Clinical trials: Nervous Vagus
Refractory Epilepsy
Acute and Long Term Effects of VNS on Memory in Patients With Refractory Epilepsy
Refractory epilepsy patients implanted with a vagus nerve stimulator perform a memory test at baseline in three conditions: invasive vagus nerve stimulation (VNS), transcutaneous vagus nerve stimulation (taVNS) and sham…
- Trial name
- NCT05031208
- Testing
- Memory task
- Where
- Belgium
- Volunteers
- 16 people
- Sponsor
- University Hospital, Ghent
Stroke, Acute
VNS-supplemented Motor Retraining After Stroke
The goal of this study is to learn more about the connections between the brain, spinal cord, and muscles and how these connections can be strengthened after neurological injury.
- Trial name
- NCT04088578
- Testing
- Training, Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Epilepsy
Trial to Assess Vagus Nerve Stimulation Therapy vs. Anti-Epileptic Drug (AED) Treatment in Children With Refractory Seizures
This is a randomized study designed to compare long-term treatment outcomes in pediatric patients with refractory seizures treated with VNS (Vagus Nerve Stimulation) Therapy versus anti-epileptic drugs (AEDs).
- Trial name
- NCT01118455
- Testing
- Vagus Nerve Stimulation (VNS) Therapy, Anti-Epileptic Drug (AED)
- Where
- 19 sites in Austria, Belgium and 3 more
- Volunteers
- 134 people
- Sponsor
- Cyberonics, Inc.
Spinal Cord Injuries, Inflammation
Neuromodulation as an Anti-inflammatory Treatment in SCI
The goal of this single-blinded randomized, controlled trial is to assess the impact of 1-hour of active transcutaneous auricular vagus nerve stimulation (taVNS) vs sham taVNS on serum biomarkers of the inflammatory reflex and…
- Trial name
- NCT05730049
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Tinnitus
Blinding and Adverse Effects of Ultrasonic Vagus Nerve Stimulation (U-VNS) in Tinnitus
The vagus nerve is a large nerve that runs from the gut to the brain. It consists of two main sections, left and right, and comprises a series of branches. One of these branches runs through the ear.
- Trial name
- BLAST II (NCT07291648)
- Testing
- Device: Ultrasound Vagus Nerve Stimulation (U-VNS)
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Nottingham
Pain, Migraine
Vagus Nerve Stimulation: Treatment for Gulf Veterans With Gulf War Illness
The researchers propose studying Gulf veterans with Gulf War Illness (GWI), characterized by a problem with widespread pain. Besides their pain, the researchers will also assess the effect of vagus nerve stimulation (VNS) in…
- Trial name
- NCT02791893
- Testing
- VNS device, Inactive device
- Where
- 4 sites in United States
- Volunteers
- 27 people
- Sponsor
- Benjamin Natelson
Survivor of Childhood Cancer, Insomnia
Transcutaneous Auricular Vagus Nerve Stimulation for Insomnia in Survivors of Childhood Acute Lymphoblastic Leukemia
This pilot study will assess the usefulness and potential effectiveness of using transcutaneous auricular vagus nerve stimulation (tVNS) for treating insomnia in adult survivors of childhood acute lymphoblastic leukemia (ALL).
- Conditions
- Survivor of Childhood Cancer, Insomnia, Acute Lymphoblastic Leukemia (ALL)
- Trial name
- NCT07191119
- Testing
- Soterix tVNS device, Sleep Quality, Neurocognitive and mental health outcomes
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- St. Jude Children's Research Hospital
Autonomic Nervous System Imbalance
Comparison of Transcutaneous Auricular Vagus and Trigeminal Nerve Stimulation
The aim of this study was to compare the results between transcutaneous auricular vagus nerve stimulation and trigeminal nerve stimulation with the results obtained from heart rate variability, pulse and blood pressure…
- Trial name
- NCT06730165
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation, Transcutaneous Auricular Trigeminal Nerve Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Stroke Treatment, Stroke
Effect of Transcutaneous Auricular Vagus Nerve Stimulation Combined With Upper Extremity Robot-Assisted Training on Upper Extremity Motor Functions in Stroke Patients
The effects of stroke on the upper extremity are a common and significant cause of long-term disability, with 65% of patients reporting an inability to participate in daily activities with the affected upper extremity after 6…
- Trial name
- NCT07257107
- Testing
- Robotics Assisted Education + taVNS
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul University - Cerrahpasa
Multiple Sclerosis (MS) - Relapsing-remitting, Multiple Sclerosis
Study to Investigate Vagus Nerve Stimulation Paired With Motor Task for Remyelination and Functional Recovery
The goal of this clinical trial is to learn if stimulating the vagus nerve in combination with a motor task in people with multiple sclerosis can improve motor function.
- Trial name
- NCT06641271
- Testing
- Closed Loop Trans-Auricular Vagus Nerve Stimulation System
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Colorado, Denver
Parkinson Disease
The Efficacy and Safety of Transcutaneous Auricular Vagus Nerve Stimulation for Anxiety in PD
This study is a double blind comparative study examining the effectiveness of the transcutaneous auricular vagus nerve stimulation treatment on Parkinson's disease patients with anxiety.
