Clinical trials: Neoplasms, Pharyngeal
Essential Hypertension, Liver Cancer
A Multicentre Study on Features of the Gut Microbiota of Patients With Critical Chronic Diseases in China
The human gut microbiome has been associated with many health factors but variability between studies limits the exploration of effects between them.
- Conditions
- Essential Hypertension, Liver Cancer, Nasopharyngeal Cancer, Pancreatic Cancer
- Trial name
- NCT05638269
- Testing
- no intervention
- Where
- 50 sites in China
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Metastatic Nasopharyngeal Carcinoma, Recurrent Nasopharyngeal Carcinoma
A Trial of LONSURF in Recurrent/Metastatic Nasopharyngeal Carcinoma
This is a single-arm, non-randomised study including patients with EBER positive nasopharyngeal carcinoma with recurrent or metastatic disease not amenable to curative treatment, who have received at least 1 regimen of platinum…
- Trial name
- NCT04627961
- Testing
- TAS-102
- Where
- Singapore
- Volunteers
- 33 people
- Sponsor
- National University Hospital, Singapore
Nasopharyngeal Carcinoma
Targeted or Chemotherapy Combined With Immunotherapy Versus Chemotherapy for PD-1 Inhibitor Refractory R/M NPC
Because most patients with R/M NPC have received long-term maintenance of immunotherapy at the time of initial treatment and the first-line treatment, there are a large number of PD-1 inhibitor refractory patients.
- Trial name
- NCT05549466
- Testing
- Apatinib, Camrelizumab, Chemotherapy (gemcitabine/ capecitabine/ docetaxel), Apatinib, Camrelizumab, Camrelizumab, Chemotherapy (gemcitabine/ capecitabine/ docetaxel)
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Sun Yat-sen University
Nasopharyngeal Carcinoma, Recurrent Nasopharyngeal Carcinoma
Toripalimab and Gemcitabine in Recurrent or Metastatic Nasopharyngeal Carcinoma.
This is an open-label, single center, pilot trial to evaluate the safety and efficacy of toripalimab and gemcitabine in patients with recurrent or metastatic nasopharyngeal carcinoma.
- Conditions
- Nasopharyngeal Carcinoma, Recurrent Nasopharyngeal Carcinoma, Metastatic Nasopharyngeal Carcinoma, Chemotherapy Effect
- Trial name
- NCT04405622
- Testing
- Toripalimab plus gemcitabine
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Sun Yat-sen University
Nasopharyngeal Carcinoma
Endostar Combination With Chemotherapy for the Metastatic Nasopharyngeal Carcinoma
The investigators designed this study to evaluate the efficiency and the acute toxicities of recombinant human endostatin (endostar) combined with chemotherapy in the metastatic nasopharyngeal carcinoma (NPC).
- Trial name
- NCT01612286
- Testing
- endostatin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zhejiang Cancer Hospital
Liver Cancer, Kidney Cancer
A Study of DC-CIK Immunotherapy in the Treatment of Solid Tumors
Main purpose of this study is through comparing with the external control, evaluation of autologous D - CIK cells immunotherapy to finish after conventional treatment of liver cancer, renal clear cell carcinoma and nasopharyngeal…
- Conditions
- Liver Cancer, Kidney Cancer, Nasopharyngeal Cancer, Lung Cancer
- Trial name
- DC-CIK (NCT04476641)
- Testing
- CELL
- Where
- China
- Volunteers
- 686 people
- Sponsor
- Sun Yat-sen University
Nasopharyngeal Carcinoma
S-1 Combined With IMRT Concurrent Chemoradiotherapy in Locally Advanced Nasopharyngeal Carcinoma
This study is a prospective phase II trial which is designed to evaluate the efficacy and safety of IMRT combined with S-1 CCRT for locally advanced NPC.
- Trial name
- NCT03668366
- Testing
- S-1
- Where
- China
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Fudan University
Nasopharyngeal Carcinoma, Radiotherapy
Dysphagia Rehabilitation for Nasopharyngeal Carcinoma Patients Post Radiotherapy
In Hong Kong, every 30 and 12.9 in 100,000 males and females respectively has nasopharyngeal carcinoma (NPC). With early detection and advances in medical care, the number of NPC survivors post radiotherapy is rapidly growing in…
- Trial name
- NCT01237704
- Testing
- Traditional rehabilitation (TR), Transcutaneous electrical stimulation (ES)
- Where
- 2 sites in Hong Kong
- Volunteers
- 160 people
- Sponsor
- Chinese University of Hong Kong
Nasopharyngeal Carcinoma
The Value of Concurrent Chemoradiotherapy for Stage II Nasopharyngeal Carcinoma
The purpose of this study is to verify the role of adding cisplatin chemotherapy to the intensity-modulated radiotherapy (IMRT) for stage II nasopharyngeal carcinoma.
- Trial name
- NCT01187238
- Testing
- cisplatin
- Where
- 3 sites in China
- Volunteers
- 84 people
- Sponsor
- Chinese Academy of Medical Sciences
Carcinoma, Squamous Cell, Head and Neck Neoplasms
De-intensification of Radiation and Chemotherapy for Low-Risk HPV-related Oropharyngeal SCC: Follow-up Study
The purpose of this research study is to learn about the effectiveness of using lower-intensity radiation and chemotherapy to treat human papillomavirus (HPV) associated low-risk oropharyngeal and/or unknown primary squamous cell…
- Conditions
- Carcinoma, Squamous Cell, Head and Neck Neoplasms, Oropharyngeal Neoplasms
- Trial name
- NCT02281955
- Testing
- Intensity Modulated Radiotherapy (IMRT), Cisplatin (or alternative), Assessment for surgical evaluation
- Where
- 5 sites in United States
- Volunteers
- 115 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Adenocarcinoma (NOS), Anal Cancer
DESTINY-PANTUMOUR04
This study will evaluate the effectiveness of T-DXd in patients with HER2-positive (IHC 3+) locally advanced, unresectable, or metastatic solid tumors who have received prior systemic treatment for metastatic or advanced disease…
- Conditions
- Adenocarcinoma (NOS), Anal Cancer, Bladder Cancer, Cervical Cancer
- Trial name
- DP-04 (NCT07124000)
- Testing
- Trastuzumab deruxtecan
- Where
- 18 sites in United States
- Volunteers
- 100 people
- Sponsor
- AstraZeneca
Oropharynx Cancer
Adaptative Radiotherapy to Decrease Xerostomia in Oropharynx Carcinoma
The Phase III study will include 174 patients with locally advanced oropharynx carcinoma, receiving all arc-IMRT (Intensity-Modulated Radiation Therapy) (70 Gy) with concomitant systemic therapy.
- Trial name
- ARTIX (NCT01874587)
- Testing
- adaptative radiotherapy
- Where
- 11 sites in France
- Volunteers
- 132 people
- Sponsor
- Center Eugene Marquis
Mouth Neoplasms, Velopharyngeal Insufficiency
A New Membrane Obturator Prothesis Concept for Soft Palate Defects
When soft palate defects lead to palatal insufficiency, the patient's quality of life is affected by difficulties swallowing, hypernasality, and poor intelligibility of speech.
- Conditions
- Mouth Neoplasms, Velopharyngeal Insufficiency, Speech Disorders, Deglutition Disorders
- Trial name
- VELOMEMBRANE (NCT04009811)
- Testing
- Suersen and membraneous obturators evaluation
- Where
- France
- Volunteers
- 4 people
- Sponsor
- University Hospital, Bordeaux
Oropharynx Cancer, Pain
Functional Outcome After Treatment for Oropharyngeal Squamous Cell Carcinoma
To investigate the treatment related effects of transoral robotic surgery (TORS) or oncological treatment of oropharyngeal squamous cell carcinoma with a 1-year follow up.
- Conditions
- Oropharynx Cancer, Pain, Swallowing Disorder, Quality of Life
- Trial name
- NCT03418909
- Testing
- Primary Trans Oral Robotic Surgery (TORS), Radio(chemo)therapy
- Where
- Denmark
- Volunteers
- 44 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Nasopharyngeal Carcinoma
Toripalimab Combined With Radiotherapy in the Treatment of Oligometastatic Nasopharyngeal Carcinoma
The aim of the study was to determine the efficacy and safety of toripalimab combined with radiotherapy in the treatment of oligometastatic nasopharyngeal carcinoma
- Trial name
- NCT05147844
- Testing
- Toripalimab
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Xinqiao Hospital of Chongqing
Nasopharyngeal Carcinoma
Intensity-modulated Radiation Therapy Combined With Cisplatin or Nedaplatin Chemotherapy in Nasopharyngeal Carcinoma
This phase II trial is studying cisplatin or nedaplatin combine with IMRT to evaluate which one is better efficacy and security in nasopharyngeal carcinoma.
- Trial name
- NCT01265147
- Testing
- Cisplatin, Nedaplatin
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Squamous Cell Carcinoma of the Head and Neck
Assessment of Efficacy and Safety of Monalizumab Plus Cetuximab Compared to Placebo Plus Cetuximab in Recurrent or Metastatic Head and Neck Cancer
This is a randomized, double-blind, multicenter, global Phase 3 study to assess the efficacy and safety of monalizumab and cetuximab, compared to placebo and cetuximab, in Participants with recurrent or metastatic head and neck…
- Trial name
- INTERLINK-1 (NCT04590963)
- Testing
- Monalizumab, Cetuximab
- Where
- 127 sites in United States, Argentina and 21 more
- Volunteers
- 370 people
- Sponsor
- AstraZeneca
Nasopharyngeal Carcinoma, Carotid Artery Diseases
Radiation-associated Carotid Artery Disease in Patients With Nasopharyngeal Carcinoma
Radiation-associated carotid vasculopathy is a common late sequelae in patients with head and neck cancer, which correlates with the incidence of stroke.
- Trial name
- NCT03568032
- Testing
- Measurement of intima media thickness of carotid artery, Detection and measurement of carotid plaques, Carotid Color Flow Duplex Testing
- Where
- China
- Volunteers
- 248 people
- Sponsor
- Fudan University
Nasopharyngeal Carcinoma, Nutritional Support
Early and Whole Course Nutritional Support by Nutren® Optimum During IMRT for Nasopharyngeal Carcinoma
Radiation therapy remains the principal treatment for nasopharyngeal carcinoma (NPC). The most frequently occurred radiation-related side effect is probably the radiation-induced oral mucositis, which affects up to 100% of NPC…
- Trial name
- NCT03344068
- Testing
- Radiotherapy, Chemotherapy, Nutren® Optimum
- Where
- China
- Volunteers
- 408 people
- Sponsor
- Sun Yat-sen University
Neurocognitive Impairment, Delirium
Neurocognitive Functioning in Patients With Newly Diagnosed Upper Aerodigestive Tract Cancer Receiving Treatment at Henry-Joyce Cancer Clinic
RATIONALE: Gathering information about how often problems with neurocognitive functioning occur in patients with newly diagnosed upper aerodigestive tract cancers may help doctors learn more about the disease.
- Conditions
- Neurocognitive Impairment, Delirium, Esophageal Cancer, Head and Neck Cancer
- Trial name
- NCT00533884
- Testing
- Assessment of therapy complications, Neurocognitive assessment, Quality-of-life assessment
- Where
- 4 sites in United States
- Volunteers
- 86 people
- Sponsor
- Vanderbilt University Medical Center
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