Clinical trials: Nervous System Complication
Painful Diabetic Neuropathy, Diabetic Neuropathy
Study of Clonidine Hydrochloride Topical Gel, 0.1% in the Treatment of Pain Associated With Diabetic Neuropathy
The purpose of the study is to determine whether clonidine gel is an effective treatment for reducing the pain associated with painful diabetic neuropathy.
- Conditions
- Painful Diabetic Neuropathy, Diabetic Neuropathy, Neuropathy
- Trial name
- NCT02068027
- Testing
- Clonidine Gel 0.1%
- Where
- 23 sites in United States
- Volunteers
- 260 people
- Sponsor
- BioDelivery Sciences International
Chronic Pain Due to Injury, Neuroma of Lower Limb
Botulinum Toxin Type A Versus Local Anesthetic Injection for Chronic Neuroma Pain After Combat-Related Amputation
Patients with combat-related amputations frequently experience persistent neuroma pain that may interfere with rehabilitation, prosthesis use, sleep, mobility, and quality of life.
- Conditions
- Chronic Pain Due to Injury, Neuroma of Lower Limb, Neural Injury, Neuroma of Upper Limb
- Trial name
- NEUROQUIET (NCT07626983)
- Testing
- Botulinum Toxin Type A (BoNT-A), Local Anesthetic Solution
- Where
- 2 sites in Ukraine
- Volunteers
- 100 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Pain, Postoperative
Intraoperative Lidocaine Infusion as a Sole Analgesic Versus Morphine in Laparoscopic Gastric Bypass Surgery
Postoperative opioid-centric pain management strategies in obese patients are accompanied by the possible development of; opioid-induced ventilatory impairment (OIVI) and hypoxemia.
- Trial name
- NCT05150756
- Testing
- Lidocaine Hydrochloride 2% Intravenous Solution [XYLOCAINE], morphine sulphate (10mg/ ml ampoule)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Delirium - Postoperative
The Effect of Aromatherapy on Delirium in Critically Elderly Patients Undergoing Fracture Surgery
The aim of this quasi-experimental study was to examine the effect of lavender aromatherapy on delirium in patients who underwent fracture surgery, were in intensive care, and were over 60 years old.
- Trial name
- NCT06772129
- Testing
- Aromatherapy
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Senay Gokdemir
Eye Injuries
Visual Outcome of Traumatic Posterior Segment Complications
to identify the demographic, the clinical characteristics and the possible predictive factors affecting long-term visual outcomes of traumatic posterior segment complications presenting to Assiut University Hospital.
- Trial name
- NCT04521283
- Volunteers
- 60 people
- Sponsor
- Assiut University
Post Operative Sore Throat, Hoarseness
Efficacy of Flurbiprofen Spray for Postoperative Sore Throat Following Double-Lumen Endobronchial Intubation
The goal of this study is to evaluate whether topical flurbiprofen reduces the incidence and severity of postoperative sore throat (POST) and hoarseness in patients undergoing double-lumen tube (DLT) intubation for elective…
- Trial name
- FLURBI-POST (NCT07163429)
- Testing
- Flurbiprofen 8.75 MG, Saline spray
- Where
- Thailand
- Volunteers
- 58 people
- Sponsor
- Kittitorn Supphapipat, MD
Parkinson's Disease Aggravated
Microbiota Modification for the Treatment of Motor Complication of Parkinson´s Disease
In recent years, abnormalities in gut microbiota have been identified in patients with Parkinson´s disease having a possible role in motor manifestations.
- Trial name
- NCT04730245
- Testing
- sodium phosphate enema, oral rifaximin and polyethylene glycol
- Where
- Mexico
- Volunteers
- 14 people
- Sponsor
- Torre Médica Santé
Covid19, Thrombosis Embolism
COVID-19 Registry to Assess Frequency, Risk Factors, Management, and Outcomes of Arterial and Venous Thromboembolic Complications
Novel coronavirus 2019 (COVID-19) has emerged as a major international public health concern. While much of the morbidity and mortality associated with COVID-19 has been attributed to acute respiratory distress syndrome (ARDS) or…
- Conditions
- Covid19, Thrombosis Embolism, DVT, Pulmonary Embolism
- Trial name
- CORONA-VTE NET (NCT04535128)
- Testing
- No intervention
- Where
- United States
- Volunteers
- 11,000 people
- Sponsor
- Brigham and Women's Hospital
Bacteriuria
Bacteriuria Eradication Through Probiotics
Many children who catheterize their bladders because of spina bifida or other neurologic disorders have bacteriuria. This can lead to urinary tract infections by bacteria from the gut which colonize the vagina and are carried…
- Trial name
- BERP (NCT00717600)
- Testing
- Lactobacillus reuteri RC-14 and Lactobacillus rhamnosus GR-1
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Baylor College of Medicine
Emergence Agitation
Effect of Induction Method in Post Operative Agitation
To compare the effect of two different induction method; mask ventilation and intravenous cannulation on emergence agitation on pediatric adenotonsillectomy
- Trial name
- NCT03252405
- Testing
- mask ventilation, intravenous cannulation
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Ahi Evran University Education and Research Hospital
Sacrococcygeal Teratoma, Neurogenic Bladder
Voiding Disorders in Children After Sacrococcygeal Teratoma Resection
Sacrococcygeal teratomas are the most common neonatal tumors and require rapid and complete resection. Tumor nerve compression and pelvic surgical sequelae may lead to many and varied voiding disorders.
