Clinical trials: Nephrotic Syndrome in Children
Autoimmune Diseases, SLE - Systemic Lupus Erythematosus
RD06-05 Universal CD19/BCMA CAR-T for Refractory Pediatric Autoimmune Diseases
This is a single-arm, open-label, phase I clinical study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of RD06-05, a universal CD19/BCMA dual-targeting chimeric antigen receptor T-cell…
- Conditions
- Autoimmune Diseases, SLE - Systemic Lupus Erythematosus, SSc-Systemic Sclerosis, IIM- Idiopathic Inflammatory Myopathies
- Trial name
- NCT07674147
- Testing
- RD06-05 CART Cell Infusion
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Nephrotic Syndrome in Children
Efficacy and Safety of Broncho-Vaxom in the First Episode of Pediatric Idiopathic Nephrotic Syndrome
The main objective is to demonstrate, from the initial episode of nephrotic syndrome (NS) in children with standard prednisolone treatment, once complete remission has occurred, that the use of Broncho-Vaxom (administration for 6…
- Trial name
- NCT05044169
- Testing
- Broncho-Vaxom
- Volunteers
- 83 people
- Sponsor
- Fang Deng
Nephrotic Syndrome in Children
Steroid Sensitive Nephrotic Syndrome in Children
Idiopathic nephrotic syndrome (INS) is one of the most common glomerular pathologies in children and corticosteroid therapy is its most effective treatment.
- Trial name
- NCT03878914
- Testing
- Corticosteroids
- Where
- 2 sites in United States, China
- Volunteers
- 34 people
- Sponsor
- Wayne State University
First Manifestation of Steroid Sensitive Nephrotic Syndrome
Efficiency of Levamisole for Maintaining Remission After the First Flare of Steroid Sensitive Nephrotic Syndrome in Children
Idiopathic Nephrotic Syndrome is sensitive to steroid in 90% of children. However, most patients relapse and become steroid-dependant, with a long lasting relapsing course.
- Trial name
- NEPHROVIR3 (NCT02818738)
- Testing
- Levamisole Hydrochloride
- Where
- France
- Volunteers
- 86 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Nephrotic Syndrome in Children, Telitacicept
Study of the Telitacicept in Pediatric Patients With Frequently Relapsing or Steroid Dependent Nephrotic Syndrome
The main objective is to evaluate the effectiveness of telitacicept in pediatric patients with frequently relapsing or steroid dependent nephrotic syndrome within the 52-week follow-up.
- Trial name
- STERN (NCT06125405)
- Testing
- Telitacicept
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Idiopathic Nephrotic Syndrome
A National Prospective Cohort of Patients With Idiopathic Nephrotic Syndrome Beginning in Childhood.
Pediatric idiopathic nephrotic syndrome (INS) is a rare disease for which the optimal therapeutic strategy has not yet been defined.
- Trial name
- PIN'SNP (NCT04207580)
- Testing
- Inclusion and follow up of pediatric patients with an idiopathic nephrotic syndrome,
- Where
- 48 sites in France, Reunion
- Volunteers
- 1,180 people
- Sponsor
- University Hospital, Limoges
Nephrotic Syndrome Steroid-Dependent, Nephrotic Syndrome Steroid-Resistant
Biomarkers and Outcome Predictors of Pediatric Nephrotic Syndrome: A Genetic, Transcriptomic, and Secretome Multiomics Study
Idiopathic Nephrotic Syndrome is a rare disease of the kidneys, which typically affects children. For most affected children there is the need of a prolonged treatment with drugs reducing the activity of the immune system, also…
- Conditions
- Nephrotic Syndrome Steroid-Dependent, Nephrotic Syndrome Steroid-Resistant, Nephrotic Syndrome in Children, Glomerulonephritis
- Trial name
- PRECISE (NCT06792448)
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Nephrotic Syndrome
Ofatumumab in Children With Drug Resistant Idiopathic Nephrotic Syndrome
Double-blind, two-parallel-arm, placebo-controlled randomized clinical trial testing the superiority of Ofatumumab versus placebo in the treatment of children with DR-INS.
- Trial name
- NCT02394106
- Testing
- Ofatumumab
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Istituto Giannina Gaslini
Nephrotic Syndrome
Efficacy And Safety Of Azithromycin To Achieve Remissionin In Children With Steroid Sensitive Nephrotic Syndrome
To compare efficacy and safety of Azithromycin versus control in children with steroid sensitive nephrotic syndrome
- Trial name
- NCT07320612
- Testing
- Azithromycin and steroids, steroids
- Where
- Pakistan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Child Health Sciences and Children's Hospital, Lahore
Idiopathic Nephrotic Syndrome
Cyclophosphamide Versus Mycophenolate Mofetil for the Treatment of Steroid-dependent Nephrotic Syndrome in Children
Idiopathic nephrotic syndrome is steroid-sensitive in more than 90% of cases in children. However 60% of cases are steroid dependent and required treatment with immunosuppressive agent.
- Trial name
- NEPHROMYCY (NCT01092962)
- Testing
- Cyclophosphamide, Mycophenolate mofetil
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Nephrotic Syndrome in Children, Minimal Change Disease
A Pilot Trial of taVNS for SRNS in Children (kidNEY-VNS)
Children with steroid resistant nephrotic syndrome (SRNS) are exposed to prolonged courses of immunosuppressant medications. Given the adverse side effect profiles and variable efficacy of these medications, there is an urgent…
- Conditions
- Nephrotic Syndrome in Children, Minimal Change Disease, Focal Segmental Glomerulosclerosis
- Trial name
- kidNEY-VNS (NCT05583942)
- Testing
- trascutaneous auricular vagus nerve stimulation
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Northwell Health
Nephrotic Syndrome
Ofatumumab Versus Rituximab in Children With Steroid and Calcineurin Inhibitor Dependent Idiopathic Nephrotic Syndrome
Open-label, two-parallel-arm, controlled randomized clinical trial testing the superiority of Ofatumumab over Rituximab in maintaining steroid- and calcineurin-inhibitor-free disease remission in SD-INS.
- Trial name
- NCT02394119
- Testing
- Ofatumumab, Rituximab
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Istituto Giannina Gaslini
Nephrotic Syndrome
Mycophenolate Mofetil in Pediatric Steroid Dependent Nephrotic Syndrome
Idiopathic nephrotic syndrome is generally responsive to steroid therapy, but some patients need other immunosuppressants to reduce steroid dependency.
- Trial name
- NCT01895894
- Testing
- Mycophenolate mofetil
- Where
- South Korea
- Volunteers
- 34 people
- Sponsor
- Seoul National University Hospital
Idiopathic Nephrotic Syndrome (INS)
Comparison of Efficacy and Safety of Albumin Versus Fresh Frozen Plasma in Managing Diuretic Resistant Edema in Children With Idiopathic Nephrotic Syndrome.
Edema is a major component of nephrotic syndrome (NS), defined by Kidney Disease Improving Global Outcomes (KDIGO) guidelines is, urine protein/creatinine ratio ≥ 2 mg/mg, and hypoalbuminemia ≤ 2.5 g/dl).
- Trial name
- ALB-FFP (NCT07685093)
- Testing
- Human Albumin 20%, Fresh Frozen Plasma
- Volunteers
- 56 people
- Sponsor
- Qamar Shafiq
Steroid-Resistant Nephrotic Syndrome, Steroid-Dependent Nephrotic Syndrome
Study on the Efficacy and Safety of Fecal Microbiota Transplantation in the Treatment of Steroid - Dependent /Steroid-resistant Nephrotic Syndrome in Children
The objective of this clinical trial was to understand whether FMT is effective in treating steroid-dependent/steroid-resistant nephrotic syndrome in children. It will also learn about the safety of FMT.
- Trial name
- NCT07003438
- Testing
- Fecal microbiota transplantation (FMT)
- Volunteers
- 120 people
- Sponsor
- Zhang Ting
Nephrotic Syndrome, Minimal Change
Adjusted Steroids Therapy in Childerens With Idiopathic Nephrotic Syndrome
The initial steroids dose for Nephrotic Syndrome is 60mg/1m2 for 6-4 weeks and the duration of the first steroid course is between 8 weeks to 6 months.
- Trial name
- AJSNS (NCT02649413)
- Testing
- Prednisone
- Where
- Israel
- Volunteers
- 75 people
- Sponsor
- Rabin Medical Center
Frequently Relapsing Nephrotic Syndrome, Steroid-Dependent Nephrotic Syndrome
Randomized Trial Evaluating Mycophenolate Mofetil in Children With Nephrotic Syndrome After Rituximab Treatment
The aim of this study is to evaluate the efficacy and safety of maintenance Mycophenolate Mofetil following single course of Rituximab in maintaining remission over 12 months among Children with frequently-relapsing or…
- Trial name
- NCT04531865
- Testing
- Rituximab, Mycophenolate Mofetil
- Where
- 4 sites in China
- Sponsor
- Children's Hospital of Fudan University
Nephrotic Syndrome
Efficacy and Safety of Rituximab to That of Calcineurin Inhibitors in Children With Steroid Resistant Nephrotic Syndrome
The vast majority of children with idiopathic nephrotic syndrome respond well to corticosteroid treatment. However, as many as 20% experience a more complicated course with steroid resistance (SRNS).
- Trial name
- NCT02382575
- Testing
- Rituximab, Tacrolimus
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Nilratan Sircar Medical College
FRNS/SDNS, Ripertamab
Study of Ripertamab in Children With Frequent Relapses or Steroid-Dependent Nephrotic Syndrome
This is an open-label randomized controlled trial to evaluate the efficacy and safety of one dose versus two doses of ripertamab in children with frequent relapses or steroid-dependent nephrotic syndrome (FRNS/SDNS).
- Trial name
- NCT07388810
- Testing
- ripertamab
- Where
- China
- Volunteers
- 312 people
- Sponsor
- Mao Jianhua
Nephrotic Syndrome in Children
The Effect of Self-Efficacy Promoting Program Using Computer Game on Proteinuria in Thai Children With Nephrotic Syndrome
Nephrotic syndrome is a medical condition where the kidneys release substantial amounts of protein into the urine, resulting in various issues such as tissue swelling and an increased susceptibility to infections.
- Trial name
- NCT06524986
- Testing
- Self-efficacy promoting program using computer game, Standard nursing care
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Chulalongkorn University