Clinical trials: Nervous System Disorders
Convulsions
Intranasal vs Buccal vs Intramuscular Midazolam for the Home and Emergency Treatment of Acute Seizures
A randomized controlled clinical trial comparing patient/ ER physician satisfaction and ease of administration of 3 non IV routes of midazolam as a rescue medication for seizure control.
- Trial name
- NCT05670509
- Testing
- administration of Nasal midazolam in home group as a rescue medication for seizure control., administration of Buccal midazolam in home group as a rescue medication for seizure control., administration of intramuscular midazolam in homegroup as a rescue medication for seizure control.
- Where
- Egypt
- Volunteers
- 305 people
- Sponsor
- Ain Shams University
ICU Nurses, Delirium, Virtual Reality
VR Training for Nurses' Delirium Management
Background: Delirium is an acute mental status change characterized by confusion, fluctuating symptoms, and inattention. It affects 11%-40% of hospitalized elderly patients and over 80% of mechanically ventilated ICU patients.
- Trial name
- NCT06880263
- Testing
- use 360 degree VR training
- Where
- Taiwan
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Tri-Service General Hospital (TSGH)
Neuromuscular Diseases
Efficacy of Intermittent Abdominal Pressure Ventilation in Neuromuscular Patients
Non-Invasive Ventilation (NIV) is an established treatment to manage respiratory muscles dysfunction in neuromuscular disease, preventing the progression of respiratory failure to intubation and/or a tracheotomy.
- Trial name
- IAPV (NCT05346263)
- Testing
- Intermittent Abdominal Pressure Ventilation, Usual ventilation
- Where
- Italy
- Volunteers
- 78 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Cryptococcal Antigenemia, HIV-1-infection
Optimizing Care for Cryptococcal Antigenemia: Evaluation of Short Course Fluconazole and ART Timing Among CrAg+ Persons With Low Titers
This randomized clinical trial will evaluate the optimal duration of fluconazole therapy and timing of antiretroviral therapy initiation among HIV-infected persons with asymptomatic cryptococcal antigenemia and low cryptococcal…
- Conditions
- Cryptococcal Antigenemia, HIV-1-infection, Cryptococcal Infection, Cryptococcal Meningitis
- Trial name
- NCT07743593
- Testing
- Immediate ART Initiation, Delayed ART Initiation, 10-Week Fluconazole
- Where
- Uganda
- Volunteers
- 505 people
- Sponsor
- University of Minnesota
Encephalitis, Tick-Borne
Evaluation of Long-Term Immunogenicity in Subjects Boosted With a TBE Vaccine for Adults
The purpose of this study it is to evalutate the persistence of antibodies after a booster immunisation with a TBE vaccine for adults
- Trial name
- NCT00311493
- Testing
- Tick-Borne Encephalitis vaccine
- Where
- Germany
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Novartis
Obstructive Sleep Apnea
Acetazolamide Add-On Therapy to OSA Surgery
Surgical procedures are routinely performed as an alternative to continuous positive airway pressure treatment in patients with obstructive sleep apnea (OSA). However, the response to surgery is often variable.
- Trial name
- ACTOS (NCT04227093)
- Testing
- Acetazolamide
- Where
- Belgium
- Volunteers
- 26 people
- Sponsor
- University Hospital, Antwerp
Strabismus, Esotropia
Risk Factors And Surgical Outcomes Of Strabismus Reoperation
Horizontal strabismus, commonly known as inward or outward deviation of the eyes, is a frequent eye condition that may require surgical correction.
- Conditions
- Strabismus, Esotropia, Exotropia
- Trial name
- RSOR (NCT07446621)
- Testing
- Horizontal Strabismus Reoperation
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Assiut University
Sickle Cell Disease, Thalassemia
Unrelated Hematopoietic Stem Cell Transplantation(HSCT) for Genetic Diseases of Blood Cells
This is a clinical trial of bone marrow transplantation for patients with the diagnosis of a genetic disease of blood cells that do not have an HLA-matched sibling donor.
- Conditions
- Sickle Cell Disease, Thalassemia, Anemia, Granuloma
- Trial name
- NCT00730314
- Testing
- Hematopoietic stem cell transplantation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Children's Hospital Los Angeles
Hemiplegic Cerebral Palsy
Bimanual Task Training and Constraint-Induced Movement Therapy in Hemiplegic Cerebral Palsy Children
Various studies have been done comparing the individual effects of the two interventions of Constraint-Induced Movement Therapy and Bimanual Task Training in Hemiplegic Cerebral Palsy Children, but this study will compare the…
- Trial name
- NCT05380011
- Testing
- Constraint Induced Movement Therapy and Bimanual Task Training, Bimanual Task Training
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Riphah International University
Healthy Volunteer, Muscular Atrophy, Spinal
A Study to Learn About the Safety of BIIB115 Injections and How BIIB115 is Processed in the Bodies of Healthy Adult Male Volunteers and of Pediatric Participants With Spinal Muscular Atrophy Who Previously Took Onasemnogene Abeparvovec
In this study, researchers will learn about a study drug called BIIB115 in healthy adult male volunteers and in participants with spinal muscular atrophy (SMA). This study will focus on children with SMA.
