Clinical trials: Nephropathy, Diabetic
Diabetic Nephropathies
Nitric Oxide (NO) Activity and Diabetic Nephropathy
Experimental data suggest that oxidative stress and endothelial dysfunction are key players in the pathogenesis of diabetic nephropathy.
- Trial name
- NCT00136188
- Testing
- Folic Acid
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Type 2 Diabetes Mellitus, Diabetic Kidney Disease
Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress (PANTHER Study)
Early diabetic kidney disease (DKD) occurs in 50-70% of youth with type 2 diabetes (T2D) and confers high lifetime risk of dialysis and premature death.
- Conditions
- Type 2 Diabetes Mellitus, Diabetic Kidney Disease, Adolescent Obesity, Pre Diabetes
- Trial name
- NCT05008276
- Testing
- Aminohippurate Sodium Inj 20%, Iohexol Inj 300 MG/ML, Dextran 40
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Petter Bjornstad
Diabetic Nephropathies
Serum Uromodulin and DN Systematic Review and Meta Analysis
Several studies have investigated the association between the changes of serum uromodulin and diabetic nephropathy (DN). However, the results are still controversial.
- Trial name
- NCT06596863
- Testing
- The association of serum uromodulin with DN, The DN patients were divided according to the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN
- Where
- Egypt
- Volunteers
- 1,774 people, healthy volunteers welcome
- Sponsor
- Tanta University
Worsening Chronic Heart Failure, Diabetic Nephropathy
A Study to Learn How Finerenone (BAY94-8862) Moves Into, Through and Out of the Body, How it Affects the Body, and How Safe it is in Adult Participants With Different Degrees of Reduced Liver Function and in Healthy Participants With Similar Age, Weight and Gender Distribution
Researchers are looking for a better way to treat people who have worsening of chronic heart failure, a long-term condition where the heart does not pump blood as well as it should, as well as to treat patients who have diabetic…
- Trial name
- NCT04881994
- Testing
- Finerenone (BAY94-8862)
- Where
- Germany
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Bayer
Inflammation, Chronic Kidney Disease
Role of Prohepcidin in Uremic Patients
The investigators aimed to study the effect of prohepcidin levels on hematologic parameters and inflammatory markers in non-diabetic uremic patients.
- Trial name
- NCT01735773
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Haseki Training and Research Hospital
Diabetic Neuropathic Pain, Renal Impairment
A Study to Learn How the Study Treatment BAY2395840 Moves Into, Through and Out of the Body, How Safe it is, and How it Affects the Body in Participants With Moderate Reduced Kidney Function and in Healthy Male and Female Participants With Normal Kidney Function
Researchers are looking for a better way to treat people who have inflammatory conditions. Inflammatory conditions may result from an increased activation of the body's natural defenses (the immune system) and are characterized…
- Conditions
- Diabetic Neuropathic Pain, Renal Impairment, Healthy Volunteers
- Trial name
- NCT05406219
- Testing
- BAY2395840
- Volunteers
- healthy volunteers welcome
- Sponsor
- Bayer
Nephropathy
Empagliflozin and Renal Oxygenation in Healthy Volunteers
SGLT-2 inhibitors belong to a new class of hypoglycemic drugs with the unique property of decreasing blood glucose through an increase in glucosuria.
- Trial name
- EMPA-REIN (NCT03093103)
- Testing
- Empagliflozin 10 mg
- Where
- Switzerland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Diabetic Kidney Disease
Evaluate the Role of Soleus Muscle Exercise in Glycaemic Control in Diabetic Kidney Disease Patients
Evaluate the role of Soleus muscle exercise in management diabetic kidney disease
- Trial name
- NCT06120569
- Testing
- Soleus ms exercise
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Nora Hussein Kamal
Diabetes Mellitus, Type 2 Diabetes
The Hong Kong Diabetes Biobank
Asia is in the midst of an epidemic of diabetes. Epidemiological figures suggest that there are more than 110 million people affected by diabetes in China, with a significant proportion of young adults already affected.
- Conditions
- Diabetes Mellitus, Type 2 Diabetes, Type 1 Diabetes, Diabetic Nephropathies
- Trial name
- HKDB (NCT05282680)
- Testing
- prospective observational study
- Where
- Hong Kong
- Volunteers
- 48,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Diabetes Mellitus, Renal Failure
The Effects of Hemodialysis on Serum Sclerostin Levels
Background: Parathyroid hormone (PTH) and 1,25-dihydroxy vitamin D (1,25-OHD) as well as mineral bone metabolism modulators like sclerostin are thought to play an important role in in diabetic patients with chronic renal failure.
