Clinical trials: Nervous System Disorders
Hydroxymethylglutaryl-CoA Reductase Inhibitors, Myopathy
Muscle Characteristics Associated With Statin Therapy
The purpose of this study is to investigate the mechanism of statin-related myopathy by evaluating muscle samples before and after statin exposure.
- Trial name
- NCT00990834
- Testing
- simvastatin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Scripps Health
Meningitis
Immunogenicity and Safety of Meningococcal (A, C, Y and W135) Conjugate Vaccine
The purpose of this observer-blind study is to evaluate the safety, reactogenicity and immunogenicity of Meninggococcal (A,C,Y and W135) Conjugate Vaccine in 2 months to 6 years-old children.
- Trial name
- NCT02003495
- Testing
- MCV-ACYW135 Vaccine Group, MPV-ACYW135 Vaccine Group, MPV-A Vaccine Group
- Where
- China
- Volunteers
- 2,195 people, healthy volunteers welcome
- Sponsor
- Beijing Minhai Biotechnology Co., Ltd
Brain Injuries
Acceptance and Commitment Therapy (ACT) and Carers
Background: Research has extensively documented the adverse impact that caring for an individual with an acquired brain injury can have including financial difficulties, social isolation, family tension and conflict, relationship…
- Trial name
- NCT02584101
- Testing
- ACT, Enhanced Treatment as Usual
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Parkinson Disease
Quantitative Imaging of Brain Glymphatic Function in Humans
Recent immunological and physiological studies have provided evidence in support of a central nervous system (CNS) lymphatic drainage system in vertebrate animals, and preliminary evidence has suggested that a similar system…
- Trial name
- NCT04768101
- Testing
- [11C]-PIB
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Tinnitus
Internet-based Versus Face-to-face Clinical Care for Tinnitus
The purpose of this study is to compare the effectiveness of a CBT-based internet intervention with face to face standard clinical care for adults with tinnitus in the United Kingdom.
- Trial name
- NCT02665975
- Testing
- CBT-based internet-intervention for tinnitus, Face-to-face clinical tinnitus care
- Where
- 3 sites in United Kingdom
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Anglia Ruskin University
Fibromyalgia
FIbromyalgia anD GenetIcs Subgroups (FIDGIS)
Fibromyalgia syndrome (FS) is characterized by widespread pain and affect 0.5 to 5 % of the general population, with a higher prevalence in women.
- Trial name
- FIDGIS (NCT04624581)
- Testing
- Electrophysiological measurement of reflex nociceptive flexion threshold (RIII reflex) using Nicolet Vicking device
- Where
- France
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Hearing Loss
Early Age-Related Hearing Loss Investigation Pilot Study
The purpose of this clinical trial pilot is to obtain feasibility and pilot data necessary to inform the hearing intervention being designed for a larger R01 clinical trial that seeks to determine whether best practice hearing…
- Trial name
- P-EARLHI (NCT05970211)
- Testing
- Phonak Audeo Lumity Receiver in Canal Hearing Aid
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Alzheimer's Disease, Parkinson's Disease
Social Cognition and Personality Changes in Alzheimer's & Parkinson's Disease & Frontotemporal Lobar Degeneration
The aim of this study is to compare personality and social cognition changes, including emotion detection and self-awareness, and neuroanatomical correlates in patients, and how that affects the caregiver-patient relationship.
- Conditions
- Alzheimer's Disease, Parkinson's Disease, Frontotemporal Lobar Degeneration
- Trial name
- NCT02964611
- Testing
- Observational Study
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Alzheimers Disease
A Study of CNP520 Versus Placebo in Participants at Risk for the Onset of Clinical Symptoms of Alzheimer's Disease
The purpose of this study is to determine the effects of CNP520 on cognition, global clinical status, and underlying AD pathology, as well as the safety of CNP520, in people at risk for the onset of clinical symptoms of AD based…
- Trial name
- GS2 (NCT03131453)
- Testing
- CNP520 50mg, CNP520 15mg
- Where
- 194 sites in United States, Argentina and 23 more
- Volunteers
- 1,145 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Alzheimer Disease, PET/MR
Application of Multi-probe PET/MR Imaging in the Diagnosis and Evaluation of Alzheimer's Disease
Alzheimer's disease (AD) is the most common cause of cognitive impairment, and its diagnosis requires a comprehensive analysis of the results of medical history, neuropsychological evaluation, imaging and laboratory tests.
