Clinical trials: Neoplasm Invasiveness
Barrett's Esophagus
Imaging Enhanced Endoscopy for the Screening of Barrett's Esophagus
Imaging enhanced endoscopy can improve the efficacy of screening of Barrett's esophagus and predict its invasiveness. There is potentially molecular change over the Barrett's esophagus in this Chinese population.
- Trial name
- NCT01976351
- Where
- Taiwan
- Volunteers
- 51 people
- Sponsor
- National Taiwan University Hospital
Adenocarcinoma of Lung
Differentiating the Invasiveness of Lung Adenocarcinoma by Dual Energy CT Parameter
The core purpose of this study is to investigate whether the extracellular volume (ECV) fraction measured in delay phase by dual energy computed tomography (DECT) can distinguish precancerous lesions from early-stage lung…
- Trial name
- NCT06441357
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Tang-Du Hospital
Hepatocellular Carcinoma Stage III
Image Driven Hepatocellular Carcinoma Invasiveness Evaluation Research
Hepatocellular carcinoma (HCC) is a highly heterogeneous malignant tumor with significant differences in invasion, proliferation ability and patient prognosis.
- Trial name
- NCT06559761
- Testing
- Hepatectomy
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Chinese PLA General Hospital
Lung Adenocarcinoma, Stage I
Improving the Intraoperative Diagnosis Accuracy of Invasiveness for Small-sized Lung Adenocarcinoma
The goal of this observational study is to improve the intraoperative diagnosis accuracy of invasiveness for small-sized lung adenocarcinoma by combining multi-modal information.
- Trial name
- NCT05830812
- Testing
- Invasiveness diagnosis
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Epithelial Ovarian Cancer, Tumor Invasiveness
A Multi-omics Study of Epithelial Ovarian Cancer
This study aims to analyze the multi-omics results between epithelial ovarian cancer (EOC) patient with different FIGO stages and pathological subtypes.
- Conditions
- Epithelial Ovarian Cancer, Tumor Invasiveness, Whole Exome Sequencing, Transcriptomics
- Trial name
- NCT03742856
- Testing
- A multi-omics analysis
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Lei Li
Ovarian Neoplasms
DOvEE - Diagnosing Ovarian & Endometrial Cancer Early
This study hopes to improve early detection of ovarian and endometrial cancers. It will determine if women with bloating, abdominal distension, abdominal/pelvic pain, increased urinary frequency and/or early satiety, benefit from…
- Trial name
- DOvEE (NCT02296307)
- Testing
- Blood test: CA-125 biomarker, Second Test: Transvaginal Ultrasound, Follow-up phone call
- Where
- 8 sites in Canada
- Volunteers
- 13,600 people
- Sponsor
- McGill University
Thyroid Nodule
Minimal Invasiveness of Endoscopic Thyroidectomy
The investigators had performed more than 250 cases of breast approach endoscopic thyroidectomy (BAET). The goal of this study is to evaluate whether BAET could be a minimally invasive procedure under the expert's hands.
- Trial name
- NCT00877630
- Where
- China
- Sponsor
- Second Military Medical University
Glioblastoma, Glioma
Magnetic Resonance Spectroscopic Imaging (MRS) and Tumor Perfusion of Human Glioblastoma Treated With Concurrent Radiation Therapy and Temozolomide
The purpose of this study is to learn whether 3 tesla (3T) MRI functional imaging will map a tumor more accurately allowing a more targeted delivery of radiation.
- Trial name
- NCT00250211
- Testing
- Functional MRI imaging and tomotherapy
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- AHS Cancer Control Alberta
Pituitary Adenoma, Neuroendocrine Tumors
Predictive Value of Serum and Tissue Molecular Markers and Imaging Features in the Invasiveness and Prognosis of Pituitary Neuroendocrine Tumors
As the clinical manifestations of pituitary neuroendocrine tumors vary greatly, 2.7-15% of them are resistant to conventional treatments such as surgery, drug therapy and radiotherapy, and often relapse or regrow in the early…
- Trial name
- NCT06015802
- Testing
- diagnosed and treated reasonably according to the clinical guidelines and clinical pathways
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Sun Yat-sen University
Cancer Colon
Significance of Cortactin Expression in Colorectal Adenocarcinomas
Colorectal carcinoma is one of the most aggressive malignant epithelial neoplasms affecting the gastrointestinal tract. The incidence of colorectal carcinoma is obviously increasing in developing countries, where the physical…
- Trial name
- NCT05225870
- Testing
- immunohistochemical staining
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Bladder Papillary Urothelial Carcinoma, Stage 0a Bladder Urothelial Carcinoma
Ultrasound and Biomarker Tests in Predicting Cancer Aggressiveness in Tissue Samples of Patients With Bladder Cancer
This research trial studies two types of tests, an ultrasound test and a biomarker test, to see how well they predict how aggressive (invasive) bladder cancer is in samples from patients with bladder cancer.
- Conditions
- Bladder Papillary Urothelial Carcinoma, Stage 0a Bladder Urothelial Carcinoma, Stage 0is Bladder Urothelial Carcinoma, Stage I Bladder Cancer With Carcinoma In Situ
- Trial name
- NCT02494635
- Testing
- Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Southern California
Colorectal Neoplasms
Invasiveness and Chemoresistance of Cancer Stem Cells in Colon Cancer
The main objective of this study is to identify and characterize subpopulations of cells with invasive capacity in colorectal cancer from primary tumor, blood and metastatic samples.
- Trial name
- NCT01577511
- Testing
- Samples and follow up
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Thyroid Tumor
Impact of Dissection Area on the Clinical Outcome of Endoscopic Thyroidectomy
The purpose of this study is to investigate whether reduced subcutaneous dissection area could offer patients more clinical benefits.
- Trial name
- ET (NCT01338597)
- Testing
- endoscopic thyroidectomy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Second Military Medical University
Invasiveness, Neoplasm
KLHL14 Expression as Predicting Factor of Invasiveness in pitNET
OBJECTIVE: The objective of this study is to evaluate the correlation between KLHL14 expression and its cytoplasm-nuclear localisation and pituitary adenomas biological behaviour with particular focus on its role in epithelial…
- Trial name
- NCT06247709
- Testing
- Immunohistochemical expression in pitNET cells of KLHL14
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- Federico II University
Pituitary Tumors
Dissecting the Mechanism of DNA Methylation on the Invasiveness of Pituitary Tumors.
DNA methylation is one of the important ways of protein post-translational modification.Pituitary adenoma (PA) is a benign neuroendocrine tumor that originates from adenohypophysial 45 cells, and accounts for 10%-20% of all…
- Trial name
- NCT05634655
- Testing
- no interventions between two groups
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Carcinoma, Renal Cell, Tumor Thrombus
Predicting Model Based on Evidence-based Pathological Diagnose Criteria for RCC Tumor Thrombus With IVC Wall Invasion
The goal of this observational study is to establish a preoperative imaging diagnostic model which highly consistent with the histopathological examinations, as well as a accurate and systematic pathological grading standard of…
- Conditions
- Carcinoma, Renal Cell, Tumor Thrombus, Neoplasm Invasiveness, Inferior Vena Cava Interruption
- Trial name
- NCT05589207
- Testing
- Vascular wall invaded
- Where
- China
- Volunteers
- 232 people
- Sponsor
- Peking University Third Hospital
Glioblastoma, Glioma, Malignant
Modulation of Ciliogenesis in Glioma Stem Cells
The study aims at investigating the cilium-related transcriptome in patients-derived glioblastoma stem cells and the potential impact of modulation of cilium players in vitro, in vivo and ex vivo in glioblastoma brain organoids.
- Trial name
- RF2019-1236878 (NCT05772767)
- Testing
- Biological sample collection, Dissecting ciliogenesis players, Validating ciliogenesis players
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS