Clinical trials: Nephrotic Syndrome in Children
Nephrotic Syndrome in Children, Telitacicept
Study of the Telitacicept in Pediatric Patients With Frequently Relapsing or Steroid Dependent Nephrotic Syndrome
The main objective is to evaluate the effectiveness of telitacicept in pediatric patients with frequently relapsing or steroid dependent nephrotic syndrome within the 52-week follow-up.
- Trial name
- STERN (NCT06125405)
- Testing
- Telitacicept
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Nephrotic Syndrome Steroid-Dependent, Interleukin 2
Treatment of Steroid Dependent Idiopathic Nephrotic Syndrome in Children With Low Doses of Interleukin 2: a Pilot Study
NIL-2 is a clinical trial designed to evaluate the efficacy and safety of low doses of Interleukin2 in the treatment of recently diagnosed, steroid dependent idiopathic nephrotic syndrome in children.
- Trial name
- NIL-2 pilote (NCT02997150)
- Testing
- IL-2 Low dose
- Sponsor
- University Hospital, Limoges
Nephrotic Syndrome in Children
Efficacy and Safety of Rituximab Versus Mycophenolate Mofetil in Children With Steroid-dependent Nephrotic Syndrome
The goal of this clinical trial is to evaluate the efficacy and safety of rituximab(RTX) and mycophenolate mofetile(MMF) in the treatment of children with low-dose steroid-dependent nephrotic syndrome(SDNS).
- Trial name
- NCT05843968
- Testing
- Rituximab, Mycophenolate Mofetil
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Children's Hospital of Chongqing Medical University
Nephrotic Syndrome in Children, Steroid-Dependent Nephrotic Syndrome
Reduce Immunosuppression With Atmp in NS ChildrEn
A phase II open-label, single arm study aimed to ascertain whether infusions of cord-blood mesenchymal stromal cells (CB-MSCs) allow to reduce or suspend the chronic immunosuppressive therapy (IS) in steroid-dependent nephrotic…
- Conditions
- Nephrotic Syndrome in Children, Steroid-Dependent Nephrotic Syndrome, Idiopathic Nephrotic Syndrome
- Trial name
- RACE (NCT04034316)
- Testing
- Cord-blood mesenchymal stromal cells
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Chronic Renal Disease and Nephrotic Syndrome
Electroencephalographic Changes in Nonconvulsive Children With Chronic Renal Disease
Chronic kidney disease (CKD) arises from many heterogeneous disease pathways that alter the function and structure of the kidney irreversibly, over months or years.
- Trial name
- NCT06185257
- Testing
- EEG
- Volunteers
- 80 people
- Sponsor
- Assiut University
Frequently Relapsing Nephrotic Syndrome, Steroid-Dependent Nephrotic Syndrome
Randomized Trial Evaluating Mycophenolate Mofetil in Children With Nephrotic Syndrome After Rituximab Treatment
The aim of this study is to evaluate the efficacy and safety of maintenance Mycophenolate Mofetil following single course of Rituximab in maintaining remission over 12 months among Children with frequently-relapsing or…
- Trial name
- NCT04531865
- Testing
- Rituximab, Mycophenolate Mofetil
- Where
- 4 sites in China
- Sponsor
- Children's Hospital of Fudan University
Nephrotic Syndrome
Angiotensin Converting Enzyme Gene Polymorphism in Children With Idiopathic Nephrotic Syndrome
Aims This study was conducted to examine the association between the ACE insertion/deletion (I/D) genotype distribution in children with idiopathic nephrotic syndrome and the response to steroid therapy.
- Trial name
- NCT00172276
- Sponsor
- National Taiwan University Hospital
Nephrotic Syndrome
Mycophenolate Mofetil in Pediatric Steroid Dependent Nephrotic Syndrome
Idiopathic nephrotic syndrome is generally responsive to steroid therapy, but some patients need other immunosuppressants to reduce steroid dependency.
- Trial name
- NCT01895894
- Testing
- Mycophenolate mofetil
- Where
- South Korea
- Volunteers
- 34 people
- Sponsor
- Seoul National University Hospital
Nephrotic Syndrome in Children
Rituximab and Targeted Nursing for Pediatric Nephrotic Syndrome
This study investigated the combined impact of rituximab and targeted nursing care versus tacrolimus and targeted nursing care on efficacy, quality of life, adverse reactions, and recurrence rate in children with challenging…
- Trial name
- NCT07049172
- Testing
- Rituximab, Targeted Nursing Care, Baseline Glucocorticoid Therapy
- Where
- China
- Volunteers
- 91 people
- Sponsor
- Wuhan Children's Hospital
Nephrotic Syndrome
Ofatumumab Versus Rituximab in Children With Steroid and Calcineurin Inhibitor Dependent Idiopathic Nephrotic Syndrome
Open-label, two-parallel-arm, controlled randomized clinical trial testing the superiority of Ofatumumab over Rituximab in maintaining steroid- and calcineurin-inhibitor-free disease remission in SD-INS.
- Trial name
- NCT02394119
- Testing
- Ofatumumab, Rituximab
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Istituto Giannina Gaslini
Lymphocyte Disorder, Nephrotic Syndrome
Characteristics of Peripheral Blood Lymphocyte Subsets in Children With PNS
The etiology and precipitating factors of PNS remain unclear. Dysfunction of immunologic function is a classic theory of the pathogenesis of PNS.
- Trial name
- NCT05392244
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Nephrotic Syndrome Steroid-Dependent, Nephrotic Syndrome Steroid-Resistant
Biomarkers and Outcome Predictors of Pediatric Nephrotic Syndrome: A Genetic, Transcriptomic, and Secretome Multiomics Study
Idiopathic Nephrotic Syndrome is a rare disease of the kidneys, which typically affects children. For most affected children there is the need of a prolonged treatment with drugs reducing the activity of the immune system, also…
- Conditions
- Nephrotic Syndrome Steroid-Dependent, Nephrotic Syndrome Steroid-Resistant, Nephrotic Syndrome in Children, Glomerulonephritis
- Trial name
- PRECISE (NCT06792448)
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico