Clinical trials: Neoplasms, Thyroid
Thyroid Cancer
Enhancing Radioiodine Incorporation Into BRAF Mutant Thyroid Cancers With the Combination of Vemurafenib and KTN3379
This is a patient pilot study testing the hypothesis that vemurafenib with the addition of KTN3379 can restore iodine incorporation in BRAF mutant (MUT), radioiodine-refractory (RAIR) thyroid cancer patients.
- Trial name
- NCT02456701
- Testing
- KTN3379, vemurafenib
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Celldex Therapeutics
Thyroid Nodules, Thyroid Cancer
AIM2: Adequate Selection of Patients for Thyroid Biopsy: Evaluation of a Shared Decision Making Conversation Aid
There is an epidemic of thyroid cancer that is harmful to patients and the medical system. The study hypothesizes that the use of an electronic conversation aid during clinical visits can help patients and clinicians collaborate.
- Trial name
- NCT04463719
- Testing
- Counseling using the electronic conversation aid, counseling by routine care
- Where
- 2 sites in United States
- Volunteers
- 107 people
- Sponsor
- University of Florida
Head and Neck Cancer
Everolimus in Treating Patients With Progressive or Recurrent, Unresectable, or Metastatic Thyroid Cancer
RATIONALE: Everolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- NCT01118065
- Testing
- everolimus
- Where
- Netherlands
- Volunteers
- 42 people
- Sponsor
- Leiden University Medical Center
Vocal Cord Paralysis, Bilateral, Airway Obstruction, Postoperative
Peri-operative BiPAP to Prevent Tracheostomy in High-Risk Bilateral Vocal-Cord Paralysis (BVCP)
Why: After thyroid or neck surgery, some patients can lose movement of both vocal cords (bilateral vocal-cord paralysis, BVCP). This can make breathing difficult and often leads to an emergency or preventive tracheostomy…
- Conditions
- Vocal Cord Paralysis, Bilateral, Airway Obstruction, Postoperative, Thyroid Neoplasms, Sleep Apnea, Obstructive
- Trial name
- BVCP-BiPAP (NCT07042971)
- Testing
- Pre-operative BiPAP Training, Post-extubation BiPAP Support, Standard Peri-operative Care
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Fujian Medical University
Thyroid Cancer
An Open-label, Multicenter, Phase II Study of Dovitinib in Advanced Thyroid Cancer
There has been no effective treatment for advanced thyroid cancer that is not amenable to surgery and that does not concentrate iodine.
- Trial name
- NCT01964144
- Testing
- Dovitinib
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Carcinoma, Non-Small-Cell Lung, Thyroid Neoplasms
A Study of LOXO-260 in Cancer Patients With a Change in a Particular Gene (RET) That Has Not Responded to Treatment
The main purpose of this study is to learn more about the safety, side effects, and effectiveness of LOXO-260. LOXO-260 may be used to treat cancer that has a change in a particular gene (known as the RET gene).
- Trial name
- NCT05241834
- Testing
- LOXO-260
- Where
- 16 sites in United States, France
- Volunteers
- 70 people
- Sponsor
- Eli Lilly and Company
Cancer
Virtual Trial to Compare Two Digital Therapeutics as Interventions for Physical and Mental Health in People With Cancer
This is a 2-arm randomized controlled study comparing how effective two therapeutic digital software devices are at improving anxiety and other indicators of psychological and physical health in patients with cancer.
- Trial name
- RESTORE (NCT05227898)
- Testing
- Device: Attune™, Device: Cerena™
- Where
- United States
- Volunteers
- 352 people
- Sponsor
- Blue Note Therapeutics
Medullary Thyroid Cancer (MTC), Cultural Adaptation
Cultural Adaptation of an Educational Tool in Medullary Thyroid Cancer
To find good information about medullary thyroid cancer that is easy to understand and reliable, so researchers aim to design some new educational materials to help.
- Trial name
- NCT07142005
- Testing
- Interviews
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- M.D. Anderson Cancer Center
Medullary Thyroid Cancer (MTC)
Pembrolizumab in Recurrent or Metastatic Medullary Thyroid Cancer
Background: Medullary thyroid cancer (MTC) is a tumor of the thyroid gland. Surgery is the only current treatment to cure it. The drug pembrolizumab (MK-3475) is a new type of cancer therapy.