- Conditions
- Sacrococcygeal Teratoma, Neurogenic Bladder, Voiding Disorders
- Trial name
- TSC-URO (NCT05182853)
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Montpellier
Diabetes Mellitus, Type 2, Polyneuropathy Diabetes
24-hour Blood Pressure Dynamics and Autonomic Adrenergic Regulation in Type 2 Diabetics
Autonomic neuropathy is a common complication of type 2 diabetes mellitus. Symptoms from cardiovascular autonomic neuropathy include, dizziness, orthostatic hypotension and insufficient heart rate and blood pressure (BP)…
- Conditions
- Diabetes Mellitus, Type 2, Polyneuropathy Diabetes, Autonomic Neuropathy, Diabetic Neuropathies
- Trial name
- NCT04208295
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Brain Ischemia, Postoperative Confusion
Impact of Remote Ischemic Preconditioning Preceding Coronary Artery Bypass Grafting on Inducing nEuroprotection
Coronary artery disease (CAD) is the leading cause of death worldwide. Patients with severe CAD are often treated with coronary artery bypass grafting (CABG).
- Trial name
- RIPCAGE (NCT02177981)
- Testing
- Remote ischemic preconditioning, Control
- Where
- Croatia
- Volunteers
- 70 people
- Sponsor
- University of Zagreb
Sleep Disorders, Kidney Diseases
Effects of Cognitive-Behavioral Therapy on Sleep Disturbance in Peritoneal Dialysis Patients
Sleep disturbance is prevalent in chronic dialysis patients and there is a negative correlation between the quality of life and overall survival and sleep disturbance in them.
- Trial name
- NCT00155441
- Testing
- cognitive-behavioral therapy
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Chronic Pain, Complex Regional Pain Syndrome
Effects of Spinal Cord Stimulation on Sensory Perceptions of Chronic Pain Patients
It's well known that Spinal cord stimulation (SCS) changes the perception of chronic pain in the area stimulated by epidural electrodes.
- Conditions
- Chronic Pain, Complex Regional Pain Syndrome, Failed Back Surgery Syndrome
- Trial name
- NCT02837822
- Testing
- Spinal cord stimulator, Implantation of a spinal cord stimulator
- Where
- 2 sites in United States, Canada
- Volunteers
- 38 people
- Sponsor
- CHU de Quebec-Universite Laval
Arrhythmia, Atrial Fibrillation
Arterial Embolism After Catheter Ablation of Atrial Fibrillation. ATRIAL FIBRILLATION
The EMBOL-AF is a multicenter, international, observational study designed as a retrospective registry that will investigate the characteristics of systemic arterial embolic events after treatment of atrial fibrillation by…
- Conditions
- Arrhythmia, Atrial Fibrillation, Ablation, Stroke, Acute
- Trial name
- EMBOL-AF (NCT06134739)
- Testing
- No intervention.
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Hospital Universitario La Paz
Extracorporeal Membrane Oxygenation Complication, Acute Brain Injury
Assessing Brain Injury Using Portable Magnetic Resonance Imaging (MRI)
This study aims to assess the feasibility of assessing acute brain injury using a portable low field MRI in patients on ECMO.
- Trial name
- SAFE MRI (NCT05469139)
- Testing
- Portable MRI acquisition
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Johns Hopkins University
Diabetes, Hypertension
Pharmacy-led Transitions of Care Intervention to Improve Medication Adherence
Socioeconomically disadvantaged populations with multiple chronic conditions have high rates of nonadherence to essential chronic disease medications after hospital discharge.
- Conditions
- Diabetes, Hypertension, High Cholesterol/Hyperlipidemia, Coronary Artery Disease
- Trial name
- MedAAAction (NCT06374277)
- Testing
- Med AAAction intervention
- Where
- 2 sites in United States
- Volunteers
- 388 people
- Sponsor
- University of Tennessee
Emergence Delirium
Preoperative Chronotype and Emergence Delirium in the Elderly
Emergence delirium (ED) is a prevalent and severe postoperative complication in elderly surgical patients. It can occur at any perioperative stage but most frequently develops during or immediately after emergence from general…
- Trial name
- NCT07722481
- Testing
- the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU)
- Where
- China
- Volunteers
- 235 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Chronic Pain, Neuralgia
Acupuncture Versus Conventional Treatment for Chronic Pain in Patients With Chronic Kidney Disease
This study evaluated acupuncture plus optimized conventional pharmacological treatment compared with optimized conventional pharmacological treatment alone for chronic pain in adults with chronic kidney disease receiving…
- Conditions
- Chronic Pain, Neuralgia, Renal Insufficiency,Chronic
- Trial name
- NCT07891819
- Testing
- Acupuncture, Optimized conventional pharmacological treatment
- Where
- Brazil
- Volunteers
- 110 people
- Sponsor
- Federal University of São Paulo
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