- Trial name
- NCT05003830
- Testing
- PET/MR
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Down Syndrome
Blood Flow in Individuals With Down Syndrome
This study focuses on physiological explanations of difficulties with physical activity and exercise in individuals with Down syndrome, by non-invasively examining cardiac output and the regulation of blood flow to working…
- Trial name
- NCT03590665
- Testing
- Hand grip exercise and lower body negative pressure
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Parkinson's Disease
Role of Dopamine on Loss Aversion Behaviour: Study on Parkinsonian Patients
Use lay language. Many decisions involve the possibility of gaining or losing relative to the status quo. The loss aversion behaviour is a cognitive concept explaining that people are more sensitive to the possibility of losing…
- Trial name
- NCT01780467
- Testing
- Role of dopamine
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Pain, Postoperative, Endodontically Treated Teeth
Post-Endodontic Instrumentation Pain After in a Single Session Associated With Photobiomodulation
The objective of this double-blind, randomized controlled clinical study will be to evaluate the effect f PBM on pain after endodontic instrumentation in the single-session treatment of upper molars and premolars.
- Trial name
- NCT06253767
- Testing
- Endodontic Treatment, Low Level Laser Therapy, Simulation Low Level Laser therapy
- Where
- Brazil
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Pain Management, Anesthesia , Analgesia
Comparison Between External Oblique Intercostal Plane Block and Rectus Sheath Block Combined With Transversus Abdominis Plane Block
Effective perioperative pain management remains a cornerstone in enhancing recovery and improving patient outcomes in laparoscopic cholecystectomy.
- Conditions
- Pain Management, Anesthesia , Analgesia, Nerve Block
- Trial name
- NCT07384000
- Testing
- External intercostal plane puncture, control group (nalbuphine), the single-puncture technique of (rectus sheath block) combined with (Transversus abdominis plane block)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Minia University
Loss of Smell, Olfactory Disorder
Olfactory Performance in Culinary Arts Students
The COVID-19 pandemic brought impaired smell and taste to the forefront of international public awareness and clinical importance.
- Trial name
- NCT06066307
- Testing
- Olfactory training
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Leigh Sowerby
Neuromuscular Diseases
Effects of Pre-event Massage Over the Neuromuscular Response
The study observes the effect of a pre-event massage on the gastrocnemius muscles over the neuromuscular response of the gastrocnemious muscles.
- Trial name
- NCT03941067
- Testing
- Pre-event massage
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Neurodegenerative Diseases, Dementia
Resource Use and Disease Course in Dementia (REDIC)
This project is based on a three-year program that aims to improve the knowledge of the socioeconomic consequences of dementia in Norway.
- Trial name
- REDIC (NCT01920100)
- Where
- 3 sites in Norway
- Volunteers
- 696 people, healthy volunteers welcome
- Sponsor
- Sykehuset Innlandet HF
Parkinson's Disease, Multiple System Atrophy
Increased Gut Permeability to Lipopolysaccharides (LPS) in Parkinson's Disease
The gut may be a portal of entry for agents that cause or contribute to the causes of Parkinson's disease (PD). The investigators are studying changes in the normal population of gut flora and in intestinal permeability and their…
- Trial name
- NCT01155492
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Learning Disability
Enhancing Self-Understanding and Social Integration of Middle School Students With Learning Disabilities
Research and intervention programs for students with learning disabilities (LD) typically address child and family characteristics without examining the school context and conditions that affect adjustment.
- Trial name
- NCT00246792
- Testing
- Group treatment
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Toronto
Spinal Cord Injuries, Dietary Habits
Assessing Dietary Requirements in Relation to Resting Metabolic Rate in Spinal Cord Injury
Assess the relationship between body composition, metabolism, and dietary needs in people with spinal cord injury compared to their healthy controls that are age and sex matched.
- Trial name
- NCT03518892
- Testing
- Resting Metabolic Rate, Body Composition, Dietary Assessment
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
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