Clinical trials: Nephropathy, Diabetic
Diabetic Nephropathy
Effect of Sulodexide in Overt Diabetic Nephropathy
The purpose of this study is to determine whether sulodexide is effective in slowing or preventing the progression of diabetic kidney disease.
- Trial name
- NCT00130312
- Testing
- Sulodexide
- Where
- 3 sites in United States, Australia and 1 more
- Volunteers
- 968 people
- Sponsor
- Keryx Biopharmaceuticals
Diabetic Nephropathies
Use of Wharton Jelly in Diabetic Nephropathy
Wharton Jelly derived Mesenchymal stem cells will be injected in the renal parenchyma of patients with Diabetic Nephropathy
- Trial name
- NCT03288571
- Testing
- Wharton Jelly Mesenchymal stem cells
- Volunteers
- 20 people
- Sponsor
- Sophia Al-Adwan
Diabetic Nephropathy
Study of LY3016859 in Participants With Diabetic Nephropathy
The purpose of this two-part study is to investigate the safety, tolerability and efficacy of LY3016859 after multiple intravenous (IV) dosing's in participants with diabetic nephropathy (DN).
- Trial name
- NCT01774981
- Testing
- LY3016859
- Where
- 7 sites in United States, Bulgaria
- Volunteers
- 60 people
- Sponsor
- Eli Lilly and Company
Diabetic Kidney Disease, Cognitive Function
Metabolism of Low Carbohydrate and Ketogenic Diet
This study will assess the preliminary efficacy of a lifestyle intervention including low-carb/ketogenic diet and exercise, enhanced by self-monitoring through health technologies on weight and diabetes outcomes (Glucose, HbA1c)…
- Conditions
- Diabetic Kidney Disease, Cognitive Function, Weight Loss, Diabetic Control
- Trial name
- NCT05071287
- Testing
- mHealth + low-fat diet, mHealth + low-carb/ketogenic diet
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Type 2 Diabetic Nephropathy
Evaluate the Efficacy and Safety of DWP16001 in Type 2 Diabetic Nephropathy with Moderate Renal Impairment Patients
This study aims to evaluate the efficacy and safety of DWP16001 in type 2 diabetic nephropathy with moderate renal impairment patients (CKD stage 3)
- Trial name
- NCT06606093
- Testing
- DWP16001 0.3mg
- Where
- South Korea
- Volunteers
- 348 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Type 2 DM /Diabetic Nephropathy
CRP to Serum Albumin Ratio in Type 2 DM é Diabetic Nephropathy
we aimed to compare C-reactive protein to serum albumin ( CAR) level of the T2DM patients with DN to those T2DM without DN
- Trial name
- NCT05681286
- Volunteers
- 70 people
- Sponsor
- Assiut University
Type 2 Diabetes Mellitus With Diabetic Nephropathy
Serum 1,25-dihydroxyvitamin D Levels in Type 2 Diabetes Mellitus Patients With Different Levels of Albuminuria
Diabetic nephropathy(DN)is a major microvascular complication of diabetes.Renal injury may be presented with the characteristics of albuminuria, and its main pathological change is glomerular sclerosis.
- Trial name
- DM (NCT01845870)
- Where
- China
- Volunteers
- 162 people
- Sponsor
- Tianjin Medical University General Hospital
Diabetic Nephropathies
TCF7L2 Gene Polymorphism and AGEs in Diabetic Nephropathy
1. To study genotypic distribution of the TCF7L2 gene polymorphism in Diabetic nephropathy. 2. To assess level of AGEs and Insulin in patients with Diabetic nephropathy. 3.
- Trial name
- NCT04084886
- Volunteers
- 100 people
- Sponsor
- Assiut University
Diabetic Kidney Disease
NEPHSTROM for Diabetic Kidney Disease
The study will investigate, primarily, the safety, feasibility and tolerability and, secondarily, the preliminary efficacy of an allogeneic bone marrow-derived Mesenchymal Stromal Cell (MSC) therapy (ORBCEL-M) in study subjects…
- Trial name
- NEPHSTROM (NCT02585622)
- Testing
- Mesenchymal Stromal Cells
- Where
- 4 sites in Ireland, Italy and 1 more
- Volunteers
- 29 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Chronic Kidney Diseases
Zibotentan and Dapagliflozin in Patients With Type 2 Diabetes and Elevated Albuminuria
The aim of this study is to test the hypothesis that the effects on albuminuria of combination treatment with the endothelin receptor antagonist zibotentan and SGLT2i dapagliflozin are complimentary and additive while the fluid…
- Trial name
- ZODIAC (NCT05570305)
- Testing
- Zibotentan, Dapagliflozin, Dapagliflozin and Zibotentan
- Where
- 7 sites in United States, Canada and 3 more
- Volunteers
- 42 people
- Sponsor
- University Medical Center Groningen
Chronic Kidney Disease Stage V
EVOO Coratina Intervention on Lipids in Non-diabetic Hypertensive Patients Undergoing Hemodialysis (EVOOC-3H)
Twenty-four non-diabetic hypertensive and hyperlipidemic patients undergoing periodic chronic hemodialysis will be enrolled for receiving extravirgin olive oil (EVOO) Coratina (12 patients) or refined olive oil (12 patients).
- Trial name
- EVOOC-3H (NCT03779529)
- Testing
- Olive oil
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione Schena
IgA Nephropathy (IgAN), Membranous Nephropathy
Raman Spectroscopy Diagnosis of Kidney Diseases
This research plan, from January 2021 to December 2024, aims to collect serum and morning urine from patients diagnosed with IgA nephropathy, idiopathic membranous nephropathy, diabetic nephropathy, and focal segmental…
- Conditions
- IgA Nephropathy (IgAN), Membranous Nephropathy, Diabetic Nephropathy, Focal Segmental Glomerulosclerosis (FSGS)
- Trial name
- NCT06760845
- Testing
- Imaging Time
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zunsong Wang
Diabetic Kidney Disease
Prevalence and Management Practice of Diabetic Kidney Disease at BADAS Affiliated Healthcare Centres in Bangladesh
Background: Diabetes is a growing public health concern in Bangladesh, with millions affected. Diabetic Kidney Disease (DKD) is a severe complication of diabetes, affecting approximately 21.3% of the diabetic population.
- Trial name
- BADAS (NCT06422598)
- Where
- 8 sites in Bangladesh
- Volunteers
- 320 people
- Sponsor
- Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders
Diabetic Nephropathy
Controlled Study to Evaluate Efficacy and Safety of α-KA Tab With Low Protein Diet (LPD) in Delaying the Progress of Type 2 Diabetic Nephropathy (DN)
Current expert opinion based consensus guidelines recommend usage of α-Keto analogues of essential amino acids in the diet of diabetic nephropathy patients, along with restricted protein diets.
- Trial name
- NCT00363987
- Testing
- Ketosteril®, diabetic diet
- Where
- China
- Volunteers
- 179 people
- Sponsor
- Fresenius Kabi
Diabetic Nephropathies
Relation Between Plasma Apelin Level and Diabetic Nephropathy in Type 2 Diabetes Patients.
Diabetic nephropathy (DN) is the commonest cause of chronic kidney disease, and proteinuria isn't determent factor for the end stage renal disease in diabetics.
- Trial name
- NCT04380584
- Testing
- plasma Apelin level
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Kidney Diseases, Diabetic Nephropathies
A Study of TRPC5 Channel Inhibitor in Patients With Diabetic Nephropathy, Focal Segmental Glomerulosclerosis, and Treatment-Resistant Minimal Change Disease
This is a phase 2a study evaluating the safety and tolerability of multiple ascending doses of GFB-887 in patients with diabetic nephropathy (DN), focal segmental glomerulosclerosis (FSGS), and treatment-resistant minimal change…
- Conditions
- Kidney Diseases, Diabetic Nephropathies, Glomerulosclerosis, Focal Segmental, Nephrosis, Lipoid
- Trial name
- NCT04387448
- Testing
- GFB-887
- Where
- 74 sites in United States
- Volunteers
- 96 people
- Sponsor
- Goldfinch Bio, Inc.
Type 2 Diabetes Mellitus, Obesity
Effect of Gastric Bypass Surgery on Diabetes Status and Microvascular Complications in Obese Type 2 Diabetic Patients
This study evaluates the long-term benefits of Roux-en-Y gastric bypass (RYGB) on type 2 diabetes mellitus, focussing on the prevalence and predictors of T2DM improvement and remission after RYGB, and subsequently relapse of type…
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Diabetic Retinopathy, Diabetic Nephropathy
- Trial name
- NCT02625649
- Where
- Denmark
- Volunteers
- 148 people
- Sponsor
- University of Aarhus
Diabetic Peripheral Neuropathy
Combined Effects of INF and OEP in Patients With Diabetic Peripheral Neuropathy
DPN often leads to balance issues, sensory deficits, and chronic pain, which can severely impact daily functioning and independence.
- Trial name
- NCT07274735
- Testing
- Intraneural facilitation therapy, Otago exercise program, Intraneural facilitation therapy with Otago exercise program
- Where
- Pakistan
- Volunteers
- 65 people
- Sponsor
- Riphah International University
Chronic Kidney Disease, Diabetic Nephropathy
Effect of Integrated CKD Care Program in Early Diabetic Nephropathy in Primary Health Care Setting.
Chronic kidney disease (CKD) is a major health problem in Thailand. Previous studies have demonstrated that integrated pre-dialysis care may slow the decline in renal function (Nephrol Dial Transplant.2009 Nov;24(11):3426-33).
- Trial name
- NCT02194790
- Testing
- Community-based Integrated CKD Care
- Where
- Thailand
- Volunteers
- 238 people
- Sponsor
- Bhumirajanagarindra Kidney Institute, Thailand
Diabetic Nephropathy
Safety and Efficacy of Aliskiren When Added to Standardized Losartan and Optimal Antihypertensive Therapy in Patients With Hypertension, Type 2 Diabetes and Proteinuria
Study of the efficacy and safety of aliskiren when added to losartan and optimal antihypertensive therapy in patients with hypertension, type 2 diabetes, and kidney disorders to monitor improvement in any of these conditions.
- Trial name
- NCT00097955
- Testing
- aliskiren
- Where
- 12 sites in United States, Canada and 10 more
- Volunteers
- 496 people
- Sponsor
- Novartis Pharmaceuticals