- Trial name
- NCT05950347
- Testing
- Active Transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Traumatic Brain Injury (TBI) Patients
Transcutaneous Vagus Nerve Stimulation for Attention and Memory
This clinical trial aims to evaluate whether transcutaneous auricular vagus nerve stimulation (taVNS), a non-invasive brain stimulation method, can improve attention and memory in veterans with traumatic brain injury (TBI) and…
- Trial name
- taVNS (NCT06723743)
- Testing
- Transcutaneous vagus nerve stimulation for attention in veterans with TBI, Soterix Medical Vagus Nerve Stimulation mini-CT
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Baylor College of Medicine
Vocal Cord Paralysis
Bilateral Laryngeal Paralysis Reinnervation
Bilateral laryngeal reinnervation induces a rise in laryngeal resistance and speech alteration. The aim of this study is to propose laryngeal reinnervation by a phrenic nerve root to patients with bilateral laryngeal paralysis.
- Trial name
- NCT00213616
- Testing
- surgical reinnervation
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Rouen
Ischemic Stroke, Upper Extremity Problem
VNS-REHAB At-Home - Post-Market Study for Using the Vivistim System® at Home
This is a single-arm post-market study of up to 150 participants, using up to 50 mobile therapists to conduct up to 36-hours at-home therapy.
- Trial name
- AT-HOME (NCT05691023)
- Testing
- Vivistim System
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- MicroTransponder Inc.
HIV Associated Polyneuropathy
Auricular Vagus Nerve Stimulation Mechanisms for HIV-Associated Peripheral Neuropathy
This study looks at a non-invasive ear stimulation treatment to better understand nerve pain in people living with HIV. The study aims to assess how the body and nervous system respond to this treatment, including changes in…
- Trial name
- NCT07822932
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (AVNS)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Miami
Alzheimer Disease
Implantable Vagus Nerve Stimulation Modulation of Coeruleus-Norepinephrine Network for Mild-Moderate AD Patients
A randomized controlled clinical study will be conducted in Xuanwu Hospital of Capital Medical University. This study initially explore the effect of selective vagus nerve(C fiber) stimulation on mild-to-moderate AD patients, in…
- Trial name
- NCT05575271
- Testing
- Vagus Nerve Stimulation Modulation of the Coeruleus-Norepinephrine Network
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Xuanwu Hospital, Beijing
Systemic Lupus Erythematosus, Autonomic Dysfunction
Vagus Nerve Stimulation for Systemic Lupus Erythematous
This trial uses a double blinded, randomized 1:1 (active:sham) placebo controlled, parallel group design, investigating the effects of transcutaneous vagus nerve stimulation (tVNS) in patients with systemic lupus erythematosus…
- Conditions
- Systemic Lupus Erythematosus, Autonomic Dysfunction, Autonomic Neuropathy, Fatigue
- Trial name
- SLE-VNS (NCT05315739)
- Testing
- Non-invasive transcutaneous vagus nerve stimulation (tVNS)
- Where
- Denmark
- Volunteers
- 75 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Paralysis, Unilateral, Vocal Cord
APrevent Vocal Implant System (VOIS) for Adjustable Treatment of Unilateral Vocal Fold Paralysis (UVFP)
The objective of this study is to evaluate pre- and intraoperative voice quality, the degree of vocal fold closure and the Maximum Phonation Time (MPT), first determined after temporary APrevent® VOIS implantation and then after…
- Trial name
- NCT03864757
- Testing
- thyroplasty implant
- Where
- Austria
- Volunteers
- 8 people
- Sponsor
- APrevent Biotech GmbH
Spinal Cord Injury (SCI), Gait
Closed-Loop Vagus Nerve Stimulation (CLV) for Recovery of Gait After Spinal Cord Injury (SCI)
The purpose of this study is to evaluate the safety, feasibility, and preliminary effectiveness of the ReWire system, which delivers vagus nerve stimulation (VNS) paired with lower limb rehabilitation to improve gait in…
- Conditions
- Spinal Cord Injury (SCI), Gait, Reduced Physical Activity, Lower Limb Functions
- Trial name
- NCT07689227
- Testing
- CLV
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas at Dallas
Healthy Participants, Anxiety Disorders (With High Anxiety Symptoms)
tVNS and Approach-Avoidance Behavior in Anhedonia and Anxiety
This study investigates if anhedonia and anxiety symptoms are associated with alterations in reinforcement learning, effort trade-offs for wins vs. punishments, and foraging behavior under threat.
- Conditions
- Healthy Participants, Anxiety Disorders (With High Anxiety Symptoms), Depressive Disorders (With High Anhedonia Symptoms), Comorbid Depression and Anxiety Disorder (With High Anhedonia and High Anxiety Symptoms)
- Trial name
- NCT07476469
- Testing
- tVNS
- Where
- Germany
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Dr. Nils B. Kroemer