Clinical trials: Nervous System Disorder
Cerebral Palsy, Hypoxic-Ischemic Encephalopathy
Therapeutic Intervention Supporting Development From NICU to 6 Months for Infants Post Hypoxic-Ischemic Encephalopathy
The purpose of this study is to evaluate the feasibility and begin to evaluate the effect of a sensorimotor intervention (SMI) provided in the first 6 months of life for infants with hypoxic-ischemic encephalopathy.
- Trial name
- NCT05130528
- Testing
- Sensorimotor Intervention
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- University of Southern California
Phenylketonurias
Study of Phenoptin to Increase Phenylalanine Tolerance in Phenylketonuric Children on a Phenylalanine-restricted Diet
The primary objective of this trial is to evaluate the ability of Phenoptin to increase phenylalanine (phe) tolerance in children with phenylketonuria who are following a phe-restricted diet.
- Trial name
- NCT00272792
- Testing
- Sapropterin Dihydrochloride
- Where
- 9 sites in United States
- Volunteers
- 45 people
- Sponsor
- BioMarin Pharmaceutical
Polymyositis, Dermatomyositis
A Study of Ustekinumab in Participants With Active Polymyositis and Dermatomyositis Who Have Not Adequately Responded to One or More Standard-of-care Treatments
The purpose of this study is to evaluate the efficacy of ustekinumab in participants with active polymyositis (PM)/dermatomyositis (DM) despite receiving 1 or more standard-of-care treatments (for example, glucocorticoids and/or…
- Trial name
- NCT03981744
- Testing
- Ustekinumab 6 mg/kg, Ustekinumab 90 mg
- Where
- 32 sites in Japan
- Volunteers
- 51 people
- Sponsor
- Janssen Pharmaceutical K.K.
Hemorrhagic Shock, Acute Blood Loss Anemia
Low-Titer O Positive Whole Blood Versus Component Therapy for Emergent Transfusion in Trauma Patients
Adult male patients brought to the emergency department as Level A trauma activations who are receiving emergency blood transfusion. Objectives 1.
- Conditions
- Hemorrhagic Shock, Acute Blood Loss Anemia, Traumatic Brain Injury
- Trial name
- NCT05081063
- Testing
- Routine labs
- Where
- United States
- Volunteers
- 199 people
- Sponsor
- Loma Linda University
Parkinson Disease
Survey on PD Patients With Depressive Symptoms
The primary objective of this investigation is to conduct a 12-week prospective survey in PD patients with depressive symptoms treated with BI Sifrol Tablets (hereinafter referred to as this drug) in the routine clinical settings…
- Trial name
- NCT00614575
- Where
- 238 sites in Japan
- Volunteers
- 1,089 people
- Sponsor
- Boehringer Ingelheim
Migraine
Efficacy of Erenumab on Functional Impact of Migraine
The purpose of this study is to assess the efficacy of erenumab on functional impact due to Migraine in adults.
- Trial name
- NCT04465357
- Testing
- Erenumab-Aooe 140 MG/ML [Aimovig]
- Where
- 3 sites in United States
- Volunteers
- 55 people
- Sponsor
- Merle Diamond
Cervical Spinal Cord Injury, Spine Injury
Dose Escalation Study of AST-OPC1 in Spinal Cord Injury
The purpose of this study is to evaluate the safety of cross sequential escalating doses of AST-OPC1 administered among 5 cohorts at a single time-point between 21 and 42 days post injury, inclusively, to subjects with subacute…
- Conditions
- Cervical Spinal Cord Injury, Spine Injury, Spinal Cord Trauma
- Trial name
- NCT02302157
- Testing
- AST-OPC1
- Where
- 9 sites in United States
- Volunteers
- 25 people
- Sponsor
- Lineage Cell Therapeutics, Inc.
Progressive Supranuclear Palsy (PSP)
An Extension Study of ABBV-8E12 in Progressive Supranuclear Palsy (PSP)
The purpose of this study was to assess the long-term safety and efficacy of ABBV-8E12 (tilavonemab) in participants with progressive supranuclear palsy (PSP).
- Trial name
- NCT03391765
- Testing
- ABBV-8E12
- Where
- 42 sites in United States, Australia and 3 more
- Volunteers
- 142 people
- Sponsor
- AbbVie
Pain, Low Back Pain
Longterm Safety Study of BEMA Buprenorphine in Subjects With Chronic Pain
The purpose of this study is to determine whether BEMA Buprenorphine is safe in the treatment of chronic pain.
- Conditions
- Pain, Low Back Pain, Osteoarthritis, Neuropathic Pain
- Trial name
- NCT01298765
- Testing
- BEMA Buprenorphine
- Where
- 26 sites in United States
- Volunteers
- 302 people
- Sponsor
- BioDelivery Sciences International
Ischemic Stroke, Intracranial Hematoma
Investigation of Clot in Ischemic Stroke and Hematoma Evacuation
The aim of the study is to collect and analyze specimen from ischemic stroke patients undergoing thrombectomy procedures and from patients undergoing minimally invasive surgery for intracranial hematoma evacuation.
- Trial name
- INSIGHT (NCT04693767)
- Testing
- Mechanical thrombectomy, Minimally invasive surgery
- Where
- 27 sites in United States
- Volunteers
- 400 people
- Sponsor
- Penumbra Inc.
Brain and Central Nervous System Tumors
Bevacizumab in Treating Patients With Recurrent or Progressive Glioma
RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- NCT00337207
- Testing
- bevacizumab
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- Northwestern University
Parkinson Disease
a PMS on Safety Profile of Pramipexole in Chinese Parkinson Disease Patients
This is an open-label, multicenter, non-interventional, prospective observational study. we collect the safety information of pramipexole over 12w treatment.
- Trial name
- NCT01361009
- Testing
- pramipexole
- Where
- 103 sites in China
- Volunteers
- 2,017 people
- Sponsor
- Boehringer Ingelheim
Huntington's Disease
Examination of Quantitative Electroencephalographic (QEEG) Biomarkers in Huntington's Disease
The pace of basic science research defining the mechanisms of selective neuronal degeneration in Huntington disease (HD) has far exceeded the pace of translation of this information into clinically effective treatments for the…
- Trial name
- HD (NCT00670709)
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Hearing Loss, Sensorineural
Evaluation of Speech-in-noise Performance in Cochlear Implant Recipients With a CROS Device on the Contralateral Ear
Speech understanding in noise remains the greatest challenge for people using cochlear implants, particularly when the speech of interest comes from the side of the head opposite to the implant.
- Trial name
- NCT03867396
- Testing
- CROS, Hearing Aid, Cochlear Implant Alone
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Colorado, Denver
Normal Tension Glaucoma
Systemic Glutathione Level in Normal Tension Glaucoma
The purpose of this study is to evaluate whether systemic glutathione level is decreased in patients with normal tension glaucoma.
- Trial name
- NCT00570362
- Where
- South Korea
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Agitation, Dementia
Dexmedetomidine in the Treatment of Agitation Associated With Dementia (TRANQUILITY III)
A study to determine the safety and efficacy of BXCL501 dosing for episodes of agitation associated with dementia when they occur (given as needed [PRN]), for a maximum of 168 doses within a 12-week treatment period.
- Trial name
- NCT05665088
- Testing
- BXCL501
- Where
- 7 sites in United States
- Volunteers
- 13 people
- Sponsor
- BioXcel Therapeutics Inc
Chronic Obstructive Pulmonary Disease (COPD)
Efficacy and Safety Study of Tesamorelin in Chronic Obstructive Pulmonary Disease (COPD) Subjects With Muscle Wasting
A significant proportion of COPD subjects experience muscle wasting, which has been associated with increased morbidity, impaired physical functioning, and a poor quality of life.
- Trial name
- NCT01388920
- Testing
- Tesamorelin
- Volunteers
- 3 people
- Sponsor
- Theratechnologies
Neuralgia, Postherpetic
A Clinical Study in Subjects With Neuropathic Pain From PHN Who Have Had an Inadequate Response to Gabapentin Treatment
The purpose of this study is evaluate the difference between two doses of gabapentin enacarbil (XP13512/GSK1838262), hereafter referred to as GEn, on pain associated with post-herpetic neuralgia.
- Trial name
- NCT00617461
- Testing
- GEn 1200mg/day, GEn 3600mg/day
- Where
- 53 sites in United States, Germany
- Volunteers
- 96 people
- Sponsor
- XenoPort, Inc.
Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis Registry Rhineland-Palatinate
There is a lack of prospective and population-based epidemiological data on amyotrophic lateral sclerosis in Germany so far. The purpose of this registry is to investigate the incidence, course and phenotypic variety of ALS in…
- Trial name
- NCT01955369
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Klinikum Ludwigshafen
Stroke
Thrombolysis in Pediatric Stroke (TIPS)
Thrombolysis in Pediatric Stroke (TIPS) is a five-year multi-center international safety and dose-finding study of intravenous (IV) tPA in children with acute ischemic stroke (AIS) to determine the maximal safe dose of…
- Trial name
- TIPS (NCT01591096)
- Testing
- Tissue plasminogen activator (Activase®)
- Where
- 15 sites in United States, Canada
- Volunteers
- 1 people
- Sponsor
- Seattle Children's Hospital
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