Clinical trials: Nervous System Disorders
Primary Insomnia
Sleep Homeostasis in Primary Insomnia
About 10% of the population is believed to suffer from Primary Insomnia. It is also believed that people with chronic insomnia have a sleep system that is essentially out of alignment (we call this "homeostatic dysregulation").
- Trial name
- NCT00256503
- Testing
- Cognitive-Behavioral Therapy for Insomnia
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Poliomyelitis, Tetanus
Immunogenicity and Safety Study in Infants of GlaxoSmithKline Biologicals' Infanrix Hexa™ (DTPa-HBV-IPV/Hib) Vaccine
This study evaluates the immunogenicity and safety of Infanrix hexa™ (DTPa-HBV-IPV/Hib) when administered as a primary vaccination course to Indian infants according to a 6-10-14 weeks or a 2-4-6 months schedule.
- Conditions
- Poliomyelitis, Tetanus, Acellular Pertussis, Haemophilus Influenzae Type b
- Trial name
- NCT01353703
- Testing
- Infanrix hexa™
- Where
- 4 sites in India
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pain, Inflammation
Hyperbaric Oxygen Therapy Attenuates Central Sensitization Induced by a Thermal Injury in Human Volunteers (HBO)
The hypothesis of this investigation is to observe if HBO have an anti-inflammatory effect in humans induced by tonic heat stimulation.
- Conditions
- Pain, Inflammation, Hyperalgesia
- Trial name
- NCT02025686
- Testing
- Hyperbaric Oxygen, Normal ambient conditions
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Per Rotbøll Nielsen
Hypersomnia in Children
Amylase and Hypersomnia
Hypersomnia is defined as a reduced ability to remain awake during the day. There are basically two types of central hypersomnia: narcolepsy and idiopathic hypersomnia.
- Trial name
- Amylase (NCT01926405)
- Testing
- saliva collection
- Where
- France
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Irreversible Pulpitis, Tooth Extraction
Efficacy of Computer Controlled Intraosseous Anesthesia in Pediatric Dental Patients
To evaluate the effectiveness of intra-osseous anesthesia using Quicksleepr5 in pain elimination during dental treatment in maxillary and mandibular primary molars, compared to conventional anesthesia.
- Trial name
- NCT06245161
- Testing
- Quicksleeper5, conventional anesthesia
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Traumatic Brain Injury, Depression
A Trial of Two On-Line Interventions for Child Brain Injury
The primary aims of this project are to examine the feasibility and relative efficacy of two models of on-line intervention for families of children with traumatic brain injury: one, a model emphasizing cognitive appraisals and…
- Conditions
- Traumatic Brain Injury, Depression, Anxiety Disorders
- Trial name
- NCT00178022
- Testing
- Case management and problem solving therapy
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Epilepsy
Precision Medicine in the Treatment of Epilepsy
Primary objectives: The purpose of this study is to identify single and composite biomarkers (from neuroimaging, electrophysiological, and non-imaging biological measures), clinical measures (from cognitive, psychometric, and…
- Trial name
- BDE (NCT05450822)
- Testing
- Levetiracetam, Levetiracetam Tablets, Lamotrigine tablet
- Where
- Denmark
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Gitte Moos Knudsen
Bipolar Disorder, Mania
Virtual Darkness as Additive Treatment in Mania
In this randomized controlled study we will investigate the effect of blue-blocking goggles or screens (virtual darkness therapy) on manic symptoms in bipolar disorder compared to placebo.
- Trial name
- VATMAN (NCT01818622)
- Testing
- Blue-blocking goggles/screens, Clear-lensed goggles
- Where
- 2 sites in Norway
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Helse Fonna
Fibromyalgia
Effectiveness of Pain Neuroscience Education and Strength Training in Fibromyalgia
The main goal of this study is to get to know if applying both, pain neuroscience education (PNE) plus strength training (ST) will reduce the pain of fibromyalgia (FM).
