Clinical trials: Nervous System Disorders
Late Onset Alzheimer Disease
Response to Donepezil, Drug Plasma Concentration and the CYP2D6 and APOE Genetic Polymorphisms
Pharmacological treatment of AD is currently based on cholinesterase inhibitors (ChEI) and memantine, which have been shown to lead to modest, although effective, clinical benefits.
- Trial name
- NCT03349320
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Breast Neoplasm Female, Symptom Cluster
Effects of a Traditional Chinese Exercise Program on Symptom Cluster in Breast Cancer Patients
The Medical Research Council Framework for Developing and Evaluating Complex Interventions (MRC Framework) will be utilized to develop and evaluate an evidence-based tai chi intervention for managing the symptom cluster of…
- Conditions
- Breast Neoplasm Female, Symptom Cluster, Tai ji
- Trial name
- NCT04190342
- Testing
- control group, tai chi group
- Where
- 2 sites in China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Charles Darwin University
Healthy Participants, Anxiety Disorders (With High Anxiety Symptoms)
tVNS and Approach-Avoidance Behavior in Anhedonia and Anxiety
This study investigates if anhedonia and anxiety symptoms are associated with alterations in reinforcement learning, effort trade-offs for wins vs. punishments, and foraging behavior under threat.
- Conditions
- Healthy Participants, Anxiety Disorders (With High Anxiety Symptoms), Depressive Disorders (With High Anhedonia Symptoms), Comorbid Depression and Anxiety Disorder (With High Anhedonia and High Anxiety Symptoms)
- Trial name
- NCT07476469
- Testing
- tVNS
- Where
- Germany
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Dr. Nils B. Kroemer
Insomnia
Noradrenergic Dysregulation, Sleep and Cognition in Older Adults With Insomnia
This study investigates the relationship between the noradrenergic (NA) system, sleep quality, and cognitive function in older adults with insomnia - a population at elevated risk for Alzheimer's disease-related dementias (ADRD)…
- Trial name
- NASC (NCT06694441)
- Testing
- Light Exposure
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Taste, Altered
Fatty Acid Taste Rating With or Without Sour Taste Adaptation
We are trying to figure out whether the fatty acid taste is differentiated from sour taste.
- Trial name
- NCT04248374
- Testing
- Taste Intensity
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Purdue University
Epilepsy, Temporal Lobe, Temporal Lobe
Light Scattering Spectroscopy to Determine Brain Tumors
This study will use light scattering spectroscopy (LSS) to analyze brain tissue removed from patients during brain surgery to determine if this new technology can be used to differentiate between normal and cancerous cells.
- Trial name
- NCT00067418
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Neurologic Deficits
NeuroVision vs Standard Neuromonitoring
The purpose of this study is to perform a prospective, randomized, controlled clinical trial to assess the utility of IONM in patients undergoing primary, single or multilevel lateral spinal procedures.
- Trial name
- NCT04639297
- Testing
- NeuroVision® IONM, Hospital Based IONM
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Stroke, Ischemic, Healthy
Stochastic Resonance Stimulation in Brain Plasticity and Post Stroke Motor Recovery
This study evaluates the effectiveness of stochastic resonance electric stimulation on neuromuscular control and proprioception in healthy and individuals with stroke.
- Trial name
- NCT03839810
- Testing
- stochastic resonance electrical stimulation
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Obstructive Sleep Apnea
Cardiovascular Impact of Obstructive Sleep Apnea Treatment in Normotensive Patients
Recent evidences suggest that obstructive sleep apnea (OSA) can contribute to cardiovascular disease even in the absence of hypertension.
