Clinical trials: Nervousness
Gaucher Disease
Plant Cell Expressed Recombinant Human Glucocerebrosidase Extension Trial
Gaucher disease, the most prevalent lysosomal storage disorder, is caused by mutations in the human glucocerebrosidase gene (GCD) leading to reduced activity of the lysosomal enzyme glucocerebrosidase and thereby to the…
- Trial name
- NCT00705939
- Testing
- Taliglucerase alfa
- Where
- 11 sites in United States, Australia and 6 more
- Volunteers
- 45 people
- Sponsor
- Pfizer
Huntington Disease
PHysical Activity and Exercise Outcomes in Huntington's Disease
Huntington's disease (HD) is a genetic, degenerative neurological disease that affects individuals in their third-fourth decade of life and individuals can live 15-20 years with manifest HD.
- Trial name
- PACE-HD (NCT03344601)
- Testing
- physical activity
- Where
- 6 sites in United States, Germany and 1 more
- Volunteers
- 116 people
- Sponsor
- Cardiff University
Infant Botulism, Botulism
Study of Human Botulism Immunoglobulin in Infants With Botulism
OBJECTIVES: I. Determine the safety of human botulism immune globulin (BIG) in patients with infant botulism by monitoring side effects (e.g., rash, fever, hypotension, and anaphylaxis). II.
- Trial name
- NCT00004401
- Testing
- botulism immune globulin
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- California Department of Health Services
Epilepsies
VNS Algorithm for Advanced Dosing
The goal of this clinical trial is to compare the standard programming of the VNS device (Control) to a modified programming (Augusta Way) in adults with epilepsy.
- Trial name
- NCT07725601
- Testing
- Rapid Titration VNS programming, Standard VNS programming
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Fernando Vale
Neuromuscular Diseases, Respiration, Artificial
Quality of Life in Ventilator-dependant Neuromuscular Patients
This study aims at evaluating the quality of life of patients with slowly progressive neuromuscular disorders who are dependant on mechanical ventilation (daily usage ≥ 16h).
- Conditions
- Neuromuscular Diseases, Respiration, Artificial, Tracheostomy, Noninvasive Ventilation
- Trial name
- EqualVENT (NCT04652401)
- Where
- France
- Volunteers
- 119 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Tuberous Sclerosis, Neurofibromatoses
Topical Rapamycin Therapy to Alleviate Cutaneous Manifestations of Tuberous Sclerosis Complex (TSC) and Neurofibromatosis I (NF1)
This study is a prospective, randomized, double-blind, placebo-controlled evaluation of the safety of a topically applied formulation of rapamycin to cutaneous fibromatous lesions in subjects with Tuberous Sclerosis Complex (TSC)…
- Conditions
- Tuberous Sclerosis, Neurofibromatoses, Angiofibroma, Neurofibroma
- Trial name
- NCT01031901
- Testing
- Skincerity, Skincerity plus sirolimus/rapamycin, Skinercity plus sirolimus/rapamycin
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Coronary Artery Bypass, Myocardial Infarction
The Effect Of Acadesine On Reducing Cardiovascular and Cerebrovascular Adverse Events In Coronary Artery Bypass Graft (CABG) Surgery (Study P05633 AM1)(TERMINATED)
The purpose of this study is to determine whether acadesine is effective in reducing the cardiovascular and cerebrovascular adverse events in high-risk participants undergoing CABG surgery.
- Conditions
- Coronary Artery Bypass, Myocardial Infarction, Ventricular Dysfunction, Left, Stroke
- Trial name
- RED-CABG (NCT00872001)
- Testing
- Acadesine, Normal Saline
- Volunteers
- 3,080 people
- Sponsor
- Merck Sharp & Dohme LLC
Pain, Postoperative; Anesthesia, Regional
Analgesic Efficacy of Ultrasound Guided Paravertebral Block in Percutaneous Nephrolithotomy Patients
The aim of this study is to investigate the analgesic effects of thoracal paravertebral block in the patients undergoing percutaneous nephrolitotomy. Paravertebral block was applied to the study group.
- Trial name
- NCT04406012
- Testing
- paravertebral block
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Diphtheria, Tetanus
Study of the Booster Effect of DTaP-IPV-Hep B-PRP~T Combined Vaccine or Infanrix Hexa™ and Prevenar™ in Healthy Infants
This is a follow-up of the primary series vaccination schedule in Study A3L24 (NCT01177722). The objectives are: To describe the antibody persistence to any antigen contained in the investigational DTaP-IPV-Hep B-PRP-T vaccine…
- Conditions
- Diphtheria, Tetanus, Whooping Cough, Hepatitis B
- Trial name
- NCT01444781
- Testing
- DTaP-IPV-Hep B-PRP~T combined vaccine + Pneumococcal polysaccharide, DTaP-Hep B-IPV // Hib Vaccine + Pneumococcal polysaccharide, DTaP-IPV-Hep B-PRP~T + Pneumococcal polysaccharide vaccine
- Where
- 2 sites in Colombia, Costa Rica
- Volunteers
- 1,106 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Hemorrhagic Stroke
Clinical Evaluation of Shengdi Dahuang Decoction in the Treatment of Acute Hemorrhagic Stroke
The purpose of this study is to assess the efficacy and safety of Shengdi Dahuang Decoction in the treatment of acute hemorrhagic stroke by the randomized, controlled, double-blind, multi-center trial design project.
