Clinical trials: Nephrolithiasis
Urologic Injuries, Disorder of Urinary Stent
Indwelling Stent Discoloration Project
The aim of this study is to identify the root cause for the significant discolouration of Boston Scientific Percuflex based stents.
- Conditions
- Urologic Injuries, Disorder of Urinary Stent, Kidney Calculi, Urinary Tract Obstruction Due to Specified Cause
- Trial name
- NCT02007980
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Kidney Stone, Calculi, Renal
Our Stone Fixation Technique to Improve Efficiency and Results of Peumatic Lithotripsy in Suction Mini-PCNL.
Prospective study to assist safty and efficieny of our technique of using peumatic lithotripsy with suction mini-pcnl.
- Trial name
- NCT07328659
- Testing
- Peumatic lithotripsy in mini-pcnl
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Yasser Gamil Elnagar
Renal Stone, Pediatric
Flexible Ureteroscopy Versus Mini- Percutaneous Nephrolithotomy in Management of Pediatric Renal Stones Less Than 2 cm
This single-center, prospective, two-arm randomized controlled trial included 58 patients younger than 18 years who were allocated 1:1 to Mini-PCNL or FURS between June 2023 and December 2024.
- Trial name
- NCT07870200
- Testing
- Group A :Flexible ureteroscope group, Group B : Mini perc group
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Elsayed Abdelhalim Elsayed
Determine the Efficacy and Safety of SWL in Renal Stones Larger Than 2 cm in Pediatric Age Group
Extracorporeal Shock Wave Lithotripsy for Treatment of Large Pediatric Renal Pelvic Stone Burden More Than 2 cm
Extracorporeal shock wave lithotripsy (SWL) was first described for pediatric nephrolithiasis in 1986; SWL has been a mainstay of treatment for both renal and ureteral calculi in children .
- Trial name
- NCT05293613
- Testing
- extracorporeal shock wave lithotripsy
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sohag University
Urolithiasis
sipIT2: Improving Adherence to Fluid Intake Guidelines for Kidney Stone Prevention
The purpose of this study is to examine the feasibility of using sipIT tools (i.e., wrist-worn sensors, smart water bottles, mobile applications) to increase compliance with physician-recommended fluid consumption guidelines in…
- Trial name
- NCT05196113
- Testing
- sipIT
- Where
- 2 sites in United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Stone, Kidney
Evaluation of Retrograde Intra Renal Surgery in the T-tilted Position
To evaluate the effect of the T-tilted position on the stone-free rate compared to the standard lithotomy position in retrograde intrarenal surgeries.
- Trial name
- RIRS (NCT06860113)
- Testing
- T-tilting of the patient during surgery, standard lithotomy position
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Kidney Calculi, Urinary Tract Infections
Is it Necessary for Patients With a Positive Urine Culture to Achieve a Negative Result After Antimicrobial Treatment Before Undergoing Percutaneous Nephrolithotomy?
Objective: The current European Association of Urology (EAU) guidelines do not provide clear recommendations on whether patients with a positive urine culture(UC) should wait until the culture turns negative following…
- Conditions
- Kidney Calculi, Urinary Tract Infections, Sepsis
- Trial name
- NCT06210425
- Where
- China
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Junhao Zheng
Kidney Calculi, Ureteral Calculi
Impact of Humid-Heat on Gut-Tryptophan-Stone Pathway
Investigating the differences in gut microbiota composition and tryptophan metabolite levels between kidney stone patients and healthy individuals, with special focus on: 1.
- Trial name
- NCT07043374
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Nephrolithiasis, Urinary Tract Infections
A Randomized Trial of Preoperative Prophylactic Antibiotics Prior to Kidney Stone Surgery (Percutaneous Nephrolithotomy [PCNL])
When patients are going to have surgery to remove large kidney stones (percutaneous nephrolithotomy [PCNL]), it is not clear whether the patients benefit from a course of prophylactic preoperative oral antibiotics; currently both…
- Trial name
- NCT02384200
- Testing
- nitrofurantoin monohydrate/macrocrystalline capsules, ampicillin, gentamicin
- Where
- 8 sites in United States, Canada
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Kidney Stone
Oxalate Formation From Ascorbic Acid
The purpose of this basic research study is to determine the contribution of endogenous ascorbic acid (AA) turnover to urinary oxalate excretion in both normal BMI and obese adult non-stone formers and calcium oxalate stone…
- Trial name
- NCT04603898
- Testing
- Low Oxalate Diet, Carbon-13 Ascorbic Acid Oral Load
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Hyperoxaluria
A Novel Approach for Reducing Hyperoxaluria and Kidney Stone Risk.
