Clinical trials: Nervous System Complication
Overactive Bladder
OnabotulinumtoxinA (onaBoNT-A) Versus Oral Oxybutynin ER
Overactive bladder is a condition associated with symptoms of feeling the urge to urinate, urinating often, and may or may not be accompanied by leakage of urine.
- Trial name
- NCT01050114
- Testing
- onaBoNT-A, Oxybutynin ER
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Christopher Patrick Smith
Anesthesia, Local, Nerve Pain
SEQ Block for Perioperative Analgesia in Acetabular Surgery
The study will evaluate ultrasound guided SEQ block: single puncture combined lumbar erector spinae plane block and paraspinous sagittal shift (PSSS) quadratus lumborum block when compared with conventional intravenous morphine…
- Conditions
- Anesthesia, Local, Nerve Pain, Pain, Postoperative, Acetabular Fracture
- Trial name
- NCT04688814
- Testing
- Single puncture combined lumbar erector spinae plane block and quadrates lumborum block, Morphine Sulfate
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Alexandria University
Urinary Tract Infection
Safety and Efficacy of PP4001 for the Treatment of Symptoms Associated With Uncomplicated Urinary Tract Infection
PP4001 is a medication not yet approved by the US FDA. This is a phase 2, multi-center, randomized, double-blind study of 3 doses of PP4001 versus placebo in the treatment of symptoms associated with uncomplicated urinary tract…
- Trial name
- NCT01406587
- Testing
- PP4001
- Where
- 25 sites in United States
- Volunteers
- 261 people
- Sponsor
- Pinnacle Pharmaceuticals, Inc.
Postoperative Pain After a Total Knee Arthroplasty
Post-operative Analgesic Effect of Oral Nefopam
Primary knee arthroplasty by total prosthesis is a painful surgery, performed on patients with advanced gonarthrosis (stage III), thus already presenting hyperalgesia and hyperalgesia and allodynia.
- Trial name
- NefPO (NCT04576078)
- Testing
- Oral nefopam
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Diabetic Polyneuropathy, Sleep Hygiene
The Effect of Sleep Hygiene Education on Sleep Quality and Quality of Life in Patients With Painful Diabetic Polyneuropathy
This randomized controlled study was designed to the effect of sleep hygiene education on sleep quality and quality of life in patients with painful diabetic polyneuropathy The study was conducted between January 2025 and January…
- Conditions
- Diabetic Polyneuropathy, Sleep Hygiene, Pain
- Trial name
- NCT07646743
- Testing
- sleep hygiene education, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Trakya University
Parkinson's Disease, Overactive Bladder
Anticholinergic Therapy for Overactive Bladder in Parkinson's Disease
The purpose of this research study is to investigate the cognitive (thinking, memory, knowledge, intelligence) side effects of two medications commonly used to treat overactive bladder (OAB) symptoms in veteran patients with…
- Trial name
- NCT00892450
- Testing
- Oxybutynin and darifenacin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- US Department of Veterans Affairs
Gait Disorders, Neurologic, Urinary Incontinence, Urge
Time to be Ready to Void: a New Tool to Assess the Time Needed to Perform Micturition in Multiple Sclerosis
The aim of the study is to create a specific test to assess the global time required to go to the toilet and to perform micturition, at the moment the patient decides to urinate in multiple sclerosis population, and to assess its…
- Conditions
- Gait Disorders, Neurologic, Urinary Incontinence, Urge, Multiple Sclerosis
- Trial name
- NCT04024085
- Testing
- completion of the test created Time to be Ready to Void
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Gérard Amarenco
Diabetic Polyneuropathy
A Study of CGRP Monoclonal Antibody to Treat Diabetic Neuropathy
The main purpose of this study is to compare the change in pain intensity during treatment with a CGRP monoclonal antibody (eptinezumab) compared with placebo treatment in patients with painful diabetic polyneuropathy (DPN).
- Trial name
- NCT05937152
- Testing
- Eptinezumab
- Where
- 3 sites in United States, Denmark
- Sponsor
- Mayo Clinic
Postoperative Pain
Massage After Surgery To Help Treat Post-Operative Pain
Postoperative pain is often undertreated. Although studies have demonstrated that many patients experience a substantial degree of unrelieved pain following operative procedures and that this pain can increase the incidence of…
- Trial name
- NCT00057148
- Testing
- massage treatment
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- US Department of Veterans Affairs
Parkinson's Disease, Overactive Bladder
Safety and Efficacy of Botulinum Toxin A for Treatment of Overactive Bladder in Parkinson's Disease
A randomized controlled trial is to be conducted to confirm the efficacy and safety of intramuscular injection of botulinum toxin in the treatment of Parkinson's bladder overactivity.
- Conditions
- Parkinson's Disease, Overactive Bladder, Onabotulinumtoxin A
- Trial name
- NCT05997043
- Testing
- oral anti-Parkinson drugs and injection of botulinum toxin, oral anti-Parkinson's drugs
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhujiang Hospital
Diabetic Polyneuropathy, Diabetes Mellitus, Type 2
Driving with Neuropathy
This study is a proof-of-concept randomised controlled trial (RCT). The goal of the study is to investigate the effectiveness of a feedback intervention to improve use of the accelerator pedal in patients driving with diabetes…
- Trial name
- NCT06739135
- Testing
- Visual feedback training
- Where
- United Kingdom
- Volunteers
- 115 people
- Sponsor
- Manchester Metropolitan University
Postoperative Complications, Psychosomatic Disorder
Development of Machine Learning Models for the Prediction of Complications After Colonic, Colorectal and Small Intestine Anastomosis in Psychiatric and Non-psychiatric Patient Collectives (P-Study)
Our study aims to lay the basis for a predictive modeling service for postoperative complications and prolonged hospital stay in patients suffering from psychiatric diseases undergoing colorectal surgery.
- Conditions
- Postoperative Complications, Psychosomatic Disorder, Psychiatric Disorder, Cancer
- Trial name
- NCT05257863
- Where
- Switzerland
- Volunteers
- 10,000 people
- Sponsor
- Dr. Med Anas Taha
Arthroplasty Complications, Pain, Joint
Efficacy of iPACK After Unilateral TKA
Total knee arthroplasty (TKA) is a common orthopedic procedure associated with severe postoperative pain which may limit patient rehabilitation and hospital discharge.
- Conditions
- Arthroplasty Complications, Pain, Joint, Arthritis Knee, Regional Anesthesia Morbidity
- Trial name
- NCT04565093
- Testing
- iPACK, Periarticular local infiltration analgesia (LIA)
- Where
- Saudi Arabia
- Volunteers
- 80 people
- Sponsor
- King Khalid University Hospital
Spinal Cord Injuries, Urinary Bladder, Overactive
Prevention of Bladder Dysfunction in Acute Spinal Cord Injury
This study is a double blind, randomized, placebo controlled trial to explore the effect of early treatment with Onabotulinumtoxin A in patients with acute complete motor spinal cord injury (SCI) on the development of neurogenic…
- Trial name
- BOT-SCI (NCT01698138)
- Testing
- Onabotulinumtoxin A
- Where
- 2 sites in Norway
- Volunteers
- 20 people
- Sponsor
- Oslo University Hospital
Pain, Postoperative, Hip Arthroplasty
CMP vs Fascia Iliaca Block
Complete motorsparing protocol (CMP) has been developed to try to minimize the motor nerve block that is created when using Facia iliaca nerve block.
- Trial name
- NCT04426058
- Testing
- CMP, Fascia Illica
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Loyola University
Inguinal Hernia, Postoperative Pain
Comparison of Lornoxicam and Paracetamol for Pre-emptive Intravenous Analgesia for Elective Inguinal Hernia Repair
The purpose of this study is to determine whether lornoxicam or paracetamol is more effective in providing pre-emptive analgesia for adult patients undergoing elective unilateral inguinal hernia repair under general anesthesia.
- Trial name
- NCT01069055
- Testing
- Sterile Saline, Intravenous lornoxicam, Intravenous paracetamol
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Diskapi Teaching and Research Hospital
Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC)
18F-T2 PET/CT Imaging for CAIX Positive Solid Tumors
The goal of this clinical trial is to evaluate the diagnostic value of CAIX protein specific probe 18F-T2 in PET/CT imaging in participants with solid tumors.
- Conditions
- Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC), Colorectal Cancer, Cervical Cancer
- Trial name
- NCT07557225
- Testing
- 18F-T2 PET/CT
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Critical Illness, Sedation Complication
Sedation, ANalgesia and Delirium MANagement in Intensive Care Unit
Patients with acute severe health problems often need to be admitted to specialised hospital wards called Intensive Care Units (ICUs) where they can receive emergency treatment such as mechanical ventilation to support their…
- Conditions
- Critical Illness, Sedation Complication, Intensive Care Unit Delirium, Analgesia
- Trial name
- SAnDMAN (NCT05027217)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 3,421 people
- Sponsor
- University of Oxford
Surgical Wound, Post Operative Pain
Effect of Preemptive Etoricoxib and Dexamethasone on Wound Healing and Clinical Parameters After Third Molar Surgery
The goal of this clinical trial is to compare preemptive single-dose selective cyclooxygenase 2 (COX-2) inhibitor - etoricoxib and dexamethasone use in systemically healthy patients during the surgical extraction of impacted…
- Trial name
- NCT05791721
- Testing
- Etoricoxib 90 Mg Oral Tablet, Dexamethasone 4mg
- Where
- Serbia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
Adult Nocturnal Enuresis, Urinary Incontinence (UI)
This Study Will Collect Clinical and Patient Reported Experience Data From Participants Requiring Urine Output Management Overnight in the Home Setting.
This post-market study will assess the performance of and user experience with the PureWick™ System in a home setting. The study will also observe safety of the study device and collect information from participants about their…
- Trial name
- PUREST (NCT06666426)
- Testing
- PureWick System, Hollister Female Urinary Pouch External Collection Device
- Where
- 15 sites in United States
- Volunteers
- 171 people
- Sponsor
- C. R. Bard
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