Clinical trials: Nerve; Disorder, Sympathetic
Hepatocellular Carcinoma
Intravascular Radiofrequency Ablation of Sympathetic Nerves for the Treatment of Hepatocellular Carcinoma
Patients who met the inclusion criteria were treated with endovascular radiofrequency ablation and desympathetic nerve surgery. After enrollment, endovascular radiofrequency ablation and desympathetic surgery were performed.
- Trial name
- NCT06694636
- Testing
- endovascular radiofrequency ablation and desympathetic nerve surgery
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Zhongda Hospital
Alcohol Drinking, Binge Drinking
Reducing Blood Pressure in Mid-life Adult Binge Drinkers
This study has two phases: Phase 1 is to examine blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers vs. alcohol abstainers/moderate drinkers.
- Conditions
- Alcohol Drinking, Binge Drinking, Blood Pressure, Alcohol Abstinence
- Trial name
- NCT05522075
- Testing
- Exercise Training, Alcohol Abstinence Intervention
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Cardiovascular Diseases
Transcutaneous Electrical Nerve Stimulation on Nervous System in Patients With Hypertension.
Hypertension has high prevalence and poor control rates and is considered one of the major modifiable risk factors for cardiovascular system diseases, and one of the most important public health problems.
- Trial name
- NCT02292199
- Testing
- TENS High Frequency, TENS Low Frequency
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Radionuclide Imaging (MIBG Scintigraphy), Exercise Test
The Effects of Continuous Positive Airway Pressure (CPAP) on Sympathetic Activity in Different Sites of Activation
Recent evidences suggest that obstructive sleep apnea (OSA) can contribute to cardiovascular disease even in the absence of hypertension.
- Conditions
- Radionuclide Imaging (MIBG Scintigraphy), Exercise Test, Blood Pressure Monitoring, Ambulatory, Sympathetic Nerve Activity
- Trial name
- NCT01336335
- Testing
- CPAP
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo
Whiplash Associated Disorder (WAD)
Transauricular Vagus Nerve Stimulation for Chronic Whiplash Associated Disorders
Approximately 50% of people with chronic whiplash-associated disorders (WAD) continue to report the presence of symptoms 12 months post-injury.
- Trial name
- NCT07055373
- Testing
- Transauricular Vagal Nerve Stimulation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Calgary
Cancer, Malignant Tumors, Abdominal Cancer
Neurolytic Block Techniques In Abdominal Visceral Cancer Pain
The neurolytic blocks of sympathetic chains are commonly used for the treatment of cancer-related pain. This study aims to compare celiac plexus neurolysis and splanchnic nerve neurolysis for the treatment of abdominal visceral…
- Conditions
- Cancer, Malignant Tumors, Abdominal Cancer, Cancer Pain, Visceral Pain
- Trial name
- CONCERN (NCT06978673)
- Testing
- Splanchnic nerve neurolysis - 5 ml of absolute alcohol (100%), Celiac Plexus Neurolysis - 5 ml of absolute alcohol (100%)
- Where
- Brazil
- Volunteers
- 64 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Atrial Fibrillation
Renal Nerve Denervation After Pulmonary Vein Isolation for Persistent Atrial Fibrillation
Atrial fibrillation (AF) is the most common arrhythmia and it is associated with significant morbidity and mortality. Electrical isolation of the pulmonary vein (PVI) by radiofrequency energy or cryoablation has been shown to be…
- Trial name
- NCT03246568
- Testing
- Renal Nerve Denervation, Pulmonary vein isolation
- Where
- Hong Kong
- Volunteers
- 3 people
- Sponsor
- Chinese University of Hong Kong
Diabetes Mellitus
Sympathetic Nerve Activity During Hypoglycemia and Exercise
The purpose of this study is to determine if either hypoglycemia or exercise cause differential responses in muscle and skin sympathetic nerve activity.
- Trial name
- NCT00608348
- Testing
- Hyperinsulinemic glucose clamp procedures, moderate exercise
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Cardiovascular Disease
Cardiometabolic Benefits of Omega-3 Polyunsaturated Fatty Acids
Omega 3 fatty acids have been shown to provide a number of cardiometabolic benefits in both healthy and at risk populations. Specifically, the daily consumption of fish oil supplements has been reported to reduce blood…
- Trial name
- TGIF (NCT03378232)
- Testing
- High EPA Supplement, High DHA Supplement
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Hypertension, Heart Failure
Intravascular Ultrasound Evaluation of Renal Nerves in Different Diseases
Sympathetic hyperactivity is a causal or a promoting factor in many diseases, under these conditions, some morphology changes due to the hyperactivity occur.