- Trial name
- NCT04200781
- Testing
- Granules of Shengdi Dahuang Decoction
- Where
- 5 sites in China
- Volunteers
- 464 people
- Sponsor
- ShuGuang Hospital
Parkinson Disease
Impulse Control Disorders in Parkinson's Patients Treated With Pramipexole and Other Agents (DOMINION Study)
The purpose is to explore the frequency of impulse control disorders in Parkinson's patients treated with different Parkinson's medications.
- Trial name
- NCT00617019
- Where
- 49 sites in United States, Canada
- Volunteers
- 3,234 people
- Sponsor
- Boehringer Ingelheim
Intracranial Hemorrhages
Colchicine for the Prevention of Vascular Events After an Acute Intracerebral Hemorrhage
The overall goal is to establish the safety and efficacy of colchicine in ICH patients for the prevention of major cardiovascular events and brain injury.
- Trial name
- CoVasc-ICH (NCT05159219)
- Testing
- Colchicine Pill
- Where
- 11 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Population Health Research Institute
Critical Illness, Physical Disability
Neuromuscular Electrical Stimulation (NMES) Preserves Muscle Mass in Intensive Care Unit (ICU)
Background: Low-frequency neuromuscular electrical stimulation (NMES) attenuates the loss of muscle mass of Intensive Care Unit (ICU) patients.
- Conditions
- Critical Illness, Physical Disability, Muscle Atrophy
- Trial name
- NCT05287919
- Testing
- Patients received the standard physical therapy (SPT) programme (passive mobilization) twice a day., Patients received the low-frequency neuromuscular electrical stimulation (NMES), Patients received the medium-frequency neuromuscular electrical stimulation (NMES)
- Where
- Chile
- Volunteers
- 54 people
- Sponsor
- Gabriel Nasri Marzuca-Nassr
Parkinson's Disease, Parkinsonian Disorders
Gait Analysis in Neurological Disease
The purpose of this study is to investigate whether speed-dependent measures of gait (so called gait signatures) can be identified in patients with neurological conditions that affect gait, particularly in subjects with…
- Conditions
- Parkinson's Disease, Parkinsonian Disorders, Atypical Parkinson Disease, Progressive Supranuclear Palsy
- Trial name
- NCT02994719
- Testing
- Anti-Parkinson medication, Deep Brain Stimulation
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Fibromyalgia
Exploration the Mechanism of Ba-Duan-Jin in the Treatment of Fibromyalgia Based on Brain-gut Axis
To investigate the mechanism by Ba-Duan-Jin in the treatment of fibromyalgia. Twenty eligible fibromyalgia patients were selected, and were trained and guided online by an experienced Ba-Duan-Jin instructor with reference to the…
- Trial name
- NCT06410430
- Testing
- Ba-Duan-Jin
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Alzheimer Disease 10, Dementia
Cognitive Stimulation Therapy
The concept of cognitive stimulation in AD is one of the most popular approaches. Cognitive Stimulation Therapy (CST) is stated to be evidence-based best practice with robust clinical trials, administered according to specific…
- Conditions
- Alzheimer Disease 10, Dementia, Apathy, Anxiety
- Trial name
- NCT05808530
- Testing
- Cognitive Stimulation Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Hasan Kalyoncu University
Multiple Sclerosis, Self Efficacy
Unidimensional Self-Efficacy Scale for Multiple Sclerosis (USE-MS) Turkish Adaptation
Multiple Sclerosis (MS) is a chronic, inflammatory, demyelinating, autoimmune disease of the central nervous system. Despite functional limitations and unpredictable disease course, individuals with MS are aimed to maintain…
- Trial name
- NCT06231030
- Testing
- Validity, Reliability and Adaptation
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 176 people
- Sponsor
- Nigde Omer Halisdemir University
Stroke
Minimal Clinically Important Difference of Clinical Test of Sensory Interaction on Balance in Individuals
"Stroke is a major cause of disability worldwide, often leading to balance impairments due to deficits in sensory integration and motor control.
- Trial name
- NCT06905730
- Testing
- sensory integration deficits in balance
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Superior University
Parkinson's Disease
Piloting a Novel, Mobile Cognitive Tracking and Training Tool for Patients With Parkinson's Disease (PD)
The overall goal of this research proposal is to develop an adjunct to standard treatments that 'correct' disrupted neural circuitry in Parkinson's Disease (PD) patients.
- Trial name
- NCT02922530
- Testing
- Computerized Plasticity-based Adaptive Cognitive Training, Commercially available computerized training
- Volunteers
- healthy volunteers welcome
- Sponsor
- Posit Science Corporation
Obstructive Sleep Apnea
Zolpidem on CPAP Acclimatization in OSA
Obstructive sleep apnea (OSA) is a sleep disorder characterized by a cessation or significant decrease in airflow during sleep. CPAP is the preferred therapy and has high effectiveness at all levels of OSA severity.
- Trial name
- NCT06084130
- Testing
- Zolpidem
- Volunteers
- 30 people
- Sponsor
- Siriraj Hospital
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