Clinical trials: Nerve Condition
Obstructive Sleep Apnea, Sleep Apnea
Hypoglossal Nerve Stimulation Therapy in Patients With Obstructive Sleep Apnea: Belgian Registry
Hypoglossal nerve stimulation (HNS) therapy (Inspire system) is intended for the treatment of patients with moderate to severe obstructive sleep apnea (OSA) who cannot be effectively treated with the first-line treatment options.
- Conditions
- Obstructive Sleep Apnea, Sleep Apnea, Apnea
- Trial name
- B-HNS (NCT06332404)
- Testing
- Hypoglossal nerve stimulation Inspire system (Inspire Medical Systems Inc., USA)
- Where
- 2 sites in Belgium
- Volunteers
- 225 people
- Sponsor
- University Hospital, Antwerp
Glioblastoma
Feasibility Study of Modified Atkins Ketogenic Diet in the Treatment of Newly Diagnosed Malignant Glioma
The purpose of this research study is to see if people can produce ketones in their blood with the modified Atkins diet. Modified Atkins diet is a diet that produces ketones in your blood by restricting carbohydrates to <20 grams…
- Trial name
- NCT03278249
- Testing
- Modified Atkins Ketogenic Diet
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Cincinnati
Ependymoma, Brainstem Glioma
A Pilot Study Evaluating 18F-L-Thymidine (FLT) PET Imaging in Children With Gliomas
Background: Children with brain tumors often have magnetic resonance imaging (MRI) scans to see if the tumor has responded to therapy or to see if the tumor has grown.
- Conditions
- Ependymoma, Brainstem Glioma, Astrocytoma, Glioblastoma Multiforme
- Trial name
- NCT01117155
- Sponsor
- National Cancer Institute (NCI)
Diabetic Polyneuropathy
Surgical Decompression for Diabetic Neuropathy in the Foot
The purpose of the study is to determine whether or not surgical decompression of the common peroneal, tibial, and deep peroneal nerves in the legs of persons with diabetic peripheral neuropathy is effective treatment.
- Trial name
- NCT01006915
- Testing
- Surgery
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Timothy J. Best Medicine Professional Corporation
Bell Palsy
Screening for Prognostic Biomarkers of Severe Bell's Palsy in Adults
Bell's palsy (idiopathic peripheral facial palsy) is the most common cause of facial palsy, which is related to the inflammation of the facial nerve, possibly induced by herpesvirus reactivation.
- Trial name
- BIOFIPS (NCT05582915)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 130 people
- Sponsor
- University Hospital, Montpellier
Erectile Dysfunction, Electric Stimulation
Treatment With Peripheral Nerve Stimulation of the Pudendal Nerve in Patients With Erectile Dysfunction
Erectile dysfunction is known as any alteration that produces a modification in the erectile response, whether of organic, psychogenic or relational cause.
- Conditions
- Erectile Dysfunction, Electric Stimulation, Pudendal Nerve
- Trial name
- NEEP (NCT06397625)
- Testing
- Percutaneous electrical neurostimulation
- Where
- Spain
- Volunteers
- 72 people
- Sponsor
- Camilo Jose Cela University
Progressive Supranuclear Palsy
Rehabilitation in Patients With Progressive Supranuclear Palsy
The investigators evaluate whether an aerobic, intensive, goal based and multidisciplinary rehabilitation treatment, previously conceived for Parkinson's disease, is effective for patients with progressive supranuclear palsy and…
- Trial name
- PSP-MIRTLoko (NCT02109393)
- Testing
- MIRT, MIRT+Lokomat
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Brain Cancer, Brain Neoplasm
Combination Adenovirus + Pembrolizumab to Trigger Immune Virus Effects
Glioblastoma (GBM) and gliosarcoma (GS) are the most common and aggressive forms of malignant brain tumor in adults and can be resistant to conventional therapies.
- Conditions
- Brain Cancer, Brain Neoplasm, Glioma, Glioblastoma
- Trial name
- CAPTIVE (NCT02798406)
- Testing
- DNX-2401, pembrolizumab
- Where
- 15 sites in United States, Canada
- Volunteers
- 49 people
- Sponsor
- DNAtrix, Inc.
Melanoma
Evaluation of the Safety and Tolerability of i.v. Administration of a Cancer Vaccine in Patients With Advanced Melanoma
The purpose of this study is to determine the safety and tolerability of intravenous administration of a tetravalent RNA-lipoplex cancer vaccine targeting four tumor-associated antigens in patients with advanced melanoma.
- Trial name
- Lipo-MERIT (NCT02410733)
- Testing
- Lipo-MERIT
- Where
- 4 sites in Germany
- Volunteers
- 119 people
- Sponsor
- BioNTech SE
Glaucoma
A Study About the Safety of ASP2767 and Whether it Helps People With Glaucoma-Related Optic Nerve Damage
Open-angle glaucoma is the most common type of glaucoma, a disease that damages the nerves in the eye and can lead to vision loss. Current treatments include eye drops, laser treatment, and surgery that help lower eye pressure.
- Trial name
- NCT07770685
- Testing
- ASP2767, Prophylactic Regimen A, Prophylactic Regimen B
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Back Pain, Muscle Pain
Transcutaneous Electrical Nerve Stimulation for Back Pain in the Emergency Department (TENS-ED)
The effectiveness of Transcutaneous Electrical Nerve Stimulation (TENS) to reduce pain scores for patients with acute back pain in an ambulatory emergency department (ED) population will be examined in this dual-center, cluster…
- Conditions
- Back Pain, Muscle Pain, Acute Pain, Lower Back Pain
- Trial name
- TENS-ED (NCT05601843)
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS)
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Sam Brophy
Recurrent Melanoma, Stage IV Melanoma
Vaccine Therapy and Sargramostim in Treating Patients With Stage IV Malignant Melanoma
This randomized pilot clinical trial studies vaccine therapy and sargramostim in treating patients with stage IV malignant melanoma.
