Clinical trials: Nervous System Disorders
Poliomyelitis
Study to Evaluate Safety and Immunogenicity of nOPV2 at Different Intervals in Infants
Study to determine immunogenicity and safety following administration of 2 doses of novel oral poliovirus vaccine type 2 (nOPV2) given at different intervals of 1 week or 2 weeks or the standard 4-week interval in infants
- Trial name
- NCT05033561
- Testing
- nOPV2
- Where
- 2 sites in Dominican Republic
- Volunteers
- 905 people, healthy volunteers welcome
- Sponsor
- Fidec Corporation
Neonatal Seizures
Efficacy of Intravenous Levetiracetam in Neonatal Seizures
A new anticonvulsant, levetiracetam will be studied to treat seizures in newborn infants. Current treatments for the brain damaging complication of neonatal seizures are unsatisfactory.
- Trial name
- NEOLEV2 (NCT01720667)
- Testing
- Intravenous levetiracetam, Intravenous phenobarbital
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Richard H. Haas
MPN (Myeloproliferative Neoplasms)
A Study of INCB050465 in Combination With Ruxolitinib in Subjects With Myelofibrosis
The purpose of this study is to evaluate the safety, tolerability, and efficacy of the combination of parsaclisib and ruxolitinib in subjects with myelofibrosis.
- Trial name
- NCT02718300
- Testing
- Parsaclisib, Ruxolitinib
- Where
- 39 sites in United States
- Volunteers
- 74 people
- Sponsor
- Incyte Corporation
Epilepsy
A Double-blind, Randomised, Placebo-controlled, Rising Multiple Dose Study to Investigate the Safety, Tolerability, Steady State Pharmacokinetic Profile and CNS Effects of BIA 2-093
The purpose of this study is to investigate the safety and tolerability of multiple dose regimens of BIA 2-093 in healthy young male volunteers
- Trial name
- NCT02171234
- Testing
- BIA 2-093
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Hemorrhoid
Study of Pain Control in Hemorrhoidectomy
Patients will get an injection of either SKY0402 or placebo during hemorrhoid surgery, and their pain and pain medicine use will be monitored.
- Trial name
- NCT00890721
- Testing
- SKY0402
- Where
- Poland
- Volunteers
- 189 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Atherosclerosis
Accelerated Atherosclerosis in High Risk Population Groups: An Assessment by Magnetic Resonance Imaging
The goal of this study is to assess a slimy substance that settles/deposits along blood vessel wall. This slimy substance is called plaque. Plaque could be made up of fat, calcium or both. Plaque deposition narrows the vessels.
- Trial name
- NCT02114697
- Testing
- Statin therapy, Lifestyle modification
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Emory University
Sleep Disordered Breathing, Sleep Apnea, Central
Evaluation of Software Enhancements to the Respironics BiPAP Auto Servo Ventilation (AutoSV) Device
This study is being undertaken to collect data from Respironics Inc's BiPAP Auto Servo Ventilation 3 (autoSV3) and compare with data from Respironics, Inc's BiPAP autoSV2, to confirm that the algorithms in the BiPAP autoSV3…
- Trial name
- AUTOSV3 (NCT00720213)
- Testing
- Respironics BiPAP autoSV2, Respironics BiPAP autoSV3
- Where
- 5 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Philips Respironics
Tremor, Action Tremor
Deep Brain Stimulation (DBS) for the Suppression of Tremor
The purpose of the proposed study is to demonstrate the safety and efficacy of the ANS Totally Implantable Deep Brain Stimulation System in the VIM nucleus of the thalamus implanted for the treatment of tremor due to essential…
- Conditions
- Tremor, Action Tremor, Essential Tremor, Tremor, Limb
- Trial name
- NCT02087046
- Testing
- ANS Totally Implantable Deep Brain Stimulation System
- Where
- 12 sites in United States
- Volunteers
- 127 people
- Sponsor
- Abbott Medical Devices
Late Infantile Metachromatic Leukodystrophy
Open-Label Extension Study of Recombinant Human Arylsulfatase A (HGT-1111) in Late Infantile MLD
This is a multi-center, open-label, extension study of patients with late infantile MLD who have previously completed clinical study HGT-MLD-048 (NCT00633139), defined as the completion of all Week 52 procedures.
- Trial name
- NCT00681811
- Testing
- HGT-1111
- Where
- Denmark
- Volunteers
- 11 people
- Sponsor
- Shire
Infantile Spasms
Phase 3 Trial of Cannabidiol (CBD; GWP42003-P) for Infantile Spasms: Open-label Extension Phase (GWPCARE7)
This trial consists of 3 parts: a pilot safety phase, a pivotal randomized controlled phase, and an open-label extension phase. The open-label extension phase only will be described in this record.
- Trial name
- NCT02954887
- Testing
- GWP42003-P
- Where
- 7 sites in United States, Poland
- Volunteers
- 9 people
- Sponsor
- Jazz Pharmaceuticals
Primary Insomnia
The Role of Partial Reinforcement in the Long Term Management of Insomnia
The lack of scientific attention devoted to the placebo effect as a phenomenon in its own right probably reflects the paucity of theoretical positions within which to organize the existing data and design new research.
- Trial name
- ADER (NCT00662155)
- Testing
- Zolpidem
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- University of Pennsylvania
Obstructive Sleep Apnea (OSA)
The Efficacy of a New Mathematical Formula to Predict Continuous Positive Air Pressure With an Oronasal Mask Interface.
Subjects will all have a two week baseline period in which they will use a nasal mask using an air view CPAP machine (which records all data).
- Trial name
- NCT02816255
- Testing
- Full Face Mask with same CPAP Pressure, Full Face Mask with new Pressure
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Weill Medical College of Cornell University
Carotid Artery Disease
Dose-Finding, Feasibility Study of Optison in Contrast Enhanced U/S for the Detection of Carotid Artery Disease
The purpose of this study is to find the optimal dose from 3 different dose levels - 0.15 mL, 0.5 mL and 1.5 mL of Optison in assessing the presence of disease of the carotid arteries when comparing pre-contrast to post-contrast…
- Trial name
- NCT01394926
- Testing
- Optison
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- GE Healthcare
Tinnitus
Auditory-somatosensory Stimulation to Alleviate Tinnitus
The purpose of this study is to develop and test a subject operated device to lessen tinnitus (ringing in the ear), based on subject-feedback for stimulus presentation.
- Trial name
- NCT02974543
- Testing
- Active Treatment: Bimodal auditory-somatosensory stimulation
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Michigan
Williams Syndrome, Anxiety
Buspirone Treatment of Anxiety in Williams Syndrome
The purpose of this study is to do a preliminary assessment of whether buspirone is effective, safe, and tolerable in the treatment of anxiety in children, adolescents, and adults with Williams syndrome.
- Trial name
- NCT04807517
- Testing
- Buspirone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Postherpetic Neuralgia
A Crossover Study to Evaluate the Safety, Tolerability and Efficacy of XPF-002 in Subjects With Postherpetic Neuralgia (PHN)
The purpose of this trial is to determine if XPF-002 is safe and effective for the treatment of pain in subjects with Postherpetic Neuralgia
- Trial name
- XEN402 (NCT01195636)
- Testing
- XPF-002
- Where
- 24 sites in United States
- Volunteers
- 70 people
- Sponsor
- Xenon Pharmaceuticals Inc.
Parkinson Disease
Connect.Parkinson: Connecting Individuals With Parkinson Disease to Specialists in Their Homes
Connect.Parkinson is a randomized comparative effectiveness study, comparing usual care enhanced with educational materials to usual care, educational materials, and the delivery of specialty care via telemedicine into patient's…
- Trial name
- NCT02038959
- Testing
- Virtual Visits
- Where
- 20 sites in United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Parkinson Disease
PS128 May Improve Off Duration on Parkinson's Disease
The purpose of this study is to investigate the short term effects (12 Weeks) of Lactobacillus plantarum PS128 (PS128) on Parkinson's disease (PD) symptoms.
- Trial name
- NCT04389762
- Testing
- daily ingestion of Lactobacillus plantarum PS128
- Where
- Taiwan
- Volunteers
- 26 people
- Sponsor
- Professor Lu Neurological Clinic
Spinal Cord Injury, Hypogonadism
Testosterone Replacement Therapy in Chronic Spinal Cord Injury
It has long been recognized that co-morbidity associated with multiple metabolic syndrome, such as adverse body composition, insulin resistance and autonomic nervous system impairment, may lead to significant increase in…
- Trial name
- NCT00266864
- Testing
- Testosterone Transdermal System (Androderm 5 mg patch)
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- VA Office of Research and Development
Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma
Alisertib and Fractionated Stereotactic Radiosurgery in Treating Patients With Recurrent High Grade Gliomas
This phase I trial studies the side effects and best dose of alisertib when combined with fractionated stereotactic radiosurgery in treating patients with high-grade gliomas that have returned after previous treatment with…
- Conditions
- Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma, Adult Anaplastic Oligodendroglioma, Adult Brain Stem Glioma
- Trial name
- NCT02186509
- Testing
- Hyperfractionated radiation therapy, Stereotactic radiosurgery, Alisertib
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
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