Clinical trials: Nervous System Complication
Stem Cell Transplant Complications, Delirium
Delirium in Children Undergoing Stem Cell Transplantation
Children undergoing stem cell transplants are at risk for delirium, a temporary change in thinking and behavior. This study will define delirium rates, risk factors, and outcomes.
- Trial name
- NCT04937400
- Testing
- Daily screening for delirium
- Where
- 6 sites in United States, Canada
- Volunteers
- 1,040 people
- Sponsor
- Weill Medical College of Cornell University
Urinary Incontinence, Stress, Multiple Sclerosis
Stress Urinary Incontinence in Women With Multiple Sclerosis
Objective: To report the prevalence and risk factors of stress urinary incontinence (SUI) and the prevalence of intrinsic sphincter deficiency in women with multiple sclerosis (MS).
- Trial name
- UROSEP (NCT03332654)
- Testing
- Determine prevalence of stress urinary incontinence
- Volunteers
- 363 people
- Sponsor
- Lille Catholic University
Neurogenic Bladder
Comparison of Mobile Education and Face-to-Face Intermittent Catheterization Education
Today, Clean Intermittent Catheterization (CIC) is widely used to drain urine accumulated in the bladder in acute or chronic problems such as neurogenic bladder and prostate hypertrophy.The success of the technique depends…
- Trial name
- NCT06917027
- Testing
- education
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Hyperalgesia, Opioid Use
Hyperalgesia, Persistent Pain, and Fentanyl Dosing in On-Pump Coronary Artery Bypass Grafting
Randomized, double-blinded, three arm study in adult patients undergoing first time coronary artery bypass grafting (CABG) surgery with median sternotomy.
- Conditions
- Hyperalgesia, Opioid Use, Pain, Postoperative, Pain, Chronic
- Trial name
- NCT03450161
- Testing
- Fentanyl dosing schemes
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- University Hospital, Ghent
Spinal Cord Injuries
Early BOTOX After Spinal Cord Injury
The investigators would like to improve our understanding of how early intervention with the use of bladder chemodenervation can preserve bladder function in those with a new SCI.
- Trial name
- NCT06793683
- Testing
- Bladder chemodenervation (Botox)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Washington
Postoperative Cognitive Dysfunction, Postoperative Delirium
Neuroimaging Combining Biomarkers for Identifying Long-term Cognitive Dysfunction and Delirium
Postoperative Cognitive Dysfunction(POCD) is commonly seen in cardiac surgery, which may lead to poor pognosis. Cerebral small vessel disease(CVSD) is refer as the main resource of delirium among elderly people.
- Conditions
- Postoperative Cognitive Dysfunction, Postoperative Delirium, Cerebral Small Vessel Diseases, Covert Postoperative Stroke
- Trial name
- NeuroIDEA (NCT05594966)
- Testing
- multimodal MRI
- Where
- China
- Volunteers
- 211 people
- Sponsor
- RenJi Hospital
Neuralgia
P4 (Pregabalin for Peripheral Posttraumatic Pain)
To evaluate the efficacy of pregabalin compared to placebo in the treatment of posttraumatic peripheral neuropathic pain
- Trial name
- P4 (NCT00292188)
- Testing
- pregabalin
- Where
- 44 sites in Belgium, Canada and 9 more
- Volunteers
- 255 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Postoperative Pain
Low Dose Ketamine Infusion for Postoperative Analgesia After Total Knee Arthroplasty
This study evaluates continous infusion of low-dose ketamine during intraoperative and postoperative periods at three different doses to provide postoperative analgesia in total knee arthroplasty cases.
- Trial name
- NCT04085588
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Mustafa Kemal University
Diabetic Neuropathy
FDGL Dose-Finding Study for Diabetic Neuropathy
This study investigates the optimal dose of fermented deglycyrrhizinated licorice (FDGL) that maximizes both safety and efficacy in managing diabetic neuropathy complications in adults.
- Trial name
- NCT07117942
- Testing
- Fermented Deglycyrrhizinated Licorice (FDGL)
- Where
- Egypt
- Volunteers
- 485 people
- Sponsor
- Helwan University
Painful Diabetic Neuropathy, Diabetic Neuropathies, Painful
Graded Exposure in Patients With Painful Diabetic Neuropathy
Objective: To investigate the effects of a cognitive behavioural intervention targeting specific fears in patients with painful diabetic neuropathy, on physical activity and quality of life.
- Conditions
- Painful Diabetic Neuropathy, Diabetic Neuropathies, Painful, Neuralgia, Diabetic
- Trial name
- PDN&GEXP (NCT03066570)
- Testing
- Graded Exposure
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Maastricht University Medical Center
Turner Syndrome, Renal Insufficiency, Chronic
Study to Define Optimal IGF-1 Monitoring in Children Treated With NutropinAq
The main purpose of this study is to establish an optimal monitoring regimen in NutropinAq treated children, using newly developed capillary blood spot IGF-1 measurement technology.
