Clinical trials: Nephrolithiasis
Urolithiasis
A Trial Comparing Efficacy of HM3 Versus F2 Lithotripters for Stone Fragmentation
The older lithotripter, HM3, has over 90% stone-free rate in most studies. However, it's less transportable than the new model, F2.
- Trial name
- NCT00913159
- Testing
- Extracorporeal Shock Wave Lithotripsy (ESWL)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Washington University School of Medicine
Kidney Stones
Dual Approach External Oblique Fascial Plane Block Versus Erector Spinae Plane Block for Post Operative Analgesia in Percutaneous Nephrolithotomy
Here is a patient-friendly, ClinicalTrials.gov-compliant Brief Summary written in plain language, avoiding technical jargon as much as possible while remaining accurate.
- Trial name
- BLOCK-PCNL (NCT07359391)
- Testing
- Erector Spinae Plane Block, Dual External Oblique Fascial Plane Block, General Anesthesia
- Volunteers
- 90 people
- Sponsor
- Zagazig University
Urolithiasis, Kidney Stone
Flexible Ureteroscopy With Tip-bendable Suction Ureteral Access Sheath Versus Mini-Percutaneous Nephrolithotomy for Treatment of 2-3cm Renal Stones
Background: Percutaneous nephrolithotomy (PCNL) is the first-line treatment for renal stones larger than 2 cm according to EAU and AUA guidelines.
- Trial name
- NCT06526390
- Testing
- f-URS, mini-PCNL
- Where
- China
- Volunteers
- 720 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Pediatric Kidney Disease
Ultrasonic vs. Fluoroscopic Guided PNL in Pediatric Renal Stones
Percutaneous Nephrolithotomy (PNL) was accepted as a treatment modality for large renal stones since 1980. Although radiation exposure during PNL is within the safe limits for expert endourologist, the mutagenic hazard is still…
- Trial name
- NCT03250559
- Testing
- Percutaneous nephrolithotomy
- Where
- Egypt
- Volunteers
- 6 people
- Sponsor
- Assiut University
Nephrolithiasis, Urolithiasis
Vitamin D Repletion in Stone Formers With Hypercalciuria
Vitamin D plays a critical role in maintaining bone health, as well as preventing cardiovascular disease, cancer, and various autoimmune diseases, such as diabetes.
- Conditions
- Nephrolithiasis, Urolithiasis, Idiopathic Hypercalciuria, Vitamin D Deficiency
- Trial name
- NCT01295879
- Testing
- Ergocalciferol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- New York Presbyterian Hospital
Kidney Stone
Outcomes in Lower Pole Kidney Stone Management Using Mini-PCNL Compared With Retrograde Intra Renal Surgery
Due to the anatomic characteristics of the lower calyx, lower pole stones are difficult to be eliminated through the ureter, even if the stones had been fragmented.
- Trial name
- NCT05714423
- Testing
- Mini-PCNL, RIRS
- Where
- Pakistan
- Volunteers
- 150 people
- Sponsor
- Services Hospital, Lahore
Kidney Stones, Ureteral Stones
The Efficacy of Tamsulosin in the Treatment of Ureteral Stones in Emergency Department Patients
To determine if emergency department patients with acute ureteral colic pain due to a ureteral stone who are treated with tamsulosin, versus placebo, will experience a shorter time to passage of their stone or resolution of their…
- Trial name
- NCT00448123
- Testing
- Tamsulosin
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Robert Swor
Urolithiasis
Multi-Center Comparison of Dual Lumen Versus Single Lumen Ureteroscopes
Urolithiasis (kidney stones) is a common disease process affecting people all across the world. Usually, if the stone size is small, it is able to pass through the urinary system and exit the bladder on its own with no treatment.
- Trial name
- NCT02123082
- Testing
- Storz single Lumen Ureteroscope, Dual Lumen Ureteroscope
- Where
- United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Pediatric Kidney Disease
Shockwave Lithotripsy (SWL) Versus SWL and Oral Dissolution Therapy (ODT) For Paediatrics Radiolucent Renal Stone
To conduct a RCT comparing SWL versus combined ODT and SWL as non-invasive methods for management of paediatrics radiolucent renal stone.
- Trial name
- NCT05896345
- Testing
- SWL, SWL and ODT
- Where
- Egypt
- Volunteers
- 76 people
- Sponsor
- Mansoura University
Kidney Stone
Reducing Opioid Prescription After Kidney Stone Removal Surgery
The purpose of this study is to implement and assess a standard way of prescribing opioid pain medication following PCNL (a kidney stone removal surgery) to ensure patients are being discharged with an appropriate quantity of…
- Trial name
- NCT05353478
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Nephrolithiasis
Tract Closure in PCNL
This is a prospective, randomized controlled trial evaluating the effect of a hemostatic agent on tract-related bleeding during percutaneous nephrolithotomy (PCNL).
- Trial name
- NCT07668817
- Testing
- Floseal, Surgicel, Surgiflo
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Renal Stones
Ureteroscopic Lithotripsy for Renal Stones Using a Sheathless Approach or Using a Flexible and Navigable Ureteral Access Sheath (FANS)
The primary aim of the study is to compare stone free rates following ureteroscopic (URS) lithotripsy for renal stones with Thulium Fiber Laser (TFL) using a sheathless approach (low power laser settings) or using a flexible and…
- Trial name
- NCT07741084
- Testing
- Sheathless URS, FANS, low power, FANS, high power
- Where
- Norway
- Volunteers
- 225 people
- Sponsor
- Haukeland University Hospital
Kidney Stone
Influence of Obesity on Endogenous Oxalate Synthesis
There is increasing evidence that obesity is associated with increased urinary oxalate excretion, an important risk factor for calcium oxalate stone formation.
- Trial name
- NCT03704350
- Testing
- controlled diet
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Kidney Stones
Flexible Ureteroscopy With a Flexible and Navigable Suction Ureteral Access Sheath Versus Mini-Percutaneous Nephrolithotomy for 1-2 cm Lower Pole Kidney Stones
This study, known as the FLAME Trial (Flexible ureteroscopy for Lower pole stones And Mini-pErcutaneous nephrolithotomy), is an international, multicenter, randomized, non-inferiority trial.
- Trial name
- FLAME (NCT07159035)
- Testing
- Flexible ureteroscopy with FANS, Mini-percutaneous nephrolithotomy (mini-PCNL)
- Where
- China
- Volunteers
- 640 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Nephrolithiasis, Postoperative Pain
Effect of a Low-Dose Ketamine-Dexmedetomidine-Based Opioid-Sparing Anesthesia Protocol on Postoperative Quality of Recovery After Percutaneous Nephrolithotomy
Percutaneous nephrolithotomy (PCNL) is a minimally invasive surgical procedure used to remove large or complex kidney stones. Although effective, dilation of the surgical tract and the placement of a nephrostomy tube cause…
- Conditions
- Nephrolithiasis, Postoperative Pain, Quality of Recovery
- Trial name
- NCT07855068
- Testing
- Ketamine and Dexmedetomidine, Fentanyl
- Volunteers
- 100 people
- Sponsor
- Assiut University
Kidney Calculi, Kidney Diseases
Methocarbamol vs Oxybutynin for Management of Pain and Discomfort S/P Ureteroscopy Procedure
Stone disease is a common condition, affecting approximately 9% of Americans in 2007. It causes great morbidity and is also a costly condition, estimated to cost the US healthcare system approximately 3.79 billion dollars in…
- Conditions
- Kidney Calculi, Kidney Diseases, Nephrolithiasis, Urolithiasis
- Trial name
- NCT05100017
- Testing
- Methocarbamol, Oxybutynin
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Northwestern University
Urinary Tract Infection Bacterial, Nephrolithiasis
Blood Parameters as a Predictor of Fever After Percutaneous Nephrolithotomy
To investigate the relationship between neutrophil count, lymphocyte count, neutrophil-to-lymphocyte count ratio (NLR), and postoperative fever in patients undergoing percutaneous nephrolithotomy (PNL).
- Trial name
- NCT03774940
- Testing
- peripheric blood count
- Where
- Turkey (Türkiye)
- Volunteers
- 519 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Renal Calculi
The 18F Peel-way Sheath Versus the 18F Access Sheath With a Suction-evacuation Function MPCNL for the Management of 2-5cm Size Kidney Stones
Percutaneous nephrolithotomy (PNL) has been considered as the first-line choice for the management of >20mm kidney stones. Microchannel percutaneous nephrolithotomy (Mini PCNL) which takes nephrolithotomy channel size less than…
- Trial name
- NCT03206515
- Testing
- 18F Peel-Way Sheath, 18F access sheath with a suction-evacuation function
- Where
- China
- Volunteers
- 86 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Calcium Oxalate Urolithiasis
Oxalobacter Formigenes Colonization and Urinary Oxalate Excretion
The purpose of this research study is to assess the efficacy of ingesting a small amount of the harmless bacterium Oxalobacter formigenes in establishing residence in the guts of healthy participants and to determine whether this…
- Trial name
- NCT03752684
- Testing
- Moderately high oxalate/low calcium diet non-colonized, Oxalobacter formigenes, Moderately high oxalate/low calcium diet colonized
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Nephrolithiasis, Low Urine Volume
Hidrate Me Smart Water Bottle Use in Patient With Nephrolithiasis
The primary objective of this study would be to determine whether utilization of this technology improves adherence to recommended increases in hydration for stone forming patients with low urine volume relative to standard…
- Trial name
- HidrateMe (NCT02938884)
- Testing
- HidrateSpark Water Bottle
- Where
- 4 sites in United States
- Volunteers
- 85 people
- Sponsor
- University of Minnesota