Clinical trials: Nerve; Disorder, Sympathetic
Familial Dysautonomia
Dexmedetomidine Sublingual Film for the Ambulatory Treatment of Hyperadrenergic Autonomic Crisis in Patients With Familial Dysautonomia
The purpose of this placebo controlled interventional study is to collect preliminary data on administering dexmedetomidine in patients with Familial Dysautonomia (FD) during a rapid cessation of autonomic crisis.
- Trial name
- NCT06148311
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- NYU Langone Health
Diabetes Mellitus, Type 2, Metabolic Associated Fatty Liver Disease
Correlation Between Serum Nociceptin and Sympathetic Nerve Activity in Diabetic Patients With MAFLD
This observational study aims to investigate the relationship between serum nociceptin levels and sympathetic nervous system activity in patients with both type 2 diabetes mellitus (T2DM) and metabolic associated fatty liver…
- Trial name
- NCT07663682
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Second Hospital of Shanxi Medical University
Chronic Pain, Complex Regional Pain Syndromes
The Success of Lumbar Sympathetic Ganglion Block Using Lower Extremity Perfusion Index
The patient, who is experiencing chronic pain in the lower extremities persisting for more than three months, is scheduled to undergo lumbar sympathetic ganglion block.
- Conditions
- Chronic Pain, Complex Regional Pain Syndromes, Peripheral Neuropathy, Post Herpetic Neuralgia
- Trial name
- NCT06241820
- Testing
- Lumbar Sympathetic Ganglion Block
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Jeongsoo Kim
Complex Regional Pain Syndromes, Complex Regional Pain Syndrome Type I of the Upper Limb
Embodied Virtual Reality for Chronic Pain
Virtual reality creates interactive, multimodal sensory stimuli that have demonstrated considerable success in reducing pain. Much research so far has focused on VR's ability to shift patients' attention away from pain; however…
- Conditions
- Complex Regional Pain Syndromes, Complex Regional Pain Syndrome Type I of the Upper Limb, Complex Regional Pain Syndrome I (CRPS I), Complex Regional Pain Syndrome I of Upper Limb
- Trial name
- NCT05160038
- Testing
- Embodied virtual reality
- Where
- Switzerland
- Volunteers
- 29 people
- Sponsor
- University of Zurich
Heart Failure
Renal Sympathetic Modification in Patients With Heart Failure
The purpose of this study is to observe the incident of composite cardiovascular events after renal sympathetic modification using THERMOCOOL® catheter in patients with heart failure, and evaluate safety and efficacy of the…
- Trial name
- NCT01402726
- Testing
- renal sympathetic modification
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Chronic Insomnia
Impact of Suvorexant on Sympathetic Nerve Activity and Baroreflex Function in Chronic Insomnia
This study aims to evaluate the effect of Suvorexant on sympathetic nerve activity and baroreflex function in subject with chronic insomnia.
- Trial name
- NCT03768713
- Testing
- Suvorexant
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Montana State University
Dysautonomia, Familial, Baroreflex Failure Syndrome
Carbidopa for the Treatment of Excessive Blood Pressure Variability
The overall study objectives are to determine whether carbidopa (Lodosyn®) is safe and well tolerated and to assess whether it can inhibit catecholamine-induced paroxysmal hypertension and normalize or reduce the exaggerated…
- Trial name
- CarbiFD (NCT02553265)
- Testing
- Carbidopa Low-Dose, Carbidopa High-Dose
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- NYU Langone Health
Complex Regional Pain Syndrome, Postherpetic Neuralgia
Comparison of the Efficacy of the Ultrasound With Fluoroscopy in Guidance of Lumbar Sympathetic Block
This study compares the efficacy of the ultrasound with fluoroscope in guidance of lumbar sympathetic block (LSB). The goals of the study are; 1) To show that US-guided LSB results in shorter performance time compared to…
- Conditions
- Complex Regional Pain Syndrome, Postherpetic Neuralgia, Diabetic Polyneuropathy, Peripheral Neuropathy
- Trial name
- NCT02737527
- Testing
- 24G intravenous route for Lumbar Sympathetic Block (LSB):, 15-cm Chiba needle for Lumbar Sympathetic Block (LSB), Ultrasound for Lumbar Sympathetic Block (LSB)
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University
Hypertension, Vascular Stiffness
Transcutaneous Electrical Nerve Stimulation (TENS) on Arterial Stiffness and Blood Pressure
Uncontrolled blood pressure represents the main factor in the development of target organ lesions and, consequently, cardiovascular events, which are the leading cause of morbidity and mortality worldwide.