- Trial name
- OSA-NORMO (NCT00741520)
- Testing
- CPAP
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Chronic Insomnia, Sleepiness
Sleep Time and Insomnia Factors Among Professional Flight Members
Sleep is a physiological function that plays an essential role in many somatic, cognitive or psychological processes. Although the criteria for sleep effectiveness are multiple, its quantity is unanimously recognized as a major…
- Trial name
- SOMNAVI (NCT04761796)
- Testing
- Sleeping condition self-questionnaire
- Where
- France
- Volunteers
- 2,700 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Brain Ischemia
Cerebral Perfusion Associated With Postural Changes: an ASL MR Perfusion Study
Postural changes are commonly used as therapeutic maneuver to enhance or reduce cerebral perfusion. For instance, in acute stroke, the patient can be positioned in head down tilt position so as to increase perfusion of cerebral…
- Trial name
- PerfIRMAVC (NCT02912546)
- Testing
- MRI
- Where
- Martinique
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University Hospital Center of Martinique
Frontotemporal Lobar Degeneration, Alzheimer Disease
PET Imaging Tau Accumulation in FTLD and Atypical Alzheimer's Using [18F]-PI-2620
The investigators will compare [18F]-PI-2620 tau PET scans from patients with frontotemporal lobar degeneration (FTLD), patients with non-amnestic presentations of Alzheimer's disease (naAD), and demographically matched…
- Conditions
- Frontotemporal Lobar Degeneration, Alzheimer Disease, Cognitively Normal
- Trial name
- NCT05456503
- Testing
- [18F]-PI-2620
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Amyotrophic Lateral Sclerosis
Optic Coherence Tomography in Patients With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis (ALS) is an adult-onset, devastating, neurodegenerative disease characterized by the loss of cortical, brain stem, and spinal motor neurons.
- Trial name
- NCT03377868
- Testing
- Optic coherence tomography, Pulmonary function test
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Stroke, Spasticity
Effects of Low-level Laser Therapy on Spasticity and Gait Parameters in Chronic Stroke Patients With Spastic Plantar Flexors
Stroke is one of the leading causes of long-term disability worldwide. Many patients who survive a stroke experience muscle stiffness (called spasticity), especially in the ankle and foot muscles, which makes walking difficult…
- Conditions
- Stroke, Spasticity, Plantar Flexors
- Trial name
- LLLT-STROKE (NCT07273591)
- Testing
- Low Level Laser Therapy, conventional physical therapy
- Where
- Pakistan
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Montiha Azeem
Intensive Care Unit Syndrome, Muscle Weakness
Inspiratory Muscle Training and Expiratory Muscle Thickness
the specific effect of IMT on expiratory muscle strength and abdominal wall thickness during weaning remains unclear. To address this significant research gap, the primary objective of our study was to evaluate the effect of IMT…
- Conditions
- Intensive Care Unit Syndrome, Muscle Weakness, Rehabilitation
- Trial name
- NCT06251791
- Testing
- conventional physiotherapy+ IMT, conventional physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Demiroglu Bilim University
Multiple Sclerosis, Stroke
A Comprehensive Assessment of Trunk, Scapula and Upper Limb in Neurological Patients. Reliability, Validity and Interrelatedness
The study aimed to provide insights in the coordination between trunk, shoulder and upper limb while reaching. Two main phases are present in this study: In phase A: the psychometric properties of two tests: Clinical Scapular…
- Trial name
- NCT04908891
- Testing
- Clinical Scapular protocol (ClinScaP), the prevalence of trunk, scapula and upper limb impairments., the interaction between trunk, scapula and upper limb impairments.
- Where
- 4 sites in Belgium
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Dementia
Dementia Communication Training Program for Novice Home Care Workers
This study aims to evaluate the effects of a dementia communication training program using a real-time interactive virtual trainer among novice home care workers.
- Trial name
- NCT07244497
- Testing
- virtual trainer-based dementia communication training, scenario-based discussions dementia communication training
- Where
- Taiwan
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Tzu Chi University
Depression Disorder, Anxiety
Impact of Nut Consumption on Mental Health in Young Adults
Nuts have a high nutrient density, and numerous studies have reported their cardiometabolic benefits. Although observational studies in adults have indicated a potential link between nut consumption and improved mental health…
- Conditions
- Depression Disorder, Anxiety, Mental Health, Stress
- Trial name
- NUTS4BRAIN-RCT (NCT07292610)
- Testing
- mixed nuts. Group A, mixed nuts. Group B, control group
- Where
- Spain
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Obstructive Sleep Apnea Syndrome
Study of Ocular Blood Flow in Patients With Glaucoma and/or Obstructive Sleep Apnea Syndrome (OSAS)
Obstructive sleep apnea syndrome (OSAS) is a common disease, with a prevalence evaluated between 5 - 7% in the general population.
- Trial name
- NCT00874913
- Testing
- measurement of ocular blood flow
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Delirium
Psychosocial Nursing Interventions on Sleep, Anxiety and Delirium in Patients Undergoing Open Heart Surgery
The goal of this study is to determine the effects of psychosocial nursing interventions applied to a patient with cardiac surgery on sleep quality, anxiety and delirium.
- Trial name
- NCT05864482
- Testing
- Psychosocial nursing intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mersin University
The first 5,000 results can be paged through. Add a filter or change the sort order to reach the rest.