- Trial name
- NCT03072160
- Testing
- Pembrolizumab
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- National Cancer Institute (NCI)
Lymph Node Metastases
the Dissection of Lymph Node Posterior to Right Recurrent Laryngeal Nerve for Papillary Thyroid Carcinoma
This study was completed in two stages. In the first stage, 2000 participants were enrolled according to the criteria. Following the principle of informed consent and voluntary consent of patients, the standard operation was…
- Trial name
- NCT03813706
- Testing
- lymph node dissection
- Volunteers
- 4,000 people
- Sponsor
- Zhejiang University
Head and Neck Cancer
Genetic Analysis in Diagnosing Thyroid Cancer in Patients With Thyroid Nodules
RATIONALE: Finding genetic markers for thyroid cancer in a biopsy specimen may help doctors diagnose thyroid cancer. PURPOSE: This clinical trial is studying how well genetic analysis works in diagnosing thyroid cancer in…
- Trial name
- NCT00316823
- Testing
- gene expression analysis, polymerase chain reaction, reverse transcriptase-polymerase chain reaction
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of California, San Francisco
Thyroid Cancer, Lymph Node
UNN-RADS Scale for Diagnosing Lymph Node Metastasis in Patients With History of Thyroid Cancer
In 2020, Sarda-Inman et al., developed the Ultrasound Neck Node Reporting and Data System (UNN-RADS) scale that allows decision-making about when it is appropriate to perform FNA of a cervical lymph node, evaluating seven…
- Trial name
- NCT06124469
- Testing
- US-guided fine needle aspiration (FNA)
- Where
- Mexico
- Volunteers
- 99 people
- Sponsor
- Instituto Mexicano del Seguro Social
Cancer, Thyroid Carcinoma
Thyroid Cancer and Sunitinib
Due to arguments showing that angiogenesis could be involved in progression of metastatic thyroid carcinoma and to objective response during previous studies with sunitinib (an angiogenic oncology drug also known as Sutent), this…
- Trial name
- THYSU (NCT00510640)
- Testing
- Sunitinib
- Where
- 15 sites in France
- Volunteers
- 71 people
- Sponsor
- University Hospital, Bordeaux
Thyroid Nodule
Skin-crease Thyroidectomy
We performed a retrospective observational-analytic study. Anatomical measurements were performed on 118 participants during an ultrasound exam, and demographic data was collected from their medical files.
- Trial name
- NCT04248114
- Testing
- Ultrasound of the Neck
- Volunteers
- 118 people
- Sponsor
- Western Galilee Hospital-Nahariya
Papillary Thyroid Carcinoma
Is Routine Dissection of Central Lymph Node Necessary for Papillary Thyroid Carcinoma, T1-2 N0?
study assigned into three groups, Group I was the control group operated by total thyroidectomy and retrospectively followed, where the other two groups Operated by Total thyroidectomy and central neck dissection.
- Trial name
- NCT04336696
- Testing
- Total thyroidectomy and central neck dissection
- Where
- Egypt
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Bassem Mohamed Sieda
Medullary Thyroid Carcinoma, Multiple Endocrine Neoplasia Type 2A
Vandetanib to Treat Children and Adolescents With Medullary Thyroid Cancer
Background: Medullary thyroid carcinoma (MTC) is common in people with a genetic disorder called multiple endocrine neoplasia (MEN).
- Conditions
- Medullary Thyroid Carcinoma, Multiple Endocrine Neoplasia Type 2A, Multiple Endocrine Neoplasia Type 2B
- Trial name
- NCT00514046
- Testing
- Vandetanib
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- National Cancer Institute (NCI)
Anaplastic Thyroid Cancer
Zanzalintinib Plus Cemiplimab for the Treatment of BRAF Wild-Type Anaplastic Thyroid Cancer
The goal of the trial is to improve this OS by 4 months (to 9.9 months) using the zanzalintinib + cemiplimab treatment combination.
- Trial name
- NCT07470489
- Testing
- Cemiplimab, Zanzalintinib
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- M.D. Anderson Cancer Center
Papillary Thyroid Cancer
Treatment Efficacy and Safety of Low-dose Radioiodine Ablation for Intermediate-risk Differentiated Thyroid Carcinoma
Primary objective: The 3-years disease-free survival was compared between low-dose group (30 mCi) and high-dose group (100 mCi).
- Trial name
- NCT04354324
- Testing
- Radioiodine
- Where
- China
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Metabolic Syndrome, Thyroid Nodule
Relationship of Metabolic Syndrome and Its Components With Thyroid Nodule(s)
To investigate the association between metabolic syndrome (MS) and thyroid nodule(s).
- Trial name
- NCT03009279
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Lin Liao
Goiter, Nodular, Total Thyroidectomy
Thyroid Cancer in Surgical Treated Multinodular Goiter
This study aims to investigate, based on existing knowledge, the incidence of occult thyroid carcinoma in a cohort of patients with MNG, providing new insights into the prevalence and characteristics of thyroid malignancies in…
- Conditions
- Goiter, Nodular, Total Thyroidectomy, Thyroid Cancer
- Trial name
- NCT06924242
- Testing
- total or partial thyroidectomy
- Where
- Italy
- Volunteers
- 223 people, healthy volunteers welcome
- Sponsor
- University of Foggia
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