Clinical trials: Neoplasms, Prostate
Hypogonadism, Male, Testosterone Deficiency
Exploring the Relationship Between Androgen Metabolism, Metabolic Disease and Skeletal Muscle Energy Balance in Men
This study relates to men with hypogonadism, a condition describing a deficiency of androgens such as testosterone. Deficiency of these hormones occurs in men due to testicular (primary) or hypothalamic-pituitary (secondary)…
- Conditions
- Hypogonadism, Male, Testosterone Deficiency, Prostate Cancer, Androgen Deficiency
- Trial name
- MMetdMH (NCT05773183)
- Testing
- Testosterone, GnRH
- Where
- Ireland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Royal College of Surgeons, Ireland
Prostate Cancer
Metformin for Rising PSA Remote Trial
Clinical trials are critical to informing the care of patients with cancer. However, only 3-5% of patients with cancer enroll in clinical trials.
- Trial name
- M-RePoRT (NCT02376166)
- Testing
- Metformin
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Matthew Galsky
Prostate Cancer (Adenocarcinoma), Prostate Biopsy
RegisterPROS - A Registry for Prostate Cancers
Prostate cancers are derived from epithelial cells in the prostate gland. Treatment options include surgery, medical (androgen signaling targeted and chemotherapy) and radiation therapy including radioligand therapy (RLT).
- Conditions
- Prostate Cancer (Adenocarcinoma), Prostate Biopsy, Prostatectomy, Radioligand
- Trial name
- RegisterPROS (NCT06872619)
- Testing
- PROSTest
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Wren Laboratories LLC
Metastatic Castration Resistant Prostate Cancer
Abiraterone Acetate in Combination With Tildrakizumab
The purpose of this study is to find out the side effects and safety of a combination of the anti-IL23 targeting monoclonal antibody tildrakizumab in combination with abiraterone acetate in men with metastatic castration…
- Trial name
- ACTIon (NCT04458311)
- Testing
- Abiraterone Acetate, Tildrakizumab
- Where
- 6 sites in Switzerland, United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Institute of Cancer Research, United Kingdom
Prostate Cancer (Diagnosis)
Early Diagnosis of PROstate CANcer for Black Men
PROCAN-B+ is a mixed-methods, two-arm, multi-centre randomised controlled trial evaluating a co-designed, peer-led intervention to encourage informed help-seeking and engagement with prostate cancer health checks and Prostate…
- Trial name
- PROCAN-B+ (NCT07620717)
- Testing
- The intervention is a two-hour workshop that includes multiple components to encourage Black men to request prostate cancer diagnosis tests., Waitlist
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Sunderland
Prostate Cancer
MRI Versus PSA in Prostate Cancer Screening
In this open randomized controlled trial, we seek to study whether prostate cancer screening using multiparametric prostate magnetic resonance imaging (mpMRI) improves the detection rate of clinically-significant prostate cancer…
- Trial name
- MVP (NCT02799303)
- Testing
- Multi-parametric MRI, PSA testing
- Where
- Canada
- Volunteers
- 1,010 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Prostatic Neoplasms, Glioma
PET/CT Imaging Study With Simultaneous Dual-nuclide Imaging Technique
This is a study using a parallel control approach and is expected to recruit 35 volunteers, including 8 prostate cancer patients, 8 neuroendocrine tumour patients, 8 glioma patients, 8 Parkinson's syndrome patients, and 3 normal…
- Conditions
- Prostatic Neoplasms, Glioma, PARKINSON DISEASE (Disorder)
- Trial name
- NCT06914427
- Testing
- PET/CT
- Where
- China
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Urinary Incontinence
Conservative Treatment of Postprostatectomy Incontinence
The primary purpose of this study is to test the effectiveness, impact on quality of life, and durability of non-surgical therapies for incontinence persisting at least one year after surgery.
- Trial name
- NCT00212264
- Testing
- Behavioral Therapy, Pelvic Floor Electrical Stimulation, Biofeedback
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Prostate Carcinoma
Genetic Information to Inform Treatment and Screening for Prostate Cancer, GIFTS Study
This trial studies the role of inherited (present at birth) mutations in cancer risk genes such as BRCA2, BRCA1, ATM, CHEK2, and others in relation to prostate cancer.
- Trial name
- GIFTS (NCT04254133)
- Testing
- Questionnaire, Biospecimen Collection, Genetic Testing
- Where
- United States
- Volunteers
- 1,360 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Latent Cancer (Prostate)
Impact on Instructional Video on Patients' Compliance With Preparation During CT Planning for Prostate Cancer
Rectal toxicity limits dose escalated intensity modulated radiotherapy (IMRT) for prostate cancer. The dose volume constraints that predict for rectal toxicity require minimizing prostate motion and rectum and bladder filling of…
- Trial name
- NCT02410291
- Testing
- Educational video
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Prostate Cancer Stage, PSMA
99mTc-QULIC-5-P1 SPECT Imaging in Patients With Prostate Cancer
99mTc-QULIC-5-P1 is a new radiotracer targeting PSMA, which is promising as an excellent imaging agent applicable to PSMA positive prostate cancer.