- Trial name
- NCT02243514
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Hypotension, Orthostatic, Hypertension
Effects of Melatonin to Reduce Nocturnal Hypertension in Patients With Neurogenic Orthostatic Hypotension
Neurogenic Orthostatic Hypotension (NOH) is clinically defined as a consistent drop in systolic blood pressure (SBP) ≥30mmHg upon standing from a seated or lying position.
- Conditions
- Hypotension, Orthostatic, Hypertension, Autonomic Nervous System Diseases
- Trial name
- NCT02963181
- Testing
- Yohimbine, Melatonin
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Arrhythmias, Cardiac
Renal Nerve Stimulation and Renal Denervation in Patients With Sympathetic Ventricular Arrhythmias
Rationale: Sympathetic activity plays an important role in the pathogenesis of ventricular tachyarrhythmia. Previous studies have shown evidence of significant heritable influences on individual responses to adrenergic…
- Trial name
- Redress VT (NCT02856373)
- Testing
- RNS and RDN
- Where
- Netherlands
- Volunteers
- 9 people
- Sponsor
- Diagram B.V.
Heart Failure
Clinical Assessment of the Treatment With Cardiac Sympathetic Blockade on Chronic Heart Failure
The purpose of this study is to evaluate the effect of Cardiac Sympathetic Blockade on Mortality, re-hospitalization rate, symptoms, quality of life, exercise tolerance, cardiac structure, systolic function, electrical activities…
- Trial name
- CSB-CHF (NCT02391142)
- Testing
- Lidocaine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Colon Cancer, Adjuvant Chemotherapy
Impact of Adjuvant Chemotherapy in Patients With Colon Cancer
The present study aims to investigate the impact of adjuvant chemotherapy with 5-FU isolated and associated with oxaliplatin in cardiac autonomic control and endothelium-dependent vascular function in patients undergoing…
- Trial name
- NCT03213444
- Testing
- adjuvant chemotherapy with 5-FU isolated, adjuvant chemotherapy with 5-FU associated with oxaliplatin
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo General Hospital
Nerve; Disorder, Sympathetic, Healthy
Skin Sympathetic Nerve Activity and Sympathetic Tone
There are many sympathetic hyperactivity diseases in the investigators' clinical practice. However, the conventional method to measure the sympathetic nerve activity had many limitations such as clinical application, data…
- Trial name
- NCT03243448
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Cardiotoxicity, Cardiovascular Disease
Effect of Anthracyclines and Cyclophosphamide on Cardiovascular Responses
The present study aims to investigate the chronic effect of treatment with doxorubicin and cyclophosphamide on neurovascular control and blood pressure in women undergoing adjuvant treatment for breast cancer.
- Conditions
- Cardiotoxicity, Cardiovascular Disease, Neurovascular Disorder, Endothelial Disfunction
- Trial name
- NCT04568161
- Testing
- Physical Characteristics, Muscular Sympathetic Nervous Activity, Cardiac Function
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- University of Sao Paulo General Hospital
Metabolic Syndrome
Renal Sympathetic Denervation in Metabolic Syndrome (Metabolic Syndrome Study)
The purpose of this clinical investigation is to determine the effects of renal sympathetic denervation on insulin resistance and muscle sympathetic nerve activity in patients with metabolic syndrome.
- Trial name
- NCT01911078
- Testing
- Renal Denervation, EnligHTN™ Renal Denervation System.
- Where
- Greece
- Volunteers
- 20 people
- Sponsor
- Abbott Medical Devices
Hypoglycemia
Hypoglycemia and Autonomic Nervous System Function
The goals of this proposal are to determine the effects of hypoglycemia on the autonomic nervous system.
- Trial name
- HypoANS (NCT01816893)
- Testing
- Hypoglycemic hyperinsulinemic clamp, Euglycemic hyperinsulinemic clamp
- Where
- 2 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Heart Failure
Effects of Low-frequency Electrical Stimulation in Patients With Advanced HF
The purpose of this study is to verify the effects of low frequency functional electrical stimulation in heart failure patients hospitalized for treatment of the syndrome.
- Trial name
- NCT01886430
- Testing
- Functional electrical stimulation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo General Hospital
COPD
Static Lung Hyperinflation and Sympathetic Nerve Activity-Associated Large Artery Stiffness in COPD Patients
The goal of this study is to evaluate the acute effects of a long-acting bronchodilator on pulmonary function, vascular function and muscle sympathetic nerve activity in individuals with COPD.
- Trial name
- NCT03611699
- Testing
- Umeclidinium / Vilanterol Dry Powder Inhaler
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Gary L. Pierce