Clinical trials: Nephrolithiasis
Stone, Kidney, Stone Ureter
Virtual Reality for Pain Control During Extracorporeal Shock Wave Lithotripsy: a Prospective, Comparative, Randomized Study at a Single Institution
The aim of this study is to prospectively analyze patient satisfaction, pain, delivered energy and clinical effectiveness of using VR as a complimentary treatment modality during SWL.
- Trial name
- NCT05183269
- Testing
- Oncomfort virtual reality monitor (Oncomfort SA, Wavre, Belgium)
- Where
- Belgium
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- AZ Sint-Lucas Gent
Obesity
Obesity and Endogenous Oxalate Synthesis
The goal of this study is to determine if obesity is associated with increased endogenous oxalate synthesis as assessed by urinary oxalate excretion, which is a known risk factor for calcium oxalate kidney stones.
- Trial name
- NCT03808090
- Testing
- Normal Individuals
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Kidney Stones
Evaluation of Eye Gaze Sharing in the Operating Room
This project aims to develop an augmented reality (AR) tool to enhance skill acquisition for endoscopic kidney stone surgery. Of the 100,000 patients who undergo an endoscopic kidney stone treatment annually in the United States…
- Trial name
- NCT07173309
- Testing
- Augmented reality
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Stones, Kidney, Ureteric Injury
Intra-ureteric Aminophylline Instillation on Flexible Ureteroscopy Procedure
in this study we are going to evaluate the efficacy of intra-ureteric aminophylline instillation in facilitating ureteric access sheath placement prior to flexible ureteroscopy in reducing ureteric injury rates.
- Trial name
- NCT06830577
- Testing
- Usage of Aminophylline prior to ureteric dilatation in Flexible uretroscopy, Sequential teflon dilator usage prior to ureteric access sheath placement in flexible uretroscopy, Aminophylline instillation and Ureteral dilators together
- Where
- Egypt
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Urolithiasis
ButOx Human Trial: An Open Label Prospective Cohort Study to Investigate the Effect of Tributyrin (Butyrate Precursor Molecule) Supplementation on Markers of Calcium Oxalate Nephrolithiasis
Kidney stone disease (KSD) is a condition where there are crystal deposits in the kidney. The gut microbiome is a community of gut bacteria which can produce substances such as short chain fatty acids (SCFAs).
- Trial name
- ButOx (NCT07004257)
- Testing
- tributyrin
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Renal Stone
Changes Post Percutaneous Nephrolithotomy
Using color doppler U/S, Abdominal U/S and radioisotope to evaluate changes of renal morphology, function and doppler parameters post Percutaneous nephrolithotomy
- Trial name
- KUB (NCT06185387)
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Assiut University
Acute Kidney Injury, Renal Calculi
Evaluation of Renal Damage After PCNL and ESWL Using Novel RNA Based Biomarkers
The study evaluate the damage effect of ESWL and PCNL on kidney tissue by measuring non-coding lnc-RNA profile in urine before and after ESWL and PCNL procedures
- Conditions
- Acute Kidney Injury, Renal Calculi, Percutaneous Nephrolithotomy, Extracorporeal Shockwave Lithotripsy
- Trial name
- NCT05077007
- Testing
- Percutaneous nephrolithotomy, Extracorporeal Shock Wave Lithotripsy
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Kidney Calculi, Ureteral Calculi
Study of Ketorolac Versus Opioid for Pain After Endoscopy
A double blind randomized controlled trial designed to compare pain control and safety with ketorolac and oxycodone in the post-operative setting for patients undergoing ureteroscopy for treatment of urinary stones.
- Trial name
- SKOPE (NCT03888144)
- Testing
- Oxycodone, Ketorolac
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Kidney Stones
Alfuzosin for Medical Expulsion Therapy of Ureteral Stones
The goal of this study is to conduct a prospective controlled trail of four currently approved Department of Defense (DOD) - formulary medications for use as medical expulsion therapy (MET) for kidney stones.
- Trial name
- MET (NCT00713739)
- Testing
- Alfuzosin, nifedipine, doxazosin
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Urinary Infections, Urolithiasis
The Effect of Preoperative Culture Timing on Postoperative Outcomes of Retrograde Intrarenal Surgery
The rate of complications (unexpected situations) after retrograde intrarenal surgery is reported to be 9-25%, and the majority of these are postoperative infections.