- Conditions
- Diabetes Mellitus, Renal Failure, Hemodialysis Access Failure
- Trial name
- sclerostin (NCT03952819)
- Testing
- serum sclerostin
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Diabetic Nephropathy Type 2, Type 2 Diabetes Mellitus
Beta-2-Trace Protein in Diabetic Nephropathy
This cross-sectional study aims to evaluate serum beta-2-trace protein levels in patients with diabetic nephropathy compared with healthy controls.
- Trial name
- NCT07919795
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Transplant Complication, Diabetic Nephropathy
Enhanced Recovery After Surgery for SPK Transplantation Recipients
108 patients underwent elective SPK surgery were randomly divided into ERAS group (E) and routine care group (T). The ERAS group was consisted of evidenced-based systematic optimization approaches, while the control group…
- Conditions
- Transplant Complication, Diabetic Nephropathy, Perioperative/Postoperative Complications
- Trial name
- NCT06095544
- Testing
- Enhanced recovery for SPK recipients
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Diabetic Nephropathy, Diabetes Mellitus
Family Investigation of Nephropathy and Diabetes (F.I.N.D.)
The Family Investigation of Nephropathy and Diabetes (FIND) is a multicenter study designed to identify genetic determinants of diabetic kidney disease.
- Conditions
- Diabetic Nephropathy, Diabetes Mellitus, Diabetic Kidney Disease, Albuminuria
- Trial name
- NCT00342927
- Where
- United States
- Volunteers
- 9,084 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 2 Diabetes
Epigenetic Contribution to the Pathogenesis of Diabetic Nephropathy in Qatari Population
The main objective is to study the epigenetic contribution to the pathophysiology of diabetic nephropathy in Qatari population.
- Trial name
- NCT02316522
- Where
- Qatar
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Diabetes Mellitus Without Complication
Prevent Diabetic Kidney Disease Among Egyptians
Study of the possibility to prevent the development of Diabetic kidney disease in type 2 diabetic patients
- Trial name
- NCT06071208
- Testing
- Gliflozin
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Diabetic Nephropathies
Effect of Exenatide on 24h-UAER in Patients With Diabetic Nephropathy
This is a multi-center, randomized, parallel study to evaluate effect of exenatide on 24h-UAER in patients with diabetic nephropathy. Screening will be made to select eligible participants before intervention.
- Trial name
- NCT02690883
- Testing
- Exenatide, Lispro
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Diabetes Mellitus, Type 2, Diabetes Complications
Arterial Stiffness and Complication Risk in Type 2 Diabetes
Background The prevalence and incidence of type 2 diabetes is increasing globally. A common complication of diabetes is the disease of the blood vessels, vascular diseases, which can cause disorders like myocardial infarction…
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Complications, Diabetic Angiopathies, Diabetic Nephropathies
- Trial name
- NCT02001532
- Where
- Denmark
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Diabetic Nephropathy
Matrix Metalloproteinases in Atherosclerosis of Chronic Kidney Disease
The purpose of this study is to determine whether matrix metalloproteinases are associated with atherosclerosis in the different stages of chronic kidney disease.
- Trial name
- MMACKD (NCT01458158)
- Where
- Greece
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Diabetic Kidney Disease (DKD)
Preliminary Study of CXCL3 As a Biomarker of Diabetic Kidney Disease
The goal of this study is to learn about CXCL3 as a biomarker for type 2 diabetic kidney disease (DKD) in adults between age of 18-80.
- Trial name
- NCT06639529
- Testing
- Tests of the expression of CXCL3 in various tissues
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Jilin University
Type II Diabetic Patients With Nephropathy
Microbial Soy Milk Consumption, Inflammation and Renal Function Among Type 2 Diabetic Patients With Nephropathy
The aim of the present study was to determine the effects of fortified soy milk with L. planetarium A7 on a cytokine receptor, an adipokine and renal function biomarkers in type II diabetic patients with nephropathy.
- Trial name
- NCT02704884
- Testing
- probiotic soy milk
- Where
- Iran
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences