Radiation Therapy
Oncoplastic Partial Mastectomy With Intraoperative Radiation Therapy (IORT) in Early Stage Breast Cancer Patients With Prior History of Chest Wall Radiation.
Prospective, Non-randomized, Single-arm.The objectives of this study are to evaluate cosmesis and perioperative complications associated with the use of intraoperative radiotherapy (IORT) at the time of partial mastectomy in…
- Trial name
- NCT05289466
- Testing
- Intraoperative Radiotherapy, Oncoplastic partial mastectomy
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Saint John's Cancer Institute
Prostate Cancer Screening
Screening for Prostate Cancer Using High Resolution Micro-ultrasound Versus Multiparametric Magnetic Resonance Imaging.
The purpose of this study is to compare whether the FDA and Health Canada approved microUS is as effective as the currently used option (MRI) for imaging the prostate gland.
- Trial name
- MUSIC-Screen (NCT06626022)
- Testing
- MRI, ExactVu
- Where
- 9 sites in United States, Canada and 3 more
- Volunteers
- 1,284 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Nerve Compression
Comparative Effects of Nerve Gliding Exercises and Conventional Grip Strength Exercises in Batters.
Cricket is transformed over the years and dynamic of batting has changed. Gone are the days, when batters used to play the game with defensive mindset.
- Trial name
- NCT06688266
- Testing
- Nerve Gliding Exercises, Hand Grip Strength Exercises
- Where
- Pakistan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Sehat Medical Complex
Obesity
Indole-3-Carbinol Effects on Estrogen Metabolism
This study will test a dietary supplement, indole-3-carbinol, for improving the estrogen profile in women across a range of body mass index.
- Trial name
- NCT00988845
- Testing
- Indole-3-carbinol
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Colorectal Cancer, Diet, Healthy
Chemerin in Colorectal Cancer and Its Relationship With Diet Quality
To investigate the relationship between serum chemerin levels of individuals with colorectal cancer and systematic inflammatory response parameters such as C-reactive protein(CRP) and albumin, and to investigate the relationship…
- Conditions
- Colorectal Cancer, Diet, Healthy, Diet Habit, Nutrition Aspect of Cancer
- Trial name
- NCT06018077
- Testing
- Dietary İntake, Biochemical parameters, Antropometric measuruments
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Rectal Neoplasms, Colon Neoplasms
Comprehensive Analysis of Gut Microbiota Signatures in Metastatic Colorectal Cancer
Colorectal cancer (CRC) is one of the most common and deadly cancers worldwide. About 1 in 4 people with CRC already have cancer spread (metastasis) when first diagnosed, and about half develop spread during their illness.
- Conditions
- Rectal Neoplasms, Colon Neoplasms, Microbiota, Metagenome
- Trial name
- NCT07154173
- Testing
- Biospecimen Collection Procedure
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Myeloma
Machine Learning in Myeloma Response
Diffusion-weighted Whole Body Magnetic Resonance Imaging (WB-MRI) is a new technique that builds on existing Magnetic Resonance Imaging (MRI) technology.
- Trial name
- MALIMAR (NCT03574454)
- Testing
- Machine Learning (ML)
- Where
- 3 sites in United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Barrett Esophagus
Longitudinal Oral Microbiome Sampling for BE
This is a longitudinal cohort study to assess the impact of repeated sampling of an oral microbiome signature for Barrett's esophagus (BE).
- Trial name
- NCT05133102
- Testing
- Sample collection
- Where
- 2 sites in United States
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Columbia University
Polycystic Ovary Syndrome (PCOS), Insulin Resistance
SCUBE Proteins in Polycystic Ovary Syndrome (IPSOS)
This study investigates circulating levels of SCUBE-1 and SCUBE-3 proteins in women with polycystic ovary syndrome (PCOS) compared with healthy controls.
- Trial name
- IPSOS (NCT07396402)
- Testing
- Blood Sample Collection for SCUBE-1 and SCUBE-3 Measurement
- Where
- Italy
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
TNBC - Triple-Negative Breast Cancer
Targeting Metastatic Breast Cancers by Alkaline Glucosodiene Molecules Via a Metabolic Pathway Phase I Clinical Trial
The diverse group of breast tumors known as triple-negative breast cancer (TNBC) which is lethally and deadly type of breast cancer and insensitive to endocrine therapy and HER2-targeted therapy because it lacks the expression of…
- Trial name
- NCT05957939
- Testing
- Alkaline Glucosodiene Molecules
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Saudi Arabia
Esophageal Neoplasms
Irreversible Electroporation(IRE) For Unresectable Esophageal Neoplasms
The purpose of this study is to evaluate the safety and efficacy of irreversible electroporation (IRE) for unresectable Esophageal Neoplasms.
- Trial name
- IRE (NCT02430701)
- Testing
- Irreversible electroporation (IRE), NanoKnife
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fuda Cancer Hospital, Guangzhou
Ovarian Cancer, Epithelial
Envafolimab, Lenvatinib Combined With VP-16 in Platinum-resistant Recurrent Epithelial Ovarian Cancer
This study is a single-arm, open-label, exploratory clinical study, the main purpose is to evaluate the combination of envafolimab, lenvatinib VP-16 in the treatment of platinum-resistant recurrent epithelial ovarian…
- Trial name
- NCT05422183
- Testing
- Envafolimab, Lenvatinib, VP-16
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Zhongda Hospital
Esophageal Cancer, Gastric Cancer
Molecular Assessment for Gastro-Esophageal Cancer
The goal of this minimally invasive interventional study is to learn if oncometabolic biomarkers, detected in the exhaled breath and blood can identify early-stage gastro-oesophageal cancer in patient at risk for…
- Conditions
- Esophageal Cancer, Gastric Cancer, Barrett Esophagus
- Trial name
- MAGEC (NCT06346054)
- Testing
- Breath analysis, Blood analysis
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Breast Cancer
Opt-in vs. Opt-out for Breast Cancer Screening
This is a randomized controlled trial that will evaluate the effectiveness two different outreach strategies for a population-based breast cancer screening program at the VA Puget Sound among average risk female Veterans who are…
- Trial name
- NCT05313737
- Testing
- Automated message, Opt-out scheduling
- Where
- United States
- Volunteers
- 871 people, healthy volunteers welcome
- Sponsor
- VA Puget Sound Health Care System
Colorectal Cancer, Circulating Tumor Cell
Clinical Significance of Detecting CEA and CK20 mRNA-positive Cells in Colorectal Cancer Patients
To determine whether the presence of circulating/disseminated tumor cells (CTCs/DTCs) in the blood and bone marrow of colorectal cancer (CRC) patients with localized disease is a negative prognostic factor, and to find…
- Trial name
- NCT03337347
- Testing
- CTC/DTC count
- Where
- Czechia
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- The Institute of Molecular and Translational Medicine, Czech Republic
Colonic Polyps, Colon Cancer
L-Menthol Injection as a Novel Technique During Colonoscopy
The primary objective of this double-blinded, prospective, randomized placebo-controlled study is to evaluate for change in endoscopic adenoma detection rates (ADR) with the use of peppermint oil solution vs placebo application…
- Trial name
- MINT-C (NCT02588248)
- Testing
- Peppermint Oil
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Lung Cancer
A Study of Participants With Advanced Non-Small Cell Lung Cancer Treated With Nivolumab in France After at Least One Prior Chemotherapy-based Treatment by Lung Initiative on Sequence Therapy
The purpose of this trial is to describe the following, for each cohort, in real world conditions in France: The characteristics and treatment sequence of patients treated with nivolumab The effectiveness of nivolumab treatment…
- Trial name
- LIST (NCT04500535)
- Where
- France
- Volunteers
- 535 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.