- Trial name
- NCT00006243
- Testing
- tyrosinase peptide, MART-1:27-35 peptide vaccine, gp100 antigen
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Analgesia, Pain, Acute
Duration of Analgesia With Dexmedetomidine and Ropivacaine in Brachial Plexus Block
This is a prospective, randomized, double blind study of adding dexmedetomidine to ropivacaine for Brachial plexus block and assessing the analgesia with VAS pain scales(0-10), Satisfaction scale by VAS scale(0-10) and time to…
- Conditions
- Analgesia, Pain, Acute, Peripheral Nerve Block
- Trial name
- NCT03385967
- Testing
- Dexmedetomidine, ropivacaine
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Medullary Thyroid Carcinoma, Small Cell Lung Cancer ( SCLC )
68Ga-labeled Cholecystokinin Receptor (CCK2R) Targeted Molecular Probes in Early Tumor Diagnosis
Evaluate the safety of the novel radioactive nuclide-labeled cholecystokinin receptor (CCK2R) targeted molecular probe, 68Ga-YQ-CC05, in clinical application, and verify its effectiveness in tumor diagnosis.
- Conditions
- Medullary Thyroid Carcinoma, Small Cell Lung Cancer ( SCLC ), Gastric Adenocarcinoma
- Trial name
- NCT07914764
- Testing
- Intravenous injection of 68Ga-YQ-CC05 for PET-CT examination
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Ischemic Stroke, Thrombotic Stroke
Autonomic Neuromodulation by Transcutaneous Nerve Stimulation in Acute Ischaemic Stroke.
Autonomic modulation by transcutaneous vagal nerve stimulation in acute ischaemic stroke requiring mechanical thrombectomy: a phase IIa, sham controlled randomised trial.
- Conditions
- Ischemic Stroke, Thrombotic Stroke, Autonomic Dysfunction, Autonomic Imbalance
- Trial name
- VANS (NCT05417009)
- Testing
- trans-cutaneous auricular sensory stimulation
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Queen Mary University of London
Knee Osteoarthritis, Primary Total Knee Arthroplasty
Evaluation of Utility of Ultrasound Guided iPACK Block for Knee Extension After Total Knee Arthroplasty.
The purpose of this study is to learn if using an Interspace between the Popliteal Artery and Capsule of the Knee (iPACK) injection technique (also called a "nerve block") that numbs the nerves going to the back part of the knee…
- Conditions
- Knee Osteoarthritis, Primary Total Knee Arthroplasty, Physical Therapy, Pain
- Trial name
- NCT03353233
- Testing
- Ropivacaine, Interspace Between the Popliteal Artery and Capsule of the Knee (iPACK) Block, Saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Duke University
Cutaneous Melanoma, Uveal Melanoma
A Study of RO7293583 in Participants With Unresectable Metastatic Tyrosinase Related Protein 1 (TYRP1)-Positive Melanomas
This is a first-in-human, multi-center clinical study to determine the safety, Maximum Tolerated Dose (MTD) and/or Optimal Biological Dose (OBD) as well as the optimal schedule for intravenous (IV) and/or subcutaneous (SC)…
- Conditions
- Cutaneous Melanoma, Uveal Melanoma, Mucosal Melanoma
- Trial name
- NCT04551352
- Testing
- RO7293583, Tocilizumab, Obinutuzumab
- Where
- 14 sites in United States, Australia and 4 more
- Volunteers
- 20 people
- Sponsor
- Hoffmann-La Roche
Lung Cancer, Non-small Cell
Effects of VNS on RT-induced Inflammation and Prognosis of Patients With NSCLC
Lung cancer (LC) remains a leading cause of death among cancers worldwide. Though radiotherapy is one of the most frequently used treatments, it increases side-effects (pain, fatigue) and inflammation, possibly leading to further…
- Trial name
- NCT03553485
- Testing
- Transcutaneous vagus nerve stimulation, Radiotherapy
- Where
- Belgium
- Volunteers
- 12 people
- Sponsor
- Vrije Universiteit Brussel
Piriformis Syndrome, Musculoskeletal Abnormalities
Comparing Two Soft Tissues Technique on Piriformis Syndrome Patients
Piriformis Syndrome is a neuromuscular condition with symptoms of pain, numbness and tingling tracing the route of the sciatic nerve, due to the nerve impingement by the piriformis muscle.
- Conditions
- Piriformis Syndrome, Musculoskeletal Abnormalities, Sciatica
- Trial name
- MPR-PIR (NCT07661485)
- Testing
- Myofascial Release, Post Isometric Relaxation
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- University of Faisalabad
Diffuse Intrinsic Pontine Glioma
CED With Irinotecan Liposome Injection Using Real Time Imaging in Children With Diffuse Intrinsic Pontine Glioma (DIPG) (PNOC 009)
This is a Phase I and Early Efficacy Study of Convection Enhanced Delivery (CED) of irinotecan liposome injection (nal-IRI) Using Real Time Imaging with Gadolinium in Children with Diffuse Intrinsic Pontine Glioma who have…
- Trial name
- NCT03086616
- Testing
- Convection Enhanced Delivery (CED) of Nanoliposomal irinotecan (nal-IRI)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Sabine Mueller, MD, PhD
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