Clinical trials: Nerve Condition
Pain, Postoperative
Erector Spinae Plane Block for Post-thoracotomy Pain
Post-thoracotomy pain is one of the most severe forms of post-operative pain. Among the most common techniques for the management of post-thoracotomy pain, there are the intercostal nerve block, and a recently described block…
- Trial name
- NCT04013815
- Testing
- erector spinae plane block with ropivacaine, Intercostal nerve block with ropivacaine
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Strabismus, Regional Anesthesia Morbidity
Peribulbar Rocuronium in Adult Strabismus Surgery
This is a prospective randomized clinical study that will be carried on adult patients aged from 21-60 years and presented for strabismus surgery under peribulbar anesthesia.
- Conditions
- Strabismus, Regional Anesthesia Morbidity, Rocuronium
- Trial name
- NCT04821817
- Testing
- Normal saline, Rocuronium
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Tanta University
Sympathetic Nervous System Diseases, Sympathetic Nervous Structure Injury
Hydroxyephedrine PET/CT in Sympathetic Nervous System Disease
To evaluate the potential usefulness of 11C/18F-HED positron emission tomography/ computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various Tau-related disease patients.
- Conditions
- Sympathetic Nervous System Diseases, Sympathetic Nervous Structure Injury, Sympathetic Nerve Injury
- Trial name
- NCT06951984
- Testing
- 11C/18F-HED
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University
Sarcopenia, Nerve Block
Regional Nerve Block for Upper Extremity Surgery in Patients With Sarcopenia
The goal of this observational study is to learn about the impact of sarcopenia (muscle loss) on the efficacy of regional nerve blocks and postoperative recovery in patients undergoing upper extremity surgery.
- Trial name
- NCT07757984
- Testing
- sarcopenia, Non-sarcopenia, General Anesthesia
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Chang Gung Memorial Hospital
Anterior Cruciate Ligament Injury, Postoperative Pain
Popliteal Plexus Block for Postoperative Pain After ACL Reconstruction
The study aims to investigate the effect of the popliteal plexus block (PPB) on postoperative pain in patients undergoing anterior cruciate ligament (ACL) reconstruction.
- Trial name
- NCT03130049
- Testing
- Popliteal plexus block
- Where
- 2 sites in Denmark
- Volunteers
- 15 people
- Sponsor
- University of Aarhus
Osteoarthritis, Knee, Pain
Diagnostic Genicular Nerve Block Prior to Radiofrequency Ablation for Knee Osteoarthritis Pain
Chronic painful knee OA is a major cause of disability in older adults. In patients whose symptoms are refractory to conservative management but who do not wish to undergo TKA or, alternatively, are not operative candidates…
- Conditions
- Osteoarthritis, Knee, Pain, Nerve; Lesion
- Trial name
- NCT02578108
- Testing
- genicular nerve diagnostic block with lidocaine (local anesthetic), genicular nerve radiofrequency ablation
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Northwestern University
Pain
TENS Efficacy in Pain Relief During Hysteroscopy
Pain Relief During Unsedated Office Hysteroscopy by Applying Transcutaneous Electrical Nerve Stimulation : Randomized controlled trial
- Trial name
- NCT04229576
- Testing
- TENs
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Glioblastoma (GBM)
Ketogenic Diet With Radiation and Chemotherapy for Newly Diagnosed Glioblastoma
This study aims to see if reducing blood sugar and increasing ketones (a metabolic product that comes from using fats for energy) can increase survival and enhance the the effects of standard radiation and chemotherapy treatments…
- Trial name
- NCT02046187
- Testing
- Ketogenic Diet, Radiation therapy, Temozolomide
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Chronic Stroke Patients
Effect of Transcutaneous Auricular Stimulation of the Vagus Nerve on Functional Connectivity in the Brain at Rest
The goal of this clinical trial is to study the effect of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on resting-state brain functional connectivity.
- Trial name
- COVAGNIRS (NCT07282106)
- Testing
- Active taVNS arm
- Where
- France
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Clinique Les Trois Soleils
Normal Tension Glaucoma
Effect of Netarsudil vs Brimonidine in NTG Patients on Latanoprost
A randomized, multicenter, investigator-masked prospective study of NTG patients currently on latanoprost 0.005% monotherapy, to study the effect of IOP change with the introduction of netarsudil 0.02% vs brimonidine 0.1%.
- Trial name
- NCT06449352
- Testing
- Netarsudil, Brimonidine
- Where
- 4 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Westlake Eye Specialists
Malignant Melanoma With Metastasis, Malignant Melanoma
Phase 2b of RAPA-201 Cell Therapy in Post-PD-(L)-1 Melanoma
The protocol is a Simon's 2-stage, non-randomized, open label, multi-site, phase 2 trial for patients with advanced metastatic, recurrent and unresectable malignant melanoma that has recurred or relapsed after prior anti-PD-(L)1…
- Conditions
- Malignant Melanoma With Metastasis, Malignant Melanoma, Malignant Melanoma Stage IIIc, Malignant Melanoma Stage IV
- Trial name
- NCT06708455
- Testing
- RAPA-201 Rapamycin Resistant T Cells, Chemotherapy Prior to RAPA-201 Therapy
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Rapa Therapeutics LLC
Postoperative Vocal Cord Mobility, Recurrent Laryngeal Nerve Injury
C-MAC D-Blade vs Macintosh for Postoperative Vocal Cord Evaluation
This study compares two different laryngoscopes-the C-MAC D-Blade videolaryngoscope and the Macintosh direct laryngoscope-for evaluating vocal cord mobility after thyroidectomy.
- Trial name
- NCT07277985
- Testing
- Videolaryngoscope (C-MAC D-Blade), Direct Laryngoscope (Macintosh)
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Inonu University
Brachial Plexus Injury, Nerve Compression
Brachial Plexus Injury After Prone Positioning
The goal of this prospective observational study is to estimate the prevalence of brachial plexus injury after prone positioning in patients with ARDS and to evaluate the safety of swimmer position.
- Trial name
- BPX (NCT05693038)
- Testing
- Electromyography, Muscle strength measurement
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Melanoma (Skin)
Vaccine Therapy With or Without Interleukin-2 in Treating Patients With Metastatic Melanoma That Has Not Responded to Previous Treatment
RATIONALE: Vaccines may make the body build an immune response to kill tumor cells. Interleukin-2 may stimulate a person's white blood cells to kill tumor cells.
- Trial name
- NCT00022438
- Testing
- aldesleukin, incomplete Freund's adjuvant, recombinant tyrosinase-related protein-2
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Esophagus Cancer, Hepatoma
Autologous CAR-T/TCR-T Cell Immunotherapy for Solid Malignancies
This is a single arm, open-label, uni-center, phase I-II study to evaluate the safety and effectiveness of CAR-T/TCR-T cell immunotherapy in treating with different malignancies patients.
- Conditions
- Esophagus Cancer, Hepatoma, Glioma, Gastric Cancer
- Trial name
- NCT03941626
- Testing
- CAR-T/TCR-T cells immunotherapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shenzhen BinDeBio Ltd.
Optic Glioma, Pediatric Brain Tumor, Optic Nerve Glioma
Modified CV Regimen in Optic Pathway Glioma
Optic pathway glioma (OPG) can result in visual deterioration. Symptomatic patients often report deficits in visual acuity (VA), visual field, visual-evoked potentials (VEPs), strabismus, proptosis, disc swelling, and other…
- Trial name
- NCT05278715
- Testing
- Carboplatin, Vincristine, Recombinant human endostatin
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Beijing Sanbo Brain Hospital
Central Nervous System Inflammation, MOG-IgG Associated Disease
Azathioprine in MOGAD
MOG-IgG associated disease (MOGAD) is a rare inflammatory disease of the central nervous system recently described. Initially reported as monophasic, data from incident cohorts suggests that around 50% of adult patients with…
- Trial name
- MOGwAI (NCT05349006)
- Testing
- Azathioprine
- Where
- 17 sites in France
- Volunteers
- 126 people
- Sponsor
- Hospices Civils de Lyon
Rectal Cancer, Low Anterior Resection Syndrome
Percutaneous Tibial Nerve Stimulation in the Treatment of Anterior Resection Syndrome After Rectal Cancer Surgery
The study aims to evaluate the efficacy of percutaneous tibial nerve stimulation (PTNS) associated with conservative therapy (arm A) for the treatment of low anterior resection syndrome (LARS) compared with only conservative…
- Trial name
- NCT02177084
- Testing
- PTNS
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Solid Tumor, Colorectal Cancer
A Study of TRK-950 in Combinations With Anti-Cancer Treatment Regimens in Patients With Advanced Solid Tumors
The main purpose of this study is to establish the safety and the recommended dose of TRK-950 in combination with FOLFIRI, Gemcitabine / Cisplatin, Gemcitabine / Carboplatin, Ramucirumab / Paclitaxel, PD1 inhibitors (Nivolumab or…
- Conditions
- Solid Tumor, Colorectal Cancer, Cholangiocarcinoma, Bladder Cancer
- Trial name
- NCT03872947
- Testing
- TRK-950, Irinotecan, Leucovorin
- Where
- 14 sites in United States, France
- Volunteers
- 138 people
- Sponsor
- Toray Industries, Inc
Parkinson's Disease (PD), Parkinsonism
Identifying Biomarkers of Parkinson's Disease Using Magnetic Resonance Imaging (MRI)
This study is designed to determine if magnetic resonance imaging (MRI) measures can be used to diagnose and monitor the progression of Parkinson's disease (PD) while distinguishing between PD and parkinsonisms [conditions that…
- Conditions
- Parkinson's Disease (PD), Parkinsonism, Progressive Supranuclear Palsy (PSP), Multiple System Atrophy (MSA)
- Trial name
- NCT01888185
- Where
- United States
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
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