Clinical trials: Nervous System Disorders
Postoperative Pain Management, Postoperative Pain
Comparative Efficacy of Sciatic and Femoral Blocks in Ankle Surgery
Comparison of Anesthetic and Postoperative Analgesic Efficacy of Femoral and Popliteal Sciatic Block vs Femoral and Anterior Sciatic Block in Ankle Surgery
- Conditions
- Postoperative Pain Management, Postoperative Pain, Analgesia, Nerve Blocks
- Trial name
- NCT06758245
- Testing
- femoral and anterior sciatic nerve block, femoral and popliteal sciatic nerve block
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Alzheimer's Disease, Dementia
A Study to Evaluate the Effects of MK-0249 and an Alzheimer's Disease Medication on Cognitive Function in Adults With Alzheimer's Disease (MK-0249-023)
This study will evaluate acute symptomatic improvements in cognitive performance in healthy elderly participants with mild-to-moderate Alzheimer's disease.
- Trial name
- NCT00874939
- Testing
- MK-0249 7.5 mg, MK-0249 25 mg, Donepezil 5mg
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Effectiveness of Application Education Intervention, Noise Induced Hearing Loss
Prevention of Noise-Induced Hearing Loss in Primary Education
The goal of this randomized controlled trial is to evaluate the effectiveness of the educational program the HoorToren in promoting recreational safe listening behavior among Dutch primary school children in group 7 (aged 10-11…
- Conditions
- Effectiveness of Application Education Intervention, Noise Induced Hearing Loss, Behavior Change Interventions, Primary School Children
- Trial name
- NCT07513077
- Testing
- HoorToren educational package
- Where
- Netherlands
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Meningomyelocele
Dual Task and Upper Extremity Performance in Children With Myelomeningocele
Myelomeningocele is a neural tube defect caused by the failure of the neural tube to close in the caudal part. The exposed spinal cord in myelomeningocele usually causes neural damage.
- Trial name
- NCT06949475
- Testing
- Single Task (Box and Block Test), Single Task (Nine Hole Peg Test), Dual Task (Box and Block Test-Kognitif Task)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Vision, Low, Blindness
Validation of Texture Changing Coatings for Use in At-Home Rapid Tests
At-home testing is an important part of mitigating the spread of COVID-19, but these tests are not accessible to people with low vision or blindness.
- Trial name
- NCT06539728
- Testing
- Interaction with Mock COVID-19 Rapid Antigen Test and Reference Surfaces, Biomechanical Measurements, Psychophysical Tasks
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Parkinson Disease
LRRK2 Activity and Markers of Parkinson's Disease in G2385R Carriers
The goals of this study are 1. To compare the functional effects of the LRRK2 G2385R variant among carriers with and without Parkinson's disease (PD) and non-carriers with and without PD 2.
- Trial name
- NCT04349865
- Where
- China
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Stroke, Acute
F.A.S.T.-BE FAST Stroke Warning Signs Study
The goal of this randomized controlled trial is to learn whether the BE FAST (Balance, Eyes, Face, Arm, Speech, and Time) acronym works at least as well or better than the F.A.S.T.
- Trial name
- NCT06483165
- Testing
- BE FAST Educational video, F.A.S.T. Educational Video
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- American Heart Association
Down Syndrome
Motor Learning Through Virtual Reality Task in Individuals With Down Syndrome
Background: Down syndrome (DS) has unique physical, motor and cognitive characteristics. Despite cognitive and motor difficulties, there is a possibility of intervention based on the knowledge of motor learning.
- Trial name
- NCT02719600
- Testing
- Virtual reality
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Sensory Disorders
Sensory Effects of Rapidly-Changing Magnetic Fields
This study is being conducted to improve magnetic resonance imaging (MRI) scans by reducing the time required for imaging. Experience has shown that unpleasant side-effects from magnetic pulses used in MRI (for example, tingling…
- Trial name
- NCT01632800
- Testing
- High pulsed magnetic fields
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Weinberg Medical Physics LLC
Sleep Deprivation
Feasibility, Acceptability and Effectiveness of the SOmNI Mobile Phone App for Sleep Promotion in Adolescents
This study evaluates the acceptability, feasibility, and efficacy of an intervention using wearable sensors and a mHealth application, SOmNI, to promote sleep for adolescents.
