Clinical trials: Nervous System Disorders
Parkinson Disease, Amyotrophic Lateral Sclerosis (ALS)
Discovery and Validation of Protein Structural Complexes in Circulating Biofluids As Novel Biomarkers for Early Diagnosis, Prognosis and Therapeutic Management of Patients Affected by Neurodegenerative Disorders
Neurodegenerative disorders (NDDs), such as Parkinson¿s disease (PD), Alzheimer¿s disease (AD), Frontotemporal dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are characterized by aggregation and intracellular accumulation…
- Conditions
- Parkinson Disease, Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), Alzheimer's Disease (AD)
- Trial name
- NCT06803784
- Testing
- Genetic: whole genome sequencing, whole exome sequencing
- Where
- Italy
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Nursing Care, Cold Application
Cold Spray for Pain and Ecchymosis After Anticoagulant Prophylaxis in Orthopedic Surgery
Heparin is a widely used anticoagulant for thrombosis prevention, and low molecular weight heparin (LMWH) has become the preferred option due to its higher bioavailability, strong antithrombotic effect, and lower risk of…
- Conditions
- Nursing Care, Cold Application, Pain, Ecchymosis
- Trial name
- NCT07195955
- Testing
- Cold Spray Application
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Mood Disturbance
Effect of Saffron Extract Supplementation on Emotional Well-being Alterations
This study aims to test whether a saffron extract represents a good candidate to improve emotional well-being in subjects with subclinical symptoms of depression, fatigue, stress or anxiety.
- Trial name
- SAFFROMFOOD (NCT05690126)
- Testing
- Saffron extract, Maltodextrin
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Neurofibromatosis Type 1
Neuropsychological Impairment and Quality of Life in Neurofibromatosis Type 1
The main objective of the study is to investigate the determinants of the quality of life in children and adults with Neurofibromatosis type 1 (NF1) and more particularly the specific impact of neuropsychological deficits.
- Trial name
- NF1-QDV (NCT01851135)
- Testing
- Neuropsychological examination and quality of life measures
- Where
- 2 sites in France
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Tension-Type Headache, Orofacial Pain
Laser Therapy on Tension-type Cephalea and Orofacial Pain in Post-covid-19 Patients
Considering the auxiliary potential effect of photobiomodulation in controlling persistent CTT and TMD-related pain in patients who have been diagnosed with COVID-19, and are recovered from the viral infection, we intend to…
- Conditions
- Tension-Type Headache, Orofacial Pain, COVID-19
- Trial name
- NCT05430776
- Testing
- Photobimodulation
- Where
- 2 sites in Brazil
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Carotid Atherosclerosis
Study of Anti-atherosclerotic Activity of Inflaminat in Asymptomatic Participants With Subclinical Atherosclerosis
The purpose of this study is to investigate the anti-atherosclerotic effect of long-term anti-inflammatory therapy (Inflaminat) in asymptomatic participants with subclinical atherosclerosis of carotid arteries.
- Trial name
- NCT01743404
- Testing
- Inflaminat
- Where
- Russia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Institute for Atherosclerosis Research, Russia
Healthy, Epilepsy
Bridging Gaps in the Neuroimaging Puzzle: New Ways to Image Brain Anatomy and Function in Health and Disease Using Electroencephalography and 7 Tesla Magnetic Resonance Imaging
The human brain presents outstanding challenges to science and medicine. Brain function and structure span broad spatial scales (from single neurons to brain-wide networks) as well as temporal scales (from milliseconds to years).
- Conditions
- Healthy, Epilepsy, Psychosis, Essential Tremor
- Trial name
- NCT05769933
- Testing
- Simultaneous EEG-fMRI at 7 Tesla, Structural MRI at 7 Tesla
- Where
- Switzerland
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- CSEM Centre Suisse d'Electronique et de Microtechnique SA - Recherche et Developpement
Lewy Body Disease
A Phase I Study of GT300 in Healthy Subjects
Descriptive safety and pharmacokinetics of GT300, exploratory biomarker effects for the evaluation of the effect of GT300 on the autophagy-lysosomal pathway (ALP), food effect on PK and fasting effect on biomarkers.
- Trial name
- NCT04963855
- Testing
- GT300, Microcrystalline cellulose
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Generian Pharmaceuticals, Inc.
Parkinson Disease, Cognitive Deficit in Attention
The Effect of Different Types of Focus Instructions in Parkinson's Rehabilitation
Parkinson's disease is the most common progressive neurodegenerative movement disorder. Common movement impairments in Parkinson's include balance and walking difficulties.