- Conditions
- Turner Syndrome, Renal Insufficiency, Chronic, Pituitary Diseases, Dwarfism
- Trial name
- OPTIMA (NCT00234533)
- Testing
- Somatropin (rDNA origin)
- Where
- 45 sites in Belgium, Czechia and 12 more
- Volunteers
- 251 people
- Sponsor
- Ipsen
Prader-Willi Syndrome, PWS-like Syndrome
GROWing Up With Rare GENEtic Syndromes
Introduction Rare complex syndromes Patients with complex genetic syndromes, by definition, have combined medical problems affecting multiple organ systems, and intellectual disability is often part of the syndrome.
- Conditions
- Prader-Willi Syndrome, PWS-like Syndrome, Silver Russel Syndrome, Congenital Hypopituitarism
- Trial name
- GROW UR GENES (NCT04463316)
- Testing
- Retrospective file studies
- Where
- Netherlands
- Volunteers
- 600 people
- Sponsor
- dr. Laura C. G. de Graaff-Herder
Pain, Pain Syndrome
Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Central Neuropathy of Any Genesis
Over the last years a rising medical need for treatment of chronic pain was identified. Based on previous findings indicating the pain modulating effects of cannabinoids in chronic pain disorders, this clinical trial investigates…
- Conditions
- Pain, Pain Syndrome, Pain, Chronic, Chronic Pain
- Trial name
- NCT06071949
- Testing
- Adezunap
- Where
- Germany
- Volunteers
- 558 people
- Sponsor
- Apurano Pharmaceuticals GmbH
Mothers, Postpartum Depression
Early Half Swaddling and Kangaroo Care Practices on Maternal Sleep Quality and Postpartum Depression in Term Babies
Aim: In this prospective, randomized controlled study, it was aimed to examine the effects of early half-swaddle and kangaroo care practices in term babies on maternal sleep quality and postpartum depression.
- Trial name
- NCT06348316
- Testing
- Half swaddle, Kangaroo care
- Where
- Turkey (Türkiye)
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Trakya University
Relapsing-Remitting Multiple Sclerosis, Urinary Incontinence
Guided Versus Non-guided Pelvic Floor Exercises for Urinary Incontinence in Relapsing-Remitting Multiple Sclerosis
The aim of the study is to evaluate the effectiveness of guided versus non guided pelvic floor exercises for urinary incontinence in patients with Relapsing-Remitting Multiple Sclerosis
- Trial name
- NCT03000647
- Testing
- Pelvic floor exercises guided by a physiotherapist, Non guided pelvic floor exercises
- Where
- Spain
- Volunteers
- 48 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Delirium, Agitation
The Effectiveness of Acupuncture for Complications in Critically Ill Patients
Introduction: Intensive care unit (ICU) is a special department in the health care facility. Although with high development of modern medicine nowadays, the average mortality rate in ICU is still around 7 to 20 %.
- Conditions
- Delirium, Agitation, Arrhythmia, Feeding Intolerance
- Trial name
- NCT04950738
- Testing
- pess tack acupuncture
- Volunteers
- 80 people
- Sponsor
- China Medical University Hospital
Aneurysmal Subarachnoid Heamorrhage, Nontraumatic Subarachnoid Haemorrhage
Cardiopulmonary Complication in Aneurysmal Subarachnoid Haemorrhage Patients
This is a prospective cohort study investigating cardiac function and cardiac biomarkers in patients with acute Aneurysmal Subarachnoid Haemorrhage (aSAH).
- Trial name
- SAHHEART (NCT01670838)
- Where
- 3 sites in Finland, Switzerland
- Volunteers
- 198 people
- Sponsor
- Kuopio University Hospital
Down Syndrome (Trisomy 21), Edwards Syndrome (Trisomy 18)
Non-Invasive Screening for Fetal Aneuploidy: A New Maternal Plasma Marker
Validate that circulating cell free fetal nucleic acid can be used to identify a direct marker for fetal aneuploidy, particularly fetal Down Syndrome (DS), that is better than surrogate markers.
- Conditions
- Down Syndrome (Trisomy 21), Edwards Syndrome (Trisomy 18), Patau Syndrome (Trisomy 13), Turner Syndrome
- Trial name
- NCT00770458
- Where
- 7 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Sequenom, Inc.
Cardiac Complications, Signs and Symptoms
Evaluation of the Effects of L-Carnitine Injection in Patients Undergoing Hemodialysis
This is a study designed to test the hypothesis that treatment with L-carnitine will improve the quality of life and some specific symptoms and signs in patients with renal failure submitted to hemodialysis.
- Conditions
- Cardiac Complications, Signs and Symptoms, Muscle Weakness, Anemia
- Trial name
- NCT00173706
- Testing
- L-Carnitine Injection
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Stroke, Acute Ischemic Stroke
Mobilisation After Endovascular Stroke Treatment
The goal of this observational study is to learn how the timing of mobilisation after endovascular thrombectomy (EVT) affects complications in patients with acute ischaemic stroke.
- Conditions
- Stroke, Acute Ischemic Stroke, Acute Ischemic Stroke AIS, Endovascular Thrombectomy
- Trial name
- MAESTRO (NCT07860333)
- Testing
- Mobilisation
- Where
- 2 sites in Finland, Sweden
- Volunteers
- 400 people
- Sponsor
- Karolinska Institutet
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