This pilot study is proposing a novel approach to directly target intestinal oxalate absorption with the drug Tenapanor, which was recently FDA-approved for treating hyperphosphatemia in patients with chronic kidney disease.
- Trial name
- NCT06481150
- Testing
- Tenapanor
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Renal Stone
Comparison Between External Oblique Intercostal Block and Erector Spinae Plane Block in PCNL
The aim of the study is to compare the post-operative analgesic effect of USG unilateral External oblique intercostal (EOI) block with Erector spinae plane block (ESPB) for after percutaneous Nephrolithotomy with a hypothesis…
- Trial name
- NCT06131151
- Testing
- External Oblique Intercostal Block, Erector Spinae Plane Block
- Where
- Egypt
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Assiut University
Overactive Bladder, Renal Colic
Preoperative Use of Darifenacin (Enablex) to Alleviate Postoperative Ureteral Stent Pain
This will be a randomized two arm prospective study to evaluate postoperative ureteral stent pain. One arm will be given 3 days of preoperative darifenacin and the control group will have the standard of care which is no…
- Conditions
- Overactive Bladder, Renal Colic, Pain, Postoperative
- Trial name
- NCT01189071
- Testing
- Darifenacin
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Appendicitis, Evidence of Cholecystectomy
Point of Care 3D Ultrasound for Various Applications: A Pilot Study
Summary 1. Purpose and Objective: The purpose of this study is to test the feasibility of rapid acquisition of point of care 3D ultrasound in obtaining abdominal and/or pelvic images.
- Conditions
- Appendicitis, Evidence of Cholecystectomy, Gallstones, Pregnancy, Ectopic
- Trial name
- NCT02831556
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Duke University
Technology, Diet Habit
Video Home Visits for Dietary Counselling
This pilot study aims to develop a protocol for home video informed dietary counseling with the goal of reducing overall sodium consumption among kidney stone formers.
- Trial name
- NCT04634851
- Testing
- Virtual home visits
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pneumothorax, Intestinal Obstruction
The Impact of Artificial Intelligence-Assisted X-ray Interpretation on Radiologists' Diagnostic Performance
This study tests whether an artificial intelligence (AI) tool helps radiologists read X-rays more accurately. Radiologists read X-rays to find diseases such as pneumonia, bone fractures, and abdominal problems.
- Conditions
- Pneumothorax, Intestinal Obstruction, Spondylolysis, Renal Calculus
- Trial name
- NCT07870928
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated Hospital of Southern Medical University
Infections, Urinary Tract, Nephrolithiasis
Preoperative Prophylactic Antibiotic Duration in Moderate to High Risk Ureteroscopy
The goal of this non-inferiority randomized controlled trial: is to test the hypothesis that the that there is no additional benefit from a longer course (7 days) versus a shorter course (2 days) of pre-operative antibiotics in…
- Trial name
- NCT06149455
- Testing
- Duration of antibiotics
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Kidney Stones, Urolithiasis
Pilot Study to Evaluate the Contribution of Gene Variants to Idiopathic Urolithiasis
Recent investigations from this group have identified that genetic variants of genes associated with monogenic forms of nephrolithiasis are expressed in idiopathic calcium oxalate kidney stone patients and could influence stone…
- Conditions
- Kidney Stones, Urolithiasis, Calcium Oxalate Urolithiasis
- Trial name
- NCT01127854
- Where
- United States
- Volunteers
- 2,900 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Kidney Stones
AR Projections for Eye-gaze Evaluation in Phantoms
This project aims to develop an augmented reality (AR) tool to enhance skill acquisition for endoscopic kidney stone surgery. Of the 100,000 patients who undergo an endoscopic kidney stone treatment annually in the United States…
- Trial name
- NCT07161024
- Testing
- Augmented reality
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Kidney Stone
Dietary Oxalate and Immune Cell Function
The purpose of this study is to evaluate mitochondrial function in white blood cells and platelets from healthy individuals following dietary oxalate intake.
- Trial name
- NCT03877276
- Testing
- Breakfast, Spinach smoothie, Kale smoothie
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham