Clinical trials: Neovascular Glaucoma
Glaucoma, Neovascular
Japanese Phase 3 Study of Aflibercept in Neovascular Glaucoma Patients
To assess the efficacy and safety of the administration of aflibercept by intravitreal injection in comparison to sham to control intraocular pressure in patients with neovascular glaucoma.
- Trial name
- VEGA (NCT02396316)
- Testing
- Aflibercept (Eylea, BAY 86-5321)
- Where
- 19 sites in Japan
- Volunteers
- 54 people
- Sponsor
- Bayer
Glaucoma, Glaucoma Eye
MicroPulse TLT - UK Study
This Prospective Interventional Study will assess the efficacy of MPTLT in the UK.
- Conditions
- Glaucoma, Glaucoma Eye, Glaucoma, Open-Angle, Glaucoma Secondary
- Trial name
- MPTLTUKS (NCT05593354)
- Testing
- Micropulse Transscleral laser therapy
- Volunteers
- 250 people
- Sponsor
- Imperial College Healthcare NHS Trust
Proliferative Diabetic Retinopathy, Macular Degeneration
Analysis of Aqueous and Vitreous Humor
Clinical Retina research studies often collect aqueous samples in hopes of estimating levels of drug or cytokines in the vitreous. Little is known about how well vitreous and aqueous correlate.
- Conditions
- Proliferative Diabetic Retinopathy, Macular Degeneration, Macular Hole, Neovascular Glaucoma
- Trial name
- ARK (NCT02067013)
- Testing
- Ranibizumab, No Ranibizumab
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- California Retina Consultants
Refractory Glaucoma
Ahmed Valve Glaucoma Implant With Adjunctive Subconjunctival Bevacizumab in Refractory Glaucoma
The investigators aim to demonstrate the efficacy and safety of subconjunctival injection of Avastin as an adjunctive therapy for Ahmed valve glaucoma implant in patients with refractory glaucoma.
- Trial name
- NCT01128699
- Testing
- Subconjunctival Avastin, Ahmed Valve implant
- Where
- Iran
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Vanak Eye Surgery Center
Intraocular Pressure, Neovascular Glaucoma
Aflibercept as Adjunctive Treatment for Filtration Surgery in Neovascular Glaucoma
Purpose: To investigate intravitreal aflibercept (IVA) injection as an adjunctive treatment to trabeculectomy with mitomycin C (TMC) and panretinal photocoagulation (PRP) for neovascular glaucoma (NVG).
- Conditions
- Intraocular Pressure, Neovascular Glaucoma, Vascular Endothelial Growth Factor Overexpression, Glaucoma Secondary to Eye Inflammation
- Trial name
- NCT04970251
- Testing
- Aflibercept Ophthalmic
- Where
- Thailand
- Volunteers
- 5 people
- Sponsor
- Siriraj Hospital
Glaucoma
Comparison of Silicone and Porous Plate Ahmed Glaucoma Valves
The purpose of this study is to evaluate and compare the clinical outcomes after implantation of the porous plate (polyethylene) (Model M4) Ahmed Glaucoma Valve with the silicone plate Ahmed Glaucoma Valve (Model FP7) in…
- Trial name
- NCT01883856
- Testing
- Silicone plate Ahmed Glaucoma Valve (Model FP7), Porous Plate Ahmed Glaucoma Valve (Model M4)
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Peter Netland, MD
Glaucoma
Will the Use of Triesence During Glaucoma Surgery Provide Lower Eye Pressure and Improve the Results of the Surgery?
The investigators hypothesize that intracameral Triesence during glaucoma surgery will provide lower intraocular pressure through better control of ocular inflammation, thus leading to a more successful filtering procedure.
- Trial name
- NCT00853905
- Testing
- Triesence, balanced salt solution BSS
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Wills Eye
Neovascular Glaucoma
Effect of Subconjunctival 5-fluorouracil on the Outcome of Ahmed Valve in Neovascular Glaucoma
Neovascular glaucoma is a common and severe type of secondary closed-angle glaucoma. Topical treatments have variable effects and unfortunately often require surgery to control IOP.
- Trial name
- NCT05316142
- Testing
- AGV with intraoperation MMC and postoperative BSS, AGV with intraoperation MMC and post operation 5FU
- Where
- Iran
- Volunteers
- 70 people
- Sponsor
- Iran University of Medical Sciences
Neovascular Glaucoma
The Effect of Conbercept Injection Through Different Routes for Neovascular Glaucoma
The neovascular glaucoma (NVG) is a refractory type of secondary glaucoma and often lead to frustrated treatment and blindness. It has been confirmed high levels of vascular endothelial growth factor (VEGF) in NVG.
- Trial name
- NCT03154892
- Testing
- Intracameral injection, Intravitreal injection
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Neovascular Age Related Macular Degeneration (AMD), Open Angle Glaucoma
TF (SENSIMED Triggerfish) in Intraocular Anti-VEGF (Vascular Endothelial Growth Factor) Injection
This is a prospective, open label study assessing the 24-hour IOP patterns using TF in patients undergoing anti-VEGF injection for the treatment of neovascular AMD (age related macular degeneration).
- Trial name
- NCT01983579
- Testing
- Intraocular anti-VEGF injection, SENSIMED Triggerfish
- Where
- Spain
- Volunteers
- 4 people
- Sponsor
- Sensimed AG
Neovascular Glaucoma
Comparison of Efficacy Between Silicone Ahmed Glaucoma Valves With and Without Intravitreal Triamcinolone Injection
The management of neovascular glaucoma (NVG) is a challenge for the ophthalmologist and surgery is frequently needed to control IOP. The success rates of a drainage device is usually lower in NVG than in other forms of glaucoma.
- Trial name
- NCT00491712
- Testing
- Glaucoma drainage implant with/without triamcinolone
- Where
- Brazil
- Volunteers
- 49 people
- Sponsor
- Federal University of São Paulo
Glaucoma, New Onset Glaucoma
Lucentis for New Onset Neovascular Glaucoma
Neovascular glaucoma is a potentially debilitating disease of the eye. Vascular eye disease such as diabetes and vein occlusions can cause the retina to release factors that promote the growth of abnormal blood vessels.
- Conditions
- Glaucoma, New Onset Glaucoma, Neovascular Glaucoma, New Onset Neovascular Glaucoma
- Trial name
- NVG (NCT00727038)
- Testing
- Ranibizumab (Lucentis)
- Sponsor
- University of Illinois at Chicago
IOP Decreased, Visual Impairment
Triple Procedure for Dense Cataractus Neovascular Glaucoma Patients
Background: One of the most difficult refractory glaucomas in treatment is the neovascular type and its association with dense cataract add to this difficulty.
- Trial name
- NVG (NCT04143620)
- Testing
- Procedure
- Where
- Egypt
- Volunteers
- 12 people
- Sponsor
- Minia University
Neovascular Glaucoma, Proliferative Diabetic Retinopathy
A Study on the Treatment Strategy of NVG Secondary to PDR
With the increasing incidence of proliferative diabetic retinopathy (PDR), subsequent neovascular glaucoma (NVG) has become one of the main causes of blindness in PDR patients, and the intraocular pressure of PDR patients with…
- Trial name
- NCT05156021
- Testing
- anti-VEGF
- Where
- China
- Volunteers
- 39 people
- Sponsor
- Ruijin Hospital
Glaucoma, Primary Open Angle Glaucoma
Ahmed Glaucoma Valve Surgery With Mitomycin-C
This study will determine the effectiveness of Mitomycin-C use in the glaucoma surgery Ahmed valve implantation. Approximately 100 patients will be enrolled, with half receiving the Mitomycin-C treatment and the other half…
- Conditions
- Glaucoma, Primary Open Angle Glaucoma, Secondary Glaucoma, Neovascular Glaucoma
- Trial name
- AMCT (NCT02805257)
- Testing
- Mitomycin-C, Balanced Salt Solution, Ahmed Glaucoma Valve Implant
- Where
- 4 sites in United States, China and 2 more
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Neovascular Glaucoma
Use of Intravitreal Aflibercept Injection for Neovascular Glaucoma
This 52 week study will assess the use of intravitreal aflibercept injections in patients with neovascular glaucoma (NVG) compared to standard of care panretinal photocoagulation.
- Trial name
- NCT01711879
- Testing
- Aflibercept
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Colorado, Denver
Glaucoma Open-Angle, Glaucoma Eye
INTEGRAL Study: A Longitudinal Study of Surgeries and Lasers in Glaucoma: Long-term Results and Success Predictors Analysed From a Large-scale Retrospective and Prospective Glaucoma Register
The study is an observational analysis of patients' medical data recorded in a large-scale register, both retrospective (for patients operated and data recorded before 2018) and prospective (for data collected after 2018) in…
- Conditions
- Glaucoma Open-Angle, Glaucoma Eye, Glaucoma; Drugs, Glaucoma, Angle-Closure
- Trial name
- NCT04381611
- Where
- Switzerland
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Dr. Kaweh Mansouri
Diabetic Retinopathy, Glaucoma, Neovascular
Intravitreal Ranibizumab Injection as Adjuvant in the Treatment of Postvitrectomy Diabetic Vitreous Hemorrhage Accompanied by Neovascular Glaucoma
To determine the efficacy of intravitreal ranibizumab injection as adjuvant therapy in the treatment of postvitrectomy diabetic vitreous hemorrhage (PDVH) accompanied by neovascular glaucoma (NVG) as a means of preventing…
- Trial name
- NCT02647515
- Testing
- ranibizumab
- Volunteers
- 18 people
- Sponsor
- Ruijin Hospital
Glaucoma, Neovascular, Ranibizumab
Intravitreal Ranibizumab (Lucentis®) for Neovascular Glaucoma- a Randomized Controlled Study
Neovascular glaucoma is a potentially blinding condition characterized by the growth of newvessels at the anterior part of the eye.
- Trial name
- NCT02914626
- Testing
- Intravitreal ranibizumab
- Volunteers
- 28 people
- Sponsor
- LEANDRO CABRAL ZACHARIAS
Neovascular Glaucoma
Minimally Invasive Suprachoroidal Drainage for the Treatment of Neovascular Glaucoma
To explore the efficacy and safety of minimally invasive suprachoroidal drainage for the treatment of advanced neovascular glaucoma
- Trial name
- NCT07201415
- Testing
- minimally invasive suprachoroidal drainage
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zhongnan Hospital