- Trial name
- NCT06723327
- Where
- Turkey (Türkiye)
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Namik Kemal University
Kidney Stones
Oxalate-Driven Host Responses in Kidney Stone Disease
This study is looking to understand the role of oxalate on kidney stone development and immunity. This study will enroll healthy participants and participants with calcium oxalate kidney stones (CaOx KS).
- Trial name
- NCT05417568
- Testing
- Low Oxalate Diet, High Oxalate Diet
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Renal Stones
RIRS Versus ESWL for the Treatment of Renal Stones
To evaluate the effectiveness of RIRS (retrograde intrarenal surgery) and ESWL (extracorporeal shockwaves lithotripsy) in the treatment of renal stone ranging form 6 to 20 mm size.
- Trial name
- NCT02645058
- Testing
- RIRS, ESWL, Rigid and flexible ureteroscope
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Kidney Stone
A RCT to Evaluate the Efficacy and Safety of Automated Needle Targeting (ANT-X) System Compared to Traditional Free Hand Puncture for Renal Access in Percutaneous Nephrolithotomy (PCNL)
Objectives: This study aims to determine if the device provides an advantage over traditional free hand puncture by comparing the number of attempts required to obtain access, time to achieve access, radiation exposure to patient…
- Trial name
- NCT05213702
- Testing
- Renal Calyx punture with traditional free hand or ANT-X device
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Nephrolithiasis
Massage Percussion for Passage of Urolithiasis Fragments After Ureteroscopy.
Flexible ureteroscopy is characterized as first-line therapy for renal stones < 2 cm in size. Stones are commonly treated with dusting or fragmentation techniques which requires passage of stone fragments after surgery.
- Trial name
- NCT05872230
- Testing
- Massage Percussion Therapy device
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Kidney Stones
Percutaneous Nephrolithotomy Versus Extracorporeal Shock Wave Lithotripsy
The investigators main hypothesis is that the stone free rate will be much higher (95%) in patients treated with PCNL than patients treated with ESWL where stone free rate is (60%) to determine which treatment is safe and prevent…
- Trial name
- NCT00873054
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- CAMC Health System
Healthy, Enteric Hyperoxaluria
Safety and Tolerability of FB-001 in Healthy Adult Volunteers and Adult Subjects With Enteric Hyperoxaluria
This Phase 1, first-in-human, randomized, double-blinded, placebo controlled study is evaluating FB-001 in healthy volunteers (Part 1) and participants diagnosed with enteric hyperoxaluria (Part 2).
- Trial name
- NCT05650112
- Testing
- FB-001
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Federation Bio Inc.
Kidney Calculi
Allopurinol Effect on MDA,NO,KIM-1 Urine Levels, RI and Renal Elastography in Kidney Stone Patients Post ESWL
Extracorporeal shock wave lithotripsy (ESWL) is accepted as the first treatment choice for most urinary stones. Still, it has adverse effects on the kidneys.
- Trial name
- NCT05414669
- Testing
- Allopurinol Tablet 300 mg, Control Group
- Where
- Indonesia
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- RSUP Prof. Dr. I.G.N.G. Ngoerahal
Kidney Stones, Kidney Calculi
Endogenous Oxalate Synthesis in Idiopathic Calcium Oxalate Kidney Stone Disease
The goal of this clinical trial study is to test if patients with idiopathic calcium oxalate kidney stones have an increased production of oxalate by the body, which would lead to increased urinary excretion of oxalate.
- Conditions
- Kidney Stones, Kidney Calculi, Urolithiasis, Urolithiasis, Calcium Oxalate
- Trial name
- NCT06989320
- Testing
- Low-oxalate diet and glycolate dosing, Oral glycolate dosing, Oral 13C- ascorbic acid dosing
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Kidney Stone
Comparing Alkalinizing Agents Efficacy on Stone Risk in Patients on a Metabolically Controlled Diet
The purpose of this study is to compare over the counter and alternative prescription urinary alkalinizing agents to slow release potassium citrate in their ability to modify urinary parameters associated with stone formation.
- Trial name
- NCT04651088
- Testing
- Potassium citrate, Sodium bicarbonate, Litholyte
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Stone;Renal
Flexible Ureteroscopy Versus Mini-Percutaneous Nephrolithotomy for Treatment of Renal Stones
Management of nephrolithiasis is evolving rapidly, and various minimally-invasive urological procedures are currently available for treating patients with renal stones, including extracorporeal shockwave lithotripsy (ESWL)…
- Trial name
- NCT03932370
- Testing
- Flexible ureteroscopy, mini-Percutaneus nephrolithotomy
- Where
- Egypt
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Assiut University