- Conditions
- Prostate Cancer Stage, PSMA, SPECT
- Trial name
- NCT06419348
- Testing
- 99mTc-QULIC-5-P1
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Obesity, Colon Cancer
Proteomic Analysis of Patients Undergoing Bariatric Surgery
The expression of proteins in the blood of obese individuals is different from the expression of proteins in healthy individuals, and is also different in individuals after bariatric surgery.
- Conditions
- Obesity, Colon Cancer, Thyroid Cancer, Esophageal Cancer
- Trial name
- NCT06787807
- Testing
- bariatric surgery
- Where
- Brazil
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Prostate Cancer, Risk Assessment
PROstate Cancer Risk Calculator for ACTionable Clinical Decision-making in Nigeria
This study is a pilot trial that builds on findings from the validation of prostate cancer risk calculators in Nigerian men. The goal of the overall study is to improve the early detection of prostate cancer in a high-risk…
- Conditions
- Prostate Cancer, Risk Assessment, Clinical Decision Support Systems, Predictive Value of Tests
- Trial name
- PROACT (NCT07733440)
- Testing
- (a) Training and (b) Supported risk assessment
- Where
- Nigeria
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Ahmadu Bello University
Prostate Cancer, Bladder Cancer
Duke Urology Database and Specimen Bank
The proposed project is aimed to build a Duke University-specific longitudinal urologic surgery database. It will be used as the main resource to support future research within Urology and Duke University.
- Conditions
- Prostate Cancer, Bladder Cancer, Erectile Dysfunction, Incontinence
- Trial name
- NCT00978991
- Where
- United States
- Volunteers
- 87,820 people, healthy volunteers welcome
- Sponsor
- Duke University
Cancer of Prostate, Anxiety
Tailored, wEb-based, Psychosocial and Physical Activity Self-Management PrOgramme
Caregivers of men with prostate cancer report high physical and emotional distress, and there is an urgent need to develop cost-effective programmes to prepare them for their roles.
- Trial name
- TEMPO (NCT04304196)
- Testing
- TEMPO, Usual care
- Where
- Canada
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- St. Mary's Research Center, Canada
TURP(Transurethral Resection of Prostate), Spinal Anesthesia
Modified Saddle Block vs Spinal Anesthesia for TURP
After obtaining informed consent, eligible patients will be enrolled in the study. Standard monitoring will be applied in the operating room and baseline blood pressure and heart rate will be recorded.
- Conditions
- TURP(Transurethral Resection of Prostate), Spinal Anesthesia, Saddle Block Anesthesia, Hypotension During Surgery
- Trial name
- NCT07841184
- Testing
- Saddle block, Spinal Anesthesia (bupivacaine)
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Medical Sciences
Polycystic Ovary Syndrome
Evaluation of Serum Prostatic Specific Antigen (PSA) After Cyproterone Compound Treatment Compared With Oral Contraceptives Pill in Hirsute Polycystic Ovary Syndrome Patients
The purpose of this study is to evaluate the effect of oral contraceptive on the serum free prostatic specific antigen (PSA)in women with polycystic ovary syndrome(PCOD)compared with cyproterone compound.
- Trial name
- PSA (NCT00955058)
- Testing
- OCP
- Where
- Iran
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University
Prostate Cancer
STHLM3 - Prostate Cancer Diagnostic Trial
STHLM3 is a paired diagnostic trial aiming to assess whether a panel of biomarkers for prostate cancer can substantially reduce the proportion of men referred to biopsy whilst maintaining sensitivity for aggressive prostate cancer
- Trial name
- STHLM3 (NCT03639649)
- Testing
- STHLM3
- Where
- Sweden
- Volunteers
- 58,818 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Prostate Cancer, Vitamin D Deficiency
Vitamin D Supplementation in RNA-seq Profiles of Single-core Prostate Samples, Among Veterans
Veterans between the ages of 50-75, who are having a prostate biopsy, will be recruited for their permission to collect an extra biopsy core for RNA-sequencing.
- Conditions
- Prostate Cancer, Vitamin D Deficiency, Stress Reaction
- Trial name
- VitD/RNA-seq (NCT04621500)
- Testing
- cholecalciferol, Standard of Care Prostate Biopsy - collection of 13th core for RNA-seq, Standard of Care Prostate Biopsies at baseline and after one year vitamin D3 supplementation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Decision Making, Shared, Prostate-Specific Antigen
Promoting Shared-decision Making in Opportunistic Screening for Prostate Cancer
In this project, the investigators aim to evaluate the most appropriate design and implementation strategy of a decision-aid to promote shared-decision making in prostate cancer screening.
- Conditions
- Decision Making, Shared, Prostate-Specific Antigen, Prostate Cancer
- Trial name
- PROSHADE (NCT05187949)
- Testing
- Mixed-method approach
- Volunteers
- 1,781 people, healthy volunteers welcome
- Sponsor
- Universidad Miguel Hernandez de Elche