Clinical trials: Nervous System Disorder
Cardiovascular Disease
Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine
SEARCH is a randomised, double-blind, multi-centre United Kingdom (UK) trial of 12,064 patients with myocardial infarction (MI) prior to study entry which aims to demonstrate whether a more intensive cholesterol lowering regimen…
- Trial name
- SEARCH (NCT00124072)
- Testing
- Simvastatin 20 mg daily, Folic acid 2 mg + vitamin B12 1 mg daily, Simvastatin 80 mg daily
- Where
- United Kingdom
- Volunteers
- 12,064 people
- Sponsor
- University of Oxford
Poliomyelitis
Safety and Reactogenicity of GlaxoSmithKline (GSK) Biologicals' IPV Vaccine (PoliorixTM) in Toddlers
The study will evaluate the safety and reactogenicity of PoliorixTM given as a single booster dose to Chinese children at 18-24 months of age.
- Trial name
- NCT00920439
- Testing
- PoliorixTM
- Where
- China
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Hypertension, Pure Autonomic Failure
Nitric Oxide and the Autonomic Nervous System
The amount of blood flowing to the different parts of the body is regulated by the autonomic (automatic) nerves and by local factors produced by the blood vessels.
- Trial name
- NCT00178919
- Testing
- L-NMMA, Trimethaphan
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Stroke
Exploring the Efficacy of Combined Task-Specific and Cognitive Strategy Training in Subacute Stroke
Novel stroke rehabilitation approaches, such as task-specific training (TST), have shown promise in improving stroke recovery components such as basic mobility and activities of daily living; however, evidence suggests these…
- Trial name
- NCT01309165
- Testing
- CO-OP, Standard Occupational Therapy
- Where
- 2 sites in United States, Canada
- Volunteers
- 35 people
- Sponsor
- St. John's Rehab Hospital
Parkinson's Disease, Hyperprolactinemia
Study On Utilization Of Cabergoline For Compliance With Risk Minimization Activities (SUCRE)
The overall goal of this study will be to assess and monitor the adherence to and effectiveness of the new prescribing guidelines for cabergoline. Specific objectives will be to assess: 1.
- Trial name
- SUCRE (NCT01270711)
- Testing
- Study Drug
- Volunteers
- 22,014 people
- Sponsor
- Pfizer
Pituitary Macroadenoma
Radioactive Iodine Implants for Pan-invasive Pituitary Macroadenomas
This study is a single arm Phase II pilot trial. Patients enrolled on the trial will undergo implantation of high activity iodine-125 seeds into their pituitary adenoma.
- Trial name
- NCT01444209
- Testing
- Iodine Implants
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Texas Southwestern Medical Center
Ischemic Stroke
POSITIVE Stroke Clinical Trial
Primary Endpoint: The primary objective is to show that AIS patients, ineligible for or refractory to treatment with IV-tPA, with appropriate image selection, treated with mechanical thrombectomy within 6-12 hours of symptom…
- Trial name
- NCT01852201
- Testing
- Endovascular Mechanical Thrombectomy
- Where
- 20 sites in United States
- Volunteers
- 33 people
- Sponsor
- Medical University of South Carolina
Epilepsy, Epilepsy, Generalized
Clobazam in Subjects With Lennox-Gastaut Syndrome
The purpose of this study is to evaluate the safety and efficacy of clobazam as adjunctive therapy in the treatment of seizures which lead to drop attacks (drop seizures) in subjects 2 to 30 years of age with Lennox-Gastaut…
- Conditions
- Epilepsy, Epilepsy, Generalized, Seizures
- Trial name
- NCT00162981
- Testing
- Clobazam Low Dose, Clobazam High Dose
- Where
- 14 sites in United States
- Volunteers
- 68 people
- Sponsor
- Lundbeck LLC
Intraventricular Hemorrhage, Subarachnoid Hemorrhage
Comparative Infection Rates for the Codman BACTISEAL TM External Ventricular Drainage (EVD) System
The purpose of this non-significant risk study is to establish initial baseline infection rates for the Codman BACTISEAL External Ventricular Drainage (B-EVD) System (Antibiotic impregnated catheter) and to compare relative rates…
- Trial name
- NCT00197392
- Testing
- Bactiseal TM EVD, Standard EVD Catheter
- Where
- 20 sites in United States, Canada and 6 more
- Volunteers
- 434 people
- Sponsor
- Codman & Shurtleff
Prader Willi Syndrome
Evaluation of Tolerance, Suckling and Food Intake After Repeated Nasals Administrations of Oxytocin in PWS Infants
The Prader-Willi syndrome (PWS) includes severe neonatal hypotonia with impaired suckling leading to failure to thrive in the most severe cases, subsequently followed by an early onset of morbid obesity with hyperphagia and…
- Trial name
- OTBB2 (NCT02205034)
- Testing
- oxytocin
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Toulouse
Restless Legs Syndrome
Rotigotine Effect on All-day Functioning and Quality of Life in Subjects With Moderate to Severe Restless Legs Syndrome (RLS)
The purpose of the study is to show that Rotigotine improves Restless Legs Syndrome (RLS) symptoms in subjects with moderate to severe RLS during both day and evening.
- Trial name
- RESTORE (NCT01569464)
- Testing
- Rotigotine
- Where
- 18 sites in United States
- Volunteers
- 150 people
- Sponsor
- UCB Pharma
Sarcopenia, Aging
Semi-Recumbent Vibration Therapy in Older Adults
This proposed prospective study will evaluate whether a novel exercise approach, seated vibration therapy, can improve function in the target population of older adults.
- Trial name
- NCT02533063
- Testing
- VibeTech One
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Parkinson Disease
Dental Appliance for Parkinson's Disease
The investigators are evaluating the immediate effect of a dental mouthpiece on gait and balance among people with Parkinson disease as well as longer-term feasibility use and the effect of the mouthpiece on sleep and quality of…
- Trial name
- DAPD (NCT04082663)
- Testing
- Dental Mouthpiece
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Washington University School of Medicine
Meningococcal Meningitis, Tetanus
Study of Menactra® in Children Aged 4 to 6 Years When Administered Concomitantly With a Fifth Dose of DAPTACEL®
The purpose of this study is to evaluate the immunogenicity and safety of the concomitant administration of Menactra® vaccine and DAPTACEL® vaccine.
- Conditions
- Meningococcal Meningitis, Tetanus, Diphtheria, Pertussis
- Trial name
- NCT00355121
- Testing
- Polysaccharide Diphtheria Toxoid Conjugate Vaccine
- Where
- 26 sites in United States
- Volunteers
- 882 people, healthy volunteers welcome
- Sponsor
- Sanofi
Pain
Lidocaine and Pain Management in First Trimester Abortions
The purpose of this study is to examine the effect of lidocaine (a numbing medication) inside the uterus on patient pain during an early abortion, compared to the paracervical block (lidocaine injected on either side of the…
- Trial name
- NCT00613821
- Testing
- Lidocaine
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Ischemic Stroke
Safety/Feasibility of Autologous Mononuclear Bone Marrow Cells in Stroke Patients
The purpose of this research study is to find out if bone marrow treatment (bone marrow aspiration and infusion of stem cells) can be safely used in adults who have recently (within 24-72 hours)suffered an acute ischemic stroke.
- Trial name
- NCT00859014
- Testing
- Autologous Bone Marrow Mononuclear Cells
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- The University of Texas Health Science Center, Houston
Epilepsy
Double Blind, Crossover Study of Fish Oil [EPA and DHA] for Intractable Partial Seizures
The purpose of this study is to determine if Omega-3 fatty acids reduce seizures and modify cardiac risk factors in people with epilepsy.
- Trial name
- FOS (NCT00871377)
- Testing
- High Dose Fish Oil, Low Dose Fish Oil
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Bacterial Infections, Virus Diseases
Safety, Tolerability, and Immunogenicity of V419 Given Concomitantly With Prevnar 13™ and RotaTeq™ (V419-005)
This is a study to assess the safety, tolerability, and immunogenicity of V419 (PR5I) when administered as an infant series at 2, 4, and 6 months of age followed by a toddler dose of DAPTACEL™, Prevnar 13™ and PedvaxHIB™ at 15…
- Trial name
- NCT01337167
- Testing
- V419, DAPTACEL™, PedvaxHIB™
- Volunteers
- 1,473 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Non Small Cell Lung Cancer (NSCLC), Metastases to the Brain
Trial of Cabozantinib (XL184) in Non-Small Cell Lung Cancer With Brain Metastases
This is an open-label phase II clinical trial designed to allow a preliminary assessment of the efficacy and safety of cabozantinib in unselected Non-Small Cell Lung Cancer (NSCLC) patients with metastases to the brain and in the…
- Trial name
- NCT02132598
- Testing
- cabozantinib
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Liza Villaruz, MD
Sleep Apnea Syndromes, Inflammation
The Effects of Obesity and Obstructive Sleep Apnea on Inflammation and Heart Disease
Obstructive sleep apnea (OSA) is a serious sleep disorder in which a person's breathing is restricted during sleep. Obese individuals with OSA are at an increased risk of inflammation and heart conditions, but it is unknown…
- Trial name
- NCT00371293
- Testing
- Weight Loss Program, CPAP therapy
- Where
- 2 sites in United States
- Volunteers
- 181 people
- Sponsor
- University of Pennsylvania
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