- Trial name
- NCT05575011
- Testing
- BIIB115
- Where
- 16 sites in Belgium, Canada and 7 more
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Biogen
Fibromyalgia
Pain Neuroscience Education and Physical Exercise Program in Fibromyalgia
This study evaluates the effects of a pain neuroscience education (PNE) and physical exercise (PE) program in women with fibromyalgia.
- Trial name
- NCT04539171
- Testing
- Pain Neuroscience Education and Physical Exercise
- Where
- Spain
- Volunteers
- 53 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Experimental Pain in Healthy Males
Characterization of Secondary Hyperalgesia in Healthy Volunteers
In this prospective trial we aim to investigate the intra-individual and inter-individual variance in secondary hyperalgesia following pain elicited by the experimental pain model: Brief Thermal Sensitization.
- Trial name
- NCT02166164
- Testing
- Brief thermal sensitization, Long thermal stimulation, Heat-pain-detection threshold
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute Ischemic Stroke
An Application That Can Provide Early Warning of Temperature Health Risks and Give Protective Suggestions or Personalized Suggestions Based on Patients' Own Secondary Prevention Risk Factors Was Applied to Intervene, and the Intervention Effect of APP on Stroke Recurrence Risk Was Analyzed
This study employs individualized temperature health risk early warning and risk factor management interventions for stroke, and explores their actual intervention effects.
- Trial name
- NCT06904664
- Testing
- Individualized temperature health risk early warning and risk factor management, Temperature health risk early warning, Risk factor management
- Volunteers
- 10,184 people
- Sponsor
- Xuanwu Hospital, Beijing
Parkinson's Disease, With Inclusion Criteria for STN Deep Brain Stimulation
Evaluation of the Safety and Efficacy of Bilateral Subthalamic Nucleus (SNT) Radiosurgery in Idiopathic Severe Parkinson's Disease Fulfilling Inclusion Criteria for STN Deep Brain Stimulation and Presenting With a Contraindication to Intracerebral Electrode Implantation.
The goal of our trial is to evaluate the tolerance and efficacy of the STN radiosurgery in Parkinsonian patients presenting with the inclusion criteria for the STN stimulation but presenting also with clear contraindications to…
- Conditions
- Parkinson's Disease, With Inclusion Criteria for STN Deep Brain Stimulation, Presenting a Contraindication to Intracerebral Electrode Implantati
- Trial name
- NCT01284699
- Testing
- Gamma Knife radiosurgery
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Orthostatic Hypotension
Frequency of Orthostatic Hypotension in Patients Who Underwent Colonoscopy
Patients who will undergo colonoscopy accompanied by sedoanalgesia will be admitted at Aksaray Training and Research Hospital Gastroenterology Clinic between May and July 2024.
- Trial name
- NCT06439498
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Ankara University
Pregnancy Related, Pregnancy Disease
Fetal Autonomic Nervous sysTem Evaluation
The autonomic nervous system (ANS) is involved in cardiovascular, metabolic and cognitive processes, so its study in the fetus can provide relevant functional diagnostic and prognostic information.
- Conditions
- Pregnancy Related, Pregnancy Disease, Pregnancy Complications, Pre-Eclampsia
- Trial name
- FANTE (NCT06330987)
- Testing
- electrocardiograph
- Where
- Italy
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University of Pisa
Ischemic Stroke
Inflammatory faCtors AfteR acUte Ischemic Stroke
ICARUS is an interventional single-centre hospital-based cohort study in patients admitted to the stroke unit with an acute ischemic stroke.
- Trial name
- ICARUS (NCT04412187)
- Testing
- [18F]-GE-180 PET, 3T MRI, immune cell profiling in blood
- Where
- 2 sites in Germany
- Volunteers
- 36 people
- Sponsor
- Martin Dichgans
Multiple Sclerosis, Relapsing-Remitting
Multiple Doses of Anti-NOGO A in Relapsing Forms of Multiple Sclerosis
This study will investigate an experimental new drug, GSK1223249 in patients diagnosed with relapsing forms of multiple sclerosis.
- Trial name
- NCT01435993
- Testing
- GSK1223249
- Where
- 2 sites in Italy, Norway
- Volunteers
- 3 people
- Sponsor
- GlaxoSmithKline
Wilson Disease
Description of Renal Involvement in Wilson's Disease
Wilson's disease (WD) is a rare genetic disorder that leads to copper accumulation in various tissues, including the liver, nervous system, heart, and kidneys.
- Trial name
- WILKID (NCT07075393)
- Testing
- full renal workup
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Acute Ischemic Stroke
Efficacy and Safety of Early Initiation of Butylphthalide Treatment in Patients With Acute Ischemic Stroke.
This study is a prospective, multicenter, randomized, open-label, blinded-endpoint trial designed to evaluate the difference in efficacy of Butylphthalide Sodium Chloride Injection treatment initiated early (\<3 hours) versus…
- Trial name
- NCT06472921
- Testing
- Butylphthalide treatment initiation time
- Where
- 2 sites in China
- Volunteers
- 204 people
- Sponsor
- Xiangya Hospital of Central South University
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