- Trial name
- SOmNI (NCT04089007)
- Testing
- SOmNI app, Control group
- Where
- Canada
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Analgesia , Open Renal Surgeries
External Oblique Intercostal Block vs Subcostal Transversus Abdominis Plane Block in Open Nephrectomy
The aim of the study is to compare the analgesic efficacy of external oblique intercostal block vs subcostal transversus abdominis plane block in patients undergoing open nephrectomy.
- Trial name
- NCT06778707
- Testing
- External Oblique Intercostal Block, Subcostal Transversus Abdominis Plane Block
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tanta University
Magnesium Deficiency
One Week of Magnesium Supplementation Lowers IL-6, Perceived Pain and Increases Post Exercise Blood Glucose in Response to Downhill Running
This study investigated the effect of magnesium supplementation on exercise performance and functional recovery in recreational endurance athletes in conjunction with measures of blood glucose, lactate, IL-6 and sIL-6R.
- Trial name
- NCT04216836
- Testing
- Magnesium oxide
- Where
- United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Worcester
Meningococcal Disease, Meningitis
Study of Sanofi Pasteur and Lanzhou Institute's Meningococcal (Group A and C) Polysaccharide Vaccine in Children
This study is part of the post-licensure commitment to evaluate the safety and immunogenicity of Meningo A+C vaccine in healthy Chinese children 2 to 6 years of age.
- Trial name
- NCT01430611
- Testing
- Meningococcal (Groups A and C) Polysaccharide Vaccine
- Where
- 2 sites in China
- Volunteers
- 666 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Neurosyphilis, Biomarkers
Cohort-Based Study of Diagnostic Biomarkers for Neurosyphilis
The goal of this observational study is to identify diagnostic biomarkers for neurosyphilis in patients with the condition. The main questions it aims to answer are: What plasma biomarkers are associated with neurosyphilis? What…
- Conditions
- Neurosyphilis, Biomarkers, Proteomics
- Trial name
- NCT06680011
- Where
- China
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Sarcopenia, High Blood Pressure
The Impact of a Resistance Training Intervention on Blood Pressure Control in Older Adults With Sarcopenia
Current prevention and treatment of high blood pressure (BP) in sarcopenia, by non-pharmacological approaches remain limited and are far from optimal.
- Conditions
- Sarcopenia, High Blood Pressure, Hypertension
- Trial name
- INERTIA (NCT04255745)
- Testing
- progressive resistance training
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Dementia, Senile, Family Members
Smart-Cloth Care System for Dementia
The purpose of this study is to develop and examine the preliminary effects of a smart cloth care system for facilitating family caregiving for persons with dementia in the home setting.
- Trial name
- NCT05063045
- Testing
- smart-cloth assisted home nursing care
- Where
- 2 sites in Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Diabetes Mellitus, Hypoglycemia
Mechanisms of Hypoglycemia Associated Autonomic Failure
Intensive glucose control in type 1 diabetes mellitus (T1DM) is associated with clear health benefits. However, despite development of insulin analogs, pump/multi-dose treatment and continuous glucose monitoring, maintaining…
- Conditions
- Diabetes Mellitus, Hypoglycemia, Autonomic Failure
- Trial name
- NCT00678145
- Testing
- naloxone, fructose, exercise
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Spina Bifida, Sensory Disorder
Sensory and Motor Proficiency For Children With Spina Bifida
Spina bifida is one of the neural tube defects that cause neuromuscular dysfunction. Spina bifida is a disease accompanied by motor paralysis, musculoskeletal problems, Arnold-Chiari malformation, osteoporosis, hydrocephalus…
- Conditions
- Spina Bifida, Sensory Disorder, Motor Disorders, Upper Extremity Dysfunction
- Trial name
- NCT05318677
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Sarcopenia
Evaluation of Sarcopenia in Women in Different Stages of Life and in Hormonal Therapy or Not
The three-year interventional study has the following objectives: The study aims to assess the prevalence of sarcopenia in menopausal women receiving hormone replacement therapy or not compared with pre-menopausal women.
- Trial name
- NCT06792201
- Testing
- SARC-F, Handgrip test, Chair stand test
- Where
- Italy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Brain Diseases
Exploratory Study Using a New Head-only PET Scanner / ExploreNeuroLF
The "NeuroLF prototype" is a small aperture PET scanner. The NeuroLF prototype will be used with patients, which have just finished their regularly scheduled PET examination on a clinical whole body PET system.
- Trial name
- NCT06344871
- Testing
- NeuroLF, Conventional PET scan
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Positrigo AG
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