- Conditions
- Hypertension, Vascular Stiffness, Autonomic Nervous System Diseases
- Trial name
- TENS (NCT02365974)
- Testing
- Transcutaneous Electrical Stimulation, No Transcutaneous Electrical Stimulation
- Volunteers
- 64 people
- Sponsor
- Hospital de Base
Autonomic Nervous System Disease, Healthy
Blood Sampling for Neurochemical and Genetic Testing
This study involves sampling blood from both normal volunteers and patients with diseases known or suspected to involve body chemicals called catecholamines.
- Conditions
- Autonomic Nervous System Disease, Healthy, Hypertension, Pheochromocytoma
- Trial name
- NCT00001147
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Hypercapnia
End Tidal CO2 and Masks: Is There a Correlation?
In light of the ongoing COVID-19 pandemic, wearing a mask has become a universal standard as an attempt to reduce the spread of COVID-19. As of 2020, more than half of all U.S.
- Trial name
- NCT06437301
- Testing
- Baseline measure of ETCO2 without mask, Baseline ETCO2 with mask, ETCO2 after 200 meter walk with mask
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- CHRISTUS Health
Vasoconstriction, Vasodilation
Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences
The main purpose of this interventional study is to examine differences in resting blood pressure control between healthy males and females. The main questions it aims to answer are: 1.
- Trial name
- STARS (NCT05997732)
- Testing
- Phenylephrine Hydrochloride, Isoproterenol Hydrochloride, Norepinephrine Bitartrate
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Metabolic Syndrome
Renal Sympathetic Modification in Patients With Metabolic Syndrome
The purpose of this study is to observe the incident of composite cardiovascular events after renal sympathetic modification using THERMOCOOL® catheter in patients with metabolic syndrome, and evaluate safety and efficacy of the…
- Trial name
- NCT01417247
- Testing
- renal sympathetic modification
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
PTSD
Efficacy of Cervical Sympathetic Blocks for PTSD
Millions of people suffer from anxiety disorders, including posttraumatic stress disorder (PTSD)-a condition that can profoundly disrupt daily life.
- Trial name
- NCT07087015
- Testing
- Cervical sympathetic nerve block, Ropivacaine, Normal Saline
- Volunteers
- 20 people
- Sponsor
- Stanford University
Heart Failure
Effects of Exercise Training on Mechanoreflex and Metaboreflex Control in Heart Failure Patients
The investigators hypothesize that exercise training would improve the mechanoreflex and metaboreflex control in heart failure patients.
- Trial name
- NCT01884142
- Testing
- Aerobic Exercise Training
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- University of Sao Paulo General Hospital
Diastolic Heart Failure, Hypertension
Denervation of the renAl sympathetIc nerveS in hearT Failure With nOrmal Lv Ejection Fraction
Increasing evidence suggests an important role of activation of the sympathetic nervous system (SNS) in the clinical phenomena of heart failure with normal left ventricular ejection fraction and hypertension.
- Trial name
- DIASTOLE (NCT01583881)
- Testing
- renal denervation
- Where
- 2 sites in Netherlands
- Volunteers
- 60 people
- Sponsor
- UMC Utrecht
Neuropathic Pain, Reflex Sympathetic Dystrophy
Effects of Vaporized Marijuana on Neuropathic Pain
This study theorized that a low dose of vaporized cannabis could alleviate nerve injury pain.
- Conditions
- Neuropathic Pain, Reflex Sympathetic Dystrophy, Peripheral Neuropathy, Post-herpetic Neuralgia
- Trial name
- NCT01037088
- Testing
- Mild dose cannabis, Low dose cannabis, Cannabis
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of California, Davis
Sudden Death, Ventricular Tachycardia
Skin Sympathetic Nerve Activity and Cardiac Arrhythmia
Sympathetic tone is important in cardiac arrhythmogenesis. The simultaneous recording of sympathetic nerve activity (SNA) and electrocardiogram (ECG) was obtained by invasive method.
- Conditions
- Sudden Death, Ventricular Tachycardia, Persistent Atrial Fibrillation
- Trial name
- SKNA (NCT04918303)
- Testing
- SKNA recording
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Bordeaux
Ventricular Tachycardia (VT)
Sympathetic Ablation for Ventricular Arrhythmias
Enrolled patients will undergo an acute procedure in which a catheter is inserted near the heart to ablate a sympathetic nerve, reducing signals that trigger ventricular arrhythmias.
- Trial name
- NCT07501819
- Testing
- Central sympathetic nerve ablation
- Volunteers
- 10 people
- Sponsor
- SymKardia
Heart Failure
Prognostic Value of Sympathetic Modulation in Patients With Heart Failure
The purpose of this study is to determine whether oscillatory pattern of sympathetic nerve activity muscle is an efficient index for the prognosis of patients with heart failure.
- Trial name
- NCT02047409
- Where
- Brazil
- Volunteers
- 160 people
- Sponsor
- University of Sao Paulo General Hospital