Clinical trials: Nephrotic Syndrome in Children
Steroid-Resistant Nephrotic Syndrome
ACTHAR Gel for Drug REsistant Nephrotic Syndrome in Children
We propose to study the use of purified porcine Acthar Gel (ACTHAR, Mallinckrodt Pharmaceuticals) for treatment of steroid resistance nephrotic syndrome (SRNS) in a prospective pilot study.
- Trial name
- ADRENL (NCT03408405)
- Testing
- Acthar Gel 80 UNT/ML Injectable Solution
- Sponsor
- Rhode Island Hospital
Steroid-Sensitive Nephrotic Syndrome
Study of Initial Steroid Treatment in Young Children With Nephrotic Syndrome
This study is a multicentric, prospective, randomized, double blind, placebo controlled trial compared the efficacy of 6 months vs.
- Trial name
- NCT04536181
- Testing
- Prednisolone
- Where
- 4 sites in China
- Sponsor
- Children's Hospital of Fudan University
Nephrotic Syndrome in Children, Nephrotic Syndrome, Minimal Change
REduced-dose Steroid PrOtocol for Childhood Nephrotic SyndromE (RESPONSE)
This is a pilot feasibility study for a proposed full-scale randomized controlled trial to evaluate the effectiveness and safety of a reduced-dose oral prednisone (steroids) regimen to treat childhood steroid-sensitive nephrotic…
- Conditions
- Nephrotic Syndrome in Children, Nephrotic Syndrome, Minimal Change, Nephrotic Syndrome, Nephrotic Syndrome，Idiopathic
- Trial name
- RESPONSE (NCT06635720)
- Testing
- Prednisone
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- The Hospital for Sick Children
Nephrotic Syndrome
Therapeutic Effect of Tacrolimus on Primary Nephrotic Syndrome in Children
To determine the efficacy of tacrolimus in the management of NS(nephrotic syndrome) , the investigators designed this prospective study.
- Trial name
- NCT01162005
- Testing
- Tacrolimus
- Where
- South Korea
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Nephrotic Syndrome
Diagnostic and Prognostic Value of Miss-1 Study in Children and Adult With Nephrotic Syndrome MISSNEPHROTIQUE
The nephrotic syndrome is a rare disease defined by a proteinuria >3g/24h and a hypoalbuminemia < 30g/L. Genetic and immune are the main causes.
- Trial name
- MISS-N (NCT03592030)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Idiopathic Nephrotic Syndrome
Cyclophosphamide Versus Mycophenolate Mofetil for the Treatment of Steroid-dependent Nephrotic Syndrome in Children
Idiopathic nephrotic syndrome is steroid-sensitive in more than 90% of cases in children. However 60% of cases are steroid dependent and required treatment with immunosuppressive agent.
- Trial name
- NEPHROMYCY (NCT01092962)
- Testing
- Cyclophosphamide, Mycophenolate mofetil
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Nephrotic Syndrome in Children
The Effect of Self-Efficacy Promoting Program Using Computer Game on Proteinuria in Thai Children With Nephrotic Syndrome
Nephrotic syndrome is a medical condition where the kidneys release substantial amounts of protein into the urine, resulting in various issues such as tissue swelling and an increased susceptibility to infections.
- Trial name
- NCT06524986
- Testing
- Self-efficacy promoting program using computer game, Standard nursing care
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Chulalongkorn University
Autoimmune Diseases, Systemic Lupus Erthematosus
Anti-CD19/BCMA CAR-NK Cells in Patients With B Cell Mediated Autoimmune Disease
this is an investigator-initiated trial aimed at evaluating the efficacy and safety of anti-CD19/BCMA CAR-NK Cells in Patients With B cell mediated autoimmune disease.
- Conditions
- Autoimmune Diseases, Systemic Lupus Erthematosus, Multi-Drug Resistant Nephrotic Syndrome, IgAN - IgA Nephropathy
- Trial name
- NCT06792799
- Testing
- anti-CD19/BCMA CAR NK cells (KN5601)
- Where
- China
- Volunteers
- 36 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Dyslipidaemia
Atorvastatin Therapy in the Treatment of Dyslipidemia in Children With Steroid Sensitive Nephrotic Syndrome
To evaluate the effectiveness and safety of Atorvastatin therapy in children with dyslipidemia in steroid sensitive nephrotic syndrome.
- Trial name
- NCT07497776
- Testing
- Atorvastatin
- Where
- Bangladesh
- Volunteers
- 100 people
- Sponsor
- National Institute of Kidney Disease and Urology (NIKDU)
Fluid Overload, Glomerulosclerosis, Focal Segmental
Interview Study of Adult and Child Patients and Parents of Children With Swelling Due to Nephrotic Syndrome.
Researchers from the University of Michigan and Northwestern University are studying people's experiences with swelling caused by Nephrotic Syndrome.
- Conditions
- Fluid Overload, Glomerulosclerosis, Focal Segmental, Edema, Membranous Nephropathy
- Trial name
- Prepare-NS (NCT05505500)
- Testing
- Interview
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Michigan
Steroid-Resistant Nephrotic Syndrome, Steroid-Dependent Nephrotic Syndrome
Study on the Efficacy and Safety of Fecal Microbiota Transplantation in the Treatment of Steroid - Dependent /Steroid-resistant Nephrotic Syndrome in Children
The objective of this clinical trial was to understand whether FMT is effective in treating steroid-dependent/steroid-resistant nephrotic syndrome in children. It will also learn about the safety of FMT.
- Trial name
- NCT07003438
- Testing
- Fecal microbiota transplantation (FMT)
- Volunteers
- 120 people
- Sponsor
- Zhang Ting
Nephrotic Syndrome, Hyperlipidemia
Pilot Study of Atorvastatin in Children With Chronic Hyperlipidemia Secondary to Nephrotic Syndrome
OBJECTIVES: I. Determine the effect of atorvastatin on the plasma levels of lipids, Lp(a), and apoproteins for treating hyperlipidemia in children with nephrotic syndrome in whom proteinuria and hyperlipidemia persist after other…
- Trial name
- NCT00004466
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Focal Segmental Glomerulosclerosis, Steroid Resistant Nephrotic Syndrome
Oral Galactose in Children With Steroid Resistant Nephrotic Syndrome
Focal Segmental Glomerulosclerosis (FSGS) is a devastating kidney disease which is difficult to treat and carries a poor prognosis, with 50% of affected children progressing to end stage renal disease (ESRD).
- Trial name
- NCT01113385
- Testing
- D-Galactose
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Children's National Research Institute
Nephrotic Syndrome in Children
Study of Adrenocorticotropic Hormone on Children With Frequent Relapse or Steroid-dependent Nephrotic Syndrome: a Prospective, Multicenter, Randomized，Open-label Clinical Trial.
Primary nephrotic syndrome accounts for approximately 90% of the total number of nephrotic syndrome in childhood and it is the most common glomerular disease in children.
- Trial name
- NCT06079788
- Testing
- Adrenocorticotrophic Hormone, Steroid
- Where
- 8 sites in China
- Volunteers
- 140 people
- Sponsor
- Mao Jianhua
Nephrotic Syndrome in Children
Study of Tacrolimus vs Mycophenolate Mofetil in Pediatric Patients With Nephrotic Syndrome
Primary nephrotic syndrome accounts for approximately 90% of the total number of nephrotic syndrome in childhood and it is the most common glomerular disease in children.
- Trial name
- STAMP (NCT04048161)
- Testing
- Tacrolimus, Mycophenolate Mofetil
- Where
- 12 sites in China
- Volunteers
- 270 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Steroid-Dependent Nephrotic Syndrome
Compare Efficacy and Safety of Repeated Courses of Rituximab to That of Maintenance Mycophenolate Mofetil Following Single Course of Rituximab Among Children With Steroid Dependent Nephrotic Syndrome
The aim of the RITURNS II study is to evaluate the efficacy and safety of Repeat courses of Rituximab to that of maintenance Mycophenolate Mofetil following single course of Rituximab in maintaining remission over 24 months among…
- Trial name
- RITURNS II (NCT03899103)
- Testing
- Rituximab, Mycophenolate Mofetil
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Nilratan Sircar Medical College
Nephrotic Syndrome
Cardiac Performance Evaluation in Children With Steroid Dependent vs Steroid Resistant Nephrotic Syndrome
nephrotic syndrome (NS) is one of the most common pediatric kidney diseases There is an increased incidence of heart disease in patients with primary nephrotic syndrome (PNS) compared to the normal population Conventional…
- Trial name
- NCT06622915
- Testing
- Tissue Doppler imaging and Conventional Echocardiography
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sohag University
Chronic Kidney Disease, Renal Transplantation
Efficacy of Usual Vitamin D Supplementation and Its Impact on Children and Adolescents Calciuria.
Vitamin D is not seen anymore only as a phosphocalcic and bone hormone, but also as having an effect on global health (anti-infective, anti-inflammatory, anti-tumour roles and cardiovascular protection).
- Conditions
- Chronic Kidney Disease, Renal Transplantation, Nephrotic Syndrome
- Trial name
- VITATOL (NCT02238418)
- Testing
- Cholecalciferol vial (100 000 UI)
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Hospices Civils de Lyon
Idiopathic Nephrotic Syndrome
A National Prospective Cohort of Patients With Idiopathic Nephrotic Syndrome Beginning in Childhood.
Pediatric idiopathic nephrotic syndrome (INS) is a rare disease for which the optimal therapeutic strategy has not yet been defined.
- Trial name
- PIN'SNP (NCT04207580)
- Testing
- Inclusion and follow up of pediatric patients with an idiopathic nephrotic syndrome,
- Where
- 48 sites in France, Reunion
- Volunteers
- 1,180 people
- Sponsor
- University Hospital, Limoges
Nephrotic Syndrome in Children
Efficacy and Safety of Broncho-Vaxom in the First Episode of Pediatric Idiopathic Nephrotic Syndrome
The main objective is to demonstrate, from the initial episode of nephrotic syndrome (NS) in children with standard prednisolone treatment, once complete remission has occurred, that the use of Broncho-Vaxom (administration for 6…
- Trial name
- NCT05044169
- Testing
- Broncho-Vaxom
- Volunteers
- 83 people
- Sponsor
- Fang Deng