Clinical trials: Nervousness
Sleep Disturbance
Acupuncture for Sleep Disturbances in Post-Deployment Military Service Members
This randomized study will evaluate the effect of a brief acupuncture therapy in addition to a brief cognitive behavioral therapy in mitigating sleep disturbances in post-deployment military service members using reliable and…
- Trial name
- NCT04031365
- Testing
- Acupuncture, Cognitive Behavioral Therapy
- Where
- Japan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Cirrhosis, Hepatic Encephalopathy
A Study of Safety and Efficacy of HPN-100 in Subjects With Cirrhosis and Episodic Hepatic Encephalopathy
This is a phase 2 study of HPN-100 in subjects with hepatic encephalopathy (HE) consisting of an open label safety lead-in (Part A), followed by randomized, double-blind, placebo-controlled treatment (Part B).
- Trial name
- HALT-HE (NCT00999167)
- Testing
- HPN-100
- Where
- 28 sites in United States
- Volunteers
- 189 people
- Sponsor
- Amgen
Healthy Volunteer, Down Syndrome
A Molecular and Functional Brain Imaging Study in Individuals With Down Syndrome and Healthy Controls Following Single Dose RG1662
This single-center, single-blind, placebo-controlled, parallel-group study with crossover component will evaluate the GABAAalpha5 receptor expression, occupancy and functional connectivity in the brains of individuals with Down…
- Trial name
- NCT01667367
- Testing
- RG1662
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Parkinson Disease, Neuro-Degenerative Disease
Conventional Physical Therapy Action Observation Therapy on Freezing of Gait and Functional Mobility in Parkinson's Disease
The goal of this study is to determine the effects of action observation therapy with conventional physical therapy on freezing gait and functional limitation in participants with Parkinson's disease.
- Trial name
- NCT07244900
- Testing
- Conventional Physical Therapy, Action Observation plus conventional Physical Therapy
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- University of Lahore
Acromegaly, Diabetes
Glucose Tolerance in Acromegaly: The Influence of GH-excess on Glucose Metabolism and Insulin Resistance
Observational, Cross-sectional, longitudinal, multi-center, diagnostic study Cross-sectional part of the study: To evaluate the influence of acromegaly on glucose tolerance Longitudinal part of the study: To evaluate the changes…
- Conditions
- Acromegaly, Diabetes, Insulin Resistance, Impaired Glucose Tolerance
- Trial name
- NCT00663000
- Where
- 6 sites in Germany
- Volunteers
- 138 people
- Sponsor
- University Hospital Tuebingen
Healthy Humans
Processing of Salient Emotional Stimuli as a Function of Tetrahydrocannabinol (THC) and Cannabidiol (CBD)
Attentional blink refers to a phenomenon where the detection of the second of two target stimuli that are presented in Short succession within a stream of stimuli is impaired.
- Trial name
- AB_THC_CBD (NCT02291536)
- Testing
- tetrahydrocannabinol, cannabidiol
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Central Institute of Mental Health, Mannheim
Amyotrophic Lateral Sclerosis
Phase III Trial of AMX0035 for Amyotrophic Lateral Sclerosis Treatment
The Phoenix Trial is a randomized double blind placebo controlled Phase III trial to evaluate the safety and efficacy of AMX0035 for treatment of ALS
- Trial name
- Phoenix (NCT05021536)
- Testing
- AMX0035
- Where
- 69 sites in United States, Belgium and 10 more
- Volunteers
- 664 people
- Sponsor
- Amylyx Pharmaceuticals Inc.
Cerebrovascular Accident, Deglutition Disorders
Exercise for Swallowing Problems After Stroke
The purpose of this study is to determine whether stroke patients with swallowing problems will show greater swallowing improvement with intense oral exercise than subjects who perform either a low intensity oral exercise or a…
- Trial name
- NCT00722111
- Testing
- lingual press, effortful swallowing, natural swallowing
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- VA Office of Research and Development
Intracranial Atherosclerosis
A Study of Implantation of CRENEOUS ENTERPRISE 2 Intracranial Stent in Participants With Severe Symptomatic Intracranial Atherosclerotic Stenosis
The purpose of this study is to evaluate the safety and effectiveness of CERENOVUS ENTERPRISE 2 intracranial stent implantation in treatment of participants with severe symptomatic intracranial atherosclerotic stenosis.
- Trial name
- NCT05316311
- Testing
- CERENOVUS ENTERPRISE 2 Intracranial Stent
- Where
- 14 sites in China
- Volunteers
- 194 people
- Sponsor
- Medos International SARL
Parkinson's Disease
A Clinical Trial of Parkinson's Disease Treatment by HiPSCs Derived Dopaminergic Neural Precursor Cells
XellSmart Biomedical (Suzhou) Co., Ltd. has closely collaborated with Shanghai East Hospital(East Hospital Affiliated To Tongji University) , using iPSC seed cells, on the development and establishment of a dopaminergic neural…
- Trial name
- hiPSC-DAP (NCT06145711)
- Testing
- hiPSC-DAP
- Where
- 2 sites in China
- Volunteers
- 3 people
- Sponsor
- Shanghai East Hospital
Parkinson Disease
Effects of Rock Climbing on Parkinson's Disease
This research study is being conducted to understand the outcomes of participation in the Up ENDing Parkinson's rock climbing program (24 sessions, or twice per week for about 12 weeks) on walking \& mobility, hand strength \&…
- Trial name
- NCT05919771
- Testing
- rock climbing
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Marymount University
Non-small Cell Lung Cancer Metastatic
High-dose Furmonertinib Combined With Bevacizumab and Intrathecal Pemetrexed Chemotherapy in Patients With EGFR-mutated Non-small Cell Lung Cancer and Meningeal Metastasis
the study conducted to evaluate the efficacy and safety of high-dose furmonertinib (160 mg qd) combined with bevacizumab and pemetrexed intrathecal chemotherapy in NSCLC patients with EGFR mutations and meningeal metastases.
- Trial name
- NCT06812871
- Testing
- furmonertinib
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Sun Yat-sen University
Moyamoya Disease, Ischemic Cerebral Infarction
NBP in Patients With Moyamoya Disease of High Risk for Ischemic Cerebrovascular Events
An extracranial-to-intracranial (EC-IC) revascularization is the most widely used treatment to improve cerebral perfusion in patients with moyamoya disease (MMD), and it has been shown to reduce the risk of subsequent stroke and…
- Conditions
- Moyamoya Disease, Ischemic Cerebral Infarction, Ischemic Stroke, Ischemic Cerebrovascular Accident
- Trial name
- NICE-MMD (NCT04205578)
- Testing
- dl-3-n-butylphthalide (NBP), Normal Saline 0.9% Infusion Solution
- Where
- 2 sites in China
- Volunteers
- 450 people
- Sponsor
- yuanli Zhao
Prader-Willi Syndrome
Gut Derived Hormones, Body Composition and Metabolism in Prader-Willi Syndrome
The purpose of this study is to investigate the effects of a GLP-1 agonist on satiety hormones in patients with Prader-Willi Syndrome (genetic defect causing obesity).
- Trial name
- NCT00551343
- Testing
- Exenatide
- Where
- Australia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Garvan Institute of Medical Research
Epilepsy, Chronic Pain
Impact of Polymorphisms of OCT2 and OCTN1 on the Kinetic Disposition of Gabapentin in Patients Undergoing Chronic Use
This study aims to evaluate the influence of genetic polymorphisms of OCTN1 and OCT2 and other possible covariates on the kinetic disposition of GAB in patients undergoing GAB chronic treatment.
- Trial name
- NCT02977208
- Testing
- Sparse blood sampling, Urine sampling, DNA extraction
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- São Paulo State University
Cerebral Palsy
PedBot Ankle Rehablitation
The primary objective of the study is to determine engagement with use and adherence to a home exercise program with our PedBotHome ankle rehabilitation device.
- Trial name
- NCT05825508
- Testing
- ankle robot
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's National Research Institute
Down Syndrome, Obstructive Sleep Apnea Syndrome
Obstructive Sleep Apnea and Neurocognitive and Cardiovascular Function in Children With Down Syndrome
Many individuals with Down syndrome (DS) have breathing problems during sleep. This is called obstructive sleep apnea syndrome (OSAS).
- Trial name
- TRIO (NCT01808508)
- Testing
- Continuous positive airway pressure
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Children's Hospital of Philadelphia
Alzheimer Disease
Tricaprilin Phase 3 ALTER-AD (Alternative-Alzheimer Disease) Study
The purpose of this study is to evaluate the effects of tricaprilin (20 g twice a day) on cognition, global function, activities of daily living, resource utilisation, safety, and tolerability, in participants with mild to…
- Trial name
- ALTER-AD (NCT05809908)
- Testing
- Tricaprilin
- Volunteers
- 535 people
- Sponsor
- Cerecin
Chronic Migraine
Use of the Tx360 Nasal Applicator in the Treatment of Chronic Migraine
Migraine imposes a substantial burden on patients in terms of diminished daily functioning, quality of life, and financial loss.
- Trial name
- Tx360 (NCT01709708)
- Testing
- Marcaine, Saline
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Tian Medical Inc.
Stroke, Transient Ischemic Attacks
Atrial Fibrillation as a Cause of Stroke and Intracranial Hemorrhage Study (The FibStroke Study)
The aim of this study is to evaluate the role of atrial fibrillation (AF) and its treatment in relation to thromboembolic events (stroke, and transient ischemic attacks) and intracranial hemorrhage.
- Conditions
- Stroke, Transient Ischemic Attacks, Intracranial Hemorrhage, Atrial Fibrillation
- Trial name
- FibStroke (NCT02146040)
- Where
- 4 sites in Finland
- Volunteers
- 5,885 people
- Sponsor
- University of Turku
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