Clinical trials: Nervous System Disorders
Poliomyelitis, Tropical Enteropathy
Exploration of the Biologic Basis for Underperformance of Oral Polio and Rotavirus Vaccines in INDIA (PROVIDE)
Oral polio and rotavirus vaccines are significantly less effective in children living in the developing world. Tropical enteropathy, which is associated with intestinal inflammation, decreased absorption and increased…
- Trial name
- NCT01571505
- Testing
- IPV vaccination
- Where
- India
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
Hearing Loss, Hearing Loss, Sensorineural
Direct-to-Consumer Hearing Aids and Listening Effort
The aim of this proposed project is to understand whether direct to consumer (DTC) hearing aids programmed to individual hearing losses, can reduce listening effort for effective communication.
- Conditions
- Hearing Loss, Hearing Loss, Sensorineural, Hearing Loss, Bilateral
- Trial name
- NCT05855005
- Testing
- DTC Hearing Aids
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Stroke, Split-belt Treadmill
Optimizing Gait Symmetry After Stroke Using Mechanical Constraints and Sensory Feedback
This single-session study aims to evaluate a novel gait training protocol that integrates mechanical constraints and sensory feedback to enhance paretic leg propulsion in individuals post-stroke.
- Conditions
- Stroke, Split-belt Treadmill, Resistance Exercise, Feedback
- Trial name
- NCT07087769
- Testing
- Treadmill Walking with Split-Belt and/or Tied-Belt Conditions, Mechanical Resistance (Pelvis and/or Ankle) depending on participant's walking capacity, Sensory Feedback Training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Postcancer Fatigue, Chronic Fatigue Syndrome
Humoral and Cellular Immune Responses After Influenza Vaccination in Patients With Postcancer Fatigue and in Patients With Chronic Fatigue Syndrome
Postcancer fatigue (PCF) is a frequently occurring, severe and invalidating problem, impairing quality of life. Patients with chronic fatigue syndrome (CFS) also suffer from severe fatigue symptoms.
- Trial name
- NCT01651754
- Testing
- Seasonal influenza vaccination
- Where
- Netherlands
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Sarcopenia
Cut-off Values of Muscle Thickness Ratio for Sarcopenia
The loss of muscle mass is one of the major diagnostic criteria for sarcopenia. Many methods are also used for the definition of sarcopenia. However there is no information about cut-off values in this respect in the literature.
- Trial name
- NCT03993405
- Testing
- Ultrasonographic evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Anhedonia
TMS Alteration of the Reward Positivity
The aim of this proposal is to demonstrate that stimulation of different brain regions differently affects the electroencephalographic feature known as the Reward Positivity (RewP).
- Trial name
- NCT05443256
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Hearing Loss, Well Aging
Development of Physical Activity Features for Ear-worn Devices
This study incorporates data collection to aid in development of software features related to physical activity for users of ear-worn devices.
- Trial name
- NCT05350046
- Testing
- Ear-worn prototype devices
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- 57GGardner
Carpal Tunnel Syndrome, Carpal Tunnel Syndrome Bilateral
Comparison of Interventions in Patients With Carpal Tunnel Syndrome
This study aims to compare two types of intervention (stretching and myofascial manipulation) in the treatment of individuals with bilateral idiopathic carpal tunnel syndrome.
- Trial name
- NCT04347746
- Testing
- stretching physiotherapy, Myofascial therapy
- Where
- Brazil
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Universidade Norte do Paraná
Anxiety
The Effects of Vibration and Pressure Interventions
This study aimed to evaluate two methods (pressure and vibration intervention) used to reduce pain during IM injections in children.
- Trial name
- NCT05656066
- Testing
- The Vibration Intervention, The Pressure Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Stroke
Towards Understanding Upper Limb Rehabilitation After Stroke
After a stroke, more than two out of three patients experience problems with upper limb movement and sensation. During the past decade, robotic technology has been increasingly used to asses these problems in a detailed and…
- Trial name
- NCT04721561
- Where
- Belgium
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Disc Herniation
The Effect of White Noise in Patients Undergoing Lumbar Disc Herniation Surgery
The aim of this clinical trial is to determine the effectiveness of listening to white noise on the sleep quality, comfort level, satisfaction level of patients after lumbar disc herniation surgery.
- Trial name
- NCT05687305
- Testing
- White Noise
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Individuals Aged 60 and Over, Individuals Who Are Physically and Mentally Suitable to Practice Pranayama Breathing Technique
Effects of Pranayama Breathing Technique on Stress Level, Sleep Quality, and Quality of Life Among Older Adults
Aging is associated with progressive tissue deterioration resulting from a continuous decline in the ability to renew homeostatic cell regeneration and replace cells lost during tissue damage.
- Conditions
- Individuals Aged 60 and Over, Individuals Who Are Physically and Mentally Suitable to Practice Pranayama Breathing Technique, Individuals Without a Malignant Respiratory System Disease (Such as Bronchial and Lung Cancer), Individuals Without a Pathological Condition Affecting Their Level of Consciousness and Concentration
- Trial name
- NCT07451756
- Testing
- Pranayama group
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Namik Kemal University
Insomnia
Noradrenergic Dysregulation, Sleep and Cognition in Older Adults With Insomnia
This study investigates the relationship between the noradrenergic (NA) system, sleep quality, and cognitive function in older adults with insomnia - a population at elevated risk for Alzheimer's disease-related dementias (ADRD)…
- Trial name
- NASC (NCT06694441)
- Testing
- Light Exposure
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Encephalitis, Encephalitis, Viral
Venezuelan Equine Encephalitis Monovalent Virus-Like Particle Vaccine
The primary objective of the study is to evaluate the safety and immunogenicity of non-adjuvanted and adjuvanted monovalent VEE VLP Vaccine in healthy adults (ages 18-50 years) when administered via intramuscular (IM) injection…
- Conditions
- Encephalitis, Encephalitis, Viral, Infectious Encephalitis, Virus Diseases
- Trial name
- VEEV (NCT03776994)
- Testing
- Vaccinations on Day 0, Day 28, and Day 140
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- SRI International
Migraine With Aura
Efficacy of Sumatriptan With Naprosyn in Migraine With Aura
This is a double-blinded placebo study, examining the efficacy of Sumatriptan with Naprosyn in the treatment of migraine with aura.
- Trial name
- NCT00893594
- Testing
- sumatriptan with naprosyn
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dent Neurologic Institute
Parkinson Disease
Effect of BIA 6-512 at Steady-state on the Levodopa Pharmacokinetics
The purpose of the study was to To investigate whether the administration of BIA 6-512 (25 mg, 50 mg, 75 mg and 100 mg) at steady-state affects the pharmacokinetics of levodopa when administered in combination with a single-dose…
- Trial name
- NCT03094156
- Testing
- BIA 6-512, Madopar® 250, Comtan®
- Where
- Portugal
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Hypertrophy, Exercise Training
Resistance Training, Detraining, and Retraining Study 2024 (TraDeRe2024)
The goals of our research project are to identify factors explaining inter-individual variation in responses to resistance training (RT) and the baseline determinants underlying an individual's sensitivity to respond to RT.
- Conditions
- Hypertrophy, Exercise Training, Skeletal Muscle Atrophy, Healthy
- Trial name
- TraDeRe (NCT06573086)
- Testing
- Resistance Training
- Where
- Finland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Jyvaskyla
Obstructive Sleep Apnea
Effects of Continuous Positive Airway Pressure (CPAP) in Heart Remodeling by Magnetic Resonance Imaging (MRI)
Obstructive sleep apnea (OSA) is independently associated with important heart remodeling that further contributes to overt heart failure.
- Trial name
- OSA-MRI (NCT00727454)
- Testing
- CPAP, No treatment
- Where
- 2 sites in Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Refractive Error - Myopia Axial, Astigmatism
Refractive Accuracy of "2WIN" and Portable Autorefractors
Youth and some adults have photoscreening refractions and hand-held auto refraction before cycloplegia refraction during new and follow up eye examinations.
- Conditions
- Refractive Error - Myopia Axial, Astigmatism, Accomodation, Visual Impairment
- Trial name
- NCT04249505
- Testing
- "2WIN" Photoscreener, "Plusoptix A12", "Retinomax"
- Where
- United States
- Volunteers
- 708 people, healthy volunteers welcome
- Sponsor
- Alaska Blind Child Discovery
Reading Disability
Noninvasive Brain Stimulation to Enhance Reading Comprehension Ability in Adults
The goal of this project is to address the urgent need for effective, scalable adult literacy interventions by integrating breakthroughs in two separate fields: 1.) the brain network science of resilience to reading disorders and…
- Trial name
- NCT05523505
- Testing
- RLN real non-invasive brain stimulation intervention, RLN and CCN real non-invasive brain stimulation intervention
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
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