- Trial name
- PNE-ST-FM (NCT04855851)
- Testing
- PAIN NEUROSCIENCE EDUCATION AND STRENGTH TRAINING, USUAL CARE
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Manuel Rebollo Salas
Alzheimer Disease, Mild Cognitive Impairment
Evaluation of a Computerized Complex Instrumental Activities of Daily Living Marker (NMI)
The proposed study is designed to evaluate the performance of the ALTOIDA™ System as a tool to assist physicians in diagnosing Alzheimer's Disease (AD) in real-world clinical settings.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Memory Disorders, Cognitive Impairment
- Trial name
- AltoidaML (NCT02843529)
- Testing
- Altoida: neuropsychological, MRI, EEG and CSF biomarkers
- Volunteers
- 548 people, healthy volunteers welcome
- Sponsor
- Altoida
Muscle Loss
The Viscoelastic Properties of Lower Extremity's Muscles
This study aims to create normative values for stiffness, tonus and elasticity in the lower extremity muscles and to determine age and gender differences.
- Trial name
- NCT04289129
- Testing
- Myotonometric evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 389 people, healthy volunteers welcome
- Sponsor
- Hasan Kalyoncu University
Multiple Sclerosis, Relapsing-Remitting, Healthy Controls
The Relationships Between Personal Identity, Autobiographical Memory and Future Thinking in People With Multiple Sclerosis
Personal identity is composed of multiple facets of the self that are constructed and nourished through memories of past experiences (i.e., autobiographical memory) and the imagination of events that may occur in the future…
- Trial name
- SELFSEP (NCT05648292)
- Testing
- Neuropsychological tests and psychological questionnaires
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Parkinson Disease, Sleep
Quantitation of Glymphatic Functioning in Sleep and Meditative States
This involves development and application of magnetic resonance imaging (MRI) methods for visualizing hemodynamic and metabolic relationships in healthy volunteers with advanced meditation experience.
- Trial name
- NCT04506892
- Testing
- Meditation
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Spinal Cord Injury + Peripheral Nerve Diseases
Assessment of Neuropathic Pain
Development of neuropathic pain is one of the most disabling sequels after spinal cord injury (SCI) and in peripheral nerve diseases.
- Trial name
- NCT02138344
- Where
- Switzerland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Sleep-Disordered Breathing
HighCycle Study: Effect of High Altitude on Sleep Disordered Breathing in Women Related to Their Menstrual Cycle Phase
Prospective cohort study investigating the menstrual cycle phase (MCP) dependent sleep disordered breathing (SDB) in women travelling to 3600 m.
- Trial name
- NCT06498544
- Testing
- Exposure to 3600 m
- Where
- Kyrgyzstan
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Dementia, Dementia Alzheimers
A Spanish-language Caregiver-Enabled Care Program
The purpose of the study is to develop and test the feasibility of a nonmedical digital health intervention, the Spanish-language Caregiver-Enabled Care Program (CECP), with Spanish-speaking caregivers of persons with dementia…
- Conditions
- Dementia, Dementia Alzheimers, Alzheimer Disease, Caregiver
- Trial name
- CECP (NCT06631144)
- Testing
- Spanish-language Caregiver-Enabled Care Program (CECP)
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Ceresti Health, Inc.
Dystonia, Cerebral Palsy
Studying Childhood-Onset Hemidystonia
Background: Childhood-onset dystonia is caused by a brain injury. It causes muscle contractions and twisting movements that the person with dystonia cannot control.
- Trial name
- NCT01432899
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Gait Disorders, Neurologic, Gait Disorder, Sensorimotor
Gait Adaptability: Tracking Locomotor Recovery After Incomplete Spinal Cord Injury
Adaptive gait assessements will be evaluated as a potential new marker for tracking locomotor recovery throughout rehabilitation of spinal cord injury subjects.
- Trial name
- NCT03343132
- Testing
- Standard locomotor therapy
- Where
- Switzerland
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Spinal Cord Injuries
Effects of Caffeine and Intermittent Hypoxia on Leg Function in Human Spinal Cord Injury
Accumulating evidence suggests that repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) is a safe and effective treatment strategy to promote meaningful functional recovery in persons with…
- Trial name
- NCT02323698
- Testing
- Caffeine, AIH
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Stroke
Development of a Genomics-based Multimodal Prediction Model for Post-stroke Vascular Dementia
To collect large-scale multimodal data, including genomic information, neuroimaging, neurophysiological measures, cognitive assessments, and clinical characteristics from stroke survivors and healthy controls.
- Trial name
- NCT07660263
- Where
- South Korea
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Seyoung Shin
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