- Conditions
- Parkinson Disease, Cognitive Deficit in Attention, Feedback, Psychological, Gait, Festinating
- Trial name
- NCT06615115
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Anhedonia
Effect of D-amphetamine on Reward Functioning
The purpose of this study is to establish the dose-response curve for therapeutic doses of d-amphetamine on tasks of motivation and reward learning in the same participants and to use d-amphetamine as a dopaminergic probe to test…
- Trial name
- NCT03369015
- Testing
- 10 mg d-amphetamine, 20mg d-amphetamine
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Sleep Quality, Anxiety Level
Hand Massage Applied To Elderly Stayıng In Nursing Homes
Hand massage; behavioral and reduce psychological symptoms, enable individuals to calm down and relax, and provide individual and care It is applied to contribute to communication between donors, to ensure reliability and ease of…
- Trial name
- NCT06872008
- Testing
- Hand Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Amasya University
Neurodegenerative Diseases
Electronic Nose for Diagnosis of Neurodegenerative Diseases Via Breath Samples
The diagnosis of neurodegenerative conditions and ADHD still mostly relies on clinical symptoms as there are no validated, inexpensive, and simple bio- markers available yet.
- Trial name
- NCT01291550
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Alzheimer Disease
Longitudinal Imaging of Microglial Activation in Different Clinical Variants of Alzheimer's Disease
The purpose of this study is to determine how inflammation is related to other changes in the brain that occur during the progression of Alzheimer's disease.
- Trial name
- ADVISe (NCT04576793)
- Testing
- 11C-ER176, 18F-MK6240, 18F-Florbetaben
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Columbia University
Healthy
Physiological Effects of Androstadienone Exposure
The reason for doing this research is to understand why different people show different responses when they smell an odor called androstadienone. Androstadienone is a chemical found in male sweat.
- Trial name
- NCT00553384
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Visual Impairment
mHealth Intervention for Improving Eye Health at Community Level
This study is a community trial that aims to establish and evaluate an mHealth screening and promotional tool for improving eye health in Iran.
- Trial name
- Vison mHealth (NCT03922347)
- Testing
- Screening program including 2 consecutive tests, Screening program with mobile health
- Where
- Iran
- Volunteers
- 3,300 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Cerebral Hemorrhage, Cerebral Ischemia
Study on Data Acquisition and Image Characteristics of Brain Multifrequency EIT in Healthy People and Patients With Brain Diseases
The goal of this observational study is to compare the differences in the features of cerebral multifrequency EIT(cMFEIT) images between healthy subjects and patients with brain diseases and to explore the possibility of applying…
- Conditions
- Cerebral Hemorrhage, Cerebral Ischemia, Cerebral Edema, Healthy
- Trial name
- NCT05796349
- Testing
- multifrequency EIT-based for detecting intracranial abnormalities
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Jieshi Ma
Cognition Disorder, Functional Brain Imaging
fMRI and NIRS Imaging for Traumatic Brain Injury
Background: The amount of blood flowing in brain areas goes up when those areas are being used for activities, such as movement or seeing.
- Trial name
- NCT01668758
- Volunteers
- healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Amblyopia, Strabismus
Attention-based Binocular Training for Impaired Stereopsis (BRAVE)
This study evaluates a novel attention-based binocular visual search training paradigm designed to improve stereopsis (stereo vision) in individuals with impaired binocular vision.
- Conditions
- Amblyopia, Strabismus, Anisometropia, Binocular Vision Abnormalities
- Trial name
- BRAVE (NCT07803458)
- Testing
- Attention-Guided Dichoptic Visual Search Training, Zero-Disparity Dichoptic Visual Search Task
- Where
- 2 sites in Hong Kong
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Centre for Eye and Vision Research
Parkinson Disease, Healthy Volunteer
Evaluation of Neuroinflammation in Parkinson's Disease Using 18F-NOS PET/CT
The research study is being conducted to test how a specialized type of Positron Emission Tomography (PET/CT) scan could potentially be useful in diagnosing or monitoring treatment in people with Parkinson's disease.
- Trial name
- NCT04062526
- Testing
- [18F]NOS
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Sleep Apnea, Obstructive
Comparison of Different Screening Score for Hypoxemic OSA (Obstructive Sleep Apnea) With the Results of a Polysomnography (PSG)
Comparison of different screening score for hypoxemic OSA (Obstructive Sleep Apnea) with the results of a polysomnography (PSG). The different screening score studied are: STOP-BANG, DES-OSA, P-SAP and OSA50.
- Trial name
- NCT02050685
- Testing
- All patients incoming in the sleep study centre for a PSG
- Where
- Belgium
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Eric DEFLANDRE, MD, FCCP
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